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Creation of a New Research Area on Metallomics

Research Project

Project/Area Number 16002009
Research Category

Grant-in-Aid for Specially Promoted Research

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Engineering
Research InstitutionNagoya University

Principal Investigator

HARAGUCHI Hiroki  Nagoya University, Graduate School of Science, Professor, 大学院・工学研究科, 教授 (70114618)

Co-Investigator(Kenkyū-buntansha) FUJIMORI Eiji  Nagoya University, Graduate School of Engineering, Research Associate, 大学院・工学研究科, 助手 (30291412)
HASEGAWA Takuya  Nagoya University, Graduate School of Engineering, Research Associate, 大学院・工学研究科, 助手 (50377800)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥176,670,000 (Direct Cost: ¥135,900,000、Indirect Cost: ¥40,770,000)
Fiscal Year 2006: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Fiscal Year 2005: ¥43,810,000 (Direct Cost: ¥33,700,000、Indirect Cost: ¥10,110,000)
Fiscal Year 2004: ¥121,030,000 (Direct Cost: ¥93,100,000、Indirect Cost: ¥27,930,000)
Keywordsmetallomics / essential trace elements / cell / metalloenzvme / all-element analysis / speciation / cell microcosm / cell microcosm opinion / 拡張元素普存説
Research Abstract

In order to promote the new research field of "metallomics", which was proposed by Haraguchi (Representative of the present project), the following research items have been investigated; (1) All elements analysis of one biological cell (salmon egg cell), (2) Chemical speciation of bio elements, (3) Application to health and environmental science. (1): All elements (78 stable isotope elements which can be conventionally treated in the standard laboratories) in salmon egg cell have been determined or detected for the first time. (2): A new separation column which is a pbosphatidylcholine-coated ODS (octadecyl silica)column was developed, and its separation characteristics was examined in order to elucidate the mechanism of chemotherapy of anemia with arsenite (AS_2O_3). As a result, the separation of arsenic compounds in blood serum became possible using this new column, which was impossible by the standard ODS column or bile acid-coated ODS column. Therefore, the present new column was … More applied to chemical speciation of arsenic compounds in blood serum, which was collected from the anemia patient treated with arsenite, and it was hind that arsenite was converted to organoarsenic compounds such as monomethyl arsenite and dimethyl arsenate. This fact suggests that chemical transformation of arsenite to organoarsenic compounds is essential for the anti-tumor effect of arsenite on anemia treatment. In addition, organic monolith column was developed to perform rapid and multi-component analysis of proteins, and the on-line and off-line detections of metalloproteins were examined with ICP-MS (inductively coupled plasma mass spectrometry) and MALDI-TOFMS, respectively.
(3): The multielement analysis and kinetic behaviors of air born particulates in urban atmosphere, and the multielement analysis of Lake Baikal water and the dissolved states of the elements in natural waters were carried out as the environmental study.
In last three years, metallomics have received great attention as the new and important scientific field in the world, and then Haraguchi is preparing as the chairman of the Organizing Committee the International Symposium on Metallomics 2007 as the first international symposium of metallomics, which will be held in Nagoya for November 28-December 1, 2007. Less

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (45 results)

All 2007 2006 2005 2004

All Journal Article (37 results) Book (8 results)

  • [Journal Article] Separation Characteristics of a Phosphatidylchorine-coated ODS Column for Direct Injection Analysis of Biological Fluid Samples.2007

    • Author(s)
      T.Hasegawa, Y.Fukumoto, J.Ishise, R.Hattori, Y.Zhu, T.Umemura, H.Haraguchi
    • Journal Title

      Bull. Chem. Soc. Jpn. 80・2

      Pages: 329-334

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Chemical Speciation of Arsenic Species in Human Blood Serum by Liquid Chromatography Using a PC-coated ODS Column with Detection by ICP-MS2007

    • Author(s)
      T.Hasegawa, Y.Wakita, Y.Zhu, H.Matsuura, H.Haraguchi, T.Umemura
    • Journal Title

