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Self-organization of chromosome territories within the cell nucleus with regard to chromosome evolution

Research Project

Project/Area Number 15KT0149
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section特設分野
Research Field Constructive Systems Biology
Research InstitutionThe Graduate University for Advanced Studies

Principal Investigator

Tanabe Hideyuki  総合研究大学院大学, 先導科学研究科, 准教授 (50261178)

Project Period (FY) 2015-07-10 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords染色体テリトリー / 染色体 / FISH法 / 3D-FISH法 / 核内配置 / テナガザル科 / 自己組織化 / 核型進化 / 転座切断点 / 霊長類
Outline of Final Research Achievements

Individual chromosomes are occupied as chromosome territories (CTs) within the cell nucleus. How are CTs spatially localized? To explore this question, I focused on the gibbons showing the highest speed of karyotypic evolution in mammals, which have over 90 evolutionary conserved breakpoints (ECBs) between human and gibbons. Spatial radial arrangement of ECBs was analyzed by 3D-FISH technique onto the human and agile gibbon cell nuclei. In a case where ECBs are randomly and uniformly distributed in the nuclear space, it can be called as self-organization, random distribution model, whereas in cases where remarkable translocation occurs in a specific radial zone, it can be called a control factor induction model. Based on the results, I concluded that the former“self-organization, random distribution model”could be applied. Several data of radial distribution of repetitive sequences suggested radial arrangements have reflected the different distributed number of repetitive elements.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (18 results)

All 2017 2016 2015 Other

All Int'l Joint Research (3 results) Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (9 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results) Remarks (2 results)

  • [Int'l Joint Research] University of Florence(Italy)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Ludwig Maximilians University, Munich(Germany)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Ludwig Maximilians University, Munich(Germany)

    • Related Report
      2015 Research-status Report
  • [Journal Article] 特集 核内イベントの時空間制御 Ⅳ.イメージング解析 3D-FISH法の新たな展開─マウス初期胚への応用2017

    • Author(s)
      田辺秀之、中家雅隆、三谷 匡
    • Journal Title

      生体の科学

      Volume: 68 Issue: 3 Pages: 237-242

    • DOI

      10.11477/mf.2425200619

    • ISSN
      0370-9531, 1883-5503
    • Year and Date
      2017-06-15
    • Related Report
      2017 Annual Research Report
  • [Journal Article] Co-Opted Megasatellite DNA Drives Evolution of Secondary Night Vision in Azara’s OwlMonkey2017

    • Author(s)
      1)Koga A, Tanabe H, Hirai Y, Imai H, Imamura M, Oishi T, Stanyon R, Hirai H
    • Journal Title

      Genome Biology and Evolution

      Volume: 9 Issue: 7 Pages: 1963-1970

    • DOI

      10.1093/gbe/evx142

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Visualization of the spatial arrangement of nuclear organization using three-dimensional fluorescence <i>in situ</i> hybridization in early mouse embryos: A new “EASI-FISH chamber glass” for mammalian embryos2017

    • Author(s)
      Nakaya M, Tanabe H, Takamatsu S, Hosokawa M, Mitani T
    • Journal Title

      Journal of Reproduction and Development

      Volume: 63 Issue: 2 Pages: 167-174

    • DOI

      10.1262/jrd.2016-172

    • NAID

      130007314628

    • ISSN
      0916-8818, 1348-4400
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Pair of Maternal Chromosomes Derived from Meiotic Nondisjunction in Trisomy 21 Affects Nuclear Architecture and Transcriptional Regulation2017

    • Author(s)
      Sayaka Omori, Hideyuki Tanabe, Kimihiko Banno, Ayumi Tsuji, Nobutoshi Nawa, Katsuya Hirata, Keiji Kawatani, Chikara Kokubu, Junji Takeda, Hidetoshi Taniguchi, Hitomi Arahori, Kazuko Wada, Yasuji Kitabatake1, and Keiichi Ozono
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 764-764

    • DOI

      10.1038/s41598-017-00714-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 核内ゲノム空間配置からみたテナガザルにおける核型高速進化2017

    • Author(s)
      田辺秀之
    • Organizer
      第34回 染色体ワークショップ・第15回 核ダイナミクス研究会合同開催
    • Place of Presentation
      かずさDNA研究所、オークラアカデミアパークホテル
    • Year and Date
      2017-01-11
    • Related Report
      2016 Research-status Report
  • [Presentation] EVOLUTIONARY CONSIDERATION FOR THE RADIAL DISTRIBUTION OF CHROMOSOME TERRITORIES IN HUMAN AND GIBBON CELL NUCLEI2017

    • Author(s)
      Hideyuki Tanabe
    • Organizer
      4D Nucleome: Cell Nucleus in Space and Time 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A NEW “EASI-FISH CHAMBER GLASS” FOR USE BY 3D-FISH TECHNIQUE: VISUALIZATION OF NUCLEAR SPATIAL ORGANIZATION IN EARLY MOUSE EMBRYOS2017

    • Author(s)
      Masataka Nakaya, Hideyuki Tanabe, Shingo Takamatsu, Misaki Hosokawa, Tasuku Mitani
    • Organizer
      4D Nucleome: Cell Nucleus in Space and Time 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 染色体テリトリー・クロマチン・DNA構造の細胞核内における空間配置の特性について2017

    • Author(s)
      田辺秀之
    • Organizer
      第40回 日本分子生物学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 染色体テリトリー・ゲノム空間配置からみたテナガザルにおける核型高速進化について2016

    • Author(s)
      田辺秀之
    • Organizer
      第67回 染色体学会年会
    • Place of Presentation
      東京大学農学部、一条ホール
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
  • [Presentation] Spatial organization of chromosome territories and repetitive DNA sequences in human and gibbon cell nuclei2016

    • Author(s)
      Hideyuki Tanabe
    • Organizer
      QBiC Symposium 2016 "Decoding Organisms by Quantitative Cell Profiling"
    • Place of Presentation
      Senri Life Science Center, Osaka
    • Year and Date
      2016-09-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ヒトおよびテナガザルにおける染色体テリトリー・反復配列DNAの細胞核内空間配置について:進化的視点よりの考察2016

    • Author(s)
      田辺秀之
    • Organizer
      第68回 日本細胞生物学会大会
    • Place of Presentation
      京都テルサ、京都
    • Year and Date
      2016-06-15
    • Related Report
      2016 Research-status Report
  • [Presentation] Global radial distribution of chromosome territories and its characteristics in relation to nuclear architecture2016

    • Author(s)
      Hideyuki Tanabe
    • Organizer
      BIT’s 6th Annual World Congress of Molecular and Cell Biology 2016
    • Place of Presentation
      Dalian International Conference Center, Dalian, China
    • Year and Date
      2016-04-25
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Global distribution of chromosome territories and nuclear architecture2015

    • Author(s)
      Hideyuki Tanabe
    • Organizer
      Invited Lecture for RcMcD
    • Place of Presentation
      RcMcD, Hiroshima University
    • Year and Date
      2015-07-17
    • Related Report
      2015 Research-status Report
    • Invited
  • [Remarks] 田辺 秀之 准教授 分子細胞遺伝学・染色体ゲノム進化学

    • URL

      http://www.esb.soken.ac.jp/research/index.html#hideyuki_tanabe

    • Related Report
      2017 Annual Research Report
  • [Remarks] 田辺秀之 研究内容

    • URL

      http://www.esb.soken.ac.jp/research/index.html#hideyuki_tanabe

    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-07-14   Modified: 2019-03-29  

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