Elucidation of neural network function in the brain

• Project/Area Number: 16069101
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo (2007-2010); Osaka University (2005-2006); Kanazawa University (2004)
• Principal Investigator: KANO Masanobu 東京大学, 大学院・医学系研究科, 教授 (40185963)
• Co-Investigator(Kenkyū-buntansha): 五十嵐 道弘 新潟大学, 大学院・医歯学総合研究科, 教授 (50193173) ; 真鍋 俊也 東京大学, 医科学研究所, 教授 (70251212) ; 大森 治紀 京都大学, 大学院・医学研究科, 教授 (30126015) ; 渡辺 雅彦 北海道大学, 大学院・医学研究科, 教授 (70210945)
• Co-Investigator(Renkei-kenkyūsha): IGARASHI Michihiro 新潟大学, 医歯学系, 教授 (50193173) ; MANABE Toshiya 東京大学, 医科学研究所, 教授 (70251212) ; OHMORI Harunori 京都大学, 大学院・医学研究科, 教授 (30126015) ; WATANABE Wasahiko 北海道大学, 大学院・医学研究科, 教授 (70210945)
• Project Period (FY): 2004 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥28,400,000 (Direct Cost: ¥28,400,000); Fiscal Year 2010: ¥3,000,000 (Direct Cost: ¥3,000,000); Fiscal Year 2009: ¥4,300,000 (Direct Cost: ¥4,300,000); Fiscal Year 2008: ¥4,500,000 (Direct Cost: ¥4,500,000); Fiscal Year 2007: ¥4,400,000 (Direct Cost: ¥4,400,000); Fiscal Year 2006: ¥4,300,000 (Direct Cost: ¥4,300,000); Fiscal Year 2005: ¥4,400,000 (Direct Cost: ¥4,400,000); Fiscal Year 2004: ¥3,500,000 (Direct Cost: ¥3,500,000)
• Keywords: 神経回路 / 形成 / 機能的成熟 / 機能発現 / 神経細胞 / 分子・細胞神経科学 / ニューロン・シナプス・神経回路 / 神経発生・神経発達・神経再生・神経再建 / 姿勢・運動制御 / 神経科学 / 機能発達 / シナプス / 発達 / 可塑性

Research Abstract

本研究は、脳の神経回路の機能解明を目指す特定領域研究(領域番号020)の総括班として、平成16年に開始された。平成16年度には、次年度に開始する計画研究及び公募研究の研究方針の決定、研究項目の策定を行い、平成17年度から21年度までは、計画研究と公募研究の円滑な進展のために、領域の年2回の領域班会議の開催、研究方針の策定、企画調整、評価、研究成果の発信等の活動を行った。脳の最大の特徴は神経細胞が単独で機能するのではなく、多くの神経細胞が連結した神経回路として機能することである。神経回路はからだが出来上がるにつれて「形成」され、成長・発達するにつれて機能的に「成熟」する。成体となるまでに、脳領域の特異性に応じて「発現」される個々の神経回路の独特な機能が完成する。これらのメカニズムを明らかにするため、本特定領域研究では、A01:神経回路の形成、A02:神経回路の機能的成熟、A03:神経回路の特異的機能発現、という3つの研究項目を設定し、12名の計画研究班員と、総勢79名の公募研究班員から構成した。班員の間で極めて活発に連携や共同研究がおこなわれ、5年間に、Nature, Science, Cell, Neuronなどの一流国際学術誌に900編を超える論文が発表された。また、新聞報道をはじめとして研究成果の一般への発信も盛んに行われた。本研究領域は平成21年度をもって終了したが、極めて多くの研究成果が得られており、共同研究をはじめとする人的交流が盛んに行われ、脳の神経回路の機能解明を目指す研究者間のネットワークが出来上がった。これらの有形・無形の財産を、今後の我が国の脳神経科学の発展のために役立てるため、平成22年度において、計画班員とこれまでに公募研究で参加した全ての公募班員の研究成果をまとめ、成果をわかりやすい形で冊子体にまとめ、本特定領域研究の集大成とした。

Research Products

• [Journal Article] Neuronal protease-activated receptor 1 drives synaptic retrograde signaling mediated by the endocannabinoid 2-arachidonoylglycerol (2011)
  • Author(s): Hashimotodani Y, Ohno-Shosaku T, Yamazaki M, Sakimura K, Kano M
  • Journal Title: J Neurosci Volume: 31 Pages: 3104-3109
  • NAID: 120002950596
  • Peer Reviewed
• [Journal Article] Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus. (2011)
