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Understanding adaptive roles of gene expression noise by manipulating noise and heredity levels

Research Project

Project/Area Number 15KT0075
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeMulti-year Fund
Section特設分野
Research Field Constructive Systems Biology
Research InstitutionThe University of Tokyo

Principal Investigator

Wakamoto Yuichi  東京大学, 大学院総合文化研究科, 准教授 (30517884)

Project Period (FY) 2015-07-10 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords遺伝子発現ゆらぎ / パーシスタンス / 薬剤耐性
Outline of Final Research Achievements

The adaptation phenomena of bacterial clonal cell populations include persistence, which occurs on the timescale of several generations, and long-term adaptation that occurs over tens to hundreds of generations. In this research project, we constructed E. coli cell strains with altered statistical properties of expression noise of survival-correlated genes. We then analyzed their drug response in detail using our unique single-cell measurement technology. We also constructed an analytical framework for quantitative evaluation of fitness landscape and selection strength based on the information of cell lineage trees and expression fluctuation. From these experiments, we revealed that multiple survival modes coexist in bacterial persistence and that long-term adaptation to drugs occurs through the remodeling of global gene expression state.

Academic Significance and Societal Importance of the Research Achievements

本研究課題の成果により、遺伝子発現のゆらぎの統計的性質が細胞集団の適応応答の関係すること、一方で、長期的に起こる適応応答は、生存関連因子の発現量の大小にほとんど依存せず発生することが明らかになった。これらの結果から、短い時間スケールで起こる適応では局所的な応答が重要な役割を果たす一方、生存細胞の中ではより安定な適応を実現するグローバルな状態変化が長い時間をかけて起こることが明らかになった。また、同一集団内で複数の生存モード、発現状態が観察されたことから、従来の集団計測の限界と1細胞時系列解析の重要性を明らかにした。これらの成果は、細菌の耐性獲得の抑制手法の確立にもつながると考えられる。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (70 results)

All 2020 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (4 results) Journal Article (11 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 10 results,  Open Access: 8 results,  Acknowledgement Compliant: 1 results) Presentation (48 results) (of which Int'l Joint Research: 20 results,  Invited: 20 results) Remarks (4 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 2 results)

  • [Int'l Joint Research] ニューヨーク大学(米国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] ニューヨーク大学(米国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] ニューヨーク大学/ロックフェラー大学(米国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] ニューヨーク大学/ロックフェラー大学(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Estimating Cellular Transcriptomes from Raman Spectra2020

    • Author(s)
      小林鉱石, 亀井健一郎, 中岡秀憲, 若本祐一
    • Journal Title

      Seibutsu Butsuri

      Volume: 60 Issue: 2 Pages: 108-110

    • DOI

      10.2142/biophys.60.108

    • NAID

      130007818360

    • ISSN
      0582-4052, 1347-4219
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 細胞のラマンスペクトルから遺伝子発現プロファイルを推定する新手法2019

    • Author(s)
      亀井健一郎, 小林鉱石, 中岡秀憲, 若本祐一
    • Journal Title

      バイオサイエンスとインダストリー

      Volume: 77 Pages: 17-21

    • NAID

      40021786782

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Linear Regression Links Transcriptomic Data and Cellular Raman Spectra2018

    • Author(s)
      Kobayashi-Kirschvink, K. J., Nakaoka, H., Oda, A., Kamei, K. F., Nosho, K., Fukushima, H., Kanesaki, Y., Yajima, S., Masaki, H., Ohta, K., Wakamoto, Y.
    • Journal Title

      Cell Systems

      Volume: 7 Issue: 1 Pages: 104-117

    • DOI

      10.1016/j.cels.2018.05.015

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aging, mortality, and the fast growth trade-off of Schizosaccharomyses pombe2017

    • Author(s)
      Nakaoka, H., Wakamoto, Y.
    • Journal Title

      PLoS Biology

      Volume: 15 Issue: 6 Pages: e2001109-e2001109

    • DOI

      10.1371/journal.pbio.2001109

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcriptomes and Raman spectra are linked linearly through a shared low-dimensional subspace2017

    • Author(s)
      Kobayashi-Kirschvink, K. J., Nakaoka, H., Oda, A., Kamei, K. F., Nosho, K., Fukushima, H., Kanesaki, Y., Yajima, S., Masaki, H., Ohta, K., Wakamoto, Y.
    • Journal Title

      bioRxiv

      Volume: NA Pages: 235580-235580

    • DOI

      10.1101/235580

    • Related Report
      2017 Research-status Report
    • Open Access
  • [Journal Article] Measurement of Environmental Response and Selection at the Single-Cell Level2017

