| Project/Area Number |
15KT0149
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 特設分野 |
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| Research Field |
Constructive Systems Biology
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| Research Institution | The Graduate University for Advanced Studies |
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Principal Investigator |
Tanabe Hideyuki 総合研究大学院大学, 先導科学研究科, 准教授 (50261178)
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| Project Period (FY) |
2015-07-10 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 染色体テリトリー / 染色体 / FISH法 / 3D-FISH法 / 核内配置 / テナガザル科 / 自己組織化 / 核型進化 / 転座切断点 / 霊長類 |
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| Outline of Final Research Achievements |
Individual chromosomes are occupied as chromosome territories (CTs) within the cell nucleus. How are CTs spatially localized? To explore this question, I focused on the gibbons showing the highest speed of karyotypic evolution in mammals, which have over 90 evolutionary conserved breakpoints (ECBs) between human and gibbons. Spatial radial arrangement of ECBs was analyzed by 3D-FISH technique onto the human and agile gibbon cell nuclei. In a case where ECBs are randomly and uniformly distributed in the nuclear space, it can be called as self-organization, random distribution model, whereas in cases where remarkable translocation occurs in a specific radial zone, it can be called a control factor induction model. Based on the results, I concluded that the former“self-organization, random distribution model”could be applied. Several data of radial distribution of repetitive sequences suggested radial arrangements have reflected the different distributed number of repetitive elements.
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