      Bull. Chem. Soc. Jpn. 80・3

      Pages: 498-502

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Speciation of Human Serum Proteins Based on Trace Metal Mapping Analysis by CIM Monolithic Disk Column HPLC/ICP-MS in Complement with Off-Line MALDI-TOFMS Analysis.2007

    • Author(s)
      T.Hasegawa, Y.Wakita, Y.Zhu, H.Matsuura, H.Haraguchi, T.Umemura
    • Journal Title

      Bull. Chem. Soc. Jpn. 80・3

      Pages: 503-506

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Chemical Characterization of Airborne Particulate Matter in Ambient Air of Nagoya, Japan, as Studied by the Multielement Determination with ICP-AES and ICP-MS.2007

    • Author(s)
      T.Fukai, T.Kobayashi, M.Sakaguchi, M.Aoki, T.Saito, E.Fujimori, H.Haraguchi
    • Journal Title

      Anal. Sci. 23・2

      Pages: 207-213

    • NAID

      10018497719

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Multielement Determination of Ultratrace Impurity Elements in High Purity Niobium Materials by On-line Matrix Separation/ and Direct Sample Injection/ Inductively Coupled Plasma Mass Spectrometry.2007

    • Author(s)
      S.Kozono, H.Haraguchi
    • Journal Title

      Talanta 72(in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Multielement Determination of Trace Metals by ICP-MS with Aid of Down-sized Chelating Resin-Packed Minicolumn for Preconcentration.2007

    • Author(s)
      D.Rahmi, Y.Zhu, E.Fujimori, T.Umemura, H.Haraguchi
    • Journal Title

      Talanta 72(in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Separation Characteristics of a Phosphatidylcholine-coated ODS Column for Direct Injection Analysis of Biological Fluid Samples.2007

    • Author(s)
      T.Hasegawa, Y.Fukumoto, J.Ishise, R.Hattori, Y.Zhu, T.Umemura, H.Haraguchi
    • Journal Title

      Bull. Chem. Soc. Jpn. 80-2

      Pages: 329-334

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Chemical Characterization of Airborne Particulate Matter in Ambient Air of Nagoya, Japan, as Studied by the Multielement Determination with ICP-AES and ICP-MS.2007

    • Author(s)
      T.Fukai, T.Kobayashi, M.Sakaguchi, M.Aoki, T.Saito, E.Fujimori, H.Haraguchi
    • Journal Title

      Anal. Sci. 23-2

      Pages: 207-213

    • NAID

      10018497719

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Chemical Speciation of Arsenic Species in Human Blood Serum by Liquid Chromatography Using a Phosphatidylcholine-coated ODS Column with Detection by ICP-MS.2007

    • Author(s)
      T.Hasegawa, J.Ishise, Y.Fukumoto, Y.Zhu, H.Matsuura, T.Umemura, H.Haraguchi, K.Yamamoto, T.Naoe
    • Journal Title

      Bull. Chem. Soc. Jpn. 80-3

      Pages: 498-502

    • NAID

      10018876940

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Speciation of Human Serum Proteins Based on Trace Metal Mapping Analysis by CIM Monolithic Disk Column HPLC/ICP-MS in Complement with Off-Line MALDI-TOFMS Analysis.2007

    • Author(s)
      T.Hasegawa, Y.Wakita, Y.Zhu, H.Matsuura, H.Haraguchi, T.Umemura
    • Journal Title

      Bull. Chem. Soc. Jpn. 80-3

      Pages: 503-506

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Chemical Speciation of Arsenic Species in Human Blood Serum by Liquid Chromatography Using a PC-coatcd ODS Column with Dctcction by ICP-MS2007

    • Author(s)
      T.Hasegawa, Y.Wakita, Y.Zhu, H.Matsuura, H.Haraguchi, T.Umemura
    • Journal Title

      Bull. Chem. Soc. Jpn. 80・3

      Pages: 498-502

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Chcmical Characterization of Airborne Particulate Mattcr in Ambicnt Air of Nagoya, Japan, as Studied by the Multielement Determination with ICP-AES and ICP-MS.2007