    • Author(s)
      中岡秀憲, 梅谷実樹, 若本祐一
    • Journal Title

      KAGAKU TO SEIBUTSU

      Volume: 55 Issue: 4 Pages: 263-268

    • DOI

      10.1271/kagakutoseibutsu.55.263

    • NAID

      130006516066

    • ISSN
      0453-073X, 1883-6852
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inferring fitness landscapes and selection on phenotypic states from single-cell genealogical data2017

    • Author(s)
      T. Nozoe, E. Kussell, and Y. Wakamoto
    • Journal Title

      PLoS Genetics

      Volume: 13 Issue: 3 Pages: e1006653-e1006653

    • DOI

      10.1371/journal.pgen.1006653

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Microfluidic lighthouse: an omnidirectional gradient generator2016

    • Author(s)
      Akihiko Nakajima, Motohiko Ishida, Taihei Fujimori, Yuichi Wakamoto, Satoshi Sawai
    • Journal Title

      Lab on Chip

      Volume: 16(22) Issue: 22 Pages: 4382-4394

    • DOI

      10.1039/c6lc00898d

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Noise-driven growth rate gain in clonal cellular populations2016

    • Author(s)
      Hashimoto, M., Nozoe, T., Nakaoka, H., Okura, R., Akiyoshi, S., Kaneko, K., Kussell, E., Wakamoto, Y.
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 113 Issue: 12 Pages: 3251-3256

    • DOI

      10.1073/pnas.1519412113

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bacterial autoimmunity due to a restriction-modification system2016

    • Author(s)
      Pleska, M., Qian, L., Okura, R., Bergmiller, T., Wakamoto, Y., Kussell, E., Guet, C. C.
    • Journal Title

      Current Biology

      Volume: 26 Issue: 3 Pages: 404-409

    • DOI

      10.1016/j.cub.2015.12.041

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 細胞表現型ゆらぎの適応的意義と1細胞統計2015

    • Author(s)
      若本祐一
    • Journal Title

      顕微鏡

      Volume: 50 Pages: 86-91

    • NAID

      130007701767

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Bacterial proteomes are predictable from cellular Raman spectra2020

    • Author(s)
      Kamei, K. F., Kobayashi-Kirschvink, K. J., Nakaoka, H., Wakamoto, Y.
    • Organizer
      APS March Meeting 2020
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Predicting transcriptomic states in living cells from Raman spectra2019

    • Author(s)
      Wakamoto, Y.
    • Organizer
      UBI-NanoLSI Joint Workshop
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Dynamic association between gene expression and fitness in adaptive resistance2019

    • Author(s)
      梅谷実樹、橋本幹弘、大倉玲子、古澤力、若本祐一
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] History Dependent Phenotypic Buffering of Bacteria against Drug Resistant Gene Deletion2019

    • Author(s)
      小金澤優太、佐藤守俊、若本祐一
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] History-dependent Maintenance of Drug Resistant Phenotypes against Resistant Gene Deletion2019

    • Author(s)
      Koganezawa, K., Sato, M., Wakamoto, Y.
    • Organizer
      qBio 2019 Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 耐性遺伝子の除去に抗した薬剤耐性表現型の履歴依存的な維持2019

    • Author(s)
      小金澤優太、佐藤守俊、若本祐一
    • Organizer
      第13回細菌学若手コロッセウム in みやぎ蔵王
    • Related Report
      2019 Annual Research Report
  • [Presentation] 耐性遺伝子の除去に抗した薬剤耐性表現型の履歴依存的な維持2019

    • Author(s)
      小金澤優太、佐藤守俊、若本祐一
    • Organizer
      第91回日本遺伝学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] History-dependent maintenance of resistant phenotype against resistant gene deletion2019

    • Author(s)
      小金澤優太、梅谷実樹、佐藤守俊、若本祐一
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 大腸菌のパーシスタンス現象で観察される多様な生存モード2019

    • Author(s)
      梅谷実樹、藤澤美穂、大倉玲子、若本祐一
    • Organizer
      第13回 日本ゲノム微生物学会 若手の会 研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Enhancement of multimodality of adaptive drug resistance at the single-cell level2019

    • Author(s)
      Miki Umetani
    • Organizer
      The 8th human ecology seminar
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Slow adaptation to low-glucose environments2019

    • Author(s)
      Nakaoka, H., Wakamoto, Y.
    • Organizer
      10th International Fission Yeast Meeting POMBE 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Prediction of Bacterial Growth Curves from Cellular Raman Spectra2019

    • Author(s)
      亀井健一郎、小林鉱石、若本祐一
    • Organizer
      第19回東京大学生命科学シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 大腸菌の進化過程における集団成長率の変化に対する1細胞レベルでの成長率のばらつきの寄与の評価2019

    • Author(s)
      山内竣平、若本祐一
    • Organizer
      2019年度(第29回)日本数理生物学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 細胞ラマンスペクトルを用いたトランスクリプトームの非破壊測定2019