  • Author(s): Yoshida T, Uchigashima M, Yamasaki M, Katona I, Yamazaki M, Sakimura K, Kano M, Yoshioka M, Watanabe M
  • Journal Title: Proc Natl Acad Sci USA Volume: 108 Pages: 3059-3064
  • NAID: 10030575938
  • Peer Reviewed
• [Journal Article] Role of pre- and postsynaptic activity in thalamocortical axon branching (2010)
  • Author(s): Yamada A, Uesaka N, Hayano Y, Tabata T, Kano M, Yamamoto N
  • Journal Title: Proc Natl Acad Sci USA Volume: 107 Pages: 7562-7567
  • Peer Reviewed
• [Journal Article] TARPs γ-2 and γ-7 are essential for AMPA receptor expression in the cerebellum (2010)
  • Author(s): Yamazaki M, Fukaya M, Hashimoto K, Yamasaki M, Tsujita M, Itakura M, Abe M, Natsume R, Takahashi M, Kano M, Sakimura K, Watanabe M
  • Journal Title: Eur J Neurosci Volume: 31 Pages: 2204-2220
  • Peer Reviewed
• [Journal Article] 長期抑圧(LTD) (2010)
  • Author(s): 谷村あさみ、橋本谷祐輝、狩野方伸
  • Journal Title: Clinical Neuroscience Volume: 28 Pages: 873-875
• [Journal Article] The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase α mediates retrograde suppression of synaptic transmission (2010)
  • Author(s): 谷村あさみ
  • Journal Title: Neuron 65 Pages: 320-327
  • Peer Reviewed
• [Journal Article] Translocation of a "winner" climbing fiber to the Purkinje cell dendrite and subsequent elimination of "losers" from the soma in developing cerebellum. (2009)
  • Author(s): Hashimoto, K, Ichikawa, R., Kitamura, K., Watanabe, M., Kano, M
  • Journal Title: Neuron 63 Pages: 106-118
  • Peer Reviewed
• [Journal Article] Synapse elimination in the central nervous system. (2009)
  • Author(s): Kano. M., Hashimoto, K
  • Journal Title: Curr Opin Neurobiol 19 Pages: 154-161
  • Peer Reviewed
• [Journal Article] Influence of parallel fiber-Purkinje cell synapse formation on postnatal development of climbing fiber-Purkinje cell synapses. (2009)
  • Author(s): Hashimoto, K., Yoshida, T., Sakimura, K., Mishina, M., Watanabe, M., Kano, M
  • Journal Title: Neuroscience 162 Pages: 601-611
  • Peer Reviewed
• [Journal Article] Endocannabinoid-mediated control of synaptic transmission. (2009)
  • Author(s): Kano, M., Ohno-Shosaku, T., Hashimotodani, Y., Uchigashima, M., Watanabe, M.
  • Journal Title: Physiol. Rev. 89 Pages: 309-80
  • Peer Reviewed
• [Journal Article] Involvement of NMDAR2A tyrosine phosphorylation in depression-related behavior. (2009)
  • Author(s): Taniguchi, S., Nakazawa, T., Tanimura, A., Kiyama, Y., Tezuka, T., Watabe, A. M., Katayama, N., Yokoyama, K., Inoue, T., Izumi-Nakaseko, H., Kakuta, S., Sudo, K., Iwakura, Y., Umemori, H., Inoue, T., Murphy, N. P., Hashimoto, K., Kano, M., Manabe, T., Yamamoto, T.
