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Thymocyte dynamics and hymus organogenesis

Research Project

Project/Area Number 16043237
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokushima

Principal Investigator

TAKAHAMA Yousuke  The University of Tokushima, Institute for Genome Research, Professor, ゲノム機能研究センター, 教授 (20183858)

Co-Investigator(Kenkyū-buntansha) TOMITA Shuhei  The University of Tokushima, Institute for Genome Research, Associate Professor, ゲノム機能研究センター, 助教授 (00263898)
Project Period (FY) 2003 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥66,000,000 (Direct Cost: ¥66,000,000)
Fiscal Year 2006: ¥22,000,000 (Direct Cost: ¥22,000,000)
Fiscal Year 2005: ¥22,000,000 (Direct Cost: ¥22,000,000)
Fiscal Year 2004: ¥22,000,000 (Direct Cost: ¥22,000,000)
KeywordsT lymphocytes / Cellular differentiation / Repertoire formation / Thymus / Chemokines / Cellular movement / Immunological tolerance / medaka / 免疫学 / 発生・分化 / ゲノム / 細胞・組織 / 移植・再生医療 / 器官構築 / CCR7 / 自己寛容 / CCL21 / CCL25
Research Abstract

T lymphocytes play a pivotal role in maintaining immunological surveillance. T lymphocytes are generated in the thymus, and it is well established that developing T lymphocytes in the thymus acquire the reactivity to foreign antigens and establish tolerance to self-antigens through the process of positive and negative selection. However, how T lymphocytes are generated and selected in thymus microenvironments is still poorly understood. This study was aimed to understand molecular programs that form functionally competent thymus, which is capable of supporting and selecting T lymphocytes, and that position developing T lymphocytes to localize within multiple thymic microenvironments for centrally shaping T-lymphocyte repertoire. We found that spatial and temporal coordination between CCR7-and CCR9-mediated chemokine signals critically regulates pre-vascular colonization of T-progenitor cells into fetal thymus. We also found that CCR7-mediated chemokine signals are essential for cortex-to-medulla migration of developing thymocytes, and that CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance to tissue-restricted antigens. Moreover, real-time imaging of intra-vital thymocytes without surgical invasion was established by using transgenic medaka (a transparent small fish species) that expresses fluorescent protein under the control of immature-lymphocyte-specific rag1. Finally, genome-wide screening of chemically mutagenized medaka identified at least 22 genes that critically regulate the formation of the thymus. Unveiling molecular machinery that is essential for establishing functional thymus and intra-thymic T lymphocyte selection should aid controlling immune diseases.

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (75 results)

All 2007 2006 2005 2004 2003

All Journal Article (70 results) Book (4 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Keratinocyte growth factor enhances post-natal T cell development via improvement in proliferation and function of thymic epithelial cells.2007

    • Author(s)
      Rossi S
    • Journal Title

      Blood. 109

      Pages: 3803-3811

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The lymphocyte guard-IANs : regulation of lymphocyte survival by IAN/GIMAP family proteins.2007

    • Author(s)
      Nitta T
    • Journal Title

      Trends in Immunology. 28

      Pages: 58-65

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Chemokines CCL19 and CCL21 promote activation-induced cell death of antigen-responding T cells.2007

    • Author(s)
      Yasuda T
    • Journal Title

      Blood. 109

      Pages: 449-456

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Keratinocyte growth factor enhances post-natal T cell development via improvement in proliferation and function of thymic epithelial cells.2007

    • Author(s)
      Rossi S, Jeker LT, Ueno T, Kuse S, Keller MP, Zuklys A, Gudkov A, Takahama Y, Krenger W, Blazar BR, Hollander GA.
    • Journal Title

      Blood. 109

      Pages: 3803-3811

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The lymphocyte guard-IANs : regulation of lymphocyte survival by IAN/GIMAP family proteins.2007

    • Author(s)
      Nitta T, Takahama Y.
    • Journal Title

      Trends Immunol. 28

      Pages: 58-65

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Chemokines CCL19 and CCL21 promote activation-induced cell death of antigen-responding T cells.2007