    • Author(s)
      T.Fukai, T.Kobayashi, M.Sakaguchi, M.Aoki, T.Saito, E.Fujimori, H.Haraguchi
    • Journal Title

      Anal. Sci. 23・2

      Pages: 207-213

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Multielement Determination of Ultratrace Impurity Elements in High Purity Niobium Materials by On-line Matrix Separation/ and Direct Sample Injection / Inductively Coupled Plasma Mass Spectrometry.2007

    • Author(s)
      S.Kozono, H.Haraguchi
    • Journal Title

      Talanta 72(in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Multielement Determination of Trace Metals by ICP-MS with Aid of Down-sized Chelating Resin-Packed Minicolumn for Preconcentration.2007

    • Author(s)
      D.Rahmi, Y.Zhu, E.Fuj imori, T.Umemura, H.Haraguchi
    • Journal Title

      Talanta 72(in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Determination of Rare Earth Elements in Seawater by ICP-MS after Preconcentration with a Chelating Resin-Packed Minicolumn.2006

    • Author(s)
      Y.Zhu, A.Itoh, E.Fujimori, T.Umemura, H.Haraguchi
    • Journal Title

      J. Alloys Compd. 408-412

      Pages: 985-988

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Preparation of Low Flow-resistant Methacrylate-based Monolithic Stationary Phases of Different Hydrophobicity and the Application to Rapid Reversed-phase Liquid Chromatographic Separation of Alkylbenzenes at High Flow Rate and Elevated Temperature.2006

    • Author(s)
      Y.Ueki, T.Umemura, Y.Iwashita, T.Odake, H.Haraguchi, K.Tsunoda
    • Journal Title

      J. Chromatogr. A 1106・1-2

      Pages: 106-111

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Partitionings of Major-to-Ultratrace Elements in Bittern as Determined by ICP-AES and ICP-MS with Aid of Chelating Resin Preconcentration2006

    • Author(s)
      S.Ji, Y.Zhu, T.Yabutani, A.Itoh, H.Haraguchi
    • Journal Title

      Bull. Chem. Soc. Jpn. 79・4

      Pages: 588-594

    • NAID

      10018122282

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Lead Isotopic Compositions of Atmospheric Suspended Particulate Matter in Nagoya City as Measured by HR-ICP-MS.2006

    • Author(s)
      Y.Zhu, K.Kashiwagi, M.Sakaguchi, M.Aoki, E.Fujimori, H.Haraguchi
    • Journal Title

      J. Nucear. Sci. Technol. 43・4

      Pages: 474-478

    • NAID

      10016801186

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Assay of Alkaline Phosphatase in Salmon Egg Cell Cytoplasm with Fluorescence Detection of Enzymatic Activity and Zinc Detection by ICP-MS in Relation to Metallomics Research2006

    • Author(s)
      T.Hasegawa, M.Sugita, K.Takatani, H.Matsuura, T.Umemura, H.Haraguchi
    • Journal Title

      Bull. Chem. Soc. Jpn. 79・8

      Pages: 1211-1214

    • NAID

      10018210830

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Preparation and Characterization of Methacrylate-based Semi-micro Monoliths for High-throughput Bioanalysis2006

    • Author(s)
      T.Umemura, Y.Ueki, K.Tsunoda, A.Katakai, M.Tamada, H.Haraguchi
    • Journal Title

      Anal. Bioanal. Chem. 386・3

      Pages: 566-571

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Preparation of Low Flow-resistant Methacrylate-based Monolithic Stationary Phases of Different Hydrophobicity and the Application to Rapid Reversed-phase Liquid Chromatographic Separation of Alkylbenzenes at High Flow Rate and Elevated Temperature.2006

    • Author(s)
      Y.Ueki, T.Umemura, Y.Iwashita, T.Odake, H.Haraguchi, K.Tsunoda
    • Journal Title

      J. Chromatogr. A, 1106-1-2

      Pages: 106-111

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Partitionings of Major-to-Ultratrace Elements in Bittern as Determined by ICP-AES and ICP-MS with Aid of Chelating Resin Preconcentration.2006

