International comparative collaboration study of frailty among the oldest old

• Project/Area Number: 15KT0091
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 特設分野
• Research Field: Neo-Gerontology
• Research Institution: Keio University
• Principal Investigator: Takayama Michiyo 慶應義塾大学, 医学部(信濃町), 講師 (60265824)
• Co-Investigator(Kenkyū-buntansha): 新井 康通 慶應義塾大学, 医学部(信濃町), 講師 (20255467)
• Co-Investigator(Renkei-kenkyūsha): IINUMA Toshimitsu 日本大学, 歯学部, 教授 (10246902) ; OGUMA Yuko 慶應義塾大学, スポーツ医学研究センター, 准教授 (00255449) ; HIRATA Takumi 慶應義塾大学, 医学部, 特任助教 (00383795) ; HIROSE Nobuyoshi 慶應義塾大学, 医学部, 特別招聘教授 (90142421)
• Research Collaborator: OSAWA Yusuke ; ABE Yukiko ; FUKUMOTO Motoko ; KOBAYASHI Satomi ; KAWASAKI Midori ; SATO Ryohei
• Project Period (FY): 2015-07-10 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 超高齢者 / フレイル / 健康長寿 / 疫学研究 / 国際比較共同研究 / 国際共同研究 / コホート研究

Outline of Final Research Achievements

The Tokyo Oldest Old survey on Total Health (TOOTH) is a multidisciplinary study of the oldest old, those 85 years of age or older. The TOOTH is composed of three waves of comprehensive health research; the first wave was performed from 2008 to 2009, the second from 2011 to 2012, and the third from 2015 to 2016. We have collected longitudinal data relating to frailty, a major factor of disability among the oldest old. A total of 218 subjects, mean age 93.4±1.7 years, participated to the third wave. Cox hazard regression analyses revealed that IADL and grip power were negatively associated with the six-year mortality.
Since effectively managing the rapid aging of society is a worldwide challenge, an international collaborative team has been organized consisting of representatives from the UK, New Zealand, the Netherlands and Japan. The Japanese representatives will manage the international comparative collaboration study of the dietary habits and oral health among the oldest old.