    • Author(s)
      Yasuda T, Kuwabara T, Nakano H, Aritomi K, Onodera T, Lipp M, Takahama Y, Kakiuchi T.
    • Journal Title

      Blood. 109

      Pages: 449-456

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The lymphocyte guard-IANs : regulation of lymphocyte survival by IAN/GIMAP family proteins.2007

    • Author(s)
      Nitta T.
    • Journal Title

      Trends Immunol. 28

      Pages: 58-65

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Coordination between CCR7-and CCR9-mediated chemokine signals in pre-vascular fetal thymus colonization.2006

    • Author(s)
      Liu C
    • Journal Title

      Blood. 108

      Pages: 2531-2539

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] IAN family critically regulates survival and development of T lymphocytes.2006

    • Author(s)
      Nitta T
    • Journal Title

      PLoS Biology. 4

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Journey through the thymus : stromal guides for T-cell development and selection.2006

    • Author(s)
      Takahama Y
    • Journal Title

      Nature Reviews Immunology. 6

      Pages: 127-135

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] CCR7-dependeent cortex-medulla migration of positively selected thymocytes is essential for establishing sentral tolerance.2006

    • Author(s)
      Kurobe H
    • Journal Title

      Immunity. 24

      Pages: 165-177

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cellular and molecular events during early thymus development.2006

    • Author(s)
      Hollander GA
    • Journal Title

      Immunological Reviews. 209

      Pages: 28-46

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Thymic involution produced by diesel exhaust particles and their constituents in mice.2006

    • Author(s)
      Tomita S
    • Journal Title

      Toxicological and Environmental Chemistry. 88

      Pages: 113-124

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Coordination between CCR7-and CCR9-mediated chemokine signals in pre-vascular fetal thymus colonization.2006

    • Author(s)
      Liu C, Saito F, Liu Z, Lei Y, Uehara S, Love PE, Lipp M, Kondo S, Manley NR, Takahama Y.
    • Journal Title

      Blood. 108

      Pages: 2531-2539

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] IAN family critically regulates survival and development of T lymphocytes.2006

    • Author(s)
      Nitta T, Nasreen M, Seike T, Goji A, Ohigashi I, Miyazaki T, Ohta T, Kanno M, Takahama, Y.
    • Journal Title

      PLoS Biology. 4:e103

      Pages: 1-13

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Journey through the thymus : stromal guides for T-cell development and selection.2006

    • Author(s)
      Takahama Y.
    • Journal Title

      Nature Rev Immunol. 6

      Pages: 127-135

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] CCR7-dependent cortex-medulla migration of positively selected thymocytes is essential for establishing central tolerance.2006

    • Author(s)
      Kurobe H, Liu C, Ueno T, Saito F, Ohigashi I, Seach N, Arakaki R, Hayashi Y, Kitagawa T, Lipp M, Boyd RL, Takahama Y.
    • Journal Title

      Immunity. 24

      Pages: 165-177

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] In vitro systems for the study of T cell development : fetal thymus organ culture and OP9-DL1 cell coculture.2006

    • Author(s)
      Ramsdell F, Zuniga-Pflucker JC, Takahama Y.
    • Journal Title

      Current Protocols in Immunology. 3.18.

      Pages: 1-18

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cellular and molecular events during early thymus development.2006

    • Author(s)
      Hollander GA, Gill J, Zuklys S, Iwanami N, Liu C, Takahama Y.
    • Journal Title

      Immunol Rev. 209

      Pages: 28-46

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Thymic involution produced by diesel exhaust particles and their constituents in mice.2006

    • Author(s)
      Tomita S, Maekawa S, Rahman M, Saito F, Kizu R, Tohi K, Ueno T, Nakase H, Gonzalez FJ, Hayakawa K, Korenaga T, Takahama Y.
    • Journal Title

      Toxicol Environ Chemistry. 88

      Pages: 113-124

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Coordination between CCR7- and CCR9-mediated chemokine signals in pre-vascular fetal thymus colonization.2006