  • Journal Title: EMBO J. 28 Pages: 3717-3729
  • Peer Reviewed
• [Journal Article] Not glutamate but endocannabinoids mediate retrograde suppression of cerebellar parallel fiber to Purkinje cell synaptic transmission in young adult rodents (2009)
  • Author(s): 谷村あさみ
  • Journal Title: Neuropharmacology 57 Pages: 157-163
  • Peer Reviewed
• [Journal Article] Validation of Aβ1-40 administration into mouse cerebroventricles as an animal model for Alzheimer disease (2009)
  • Author(s): Takeda S
  • Journal Title: Brain Res 1280 Pages: 137-147
  • Peer Reviewed
• [Journal Article] Translocation of a "winner" climbing fiber to the Purkinje cell dendrite and subsequent elimination of "losers" from the soma in developing cerebellum (2009)
  • Author(s): 橋本谷祐輝
  • Journal Title: Neuron 63 Pages: 106-118
  • Peer Reviewed
• [Journal Article] Functional coupling between mGluR1 and Ca_V3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines (2009)
  • Author(s): Hildebrand M
  • Journal Title: J Neurosci 29 Pages: 9668-9682
  • Peer Reviewed
• [Journal Article] Angiotensin receptor blocker, olmesartan, improved cerebrovascular dysfunction and prevented cognitive decline in early-stage Alzheimer disease model mouse (2009)
  • Author(s): Takeda S
  • Journal Title: Hypertension 54 Pages: 1345-1352
  • Peer Reviewed
• [Journal Article] Involvement of NMDAR2A tyrosine phosphorylation in depression-related behavior (2009)
  • Author(s): Taniguchi S
  • Journal Title: EMBO J 28 Pages: 3717-3129
  • Peer Reviewed
• [Journal Article] Synapse elimination in the central nervous system (2009)
  • Author(s): Kano M
  • Journal Title: Curr Opin Neurobiol 19 Pages: 154-161
  • Peer Reviewed
• [Journal Article] Influence of parallel fiber-Purkinje cell synapse formation on postnatal development of climbing fiber-Purkinje cell synapses (2009)
  • Author(s): 橋本谷祐輝
  • Journal Title: Neuroscience 162 Pages: 601-611
  • Peer Reviewed
• [Journal Article] カンナビノイドとシナプス機能(特集:シナプス機能とその障害の分子機構) (2009)
  • Author(s): 橋本谷祐輝
  • Journal Title: Cognition and Dementia 8 Pages: 25-31
• [Journal Article] 新しい神経伝達物質内因性カンナビノイド -逆行性シナプス伝達を担う分子- (2009)
  • Author(s): 谷村あさみ
  • Journal Title: 化学 64 Pages: 22-26
• [Journal Article] Endocannabinoid-mediated control of synaptic transmission (2009)
  • Author(s): Kano M
  • Journal Title: Physiol Rev 89 Pages: 309-380
  • Peer Reviewed
• [Journal Article] Severe neurological phenotypes of Q129 DRPLA transgenic mice serendipitously created by en masse expansion of CAG repeats in Q76 DRPLA mice (2009)
  • Author(s): Sato T
  • Journal Title: Hum Mol Genet 18(4) Pages: 723-736
  • Peer Reviewed
• [Journal Article] Influence of parallel fiber-Purkinje cell synapse formation on postnatal development of climbing fiber-Purkinje cell synapses (2009)
  • Author(s): Hashimoto K
  • Journal Title: Neuroscience (In press)(印刷中)(掲載確定)
  • Peer Reviewed
• [Journal Article] Glutamate transporters regulate lesion-induced period plasticity in the developing somatosensory cortex. (2008)
  • Author(s): Takasaki, C., Okada, R., Mitani, A., Fukaya, M., Yamasaki, M., Fujihara, Y., Shirakawa, T., Tanaka, K., Watanabe M.
  • Journal Title: J. Neurosci 28 Pages: 4995-5006
  • Peer Reviewed
• [Journal Article] Type-1 metabotropic glutamate receptor in cerebellar Purkinje cells: a key molecule responsible for long-term depression, endocannabinoid signalling and synapse elimination. (2008)
  • Author(s): Kano, M., Hashimoto, K., Tabata, T.
  • Journal Title: Philos. Trans. R. Soc. Lond. B Biol. Sci. 363 Pages: 2173-2186
  • Peer Reviewed
• [Journal Article] Type-1 metabotropic glutamate receptor in cerebellar Purkinje cells : a key molecule responsible for long-term depression, endocannabinoid signalling and synapse elimination (2008)
  • Author(s): Kano M
  • Journal Title: Philos Trans R Soc Lond B Biol Sci 363 Pages: 2173-2186
  • Peer Reviewed
• [Journal Article] Pharmacological evidence for the involvement of diacylglycerollipase in depolarization-induced endocanabinoid release. (2008)
  • Author(s): Yuki Hashimotodani
  • Journal Title: Neuropharmacology 54 Pages: 58-67
  • Peer Reviewed
• [Journal Article] Targeted patch-clamp recordings and single-cell electroporation of unlabeled neurons in vivo. (2008)
  • Author(s): Kazuo Kitamura
  • Journal Title: Nature Method 5 Pages: 61-67
  • Peer Reviewed
• [Journal Article] Presynaptic GABAB receptors modulate synaptic facilitation and depression at distinct synapses in fusiform cells of mouse dorsal cochlear nucleus. (2008)
  • Author(s): Tomohiko Irie
  • Journal Title: Biochemical and Biophysical Research Communications 367 Pages: 503-508
  • Peer Reviewed
• [Journal Article] Differential regulation of synaptic plasticity and cerebellar motor learning by the C-terminal PDZ-binding motif of GluRdelta2. (2008)
  • Author(s): Wataru Kakegawa
  • Journal Title: The Journal of Neuroscience 28 Pages: 1460-1468
  • Peer Reviewed
• [Journal Article] Postsynaptic GABAB receptor signalling enhances LTD in mouse cerebellar Purkinje cells. (2007)
  • Author(s): Kamikubo, Y., Tabata, T., Kakizawa, S., Kawakami, D., Watanabe, M., Ogura, A., Iino, M., Kano, M.
