| Budget Amount *help |
¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Outline of Final Research Achievements |
To fully understand the plasticity of neuronal circuit underlying the learning and memory in animals, we need a technique that enables large scale recordings of multiple neuronal activity and/or functional changes of synapses at the same time. For this aim, here I have developed a fluorescent imaging probe for membrane potential that reports neuronal activities in real-time. Voltage imaging enabled to observe spatio-temporal pattern of neuronal circuit and its plastic changes.
In addition, combined application of fluorescent imaging technique and sub-cellular patch-clamp method have clarified mechanisms of plasticity at various synapses in the cerebellar circuit.
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