    • Author(s)
      Liu C.
    • Journal Title

      Blood. 108

      Pages: 2531-2539

    • Related Report
      2006 Annual Research Report
  • [Journal Article] CCR7-dependent cortex-medulla migration of positively selected thymocytes is dispensable for T-cell maturation and thymic exportation but is essential for establishing central tolerance.2006

    • Author(s)
      Kurobe H.
    • Journal Title

      Immunity 24

      Pages: 165-177

    • Related Report
      2006 Annual Research Report
  • [Journal Article] IAN family critically regulates survival and development of T lymphocytes.2006

    • Author(s)
      Nitta T.
    • Journal Title

      PLoS Biology 4(4)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cellular and molecular events during early thymus development.2006

    • Author(s)
      Hollander G.
    • Journal Title

      Immunol Rev. 209

      Pages: 28-46

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Journey through the thymus : stromal guides for T-cell development and selection.2006

    • Author(s)
      Takahama Y.
    • Journal Title

      Nature Reviews Immunology 6

      Pages: 127-135

    • Related Report
      2005 Annual Research Report
  • [Journal Article] IAN family critically regulates survival and development of T lymphocytes.2006

    • Author(s)
      Nitta T., et al.
    • Journal Title

      PLoS Biology. 4(in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] CCR7-dependent cortex-medulla migration of positively selected thymocytes is essential for establishing central tolerance.2006

    • Author(s)
      Kurobe H., et al.
    • Journal Title

      Immunity 24

      Pages: 165-177

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cellular and molecular events during early thymus development.2006

    • Author(s)
      Hollander G., et al.
    • Journal Title

      Immunological Reviews 209

      Pages: 28-46

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Controlling the thymic microenvironment.2005

    • Author(s)
      Gray DH
    • Journal Title

      Current Opinion in Immunology. 17

      Pages: 137-143

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus from Aire-deficient mice.2005

    • Author(s)
      Kuroda N
    • Journal Title

      Journal of Immunology. 174

      Pages: 1862-1870

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The role of CCL21 in recruitment of T precursor cells to fetal thymi.2005

    • Author(s)
      Liu C
    • Journal Title

      Blood. 105

      Pages: 31-39

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Controlling the thymic microenvironment.2005

    • Author(s)
      Gray DHD, Ueno T, Chidgey AP, Malin M, Goldberg GL, Takahama Y, Boyd RL.
    • Journal Title

      Curr Op Immunol. 17

      Pages: 137-143

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus from Aire-deficient mice.2005

    • Author(s)
      Kuroda N, Mitani T, Takeda N, Ishimaru N, Arakaki R, Hayashi Y, Bando Y, Izumi K, Takahashi T, Nomura T, Sakaguchi S, Ueno T, Takahama Y, Uchida D, Sun S, Kajiura F, Mouri Y, Han H, Matsushima A, Yamada G, Matsumoto M.
    • Journal Title

      J Immunol. 174

      Pages: 1862-1870

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The role of CCL21 in recruitment of T precursor cells to fetal thymi.2005

    • Author(s)
      Liu C, Ueno T, Kuse S, Saito F, Nitta T, Piali L, Nakano H, Kakiuchi T, Lipp M, Hollander GA, TakahamaY.
    • Journal Title

      Blood. 105

      Pages: 31-39

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The role of CCL21 in recruitment of T precursor cells to fetal thvmus.2005

    • Author(s)
      Liu C., et al.
    • Journal Title

      Blood 105

      Pages: 31-39

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Controlling the thymic microenvironment.2005

    • Author(s)
      Gray DHD., et al.
    • Journal Title

      Current Opinion in Immunology 17

      Pages: 137-143

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The role of CCL21 in recruitment of T precursor cells to fetal thymus.2005

    • Author(s)
      Liu C, et al.
    • Journal Title

      Blood. 105

      Pages: 31-39

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Increased frequency of aberrant V(D)J recombination preparation in core RAG-expressing mice.2004