  • Journal Title: J. Physiol 585 Pages: 549-563
  • Peer Reviewed
• [Journal Article] Metabotropic glutamate receptor subtype-1 is essential for motor coordination in the adult cerebellum. (2007)
  • Author(s): Harumi Nakao
  • Journal Title: Neuroscience Research 7 Pages: 538-543
  • Peer Reviewed
• [Journal Article] Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity. (2007)
  • Author(s): Sho Kakizawa
  • Journal Title: The EMBO Journal 26 Pages: 1924-1933
  • Peer Reviewed
• [Journal Article] Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum. (2007)
  • Author(s): Motokazu Uchigashima
  • Journal Title: The Journal of Neuroscience 27 Pages: 3663-3676
  • Peer Reviewed
• [Journal Article] G protein-independent neuromodulatory action of adenosine on metabotropic glutamate signaling in mouse cerebellar Purkinje cells. (2007)
  • Author(s): Toshihide Tabata
  • Journal Title: The Journal of Physiology 581 Pages: 693-708
  • Peer Reviewed
• [Journal Article] Diminished climbing fiber innervation of Purkinje cells in the cerebellum of myosin Va mutant mice and rats. (2007)
  • Author(s): Yoshiko Takagishi
  • Journal Title: Developmental Neurobiology 67 Pages: 909-923
  • Peer Reviewed
• [Journal Article] Motor discoordination of transgenic mice overexpressing a microtubule destabilizer, stathmin, specifically in Purkinje cells. (2007)
  • Author(s): Noriaki Ohkawa
  • Journal Title: Neuroscience Research 59 Pages: 93-100
  • Peer Reviewed
• [Journal Article] Endocannabinoid signalling triggered by NMDA receptor-mediated calcium entry into rat hippocampal neurons (2007)
  • Author(s): Takako Ohno-Shosaku
  • Journal Title: The Journal of Physiology 584 Pages: 407-418
  • Peer Reviewed
• [Journal Article] Conditioned eyeblink learning is formed and stored without cerebellar granule cell transmission. (2007)
  • Author(s): Norio Wada
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America 104 Pages: 16690-16695
  • Peer Reviewed
• [Journal Article] GABA_B receptor signalling enhances LTD in mouse cerebellar Purkinje cells. (2007)
  • Author(s): Yuji Kamikubo
  • Journal Title: The Journal of Physiology 585 Pages: 549-563
  • Peer Reviewed
• [Journal Article] Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression. (2007)
  • Author(s): Shin-ichiro Kina
  • Journal Title: European Journal of Neuroscience 26 Pages: 2269-2278
  • Peer Reviewed
• [Journal Article] Drebrin attenuates the interaction between actin and myosin-V. (2007)
  • Author(s): Ryoki Ishikawa
  • Journal Title: Biochemical and Biophysical Research Communications 359 Pages: 398-401
  • Peer Reviewed
• [Journal Article] The neuropeptide nociceptin is a synaptically released endogenous inhibitor of hippocampal long-term potentiation. (2007)
  • Author(s): Saknan Bongsebandhu-phubhakdi
  • Journal Title: The Journal of Neuroscience 27 Pages: 4850-4858
  • Peer Reviewed
• [Journal Article] Axonal motility and its modulation by activity arebranch-type specific in the intact adult cerebellum (2007)
  • Author(s): Hiroshi Nishiyama
  • Journal Title: Neuron 56 Pages: 472-487
  • Peer Reviewed
• [Journal Article] Regulation of long-term depression and climbing fiber territory by GluRdelta 2 at parallel fiber synapses through its cariboxyl terminal domain in cerebellar Purkinje cells. (2007)
  • Author(s): Takeshi Uemura
  • Journal Title: The Journal of Neuroscience 27 Pages: 12096-12108
  • Peer Reviewed
• [Journal Article] Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum. (2007)
  • Author(s): Narushima, M.