    • Author(s)
      S.Ji, Y.Zhu, T.Yabutani, A.Itoh, H.Haraguchi
    • Journal Title

      Bull. Chem. Soc. Jpn. 79-4

      Pages: 588-594

    • NAID

      10018122282

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Lead Isotopic Compositions of Atmospheric Suspended Particulate Matter in Nagoya City as Measured by HR-ICP-MS.2006

    • Author(s)
      Y.Zhu, K.Kashiwagi, M.Sakaguchi, M.Aoki, E.Fujimori, H.Haraguchi
    • Journal Title

      J. Nucl. Sci. Technol. 43-4

      Pages: 474-478

    • NAID

      10016801186

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Preparation and Characterization of Methacrylate-based Semi-micro Monoliths for High-throughput Bioanalysis.2006

    • Author(s)
      T.Umemura, Y.Ueki, K.Tsunoda, A.Katakai, M.Tamada, H.Haraguchi
    • Journal Title

      Anal. Bioanal. Chem. 386-3

      Pages: 566-571

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Assay of Alkaline Phosphatase in Salmon Egg Cell Cytoplasm with Fluorescence Detection of Enzymatic Activity and Zinc Detection by ICP-MS in Relation to Metallomics Research.2006

    • Author(s)
      T.Hasegawa, M.Sugita, K.Takatani, H.Matsuura, T.Umemura, H.Haraguchi
    • Journal Title

      Bull. Chem. Soc. Jpn. 79-8

      Pages: 1211-1214

    • NAID

      10018210830

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Partitionings of Major-to-Ultratrace Elements in Bittern as Determined by ICP-AES and ICP-MS with Aid of Chelating Resin Preconcentration2006

    • Author(s)
      S.Ji.Y.Zhu, T.Yabutani, A.Itoh, H.Haraguchi
    • Journal Title

      Bull. Chem. Soc. Jpn. 79・4

      Pages: 588-594

    • NAID

      10018122282

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Multielement Detemination of Trace Metals in Seawater by Inductively Coupled Plasma Mass Spectrometry after Tandem Preconcentration Using Chelating Resin.2005

    • Author(s)
      Y.Zhu, A.Itoh, E.Fujimori, T.Umemura, H.Haraguchi
    • Journal Title

      Bull. Chem. Soc. Jpn, 78・4

      Pages: 659-667

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Evaluation of an ODS Column Modified with Zwitterionic/ Nonionic Mixed Surfactants and Its Application to Direct Injection Determination of Inorganic Anions2005

    • Author(s)
      T.Hasegawa, T.Umemura, A.Koide, K.Chiba, K.Tsunoda, H.Haraguchi
    • Journal Title

      Anal.Sci. 21・8

      Pages: 913-916

    • NAID

      10016644477

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Comparative Study on the Distributions of Precious Metals (Ru, Rh, Pd, Tr, Pt, and Au) in Industrial Waste Incineration Ashes as Determined by Tellurium Coprecipitation and ICP-MS2005

    • Author(s)
      E.Fujimori, K.Minamoko, H.Haraguchi
    • Journal Title

      Bull. Chem. Soc. Jpn, 78・11

      Pages: 1963-1969

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Fractional Distributions of Trace Metals in Surface Water of Lake Biwa.2005

    • Author(s)
      Y.Zhu, R.Hattori, D.Rahmi, S.Okuda, A.Itoh, E.Fujimori, T.Umemura, H.Haraguchi
    • Journal Title

      Bull. Chem. Soc. Jpn. 78・11

      Pages: 1970-1976

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Speciation and Excretion Patterns of Arsenic Metabolites in Human Urine after Ingestion of Edible Seaweed, Hizikia fusiforme.2005

    • Author(s)
      H.Matsuura, M.Asano, T.Hasegawa, T.Umemura, H.Haraguchi
    • Journal Title