Research Products

• [Int'l Joint Research] Newcastle大学(英国)
• [Int'l Joint Research] Auckland大学(ニュージーランド)
• [Int'l Joint Research] Leiden大学(オランダ)
• [Int'l Joint Research] Newcastle University/Institute for Ageing(英国)
• [Int'l Joint Research] Nescastle University/Institute for Ageing(英国)
• [Journal Article] Relationships between socio-clinico-demographic factors and cognitive screening scores in the oldest old living in the Tokyo Metropolitan area - Reanalysis of the Tokyo Oldest Old Survey on Total Health (TOOTH) (2018)
  • Author(s): Eguchi Y, Tasato K, Nakajima S, Noda Y, Tsugawa T, Shinagawa S, Niimura H, Hirose N, Arai Y, Mimura M
  • Journal Title: International Journal of Geriatric Psychiatry Volume: Epub Issue: 7 Pages: 926-933
  • DOI: 10.1002/gps.4873
  • Peer Reviewed
• [Journal Article] Carotid Plaque Score and Risk of Cardiovascular Mortality in the Oldest Old: Results from the TOOTH Study (2018)
  • Author(s): Hirata T, Arai Y, Takayama M, Abe Y, Ohkuma K, Takebayashi T.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 1 Pages: 55-64
  • DOI: 10.5551/jat.37911
  • NAID: 130006301203
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Relative validity of brief-type self-administered diet history questionnaire among very old Japanese aged 80 years and older. (2018)
  • Author(s): Kobayashi S, Yuan X, Sasaki S, Osawa Y, Hirata T, Abe Y, Takayama M, Arai Y, Masui Y, Ishizaki T.
  • Journal Title: Public Health Nutrition Volume: -
  • Peer Reviewed
• [Journal Article] Relationships of muscle echo intensity with walking ability and physical activity in the very old population. (2017)
  • Author(s): Osawa Y, Arai Y, Oguma Y, Hirata T, Abe Y, Azuma K, Takayama M, Hirose N.
  • Journal Title: J Aging Phys Act. Volume: 25 Issue: 2 Pages: 189-195
  • DOI: 10.1123/japa.2015-0203
  • Peer Reviewed
• [Journal Article] Identification of Dietary Patterns and their Relationships with General and Oral Health in the Very Old. (2017)
  • Author(s): Osawa Y, Arai Y,Takayama M, Hirata T, Kawasaki M, Abe Y, Iinuma T, Sasaki S, Hirose N.
  • Journal Title: Asia Pac J Clin Nutr Volume: 26 Pages: 262-270
  • Peer Reviewed / Open Access
• [Journal Article] Validation of questionnaire-assessed physical activity in comparison with objective measures using accelerometers and physical performance measures among community-dwelling adults aged >=85 years in Tokyo, Japan. (2017)
  • Author(s): Oguma Y, Osawa Y, Takayama M, Abe Y, Tanaka S, Lee IM, Arai Y.
  • Journal Title: J Phys Act Health. Volume: 14 Issue: 4 Pages: 245-252
  • DOI: 10.1123/jpah.2016-0208
  • Peer Reviewed
• [Journal Article] Perceived swallowing problems and mortality risk in very elderly people ≧ 85 years old: Results of the Tokyo Oldest Old Survey on Total Health study (2017)
  • Author(s): Iinuma T, Hirata T, Arai Y, Takayama M, Abe Y, Fukumoto M, Fukui Y, Gionhaku N
  • Journal Title: Gerodontology Volume: ー Issue: 3 Pages: 313-319
  • DOI: 10.1111/ger.12265
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The drug burden of anticholinergics and sedatives and influence on outcomes in the community-living oldest old: The Tokyo Oldest Old survey on Total Health (TOOTH) survey (2017)
  • Author(s): 佐藤 亮平, 新井 康通, 阿部 由紀子, 高山 美智代, 漆原 尚巳
  • Journal Title: Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics Volume: 54 Issue: 3 Pages: 403-416
  • DOI: 10.3143/geriatrics.54.403
  • NAID: 130006022878
  • ISSN: 0300-9173
  • Peer Reviewed / Open Access
• [Journal Article] Association between maximum occlusal force and 3-year all-cause mortality in community-dwelling elderly people (2016)
  • Author(s): Iinuma T，Arai Y，Takayama M，Abe Y，Ito T，Kondo Y，Hirose N，Gionhaku N
  • Journal Title: BMC Oral Health Volume: 16 Issue: 1 Pages: 82-82
  • DOI: 10.1186/s12903-016-0283-z
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Carotid atherosclerosis, cytomegalovirus infection, and cognitive decline in the very old: a community-based prospective cohort study. (2016)
  • Author(s): Kawasaki M, Arai Y, Takayama M, Hirata T, Takayama M, Abe Y, Niimura H, Mimura M, Takebayashi T, Hirose N.
  • Journal Title: Age (Dordr) Volume: 38（2） Issue: 2 Pages: 29-29
  • DOI: 10.1007/s11357-016-9890-5
  • Peer Reviewed
• [Journal Article] Identification of dietary patterns and their relationships with general and oral health in the very old. (2016)
  • Author(s): Osawa Y, Arai Y, Takayama M, Hirata T, Kawasaki M, Abe Y, Iinuma T, Sasaki S, Hirose N.
  • Journal Title: Asia Pacific Journal of Clinical Nutrition Volume: 印刷中
  • Peer Reviewed / Open Access
• [Journal Article] Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians. (2015)
