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Exploring of the principle of epithelial tubulogenesis by intra- and extracellular small molecules

Research Project

Project/Area Number 15KT0154
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section特設分野
Research Field Constructive Systems Biology
Research InstitutionNational Institute for Basic Biology

Principal Investigator

SUZUKI MAKOTO  基礎生物学研究所, 形態形成研究部門, 助教 (10533193)

Co-Investigator(Renkei-kenkyūsha) Ueno Naoto  基礎生物学研究所, 形態形成研究部門, 教授 (40221105)
KOYAMA Hiroshi  基礎生物学研究所, 初期発生研究部門, 助教 (10530462)
KATO Kagayaki  大学共同利用機関法人自然科学研究機構, 新分野創成センター, 特任助教 (30391915)
Research Collaborator YASUE Naoko  
Project Period (FY) 2015-07-10 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsカルシウムイオン / 神経管形成 / 頂端収縮 / アフリカツメガエル / 光操作 / ツメガエル / 細胞外ATP
Outline of Final Research Achievements

In this study, we explored the function of intracellular calcium ions in epithelial morphogenesis by using the neural tube closure of the African clawed frog as a model. As a result, we developed the technique that induces one of the cellular movements necessary for epithelial sheet deformation, called apical constriction, and revealed the molecular mechanism of it. Moreover, we proposed the mechanical basis by which the synchrony of the apical constriction affects the efficiency of tissue deformation. The results of this study are expected to contribute to the understanding of the principle of morphogenesis of various epithelial organs as well as the neural tube.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (9 results)

All 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (4 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results)

  • [Int'l Joint Research] アルバータ大学(カナダ)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Distinct intracellular Ca2+ dynamics regulate apical constriction and differentially contribute to neural tube closure.2017

    • Author(s)
      Suzuki, M., Sato, M., Koyama, H., Hara, Y., Hayashi, K., Yasue, N., Imamura, H., Fujimori, T., Nagai, T., Campbell, RE., Ueno, N.
    • Journal Title

      Development.

      Volume: 144 Issue: 7 Pages: 1307-1316

    • DOI

      10.1242/dev.141952

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mechanical regulation of three-dimensional epithelial fold pattern formation in the mouse oviduct2016

    • Author(s)
      Koyama, H., Shi, D., Suzuki, M., Ueno, N., Uemura, T., Fujimori, T.
    • Journal Title

      Biophysical Journal

      Volume: 111 Issue: 3 Pages: 650-665

    • DOI

      10.1016/j.bpj.2016.06.032

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mechanical roles of apical constriction, cell elongation, and cell migration during neural tube formation in Xenopus, Biomechanics and Modeling in Mechanobiology2016

    • Author(s)
      Yasuhiro Inoue, Makoto Suzuki, Tadashi Watanabe, Naoko Yasue, Itsuki Tateo, Taiji Adachi, Naoto Ueno
    • Journal Title

      Biomechanics and Modeling in Mechanobiology

      Volume: 15 Issue: 6 Pages: 1733-1746

    • DOI

      10.1007/s10237-016-0794-1

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Differences in the Mechanical Properties of the Developing Cerebral Cortical Proliferative Zone between Mice and Ferrets at both the Tissue and Single-Cell Levels.2016

    • Author(s)
      Nagasaka, A., Shinoda, T., Kawaue, T., Suzuki, M., Nagayama, K., Matsumoto, T., Ueno, N., Kawaguchi, A. and Miyata, T.
    • Journal Title

      Front Cell Dev. Biol.

      Volume: 25 Pages: 139-139

    • DOI

      10.3389/fcell.2016.00139

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 動物発生のバイオメカニクス2017

    • Author(s)
      上野直人, 鈴木誠, 根岸剛文.
    • Organizer
      日本機械学会第29回バイオエンジニアリング講演会
    • Place of Presentation
      ウインクあいち(愛知県・名古屋市)
    • Year and Date
      2017-01-19
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Periodic actomyosin contractility contributes to convergence movement during neurulation in zebrafish2017

    • Author(s)
      Makoto Suzuki, Naoto Ueno.
    • Organizer
      18th International Congress of Developmental Biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Distinct intracellular Ca2+ dynamics regulate apical constriction and differentially contribute to neural tube closure2017

    • Author(s)
      Makoto Suzuki, Masanao Sato, Hiroshi Koyama, Naoto Ueno.
    • Organizer
      第27回日本数理生物学会年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Distinct intracellular calcium ion dynamics regulate apical constriction and differentially con- tribute to neural tube closure2016

    • Author(s)
      Suzuki, M., Ueno, N.
    • Organizer
      The 22nd International Congress of Zoology (OIST, Okinawa)
    • Place of Presentation
      沖縄科学技術大学院大学(沖縄県・恩納村)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2015-07-14   Modified: 2019-03-29  

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