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International comparative collaboration study of frailty among the oldest old

Research Project

Project/Area Number 15KT0091
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section特設分野
Research Field Neo-Gerontology
Research InstitutionKeio University

Principal Investigator

Takayama Michiyo  慶應義塾大学, 医学部(信濃町), 講師 (60265824)

Co-Investigator(Kenkyū-buntansha) 新井 康通  慶應義塾大学, 医学部(信濃町), 講師 (20255467)
Co-Investigator(Renkei-kenkyūsha) IINUMA Toshimitsu  日本大学, 歯学部, 教授 (10246902)
OGUMA Yuko  慶應義塾大学, スポーツ医学研究センター, 准教授 (00255449)
HIRATA Takumi  慶應義塾大学, 医学部, 特任助教 (00383795)
HIROSE Nobuyoshi  慶應義塾大学, 医学部, 特別招聘教授 (90142421)
Research Collaborator OSAWA Yusuke  
ABE Yukiko  
FUKUMOTO Motoko  
KOBAYASHI Satomi  
KAWASAKI Midori  
SATO Ryohei  
Project Period (FY) 2015-07-10 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords超高齢者 / フレイル / 健康長寿 / 疫学研究 / 国際比較共同研究 / 国際共同研究 / コホート研究
Outline of Final Research Achievements

The Tokyo Oldest Old survey on Total Health (TOOTH) is a multidisciplinary study of the oldest old, those 85 years of age or older. The TOOTH is composed of three waves of comprehensive health research; the first wave was performed from 2008 to 2009, the second from 2011 to 2012, and the third from 2015 to 2016. We have collected longitudinal data relating to frailty, a major factor of disability among the oldest old. A total of 218 subjects, mean age 93.4±1.7 years, participated to the third wave. Cox hazard regression analyses revealed that IADL and grip power were negatively associated with the six-year mortality.
Since effectively managing the rapid aging of society is a worldwide challenge, an international collaborative team has been organized consisting of representatives from the UK, New Zealand, the Netherlands and Japan. The Japanese representatives will manage the international comparative collaboration study of the dietary habits and oral health among the oldest old.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (36 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (5 results) Journal Article (12 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 12 results,  Open Access: 7 results,  Acknowledgement Compliant: 2 results) Presentation (17 results) (of which Int'l Joint Research: 5 results) Remarks (2 results)

  • [Int'l Joint Research] Newcastle大学(英国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Auckland大学(ニュージーランド)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Leiden大学(オランダ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Newcastle University/Institute for Ageing(英国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Nescastle University/Institute for Ageing(英国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Relationships between socio-clinico-demographic factors and cognitive screening scores in the oldest old living in the Tokyo Metropolitan area - Reanalysis of the Tokyo Oldest Old Survey on Total Health (TOOTH)2018

    • Author(s)
      Eguchi Y, Tasato K, Nakajima S, Noda Y, Tsugawa T, Shinagawa S, Niimura H, Hirose N, Arai Y, Mimura M
    • Journal Title

      International Journal of Geriatric Psychiatry

      Volume: Epub Issue: 7 Pages: 926-933

    • DOI

      10.1002/gps.4873

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carotid Plaque Score and Risk of Cardiovascular Mortality in the Oldest Old: Results from the TOOTH Study2018

    • Author(s)
      Hirata T, Arai Y, Takayama M, Abe Y, Ohkuma K, Takebayashi T.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 25 Issue: 1 Pages: 55-64

    • DOI

      10.5551/jat.37911

    • NAID

      130006301203

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relative validity of brief-type self-administered diet history questionnaire among very old Japanese aged 80 years and older.2018

    • Author(s)
      Kobayashi S, Yuan X, Sasaki S, Osawa Y, Hirata T, Abe Y, Takayama M, Arai Y, Masui Y, Ishizaki T.
    • Journal Title

      Public Health Nutrition

      Volume: -

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationships of muscle echo intensity with walking ability and physical activity in the very old population.2017

    • Author(s)
      Osawa Y, Arai Y, Oguma Y, Hirata T, Abe Y, Azuma K, Takayama M, Hirose N.
    • Journal Title

      J Aging Phys Act.

      Volume: 25 Issue: 2 Pages: 189-195

    • DOI

      10.1123/japa.2015-0203

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of Dietary Patterns and their Relationships with General and Oral Health in the Very Old.2017

    • Author(s)
      Osawa Y, Arai Y,Takayama M, Hirata T, Kawasaki M, Abe Y, Iinuma T, Sasaki S, Hirose N.
    • Journal Title

      Asia Pac J Clin Nutr

      Volume: 26 Pages: 262-270

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Validation of questionnaire-assessed physical activity in comparison with objective measures using accelerometers and physical performance measures among community-dwelling adults aged >=85 years in Tokyo, Japan.2017

    • Author(s)
      Oguma Y, Osawa Y, Takayama M, Abe Y, Tanaka S, Lee IM, Arai Y.
    • Journal Title

      J Phys Act Health.