    • Author(s)
      若本祐一
    • Organizer
      形態解析ワークショップ ー 多様な顕微鏡を用いて
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 細胞ラマンスペクトルを用いたトランスクリプトームの非破壊測定2019

    • Author(s)
      若本祐一
    • Organizer
      農芸化学会2019年度大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] History Dependent Phenotypic Buffering of Bacteria against Drug Resistant Gene Deletion2019

    • Author(s)
      Koganezawa, Y., Sato, M., Wakamoto, Y.
    • Organizer
      Winter Q-Bio 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 1細胞レベルの成長率のキュムラントによる集団の成長率の理解2019

    • Author(s)
      山内竣平、若本祐一
    • Organizer
      定量生物学の会 第九回年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Characterization of Population Growth Rates through Cumulants of Single-cell Growth Rates2019

    • Author(s)
      Yamauchi, S., Wakamoto, Y.
    • Organizer
      Winter Q-Bio 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Measuring the changes of cellular growth rate and selection in the evolutionary process of bacteria2019

    • Author(s)
      Mori, T., Yamauchi, S., Wakamoto, Y.
    • Organizer
      Winter Q-Bio 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Multimodal persistence and its history-dependent kinetics in antibiotic-stressed Escherichia coli2019

    • Author(s)
      Fujisawa, M., Umetani, M., Wakamoto, Y.
    • Organizer
      Winter Q-Bio 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 細菌パーシスタンスにおける生存モードの多様性2018

    • Author(s)
      若本祐一
    • Organizer
      第41回分子生物学会年会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] パーシスタンス現象の1細胞解析2018

    • Author(s)
      若本祐一
    • Organizer
      第3回抗酸菌研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 特殊な細胞ヒストリーをとらえる1細胞計測技術2018

    • Author(s)
      若本祐一
    • Organizer
      第32回さんわかセミナー
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 光遺伝子操作を利用した薬剤耐性遺伝型の変化に反する耐性表現型の長期的な維持2018

    • Author(s)
      小金澤優太, 佐藤守俊, 若本祐一
    • Organizer
      第18回生命科学シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] 光遺伝学を利用した薬剤耐性における遺伝型-表現型の履歴依存性の解明2018

    • Author(s)
      小金澤優太, 佐藤守俊, 若本祐一
    • Organizer
      日本遺伝学会第90会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 光遺伝子組換えに反した薬剤耐性表現型の長期的な維持2018

    • Author(s)
      小金澤優太, 佐藤守俊, 若本祐一
    • Organizer
      生命科学系フロンティアミーティング2018
    • Related Report
      2018 Research-status Report
  • [Presentation] 有害遺伝子変異に対する表現型バッファの履歴依存性2018

    • Author(s)
      小金澤優太, 佐藤守俊, 若本祐一
    • Organizer
      第17回微生物研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] Cumulant expansion of population growth rate of cellular reproductive systems2018

    • Author(s)
      Yamauchi, S., Wakamoto, Y.
    • Organizer
      Advances in Physics of Emergent orders in Fluctuations
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] A new measure of the interrelation of cellular phenotypes in cellular reproductive systems2018

    • Author(s)
      山内竣平、若本祐一
    • Organizer
      第56回日本生物物理学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 大腸菌のパーシスタンス現象における生存モードの多様性と履歴依存性について2018

    • Author(s)
      藤澤美穂、梅谷実樹、若本祐一
    • Organizer
      生命科学フロンティアミーティング2018
    • Related Report
      2018 Research-status Report
  • [Presentation] Multimodal persistence of antibiotic-stressed Escherichia coli2018

    • Author(s)
      Fujisawa, M., Umetani, M., Wakamoto, Y.
    • Organizer
      第56回日本生物物理学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Multitudes of persistence modes and subsequent re-growing kinetics in antibiotic-stressed Escherichia coli2018

    • Author(s)
      Fujisawa, M., Wakamoto, Y.
    • Organizer
      Winter Q-Bio 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] On the linearity between Raman spectra and transcriptomes2018

    • Author(s)
      Kamei, K.F., Kobayashi-Kirschvink, K.J., Nakaoka, H., Oda, A., Ohta, K., Wakamoto, Y.
    • Organizer
      Winter Q-Bio 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Long-term maintenance of resistant phenotype against optogenetical modification of genotype in Escherichia coli2018

    • Author(s)
      Koganezawa, Y., Sato, M., Wakamoto, Y.
    • Organizer
      Winter Q-Bio 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Non-genetic adaptation of antibiotic-stressed Escherichia coli2018

    • Author(s)
      Umetani, M., Hashimoto, M., Fujisawa, M., Furusawa, C., Wakamoto, Y.
    • Organizer
      Winter Q-Bio 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Growth, Death, and Aging in Fission Yeast2017

