バイオインフォマテックスを用いたT/NK細胞リンパ腫新分類策定を目指した国際研究

• Project/Area Number: 16024225
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: 中村 栄男 愛知県がんセンター(研究所), 研究所, 研究員 (80180363)
• Project Period (FY): 2004
• Project Status: Completed (Fiscal Year 2004)
• Budget Amount: ¥6,600,000 (Direct Cost: ¥6,600,000); Fiscal Year 2004: ¥6,600,000 (Direct Cost: ¥6,600,000)
• Keywords: T-cell and NK-cell lymphoma / Bioinformatics / Case clustering / Immunophcnotype / Chemokine / International study / Prognosis / WHO classification

Research Abstract

本研究の目的は、国際研究としてT/NK細胞リンパ腫1,000例以上の臨床病理学的、免疫学的情報を網羅し、バイオインフォマテクスを用いたcase clustering解析を通じで普遍的な分類を画定することにある。解析に際しては、T細胞functional subsetsの概念を取り入れ、リンパ腫分類の新たなパラダイムの提案を目指す。当初、研究協力巻としで日・韓・独の病理学者の参加を以って開始した。本研究の過程で、新たなT/NK細胞リンパ腫新分類が必要との広汎な共通認識を得るに至り、平行してより発展的な国際共同研究体制が構築されることとなった。具体的には、平成16年度中にアジア、欧州および北米に各地域センターが設置された。地域毎に各500症例、総計1,500例のT/NK細胞腫瘍を対象としで病理学的および免疫組織学的性状の評価、さらに予後を含む臨床データを集積し、解析中である。地域センターは名古屋(愛知県がんセンター、アジア地域)、WurzburgおよびLeeds (Wurzburg大学およびLeeds大学、欧州地域)、Omaha (Nebraska大学、北米地域)である。『アジア地域センタ』としてBangkok(タイ)、Hong Kong(中国)、Seoul(韓国)、および福岡、岡山、名古屋、東京(日本)からの500例については既に臨床病理学的情報(予後、冶療反応性、国際予後指標international prognostic indexesなどを含む)と病理検体の収集を完了すると共に、まずTIA1やgranzyme Bに代表される細胞傷害性分子の発現の有無、さらにEpstein-Barr virusの関与の有無など12種類の関連マーカーを検討した。また、関連して相互の診断の検証のために、アジア地域の症例の病理中央診断reviewのための会合が、平成17年1月に名古屋でも弓たれた。

Research Products

• [Journal Article] Genome-wide array-based CGH for mantle cell lymphoma : identification of homozygous deletions of the proapoptotic gene BIM. (2005)
  • Author(s): Tagawa, H., et al.
  • Journal Title: Oncogene (in press)
• [Journal Article] p16/ INK4a gene methylation is a frequent finding in pulmonary MALT lymphomas at diagnosis. (2005)
  • Author(s): Takino, H., et al.
  • Journal Title: Mod.Pathol. (in press)
• [Journal Article] Trisomy 3 may predict a poor response of gastric MALT lymphoma to Helicobacter pylori eradication therapy. (2005)
  • Author(s): Taji, S., et al.
  • Journal Title: World J.Gastroenterol. 11 Pages: 89-93
• [Journal Article] Contig array CGH at 3p14.2 points to the FRA3B/FHIT common fragile region as the target gene in diffuse large B-cell lymphoma. (2004)
  • Author(s): Kameoka, Y., et al.
  • Journal Title: Oncogene 23 Pages: 9148-9154
• [Journal Article] Gastric MALT lymphomas are divided into three groups based on responsive-ness to Helicobacter pylori eradication and detection of API2-MALT1 fusion (2004)
  • Author(s): Inagaki, H., et al.
  • Journal Title: Am.J.Surg.Pathol. 28 Pages: 1560-1567
• [Journal Article] Methylenetetrahydrofolate Reductase Gene (MTHFR) Polymorphisms and Reduced Risk of Malignant Lymphoma. (2004)
  • Author(s): Matsuo, K, et al.
  • Journal Title: Am.J.Hematol. 77 Pages: 351-357
• [Journal Article] Cladribine Study Group Durable response but prolonged cytopenia after cladribine treatment in relapsed patients with indolent lymphomas. (2004)
  • Author(s): Ogura, M., et al.
  • Journal Title: Int.J.Hematol. 80 Pages: 267-277
• [Journal Article] Effect of hepatitis C virus infection on the risk of non-Hodgkin's lymphoma : a meta-analysis of epidemiological studies. (2004)
  • Author(s): Matsuo, K, et al.
  • Journal Title: Cancer Sci. 95 Pages: 742-752
• [Journal Article] Detection of t(14;18) in follicular lymphoma by dual-color fluorescence in situ hybridization on paraffin-embedded tissue sections. (2004)
  • Author(s): Matsumoto, Y., et al.
  • Journal Title: Cancer Gene.Cytogenet. 150 Pages: 22-26
• [Journal Article] Genome-Wide Array-Based Comparative Genomic Hybridization of Diffuse Large B-Cell Lymphoma : Comparison between CD5-Positive and CD5-Negative Cases. (2004)
  • Author(s): Tagawa, H., et al.
  • Journal Title: Cancers Res. 64 Pages: 5948-5955
• [Journal Article] CXCR3 and CCR4 Expression in T-cell and NK-cell lymphomas with Special Reference to Clinicopathological Significance in T-cell Lymphoma. (2004)
  • Author(s): Ishida, T., et al.
  • Journal Title: Clin.Cancer Res. 10 Pages: 5494-5500
• [Journal Article] Aggressive natural killer-cell leukemia revisited : large granular leukemia of cytotoxic NK cells. (2004)
  • Author(s): Suzuki, R., et al.
  • Journal Title: Leukemia 18 Pages: 763-770
• [Journal Article] Pathology review far a paediatric non-Hodgkin's lymphoma patients in Japan : report from the Japan association of childhood leukaemia study (JACLS). (2004)
  • Author(s): Nakagawa, A., et al.
  • Journal Title: Eur.J.Cancer 40 Pages: 725-733
• [Journal Article] Lack of association between DNA base excision repair gene XRCC1 Gin399Arg polymorphism and risk of malignant lymphoma in Japan. (2004)
  • Author(s): Matsuo, K., et al.
  • Journal Title: Cancer Genet.Cytogenet. 149 Pages: 77-80
• [Journal Article] Intravascular large B-cell lymphoma presenting with mass lesions in the central nervous system : A report of five cases. (2004)
  • Author(s): Imai, H., et al.
  • Journal Title: Pathol.Int. 54 Pages: 231-236
• [Journal Article] Analysis of chromosomal imbalances in de nova CD5-positive diffuse large-B-cell lymphoma detected by comparative genomic hybridization (2004)
  • Author(s): Karnan,.S., et al.
  • Journal Title: Genes Chromosomes Cancer 39 Pages: 77-81
• [Book] Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. World Health Organization Classification of Tumours. (2004)
  • Author(s): Chan, A.C.L., et al.
  • Total Pages: 2
  • Publisher: Travis, W.D., Brambilla, E., Muller-Hermelink, H.K., Harris, C.C.
• [Book] Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. World Health Organization Classification of Tumours. (2004)
  • Author(s): Nakamura, S., et al.
  • Total Pages: 1
  • Publisher: Travis, W.D., Brambilla, E., Muller-Hermelink, H.K., Harris, C.C.