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New therapeutic strategies for treatment of cancer based on basic research

Research Project

Project/Area Number 16062101
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNagoya City University

Principal Investigator

UEDA Ryuzo  Nagoya City University, 大学院・医学研究科, 教授 (20142169)

Co-Investigator(Kenkyū-buntansha) MIYAZONO Kohei  東京大学, 大学院・医学系研究科, 教授 (90209908)
SAITO Izumu  東京大学, 医科学研究所, 教授 (70158913)
IMAI Kohzoh  札幌医科大学, 学長 (60117603)
HASHIDA Mitsuru  京都大学, 大学院・薬学研究科, 教授 (20135594)
ENDO Keigo  群馬大学, 大学院・医学系研究科, 教授 (10115800)
ITOH Kyogo  久留米大学, 医学部, 教授 (50125499)
NAKAMURA Yusuke  東京大学, 医科学研究所, 教授 (70217909)
INAZAWA Johji  東京医科歯科大学, 難治疾患研究所, 教授 (30193551)
MUTO Tetsuichiro  (財)癌研究会, 癌研究所, 部長 (20110695)
TSURUO Takashi  (財)癌研究会, 癌化学療法センター, 所長 (00012667)
Project Period (FY) 2004 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥18,500,000 (Direct Cost: ¥18,500,000)
Fiscal Year 2009: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2008: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2007: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2006: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2005: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2004: ¥3,500,000 (Direct Cost: ¥3,500,000)
Keywords分子標的 / 分子標的治療 / ドラッグデリバリーシステム / 新しい物理療法 / トランスレーショナル・リサーチ / 分子創薬 / トランスレーショナルリサーチ / 新しい物療法
Research Abstract

In this project, we aimed to establish new therapeutic strategies for treatment of cancer, utilizing basic knowledge on cancer. We have shown the clinical efficacy of a defucosylated humanized anti-CCR4 antibody in patients with adult T-cell leukemia-lymphoma, effectiveness of TGF-beta receptor inhibitor on glioma-initiating cells, and potential use of FGF receptor monoclonal antibody to hepatocellular carcinoma.

Report

(7 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (36 results)

All 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article (34 results) (of which Peer Reviewed: 4 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Phase I study of KW-0761, a defucosylated anit-CCR4 antibody, in relapsed patients with adult T-cell leukemia lymphoma and peripheral T-cell lymphoma2010

    • Author(s)
      Yamamoto K
    • Journal Title

      J Clin Oncol. 28(9)

      Pages: 1591-1598

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] がん研究にかかわる特定領域研究(主な研究成果)(平成16年度-21年度)2010

    • Author(s)
      がん特、広報・企画支援委員会
    • Journal Title

      報告集(パンフレット)

      Pages: 1-33

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Defucosylated anti-CCR4 monocljonal antibody exerts potent ADCC against primary ATLL cell mediated by autologous human immune cells inNOD/Shi-scid, IL-2R qamma(null) mice in vivo.2009

    • Author(s)
      Ito A
    • Journal Title

      J Immunol 183(7)

      Pages: 4782-4791

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] POU2AF1, an amplification target at 11q23, priomotes growth of multiple myeloma cells by directly regulating expression of a B-cell maturation factor, TNFRSF172008

    • Author(s)
      Zhao, C
    • Journal Title

      Oncogene 27(1)

      Pages: 63-75

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Defucosylated AntiCC Chemokine Receptor 4 Monoclonal Antibody Combined with Immunomodulatory Cytokines: A Novel Immnuotherapy for Aggressive/Refractory Mycosis Fungoides and Sezary Syndrome2007

    • Author(s)
      Yano, H.
    • Journal Title

      Clin Cancer Res 13(21)

      Pages: 6494-6500

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling.2007

    • Author(s)
      Kano, MR., Miyazono, K., et al.
    • Journal Title

      Proc Natl Acad Sci USA. 104(9)

      Pages: 3460-3465

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Design, synthesis, and evaluation of [188Re] organorhenium-labeled antibody fragments with renal enzyme-cleavable linkage for low renal radioactivity levels.2007