    • Author(s)
      Nakaoka, H., Wakamoto, Y.
    • Organizer
      9th International Fission Yeast Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Heterogeneous response of lymphocytic cells to Mitomycin-C revealed by microfluidic single-cell time-lapse microscopy2017

    • Author(s)
      Seita, A., Wakamoto, Y.
    • Organizer
      Single-Cell Biophysics: Measurement, Modulation, and Modeling
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Differences in growth statistics in different schemes of long-term single-cell measurements2017

    • Author(s)
      Yamauchi, S., Nakaoka, H., Wakamoto, Y.
    • Organizer
      Single-Cell Biophysics: Measurement, Modulation, and Modeling
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Unique single-cell histories that adapt to antibiotic stress2017

    • Author(s)
      若本 祐一
    • Organizer
      第90回日本細菌学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Constraints and limits in the growth of microbial cells2017

    • Author(s)
      Wakamoto, Y.
    • Organizer
      Physical Approaches for Growing and Evolving Population
    • Place of Presentation
      東京大学生産技術研究所(東京都目黒区)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] バクテリアの適応ダイナミクスの1細胞解析2016

    • Author(s)
      若本祐一
    • Organizer
      生命動態システム科学四拠点・CREST・PRESTO・QBiC合同シンポジウム「生命動態の分子メカニズムと数理」
    • Place of Presentation
      シェラトンホテル広島(広島県広島市)
    • Year and Date
      2016-03-25
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Fitness and gene expression from the viewpoint of single-cell lineages2016

    • Author(s)
      Wakamoto, Y.
    • Organizer
      QBio NIG International Symposium
    • Place of Presentation
      東京大学生産技術研究所(東京都目黒区)
    • Year and Date
      2016-01-11
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Single-cell dynamics leading to drug resistance acquisition2016

    • Author(s)
      Wakamoto, Y.
    • Organizer
      International Symposium on Universal Biology
    • Place of Presentation
      東京大学本郷キャンパス(東京都文京区)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Acquisition of drug resistance at the single-cell level2016

    • Author(s)
      Wakamoto, Y.
    • Organizer
      第54回日本生物物理学会年会
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] ストレス環境に対する適応・順応を担う特殊細胞系列の解析2016

    • Author(s)
      若本 祐一
    • Organizer
      「細胞を創る」研究会9.0
    • Place of Presentation
      早稲田大学国際会議場(東京都新宿区)
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Techniques for measuring and analyzing single-cell histories and lineage trees2016

    • Author(s)
      Wakamoto, Y.
    • Organizer
      日本顕微鏡学会第59回シンポジウム
    • Place of Presentation
      帝京平成大学池袋キャンパス(東京都豊島区)
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 細胞の増殖と死に見られる定量法則2015

    • Author(s)
      若本祐一
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Growth and adaptation at the single-cell level2015

    • Author(s)
      Wakamoto, Y.
    • Organizer
      QBiC Symposium 2015: High-Dimensional Data for the Design Principles of Life
    • Place of Presentation
      理化学研究所生命システム研究センター(大阪府吹田市)
    • Year and Date
      2015-08-24
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Remarks] 若本研究室ホームページ

    • URL

      http://park.itc.u-tokyo.ac.jp/wakamoto-lab/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 若本研究室ホームページ

    • URL

      http://webpark1706.sakura.ne.jp

    • Related Report
      2018 Research-status Report 2017 Research-status Report
  • [Remarks] プレスリリース:分裂酵母における成長と死のトレードオフ

    • URL

      http://www.c.u-tokyo.ac.jp/info/news/topics/files/20170622pressrelease.pdf

    • Related Report
      2017 Research-status Report
  • [Remarks] 若本研究室ホームページ/RESEARCH

    • URL

      http://webpark1706.sakura.ne.jp/research/

    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] TRANSCRIPTOME ESTIMATION DEVICE AND TRANSCRIPTOME ESTIMATION METHOD2018

    • Inventor(s)
      Wakamoto, Y., Kobayashi, K.
    • Industrial Property Rights Holder
      Wakamoto, Y., Kobayashi, K.
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Acquisition Date
      2019
    • Related Report
      2019 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] Transcriptome estimation device and transcriptome estimation method2018

    • Inventor(s)
      Wakamoto, Y., Kobayashi, K.
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Research-status Report
    • Overseas
  • [Patent(Industrial Property Rights)] トランスクリプトーム推定装置およびトランスクリプトーム推定方法2017

    • Inventor(s)
      若本祐一、小林鉱石
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-234164
    • Filing Date
      2017
    • Related Report
      2017 Research-status Report

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Published: 2015-07-14   Modified: 2022-11-04  

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