  • Journal Title: J. Neurosci. 27 Pages: 496-506
• [Journal Article] Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus. (2007)
  • Author(s): Hashimotodani, Y.
  • Journal Title: J. Neurosci. 27 Pages: 1211-1219
• [Journal Article] GABAergic interneurons facilitate mossy fiber excitability in the developing hippocampus. (2007)
  • Author(s): Nakamura, M.
  • Journal Title: J. Neurosci. 27 Pages: 1365-1373
• [Journal Article] Interactions between plexin-A2, plexin-A4 and semaphorin 6A control lamina-restricted projection of hippocampal mossy fibers. (2007)
  • Author(s): Suto, F.
  • Journal Title: Neuron 53 Pages: 535-547
• [Journal Article] Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiologica contribution to synaptic modulation in the striatum. (2007)
  • Author(s): Uchigashima, M.
  • Journal Title: J. Neurosci. 27(in press)
• [Journal Article] Establishment and characterization of mono- and polyclonal antibodies to human intestinal fatty acid-binding protein. (2007)
  • Author(s): Kajiura, S.
  • Journal Title: Clin. Chem. Lab. Med. (in press)
• [Journal Article] Endogenous cannabinoid signaling through the CB1 receptor is essential for cerebellum-dependent discrete motor learning. (2006)
  • Author(s): Kishimoto, Y., Kano, M.
  • Journal Title: J. Neurosci 26 Pages: 8829-8837
  • Peer Reviewed
• [Journal Article] NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. (2006)
  • Author(s): Nakazawa, T., Komai, S., Watabe, A.M., Kiyama, Y., Fukaya, M., Arima-Yoshida, F., Horai, R., Sudo, K., Ebine, K., Delawary, M., Goto, J., Umemori, H., Tezuka, T., Iwakura, Y., Watanabe, M., Yamamoto, T., Manabe, T.
  • Journal Title: EMBO J. 25 Pages: 2867-2877
  • Peer Reviewed
• [Journal Article] Axonal site of spike initiation enhances auditory coincidence detection. (2006)
  • Author(s): Kuba, H., Ishii, M.T., Ohmori, H.
  • Journal Title: Nature 444 Pages: 1069-1072
  • Peer Reviewed
• [Journal Article] Localization of diacylglycerol lipase-α around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB 1 receptor. (2006)
  • Author(s): Yoshida, T.
  • Journal Title: J. Neurosci. 26 Pages: 4740-4751
• [Journal Article] Endogenous cannabinoid signaling through the CB1 receptor is essential for cerebellum-dependent discrete motor learning. (2006)
  • Author(s): Kishimoto, Y.
  • Journal Title: J. Neurosci. 26 Pages: 8829-8837
• [Journal Article] Abundant distribution of TARY γ-8 in synaptic and extrasynaptic surface of hippocampal neurons and its major role in AMPA receptor expression on spines and dendrites. (2006)
  • Author(s): Fukaya, M.
  • Journal Title: Eur. J. Neurosci. 24 Pages: 2177-2190
• [Journal Article] NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. (2006)
  • Author(s): Nakazawa, T.
  • Journal Title: EMBO J. 25 Pages: 2867-2877
• [Journal Article] Improvement of phase information at low sound frequency in nucleus magnocellularis of the chicken. (2006)
  • Author(s): Fukui, I.
  • Journal Title: J. Neurophysiol. 96 Pages: 642-651
• [Journal Article] Activation of GIRK Channels by Muscarinic Receptors and Group II Metabotropic Glutamate Receptors Suppresses Golgi Cell Activity in the Cochlear Nucleus of Mice. (2006)
  • Author(s): Irie, T.
  • Journal Title: J. Neurophysiol. 96 Pages: 2633-2644
• [Journal Article] Axonal site of spike initiation enhances auditory coincidence detection. (2006)
  • Author(s): Kuba, H.
  • Journal Title: Nature 444 Pages: 1069-1072
• [Journal Article] Miniature synaptic events elicited by presynaptic Ca^<2+> rise are selectively suppressed by cannabinoid receptor activation in cerebellar Purkinje cells. (2006)
  • Author(s): Yamasaki, M.
  • Journal Title: J.Neurosci. 26 Pages: 86-95
• [Journal Article] Hippocampal CA3 NMDA receptors are crucial for adaptive timing of trace eyeblink conditioned response. (2006)
  • Author(s): Kishimoto, Y.