    • Author(s)
      Talukder SR
    • Journal Title

      Nucleic Acids Research. 32

      Pages: 4539-4549

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] CCR7 signals are essential for cortex-medulla migration of developing thymus.2004

    • Author(s)
      Ueno T
    • Journal Title

      Journal of Experimental Medicine. 200

      Pages: 493-505

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The development of T lymphocytes in mouse fetal thymus organ culture.2004

    • Author(s)
      Ueno T
    • Journal Title

      Methods in Molecular Biology. 290

      Pages: 117-134

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Mutations affecting thymus organogenesis in medaka, Oryzias latipe.2004

    • Author(s)
      Iwanami N
    • Journal Title

      Mechanisms of Development. 121

      Pages: 779-789

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A systematic genome-wide screen for mutations affecting organogenesis in medaka, Oryzias latipes.2004

    • Author(s)
      Furutani-Seiki M
    • Journal Title

      Mechanisms of Development. 121

      Pages: 647-658

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Mutations affecting somite formation in the medaka (Oryzias latipes).2004

    • Author(s)
      Elmasri H
    • Journal Title

      Mechanisms of Development. 121

      Pages: 659-671

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Mutations affecting liver development and function in medaka, Oryzias latipes.2004

    • Author(s)
      Watanabe T
    • Journal Title

      Mechanisms of Development. 121

      Pages: 791-802

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] NF-kappaB-inducing kinase establishes self-tolerance in a thymic-stroma dependent manner.2004

    • Author(s)
      Kajiura F
    • Journal Title

      Journal of Immunology. 172

      Pages: 2067-2075

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Developmental status of CD4-CD8+ and CD4+CD8- thymocytes with medium expression of CD3.2004

    • Author(s)
      Sheard MA
    • Journal Title

      European Journal of Immunology. 34

      Pages: 25-35

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Increased frequency of aberrant V(D)J recombination preparation in core RAG-expressing mice.2004

    • Author(s)
      Talukder SR, Dudley DD, Alt FW, Takahama Y, Akamatsu Y.
    • Journal Title

      Nucleic Acids Res. 32

      Pages: 4539-4549

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Ueno T, Saito F, Kuse S, Gray DHD, Nakano H, Kakiuchi T, Lipp M, CCR7 signals are essential for cortex-medulla migration of developing thymus.2004

    • Author(s)
      Boyd RL, Takahama Y.
    • Journal Title

      J Exp Med. 200

      Pages: 493-505

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The development of T lymphocytes in mouse fetal thymus organ culture.2004

    • Author(s)
      Ueno T, Liu C, Nitta T, Takahama Y.
    • Journal Title

      Methods in Mol Biol. 290

      Pages: 117-134

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Mutations affecting thymus organogenesis in medaka, Oryzias latipe.2004

    • Author(s)
      Iwanami N, Takahama Y, Kunimatsu S, Li J, Takei R, Ishikura Y, Suwa H, Niwa K, Sasado T, Morinaga C, Yasuoka A, Deguchi T, Hirose Y, Yoda H, Henrich T, Ohara 0, Kondoh H, Furutani-Seiki M.
    • Journal Title

      Mech Dev. 121

      Pages: 779-789

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A systematic genome-wide screen for mutations affecting organogenesis in Medaka, Oryzias latipes.2004

    • Author(s)
      Furutani-Seiki M, Sasado T, Morinaga C, Suwa H, Niwa K, Yoda H, Deguchi T, Hirose Y, Yasuoka A, Henrich T, Watanabe T, Iwanami N, Kitagawa D, Saito K, Asaka S, Osakada M, Kunimatsu S, Momoi A, Elmasri H, Winkler C, Ramialison M, Loosli F, Quiring R, Carl M, Grabher C, Winkler S, Del Bene F, Shinomiya A, Kota Y, Yamanaka T, Okamoto Y, Takahashi K, Todo T, Abe K, Takahama Y, Tanaka M, Mitani H, Katada T, Nishina H, Nakajima N, Wittbrodt J, Kondoh H.
    • Journal Title