    • Author(s)
      Uehara, T., Endo, K., et al.
    • Journal Title

      Bioconjug Chem. 18(1)

      Pages: 190-198

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Dofequidar fumarate (MS-209) in combination with cyclophosphamide, doxorubicin, and fluorouracilfor patients with advanced or recurrent breast cancer.2007

    • Author(s)
      Saeki, T., Tsuruo, T., et al.
    • Journal Title

      J Clin Oncol. 25 (4)

      Pages: 411-417

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Specific recruitment of CC chemokine receptor 4-positive regulatory T cells in Hodgkin lymphoma fosters immune privilege.2006

    • Author(s)
      Ishida, T., Ueda, R., et al.
    • Journal Title

      Cancer Res. 66(11)

      Pages: 5716-5722

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Keratinocyte growth factor transduction ameliorates acute lung injury and mortality in mice.2006

    • Author(s)
      Baba, Y., Saito, I., et al.
    • Journal Title

      Hum Gene Ther. 18(2)

      Pages: 130-141

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Comparing antibody and small-molecule therapies for cancer.2006

    • Author(s)
      Imai, K., et al.
    • Journal Title

      Nature Rev Cancer 6(9)

      Pages: 714-727

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Pegylated catalase prevents metastatic tumor growth aggravated by tumor removal.2006

    • Author(s)
      Hyoudou, K., Hashida M., et al.
    • Journal Title

      Free Radical Biol. Med. 41(9)

      Pages: 1449-1458

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Nonmutated Self-Antigen-Derived Cancer Vaccine Peptides Elicit an IgE-Independent but Mast Cell-Dependent Immediate-Type Skin Reaction withoutSystemic Anaphylaxis.2006

    • Author(s)
      Yamada, A., Itoh, K., et al.
    • Journal Title

      J Immunol. 176 (2)

      Pages: 857-863

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Activation of CDCA1-KNTC2, members of centromere protein complex, involved in pulmonary carcinogenesis.2006

    • Author(s)
      Hayama, S., Nakamura, Y., et al.
    • Journal Title

      Cancer Res. 66 (21)

      Pages: 10339-10348

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Frequent silencing of the candidate tumor suppressor PCDH20 by epigenetic mechanism in non-small-cell lung cancers.2006

    • Author(s)
      Imoto, I., Inazawa, J., et al.
    • Journal Title

      Cancer Res. 66 (9)

      Pages: 4617-4626

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Indication and Benefit of Pelvic Sidewall Dissection for Rectal Cancer2006

    • Author(s)
      Sugihara, K., Muto, T., et al.
    • Journal Title

      Diseases of the Colon and Rectum 49 (11)

      Pages: 1663-1672

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effect of smad7 expression on metastasis of mouse mammary carcinoma JygMC(A) cells.2005

    • Author(s)
      Azuma, H., Miyazono, K., et al.
    • Journal Title

      J.Natl.Cancer Inst. 97(23)

      Pages: 1734-1746

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Tankyrase I as a target for telomere-directed molecular cancer therapeutics.2005

    • Author(s)
      Seimiya, H., Tsuruo, T.et al.
    • Journal Title

      Cancer Cell. 7

      Pages: 25-37

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Identification of peptide vaccine candidates for prostate cancer patients with HLA-A3 supertype alleles.2005

    • Author(s)
      Matsueda, S., Itoh, K.et al.
    • Journal Title

      Clin Cancer Res. 11

      Pages: 6933-6943

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Evaluating the Combination of Molecular Prognostic Factors in Tumor Radiosensitivity in Rectal Cancer.2005

    • Author(s)
      Komuro, Y., Muto, T., et al.
    • Journal Title

      Hapato-Gastroenterology 52

      Pages: 666-671

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Methylation-associated silencing of the nuclear receptor 112 gene in advanced-type neuroblastomas, identified by bacterial artificial chromosome array-based methylated CpG island amplification.2005

    • Author(s)
      Misawa, A., Inazawa, J., et al.
    • Journal Title

      Cancer Res. 65

      Pages: 10233-10242

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A variable number of tandem repeats Polymorphism in an E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers.2005