  • Journal Title: J.Neurosci. 26 Pages: 1562-1570
• [Journal Article] Endocannabinoid-mediated short-term suppression of excitatory synaptic transmission to medium spiny neurons in the striatum. (2006)
  • Author(s): Narushima, M.
  • Journal Title: Neurosci.Res. 54 Pages: 159-164
• [Journal Article] Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain. (2006)
  • Author(s): Miura, E.
  • Journal Title: J.Neurochem. (in press)
• [Journal Article] Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain. (2005)
  • Author(s): Kakizawa, S., Miyazaki, T., Yanagihara, D., Iino, M., Watanabe, M., Kano, M
  • Journal Title: Proc. Natl. Acad. Sci. USA. 102 Pages: 19180-19185
  • Peer Reviewed
• [Journal Article] Synaptically driven endocannabinoid release requires Ca^<2+>-assisted metabotropic glutamate receptor subtype 1 to phospholipase Cβ4 signaling cascade in the cerebellum. (2005)
  • Author(s): Maejima, T.
  • Journal Title: J.Neurosci. 25 Pages: 6826-6835
• [Journal Article] Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain. (2005)
  • Author(s): Kakizawa, S.
  • Journal Title: Proc.Natl.Acad.Sci.USA. 102 Pages: 19180-19185
• [Journal Article] Calcium signaling and synaptic modulation : Regulation of endocannabinoid-mediated synaptic modulation by calcium. (2005)
  • Author(s): Ohno-Shosaku, T.
  • Journal Title: Cell Calcium 38 Pages: 369-374
• [Journal Article] Postnatal development and synapse elimination of climbing fiber to Purkinje cell projection in the cerebellum. (2005)
  • Author(s): Hashimoto, K.
  • Journal Title: Neurosci Res. 53 Pages: 221-228
• [Journal Article] Age-dependent enhancement of hippocampal long-term potentiation and impairment of spatial learning through the Rho-associated kinase pathway in protein tyrosine phosphatase receptor type Z-deficient mice. (2005)
  • Author(s): Niisato, K.
  • Journal Title: J.Neurosci. 25 Pages: 1081-1088
• [Journal Article] Neuronal leucine-rich repeat protein 4 functions in hippocampus-dependent long-lasting memory. (2005)
  • Author(s): Bando, T.
  • Journal Title: Mol.Cell.Biol. 25 Pages: 4166-4175
• [Journal Article] Modulation of synaptic plasticity by physiological activation of M1 muscarinic acetylcholine receptors in the mouse hippocampus. (2005)
  • Author(s): Shinoe, T.
  • Journal Title: J.Neurosci. 25 Pages: 11194-11200
• [Journal Article] Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. (2005)
  • Author(s): Hoshino, M.
  • Journal Title: Neuron 47 Pages: 201-213
• [Journal Article] NR2-to-NR3B subunit conversion of NMDA receptor in early postnatal motoneurons. (2005)
  • Author(s): Fukaya, M.
  • Journal Title: Eur.J.Neurosci 21 Pages: 1432-1436
• [Journal Article] Role of Ser50 Phosphorylation in SCG10 regulation of microtubule depolymerization. (2005)
  • Author(s): Togano T
  • Journal Title: J Neurosci Res 80(4) Pages: 475-480
• [Journal Article] Myosin-Va regulates exocytosis thorugh the submicromolar Ca^<2+>-dependent binding of syntaxin-1A. (2005)
  • Author(s): Watanabe M
  • Journal Title: Mol Cell Biol 16(10) Pages: 4519-4530
• [Journal Article] Glia-derived inhibitors of axonal regrowth : Implication for the molecular strategy of axonal regeneration. (2005)
  • Author(s): Igarashi M
  • Journal Title: Acta Med Biol 53(2) Pages: 65-72
  • NAID: 110004786024
• [Journal Article] Hyperpolarization-activated cyclic nucleotide-gated cation channels regulate auditory coincidence detection in nucleus laminaris of the chick. (2005)
  • Author(s): Yamada R
  • Journal Title: J Neurosci. 25 Pages: 8867-8877
• [Journal Article] A novel Ca2+ indicator protein using FRET and calpain-sensitive linker. (2005)
  • Author(s): Takatsuka K
  • Journal Title: Biochem Biophys Res Commun. 336 Pages: 316-323
• [Journal Article] Age-dependent enhancement of hippocampal LTP and impairment of spatial learning through the ROCK pathway in protein tyrosine phosphatase receptor type Z-deficient mice. (2005)
  • Author(s): Niisato, K.