      Volume: 14 Issue: 4 Pages: 245-252

    • DOI

      10.1123/jpah.2016-0208

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Perceived swallowing problems and mortality risk in very elderly people ≧ 85 years old: Results of the Tokyo Oldest Old Survey on Total Health study2017

    • Author(s)
      Iinuma T, Hirata T, Arai Y, Takayama M, Abe Y, Fukumoto M, Fukui Y, Gionhaku N
    • Journal Title

      Gerodontology

      Volume: ー Issue: 3 Pages: 313-319

    • DOI

      10.1111/ger.12265

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The drug burden of anticholinergics and sedatives and influence on outcomes in the community-living oldest old: The Tokyo Oldest Old survey on Total Health (TOOTH) survey2017

    • Author(s)
      佐藤 亮平, 新井 康通, 阿部 由紀子, 高山 美智代, 漆原 尚巳
    • Journal Title

      Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics

      Volume: 54 Issue: 3 Pages: 403-416

    • DOI

      10.3143/geriatrics.54.403

    • NAID

      130006022878

    • ISSN
      0300-9173
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between maximum occlusal force and 3-year all-cause mortality in community-dwelling elderly people2016

    • Author(s)
      Iinuma T,Arai Y,Takayama M,Abe Y,Ito T,Kondo Y,Hirose N,Gionhaku N
    • Journal Title

      BMC Oral Health

      Volume: 16 Issue: 1 Pages: 82-82

    • DOI

      10.1186/s12903-016-0283-z

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Carotid atherosclerosis, cytomegalovirus infection, and cognitive decline in the very old: a community-based prospective cohort study.2016

    • Author(s)
      Kawasaki M, Arai Y, Takayama M, Hirata T, Takayama M, Abe Y, Niimura H, Mimura M, Takebayashi T, Hirose N.
    • Journal Title

      Age (Dordr)

      Volume: 38(2) Issue: 2 Pages: 29-29

    • DOI

      10.1007/s11357-016-9890-5

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of dietary patterns and their relationships with general and oral health in the very old.2016

    • Author(s)
      Osawa Y, Arai Y, Takayama M, Hirata T, Kawasaki M, Abe Y, Iinuma T, Sasaki S, Hirose N.
    • Journal Title

      Asia Pacific Journal of Clinical Nutrition

      Volume: 印刷中

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians.2015

    • Author(s)
      Arai Y, Martin-Ruiz CM, Takayama M, Abe Y, Takebayashi T, Koyasu S, Suematsu M, Hirose N, von Zglinicki T.
    • Journal Title

      EBioMedicine

      Volume: 2(10) Issue: 10 Pages: 1549-1558

    • DOI

      10.1016/j.ebiom.2015.07.029

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Personality, health behavior, and mortality in the very old.2017

    • Author(s)
      Michiyo Takayama, Yasumichi Arai, Takumi Hirata, Yusuke Osawa, Yukiko Abe, Toshimitsu Iinuma, Motoko Fukumoto, Midori Takayama.
    • Organizer
      the 21st IAGG World Congress of Gerontology and Geriatrics.
    • Place of Presentation
      サンフランシスコ(USA)
    • Year and Date
      2017-07-23
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 超高齢者におけるApoE遺伝子型と心血管リスクとの関連:TOOTH研究2017

    • Author(s)
      平田 匠、阿部 由紀子、高山 美智代、中澤 進、山村 憲、海老原 良典、新井康通
    • Organizer
      第59回日本老年医学会学術集会.
    • Place of Presentation
      名古屋国際会議場、愛知県名古屋市
    • Year and Date
      2017-06-14
    • Related Report
      2016 Research-status Report
  • [Presentation] Electrocardiographic abnormalities and all-cause mortality.2017

    • Author(s)
      Hirata T, Arai Y, Takayama M, Abe Y, Hirose N.
    • Organizer
      The 21st IAGG World Congress of Gerontology & Geriatrics.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Personality, health behavior, and mortality in the very old.2017

    • Author(s)
      Hirata T, Arai Y, Takayama Michiyo, Osawa Y, Abe Y, Iinuma T, Fukumoto M, Takayama Midori.
    • Organizer
      The 21st IAGG World Congress of Gerontology & Geriatrics.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 超高齢者における頸動脈プラーク進展に寄与するバイオマーカーの検討.2017

    • Author(s)
      新井康通、平田匠、阿部由紀子、高山美智代、山村憲、中澤進、海老原良典、広瀬信義.
    • Organizer
      第49回日本動脈硬化学会総会・学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 超高齢者における頸動脈プラークスコアと3年後の認知機能低下の関連,TOOTH研究.2017

    • Author(s)
      平田匠、新井康通、高山美智代、阿部由紀子、山村憲、海老原良典、広瀬信義.
    • Organizer
      第49回日本動脈硬化学会総会・学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 超高齢者におけるApoE遺伝子型と心血管リスクとの関連,TOOTH研究.2017