      Mech Dev. 121

      Pages: 647-658

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Mutations affecting liver development and function in Medaka, Oryzias latipes.2004

    • Author(s)
      Watanabe T, Asaka S, Kitagawa D, Saito K, Kurashige R, Sasado T, Morinaga C, Suwa H, Niwa K, Henrich T, Hirose Y, Yasuoka A, Yoda H, Deguchi T, Iwanami N, Kunimatsu S, Osakada M, Loosli F, Quiring R, Carl M, Grabher C, Winkler S, Del Bene F, Wittbrodt J, Abe K, Takahama Y, Takahashi K, Katada T, Nishina H, Kondoh H, Furutani-Seiki M.
    • Journal Title

      Mech Dev. 121

      Pages: 791-802

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Mutations affecting somite formation in the Medaka (Oryzias latipes).2004

    • Author(s)
      Elmasri H, Winider C, Liedtke D, Sasado T, Morinaga C, Suwa H, Niwa K, Henrich T, Hirose Y, Yasuoka A, Yoda H, Watanabe T, Deguchi T, Iwanami N, Kunimatsu S, Osakada M, Loosli F, Quiring R, Carl M, Grabher C, Winkler S, Del Bene F, Wittbrodt J, Abe K, Takahama Y, Takahashi K, Katada T, Nishina H, Kondoh H, Furutani-Seiki M.
    • Journal Title

      Mech Dev. 121

      Pages: 659-671

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] NF-kappaB-inducing kinase establishes self-tolerance in a thymic-stroma dependent manner.2004

    • Author(s)
      Kajiura F, Sun S, Nomura T, Izumi K, Ueno T, Bando Y, Kuroda N, Han H, Li Y, Matsushima A, Takahama Y, Sakaguchi S, Mitani T, Matsumoto M.
    • Journal Title

      J Immunol. 172

      Pages: 2067-2075

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Developmental status of CD4-CD8+ and CD4+CD8-thymocytes with medium expression of CD3.2004

    • Author(s)
      Sheard MA, Liu C, Takahama Y.
    • Journal Title

      Eur J Immunol. 34

      Pages: 25-35

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Increased frequency of aberrant V(D) J recombination products in core RAG-expressing mice.2004

    • Author(s)
      Talukder SR, et al.
    • Journal Title

      Nucleic Acids Res. 32

      Pages: 4539-4549

    • Related Report
      2004 Annual Research Report
  • [Journal Article] CCR7 signals are essential for cortex-to-medulla migration of developing thymocytes.2004

    • Author(s)
      Ueno T, et al.
    • Journal Title

      J Exp Med. 200

      Pages: 493-505

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Mutations affecting thymus organogenesis in medaka, Oryzias latipes.2004

    • Author(s)
      Iwanami N, et al.
    • Journal Title

      Mech Dev. 121

      Pages: 779-789

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A systematic genome-wide screen for mutations affecting organogenesis in Medaka, Oryzias latipes.2004

    • Author(s)
      Furutani-Seiki M, et al.
    • Journal Title

      Mech Dev. 121

      Pages: 647-658

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Developmental status of CD4-CD8+ and CD4+CD8- thymocytes with medium expression of CD3.2004

    • Author(s)
      Sheard MA, et al.
    • Journal Title

      Eur J Immunol. 34

      Pages: 25-35

    • Related Report
      2004 Annual Research Report
  • [Journal Article] T cell-specific disruption of aryl hydrocarbon receptor nuclear translocator gene causes resistance to 2,3,7,8-tetrachlodibenzo-p-dioxin-induced thymic involution.2003

    • Author(s)
      Tomita S
    • Journal Title

      Journal of Immunology. 171

      Pages: 4113-4120

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] In vivo treatment of class II MHC-deficient mice with anti-TCR antibody restores the generation of circulating CD4 T cells and optimal architecture of thymic medulla.2003