  • Journal Title: J.Neurosci. 25 Pages: 1081-1088
• [Journal Article] Tonotopic specialization of auditory coincidence detection in nucleus laminaris of the chick. (2005)
  • Author(s): Kuba, H
  • Journal Title: J.Neurosci. 25(8) Pages: 1924-1934
• [Journal Article] Calcium-dependence of native metabotropic glutamate receptor signaling in central neurons. (2004)
  • Author(s): Tabata, T.
  • Journal Title: Mol.Neurobiol. 29 Pages: 261-270
• [Journal Article] Distinct roles of Gα_q and Gα_<11> for Purkinje cell signaling and motor behavior. (2004)
  • Author(s): Hartmann, J.
  • Journal Title: J.Neurosci. 24 Pages: 5119-5130
• [Journal Article] Ca^<2+> activity at GABA_B receptors constitutively promotes metabotropic glutamate signaling in the absence of GABA. (2004)
  • Author(s): Tabata, T.
  • Journal Title: Proc.Natl.Acad.Sci.USA. 101 Pages: 16952-16957
• [Journal Article] Signaling complex formation of phospholipase Cβ4 with mGluR1a and IP3 receptor at the perisynapse and endoplasmic reticulum in the mouse brain. (2004)
  • Author(s): Fukaya, M.
  • Journal Title: Eur.J.Neurosci. 20 Pages: 2929-2944
• [Journal Article] Specification of the retinal fate of mouse embryonic stem cells by ectopic expression of Rx/rax, a homeobox gene. (2004)
  • Author(s): Tabata, Y.
  • Journal Title: Mol.Cell.Biol. 24 Pages: 4513-4521
• [Journal Article] Defective function of GABA-containing synaptic vesicles in mice lacking the AP-3B clathrin adaptor. (2004)
  • Author(s): Nakatsu, F.
  • Journal Title: J.Cell Biol. 167 Pages: 293-302
• [Journal Article] Tonotopic Gradients of membrane and synaptic properties for neurons of the chicken nucleus magnocellularis. (2004)
  • Author(s): Fukui, I.
  • Journal Title: J.Neurosci. 24(34) Pages: 7514-7523
• [Journal Article] P/Q-type Ca^<2+> channel α1A regulates synaptic competition on developing cerebellar Purkinje cells. (2004)
  • Author(s): Miyazaki, M.
  • Journal Title: J.Neurosci. 24 Pages: 1734-1743
• [Journal Article] Distinct cellular expressions of creatine synthetic enzyme GAMT and creatine kinases uCK-Mi and CK-B suggest novel neuron-glial relationship for brain energy homeostasis. (2004)
  • Author(s): Tachikawa, M.
  • Journal Title: Eur.J.Neurosci. 20 Pages: 144-160
• [Journal Article] NMDA Receptor GluRε/NR2 subunits are essential for postsynaptic localization and protein stability of GluRξ1/NR1 subunit. (2004)
  • Author(s): Abe, M.
  • Journal Title: J.Neurosci. 24 Pages: 9292-9304
• [Journal Article] CB1 is the major cannabinoid receptor at excitatory presynaptic site in the hippocampus and cerebellum.
  • Author(s): Kawamura, Y.
  • Journal Title: J.Neurosci. (in press)
• [Journal Article] Role of Ser50 phosphorylation in SCG10 regulation of microtubule depolymerization.
  • Author(s): Togano T
  • Journal Title: J.Neurosci.Res. (in press)
• [Journal Article] Implication to the molecular strategy of the axonal regeneration.
  • Author(s): Igarashi M
  • Journal Title: Acta Med.Biolog. (in press)(invited review)
• [Journal Article] Control of synaptic connection by glutamate receptor δ2 in the mature cerebellum.
  • Author(s): Takeuchi, T.
  • Journal Title: J.Neurosci. (in press)
• [Presentation] Activity-dependent strengthening of single climbing fiber synaptic inputs in Purkinje cells of developing cerebellum (2010)
  • Author(s): Kano, M., Kawamura, Y., Nakayama, H., Kitamura, K
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 兵庫県神戸市神戸ポートアイランド
  • Year and Date: 2010-12-07
• [Presentation] Activity-dependent elimination of redundant climbing fiber synapses during postnatal cerebellar development. (2010)
  • Author(s): Kano, M.