  • Author(s): Arai Y, Martin-Ruiz CM, Takayama M, Abe Y, Takebayashi T, Koyasu S, Suematsu M, Hirose N, von Zglinicki T.
  • Journal Title: EBioMedicine Volume: 2（10） Issue: 10 Pages: 1549-1558
  • DOI: 10.1016/j.ebiom.2015.07.029
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Personality, health behavior, and mortality in the very old. (2017)
  • Author(s): Michiyo Takayama, Yasumichi Arai, Takumi Hirata, Yusuke Osawa, Yukiko Abe, Toshimitsu Iinuma, Motoko Fukumoto, Midori Takayama.
  • Organizer: the 21st IAGG World Congress of Gerontology and Geriatrics.
  • Place of Presentation: サンフランシスコ（USA）
  • Year and Date: 2017-07-23
  • Int'l Joint Research
• [Presentation] 超高齢者におけるApoE遺伝子型と心血管リスクとの関連：TOOTH研究 (2017)
  • Author(s): 平田 匠、阿部 由紀子、高山 美智代、中澤 進、山村 憲、海老原 良典、新井康通
  • Organizer: 第59回日本老年医学会学術集会.
  • Place of Presentation: 名古屋国際会議場、愛知県名古屋市
  • Year and Date: 2017-06-14
• [Presentation] Electrocardiographic abnormalities and all-cause mortality. (2017)
  • Author(s): Hirata T, Arai Y, Takayama M, Abe Y, Hirose N.
  • Organizer: The 21st IAGG World Congress of Gerontology & Geriatrics.
  • Int'l Joint Research
• [Presentation] Personality, health behavior, and mortality in the very old. (2017)
  • Author(s): Hirata T, Arai Y, Takayama Michiyo, Osawa Y, Abe Y, Iinuma T, Fukumoto M, Takayama Midori.
  • Organizer: The 21st IAGG World Congress of Gerontology & Geriatrics.
  • Int'l Joint Research
• [Presentation] 超高齢者における頸動脈プラーク進展に寄与するバイオマーカーの検討． (2017)
  • Author(s): 新井康通、平田匠、阿部由紀子、高山美智代、山村憲、中澤進、海老原良典、広瀬信義．
  • Organizer: 第４９回日本動脈硬化学会総会・学術集会
• [Presentation] 超高齢者における頸動脈プラークスコアと３年後の認知機能低下の関連，TOOTH研究． (2017)
  • Author(s): 平田匠、新井康通、高山美智代、阿部由紀子、山村憲、海老原良典、広瀬信義．
  • Organizer: 第４９回日本動脈硬化学会総会・学術集会
• [Presentation] 超高齢者におけるApoE遺伝子型と心血管リスクとの関連，TOOTH研究． (2017)
  • Author(s): 平田匠、阿部由紀子、高山美智代、中澤進、山村憲、海老原良典、新井康通．
  • Organizer: 第５９回日本老年医学会学術集会・第３０回日本老年学会総会
• [Presentation] 東京在住超高齢者コホートTOOTH 薬剤負荷が患者アウトカムに与える影響． (2016)
  • Author(s): １．佐藤亮平、新井康通、阿部由紀子、髙山美智代、漆原尚巳．
  • Organizer: 第37回日本臨床薬理学会学術総会.
  • Place of Presentation: 米子コンベンションセンター、鳥取県米子市
  • Year and Date: 2016-12-01
• [Presentation] 口腔の働きが超高齢者の健康におよぼす影響 口腔機能が健康寿命の延伸に及ぼす影響． (2016)
  • Author(s): 飯沼利光、福本宗子、新井康通、近藤雄学、塩田洋平、李 淳、伊藤智加、髙山美智代、広瀬信義、祇園白信仁．
  • Organizer: 第23回日本歯科医学会総会.
  • Place of Presentation: 福岡国際会議場、福岡県福岡市
  • Year and Date: 2016-10-21
• [Presentation] 超高齢者における頸動脈プラークスコアと心血管疾患死亡の関連 TOOTH研究． (2016)
  • Author(s): 平田 匠、新井康通、髙山美智代、阿部由紀子、山村 憲、海老原良典、広瀬信義．
  • Organizer: 第48回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 京王プラザホテル、東京都新宿区
  • Year and Date: 2016-07-14
• [Presentation] 超高齢者コホート研究における脱落群の要因についての検討． (2016)
  • Author(s): 新井康通、髙山美智代、平田 匠、大澤祐介、阿部由紀子、中澤 進、山村 憲、海老原良典、広瀬信義．
  • Organizer: 第58回日本老年医学会学術集会.
  • Place of Presentation: 石川県立音楽堂、石川県金沢市
  • Year and Date: 2016-06-08
• [Presentation] 超高齢者の生命予後に影響する因子の多面的検討：６年間の縦断研究TOOTHより (2016)
  • Author(s): 高山 美智代, 新井 康通, 飯沼 利光, 高山 緑, 中澤 進, 山村 憲, 清水 健一郎, 海老原 良典, 広瀬 信義.
  • Organizer: 第58回日本老年医学会学術集会
  • Place of Presentation: 石川県立音楽堂（石川県金沢市）
  • Year and Date: 2016-06-08
• [Presentation] 超高齢者における3年間の骨折発症に関する危険因子の検討：TOOTH研究 (2016)
  • Author(s): 平田 匠, 高山 美智代, 新井 康通, 大澤 祐介, 阿部 由紀子, 中澤 進, 山村 憲, 海老原 良典, 広瀬 信義.
  • Organizer: 第58回日本老年医学会学術集会
  • Place of Presentation: 石川県立音楽堂（石川県金沢市）
  • Year and Date: 2016-06-08
• [Presentation] 地域在住85歳以上高齢者における食事パターンと口腔機能との関連性 (2015)
  • Author(s): 大澤 祐介, 高山 美智代, 広瀬 信義, 新井 康通.
  • Organizer: 第37回日本臨床栄養学会総会/第36回日本臨床栄養協会総会/第13回大連合大会
  • Place of Presentation: 都市センターホテル（東京都千代田区）
  • Year and Date: 2015-10-02
• [Presentation] 超高齢者において頸動脈プラークスコアは心血管疾患の新規発症と関連する TOOTH研究 (2015)
  • Author(s): 平田 匠, 新井 康通, 高山 美智代, 阿部 由紀子, 山村 憲, 海老原 良典, 広瀬 信義.
  • Organizer: 第47回日本動脈硬化学会総会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2015-07-10
• [Presentation] Correlates of cognitive impairment in the very old in different cultures: Japan and the UK. (2015)
  • Author(s): Arai Y, Robinson L, Granic A, Jagger C, Takayama M, Osawa Y.
  • Organizer: British Society of Gerontology Annual Conference
  • Place of Presentation: ニューカッスル（イギリス）
  • Year and Date: 2015-07-10
  • Int'l Joint Research
• [Presentation] Biomedical and lifestyle factors for cognitive decline in the very old. (2015)
  • Author(s): Osawa Y, Arai Y, Takayama M.
  • Organizer: British Society of Gerontology Annual Conference,
  • Place of Presentation: ニューカッスル（イギリス）
  • Year and Date: 2015-07-10
  • Int'l Joint Research
• [Remarks] 長寿社会における高齢者の暮らし方に関する学術調査（TOOTH)
  • URL: http://www.keio-centenarian.com/study/kourei
• [Remarks] 慶應義塾大学医学部百寿総合研究センター 85歳高齢者研究
  • URL: http://www.keio-centenarian.com/study/kourei