    • Author(s)
      Nasreen M
    • Journal Title

      Journal of Immunology. 171

      Pages: 3394-3400

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Defective brain development in mice lacking HIF-1 alpha in neural cells.2003

    • Author(s)
      Tomita S
    • Journal Title

      Molecular and Cellular Biology. 23

      Pages: 6739-6749

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of CpG methylation on RAG1/RAG2 reactivity : implications of direct and indirect mechanism for controlling V(D)J cleavage.2003

    • Author(s)
      Nakase H
    • Journal Title

      EMBO Reports. 4

      Pages: 774-780

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Deletion of the RAG2 C-terminus leads to impaired lymphoid development in mice.2003

    • Author(s)
      Akamatsu Y
    • Journal Title

      Proceedings of National Academy of Sciences USA. 100

      Pages: 1209-1214

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] T cell-specific disruption of aryl hydrocarbon receptor nuclear translocator gene causes resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced thymic involution.2003

    • Author(s)
      Tomita S, Jiang HB, Ueno T, Takagi S, Tohi K, Maekawa S, Miyatake A, Furukawa A, Gonzalez FJ, Takeda J, Ichikawa Y, Takahama, Y.
    • Journal Title

      J Immunol. 171

      Pages: 4113-4120

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] In vivo treatment of class II MHC-deficient mice with anti-TCR antibody restores the generation of circulating CD4 T cells and optimal architecture of thymic medulla.2003

    • Author(s)
      Nasreen M, Ueno T, Saito F, Takahama Y.
    • Journal Title

      J Immunol. 171

      Pages: 3394-3400

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Defective brain development in mice lacking HIF-1 alpha in neural cells.2003

    • Author(s)
      Tomita S, Ueno M, Sakamoto M, Kitahama Y, Ueki M, Maekawa N, Sakamoto H, Gassmann M, Kageyama R, Ueda N, Gonzalez FJ, Takahama Y.
    • Journal Title

      Mol Cell Biol. 23

      Pages: 6739-6749

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of CpG methylation on RAG1/RAG2 reactivity : implications of direct and indirect mechanism for controlling V(D)J cleavage.2003

    • Author(s)
      Nakase H, Takahama Y, Akamatsu Y.
    • Journal Title

      EMBOR. 4

      Pages: 774-780

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Deletion of the RAG2 C-terminus leads to impaired lymphoid development in mice.2003

    • Author(s)
      Akamatsu Y, Monroe R, Dudley DD, Elkin SK, Gartner F, Talukder SR, Takahama Y, Alt FW, Bassing CH, Oettinger MA.
    • Journal Title

      Proc Natl Acad Sci USA. 100

      Pages: 1209-1214

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] Current Protocols in Immunology. (Section 3.18) In vitro systems for the study of T cell development : fetal thymus organ culture and OP9-DL1 cell coculture.2006

    • Author(s)
      Ramsdell F
    • Total Pages
      5100
    • Publisher
      John Wiley & Sons
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] Current Protocols in Immunology2006

    • Author(s)
      Ramsdell F.
    • Total Pages
      18
    • Publisher
      John Wiley & Sons, Inc.
    • Related Report
      2006 Annual Research Report
  • [Book] Basic Cell Culture Protocols2005

    • Author(s)
      Ueno T., et al.
    • Publisher
      Humana Press, New Jersey, USA
    • Related Report
      2005 Annual Research Report
  • [Book] Basic Cell Culture Protocols2004

    • Author(s)
      Ueno T, et al.
    • Total Pages
      17
    • Publisher
      Humana Press, NJ, USA
    • Related Report
      2004 Annual Research Report
  • [Patent(Industrial Property Rights)] 胸腺器官発生因子TOF1及びTOF2両遺伝子とその用途2004

    • Inventor(s)
      高浜洋介, 冨田修平
    • Industrial Property Rights Holder
      徳島大学, 高浜洋介, 冨田修平
    • Patent Publication Number
      2006-101828
    • Filing Date
      2004
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2004-04-01   Modified: 2018-03-28  

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