    • Author(s)
      平田匠、阿部由紀子、高山美智代、中澤進、山村憲、海老原良典、新井康通.
    • Organizer
      第59回日本老年医学会学術集会・第30回日本老年学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 東京在住超高齢者コホートTOOTH 薬剤負荷が患者アウトカムに与える影響.2016

    • Author(s)
      1.佐藤亮平、新井康通、阿部由紀子、髙山美智代、漆原尚巳.
    • Organizer
      第37回日本臨床薬理学会学術総会.
    • Place of Presentation
      米子コンベンションセンター、鳥取県米子市
    • Year and Date
      2016-12-01
    • Related Report
      2016 Research-status Report
  • [Presentation] 口腔の働きが超高齢者の健康におよぼす影響 口腔機能が健康寿命の延伸に及ぼす影響.2016

    • Author(s)
      飯沼利光、福本宗子、新井康通、近藤雄学、塩田洋平、李 淳、伊藤智加、髙山美智代、広瀬信義、祇園白信仁.
    • Organizer
      第23回日本歯科医学会総会.
    • Place of Presentation
      福岡国際会議場、福岡県福岡市
    • Year and Date
      2016-10-21
    • Related Report
      2016 Research-status Report
  • [Presentation] 超高齢者における頸動脈プラークスコアと心血管疾患死亡の関連 TOOTH研究.2016

    • Author(s)
      平田 匠、新井康通、髙山美智代、阿部由紀子、山村 憲、海老原良典、広瀬信義.
    • Organizer
      第48回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      京王プラザホテル、東京都新宿区
    • Year and Date
      2016-07-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 超高齢者コホート研究における脱落群の要因についての検討.2016

    • Author(s)
      新井康通、髙山美智代、平田 匠、大澤祐介、阿部由紀子、中澤 進、山村 憲、海老原良典、広瀬信義.
    • Organizer
      第58回日本老年医学会学術集会.
    • Place of Presentation
      石川県立音楽堂、石川県金沢市
    • Year and Date
      2016-06-08
    • Related Report
      2016 Research-status Report
  • [Presentation] 超高齢者の生命予後に影響する因子の多面的検討:6年間の縦断研究TOOTHより2016

    • Author(s)
      高山 美智代, 新井 康通, 飯沼 利光, 高山 緑, 中澤 進, 山村 憲, 清水 健一郎, 海老原 良典, 広瀬 信義.
    • Organizer
      第58回日本老年医学会学術集会
    • Place of Presentation
      石川県立音楽堂(石川県金沢市)
    • Year and Date
      2016-06-08
    • Related Report
      2015 Research-status Report
  • [Presentation] 超高齢者における3年間の骨折発症に関する危険因子の検討:TOOTH研究2016

    • Author(s)
      平田 匠, 高山 美智代, 新井 康通, 大澤 祐介, 阿部 由紀子, 中澤 進, 山村 憲, 海老原 良典, 広瀬 信義.
    • Organizer
      第58回日本老年医学会学術集会
    • Place of Presentation
      石川県立音楽堂(石川県金沢市)
    • Year and Date
      2016-06-08
    • Related Report
      2015 Research-status Report
  • [Presentation] 地域在住85歳以上高齢者における食事パターンと口腔機能との関連性2015

    • Author(s)
      大澤 祐介, 高山 美智代, 広瀬 信義, 新井 康通.
    • Organizer
      第37回日本臨床栄養学会総会/第36回日本臨床栄養協会総会/第13回大連合大会
    • Place of Presentation
      都市センターホテル(東京都千代田区)
    • Year and Date
      2015-10-02
    • Related Report
      2015 Research-status Report
  • [Presentation] 超高齢者において頸動脈プラークスコアは心血管疾患の新規発症と関連する TOOTH研究2015

    • Author(s)
      平田 匠, 新井 康通, 高山 美智代, 阿部 由紀子, 山村 憲, 海老原 良典, 広瀬 信義.
    • Organizer
      第47回日本動脈硬化学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2015-07-10
    • Related Report
      2015 Research-status Report
  • [Presentation] Correlates of cognitive impairment in the very old in different cultures: Japan and the UK.2015

    • Author(s)
      Arai Y, Robinson L, Granic A, Jagger C, Takayama M, Osawa Y.
    • Organizer
      British Society of Gerontology Annual Conference
    • Place of Presentation
      ニューカッスル(イギリス)
    • Year and Date
      2015-07-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Biomedical and lifestyle factors for cognitive decline in the very old.2015

    • Author(s)
      Osawa Y, Arai Y, Takayama M.
    • Organizer
      British Society of Gerontology Annual Conference,
    • Place of Presentation
      ニューカッスル(イギリス)
    • Year and Date
      2015-07-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Remarks] 長寿社会における高齢者の暮らし方に関する学術調査(TOOTH)

    • URL

      http://www.keio-centenarian.com/study/kourei

    • Related Report
      2017 Annual Research Report
  • [Remarks] 慶應義塾大学医学部百寿総合研究センター 85歳高齢者研究

    • URL

      http://www.keio-centenarian.com/study/kourei

    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-07-14   Modified: 2022-06-16  

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