      Bull. Chem. Soc. Jpn. 78・11

      Pages: 1977-1981

    • NAID

      10016845092

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Speciation of Mercury in Salmon Egg Cell Cytoplasm in Relation with Metallomics Research.2005

    • Author(s)
      T.Hasegawa, M.Asano, K.Takatani, H.Matsuura T.Umemura, H.Haraguchi
    • Journal Title

      Talanta 68

      Pages: 465-469

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Multielement Determination of Trace Metals in Seawater by ICP-MS Using a Chelating Resin-Packed Minicolumn for Preconcentration.2005

    • Author(s)
      Y.Zhu, A.Itoh, H.Haraguchi
    • Journal Title

      Bulletin of the Chemical Society of Japan 78・1

      Pages: 107-115

    • NAID

      10014271857

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Speciation of Some Biometals in Salmon Egg Cell Cytoplasm by Two-Dimensional HPLC/ICP-MS2004

    • Author(s)
      H.Matsuura, K.Takatani, M.Sugita, T.Hasegawa, T.Umemura, H.Haraguchi
    • Journal Title

      Biomedical Research on Trace Elements 15・4

      Pages: 345-347

    • NAID

      10028287339

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Multielement Analysis of Commercial Mineral Waters by Chelating Resin Preconcentration and ICP-MS2004

    • Author(s)
      H.Haraguchi, Y.Zhu, R.Hattori, A.Itoh, E.Fujimori, T.Umemura
    • Journal Title

      Biomedical Research on Trace Elements 15・4

      Pages: 355-357

    • NAID

      10028287379

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Gadolinium Anomaly in the Distributions of Rare Earth Elements Observed for Coastal Seawater and River Waters around Nagoya City2004

    • Author(s)
      Y.Zhu, M.Hoshino, H.Yamada, A.Itoh, H.Haraguchi
    • Journal Title

      Bulletin of the Chemical Society of Japan 77・10

      Pages: 1835-1842

    • NAID

      10013737559

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Enrichment of the Elements in Industrial Waste Incineration Bottom Ashes Obtained from Three Different Types of Incinerators as Studied by ICP-AES and ICP-MS.2004

    • Author(s)
      K.Minamoto, S.Iwata, E.Fujimori, K.Chiba, H.Haraguchi
    • Journal Title

      Journal of Materials Cycles and Waste Management 6

      Pages: 73-79

    • NAID

      10012030007

    • Related Report
      2004 Annual Research Report
  • [Book] 実験化学講座 改訂5版「分析化学」2007

    • Author(s)
      藤森英治, 原口紘〓(分担執筆)
    • Total Pages
      720
    • Publisher
      丸善
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] NARUZEN2007

    • Author(s)
      E.Fujimori, H.Haraguchi et al.
    • Total Pages
      720
    • Publisher
      JIKKENN KAGAKU KOZA (5th Edition) "Analytical Chemistry"
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 分析化学(実験化学講座)(改訂5版)2007

    • Author(s)
      藤森英治, 原口紘き(分担執筆)
    • Total Pages
      720
    • Publisher
      丸善
    • Related Report
      2006 Annual Research Report
  • [Book] 生命元素事典2006

    • Author(s)
      桜井 弘, 原口 紘〓 他
    • Total Pages
      440
    • Publisher
      オーム社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] OHMU-SHA2006

    • Author(s)
      H.Sakurai, H.Haraguchi et al.
    • Total Pages
      440
    • Publisher
      SEIMEI-GENSO-JITEN
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 生命元素事典2006

    • Author(s)
      桜井 弘, 原口 紘き 他
    • Total Pages
      440
    • Publisher
      オーム社
    • Related Report
      2006 Annual Research Report
  • [Book] 生命と金属の世界2005

    • Author(s)
      原口紘き
    • Total Pages
      385
    • Publisher
      放送大学教育振興会
    • Related Report
      2005 Annual Research Report
  • [Book] 生命と金属の世界2005

    • Author(s)
      原口 紘き
    • Total Pages
      485
    • Publisher
      放送大学教育振興会
    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2018-03-28  

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