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Elucidation of insulin signal transduction mechanism with mathematical analysis of network dynamics

Research Project

Project/Area Number 15KT0108
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section特設分野
Research Field Mathematical Sciences in Search of New Cooperation
Research InstitutionKyushu University

Principal Investigator

Matsuzaki Fumiko  九州大学, 生体防御医学研究所, 助教 (10631773)

Co-Investigator(Kenkyū-buntansha) 今井 哲郎  東京情報大学, 看護学部, 研究員 (10436173)
宇田 新介  九州大学, 生体防御医学研究所, 准教授 (20599609)
久保田 浩行  九州大学, 生体防御医学研究所, 教授 (40376603)
Co-Investigator(Renkei-kenkyūsha) MATSUMOTO Masaki  九州大学, 生体防御医学研究所・プロテオミクス分野, 准教授 (60380531)
Project Period (FY) 2015-07-10 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsインスリン情報伝達機構 / リン酸化プロテオミクス
Outline of Final Research Achievements

In this project, we focused on insulin signal transduction to see this phenomenon and its dynamic characteristics as completely as we could. Phosphoproteomics of time series liver samples taken during a four-hour period after insulin treatment was performed and the data were analyzed using statistical, infomatics and mathematical approaches. As a result, the dynamics of an insulin signaling transduction network with around 10,000 nodes representing protein phosphorylation, and its relation to various biological function were revealed. Furthermore, ordinary differential equation models among insulin, insulin signaling molecules and other protein phosphorylation were built on a large scale and the dynamics of the entire insulin signaling transduction network were characterized quantitatively.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (9 results)

All 2018 2017 2016 2015 Other

All Presentation (8 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Remarks (1 results)

  • [Presentation] Analysis of a coauthor network of nursing researchers2018

    • Author(s)
      Tetsuo Imai, Takayasu Kawaguchi
    • Organizer
      2018 International Symposium on Nonlinear Theory and Its Applications
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] トランスオミクスデータを用いた代謝システム解析の試み2017

    • Author(s)
      松崎芙美子
    • Organizer
      JSBi九州地域部会セミナー
    • Place of Presentation
      下関
    • Year and Date
      2017-03-11
    • Related Report
      2016 Research-status Report
  • [Presentation] 定量的トランスオミクス解析の試み2017

    • Author(s)
      松崎芙美子, 宇田新介, 久保田浩行
    • Organizer
      定量生物学の会 第八回年会
    • Place of Presentation
      岡崎
    • Year and Date
      2017-01-08
    • Related Report
      2016 Research-status Report
  • [Presentation] Metabolic systems analysis with multi-omics data2017

    • Author(s)
      Fumiko Matsuzaki
    • Organizer
      9th International Conference and Exhibition on Metabolomics and Systems Biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 日本の看護学研究における研究者ネットワークの分析2017

    • Author(s)
      今井哲郎, 川口孝泰
    • Organizer
      第14回情報処理学会ネットワーク生態学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] ウェブページのランク付け指標の妥当性の検証2016

    • Author(s)
      永田裕史, 今井哲郎,吉澤康介, 三宅修平
    • Organizer
      第49回日本大学生産工学部学術講演会
    • Place of Presentation
      習志野
    • Year and Date
      2016-12-03
    • Related Report
      2016 Research-status Report
  • [Presentation] Webページの評価指標の妥当性の評価2016

    • Author(s)
      永田裕史, 今井哲郎,吉澤康介, 三宅修平
    • Organizer
      第13回ネットワーク生態学シンポジウム
    • Place of Presentation
      木更津
    • Year and Date
      2016-08-22
    • Related Report
      2016 Research-status Report
  • [Presentation] Absolute quantification of all human metabolic enzymes and metabolic systems analysis2015

    • Author(s)
      Fumiko Matsuzaki, Masaki Matsumoto, Kiyotaka Oshikawa, Fumihide Shiraishi, Keiichi Nakayama
    • Organizer
      International Symposium on Synthetic Systems Biology
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Remarks] 九州大学 生体防御医学研究所 統合オミクス分野

    • URL

      http://www.bioreg.kyushu-u.ac.jp/labo/omics/

    • Related Report
      2017 Annual Research Report 2016 Research-status Report 2015 Research-status Report

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Published: 2015-07-14   Modified: 2019-03-29  

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