    • Author(s)
      Tsuge, M., Nakamura, Y., et al.
    • Journal Title

      Nature Genetics. 37

      Pages: 1104-1107

    • Related Report
      2005 Annual Research Report
  • [Journal Article] In vitro system to estimate renal brush border enzyme-mediated cleavage of peptide linkages for designing radiolabeled antibody fragments of low renal radioactivity levels.2005

    • Author(s)
      Fujioka, Y., Endo, K., et al.
    • Journal Title

      Bioconjugate Chemistry 16

      Pages: 1610-1616

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Mechanisms for the apoptosis of small cell lung cancer cells induced by anti-GD2 monoclonal antibodies : Roles of anoikis.2005

    • Author(s)
      Aixinjueluo, W., Ueda, R., et al.
    • Journal Title

      J Biol Chem. 280(33)

      Pages: 29828-29836

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Production of viral vectors using recombinase-mediated cassette exchange.2005

    • Author(s)
      Nakano, M., Saito, I., et al.
    • Journal Title

      Nucleic Acids Res. 33

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors.2005

    • Author(s)
      Alazzouzi, H., Imai, K., et al.
    • Journal Title

      Cancer Res. 65

      Pages: 10170-10173

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Interaction with blood components plays a crucial role in asialoglycoprotein receptor-mediated in vivo gene transfer by galactosylated lipoplex2005

    • Author(s)
      Fumoto, S., Hashida, M., et al.
    • Journal Title

      J Pharmacology and Experimental Therapeutics 315(2)

      Pages: 484-493

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The CC chemokine receptor 4 as a novel specific molecular target for immunotherapy in adult T-cell leukemia/lymphoma.2004

    • Author(s)
      Ishida, T., Ueda, R.et al.
    • Journal Title

      Clin.Cancer Res. 10

      Pages: 7529-7539

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Coordinate regulation of cell growth and differentiation by TGF-beta superfamily and Runx proteins.2004

    • Author(s)
      Miyazono, K. et al.
    • Journal Title

      Oncogene 23

      Pages: 4232-4237

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Synergistic effect of histone deacetylase inhibitors FK228 and m-carboxycinnamic acid bis-hydroxamide with proteasome inhibitors PSI and PS-341 against gastrointestinal adenocarcinoma cells.2004

    • Author(s)
      Adachi, M., Imai, K.et al.
    • Journal Title

      Clin.Cancer Res. 10

      Pages: 3853-3862

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Enhanced hepatocyte-selective in vivo gene expression by stabilized galactosylated liposome/plasmid DNA complex using sodium chloride for complex formation.2004

    • Author(s)
      Fumto, S., Hashida M.et al.
    • Journal Title

      Mol.Ther. 10

      Pages: 719-729

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Positron emission tomographic imaging with 11C-choline in differential diagnosis of head and neck tumors : comparison with 18F-FDG PET.2004

    • Author(s)
      Khan, N., Endo, K.et al.
    • Journal Title

      Ann.Nucl.Med. 18

      Pages: 409-417

    • NAID

      10017670306

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Identification of peptide vaccine candidates sharing among HLA-A3+, -A11+, -A31+, and -A33+ cancer patients.2004

    • Author(s)
      Takedatsu, H., Itoh, K.et al.
    • Journal Title

      Clin.Cancer Res. 10

      Pages: 1112-1120

    • Related Report
      2004 Annual Research Report
  • [Journal Article] がんの免疫療法とトランスレーショナル・リサーチ 特集:がんの研究 免疫・予防,診断・治療研究と将来展望2004

    • Author(s)
      小松弘和, 上田龍三
    • Journal Title

      学術月報

      Pages: 973-978

    • Related Report
      2004 Annual Research Report
  • [Book] がん研究に係わる特定領域研究(主な成果)(平成16年度-21年度)報告集2010

    • Author(s)
      上田龍三, 他
    • Publisher
      がん特定研究広報・企画支援委員会(パンフレット)
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://gantoku3.umin.jp/

    • Related Report
      2009 Final Research Report

URL: 

Published: 2004-04-01   Modified: 2018-03-28  

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