  • Organizer: 3rd International Workshop : Molecular and Cellular Mechanisms of Axon Degeneration
  • Place of Presentation: Eibsee Hotel, Eibsee, Germany
  • Year and Date: 2010-10-05
• [Presentation] 登上線維の発達過程におけるP/Q型電位依存性カルシウムチャネルの役割 (2010)
  • Author(s): 橋本浩一、辻田実加、喜多村和郎、宮崎太輔、山崎真弥、Hee-Sup Shin、渡辺雅彦、崎村建司、狩野方伸
  • Organizer: 第33回日本神経科学大会 第53回日本神経化学会大会 合同大会NEURO2010
  • Place of Presentation: 兵庫県神戸市神戸コンベンションセンター
  • Year and Date: 2010-09-04
• [Presentation] TARP γ2、γ7は小脳AMPA型グルタミン酸受容体の機能的構成成分である (2010)
  • Author(s): 山崎真弥、深谷昌弘、橋本浩一、山崎美和子、板倉誠、高橋正身、狩野方伸、渡辺雅彦、崎村建司
  • Organizer: 第33回日本神経科学大会 第53回日本神経化学会大会 合同大会NEURO2010
  • Place of Presentation: 兵庫県神戸市神戸コンベンションセンター
  • Year and Date: 2010-09-03
• [Presentation] 中枢神経系の組織培養細胞における効果的な神経活動の操作 (2010)
  • Author(s): 三國貴康、上阪直史、狩野方伸
  • Organizer: 第33回日本神経科学大会 第53回日本神経化学会大会 合同大会NEURO2010
  • Place of Presentation: 兵庫県神戸市神戸コンベンションセンター
  • Year and Date: 2010-09-02
• [Presentation] GluD2(GluRσ2)ノックアウトマウスの小脳プルキンエ細胞集団の2光子カルシウムイメージング解析 (2010)
  • Author(s): 橋爪幹、喜多村和郎、崎村建司、狩野方伸
  • Organizer: 第33回日本神経科学大会 第53回日本神経化学会大会 合同大会NEURO2010
  • Place of Presentation: 兵庫県神戸市神戸コンベンションセンター
  • Year and Date: 2010-09-02
• [Presentation] 小脳を延髄との共培養標本を用いたシナプス発達のメカニズムを解明するためのアプローチ方法 (2010)
  • Author(s): 上阪直史、三國貴康、狩野方伸
  • Organizer: 第33回日本神経科学大会 第53回日本神経化学会大会 合同大会NEURO2010
  • Place of Presentation: 兵庫県神戸市神戸コンベンションセンター
  • Year and Date: 2010-09-02
• [Presentation] Spike timing-dependent strengthening of climbing fiber inputs in developing cerebellum. (2010)
  • Author(s): Kano, M.
  • Organizer: Jacques Monod Conference
  • Place of Presentation: Biological Station, CNRS, Roscoff, France
  • Year and Date: 2010-07-01
• [Presentation] 中枢神経系の組織培養細胞への遺伝子導入方法の応用 (2010)
  • Author(s): 三国貴康、上阪直史、狩野方伸
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 岩手県盛岡市マリオス盛岡嗜眠文化ホール
  • Year and Date: 2010-05-21
• [Presentation] 小脳登上線維-プルキンエ細胞シナプスの生後発達におけるP/Q型電位依存性カルシウムチャネルの役割 (2010)
  • Author(s): 橋本浩一、辻田実加、宮崎太輔、山崎真弥、喜多村和郎、Hee-sup Shin、渡辺雅彦、崎村建司、狩野方伸
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 岩手県盛岡市マリオス盛岡市民文化ホール
  • Year and Date: 2010-05-19
• [Presentation] Protease-activated receptor 1 induces suppression of inhibitory synaptic transmission in the hippocampus (2009)
  • Author(s): Hashimotodani Y
  • Organizer: 39^<th> Annual meeting of the Society for Neuroscience
  • Place of Presentation: アメリカ、シカゴ McCormick Place
  • Year and Date: 2009-10-20
• [Presentation] Adenosine A1 receptor regulates mGluR1 signaling and LTD in cerebellar Purkinje cells (2009)
  • Author(s): Kamikubo Y
  • Organizer: 39^<th> Annual meeting of the Society for Neuroscience
  • Place of Presentation: アメリカ、シカゴ McCormick Place
  • Year and Date: 2009-10-19
• [Presentation] Analysis of the physiological function of cerebellar AMPA receptor subunits using Purkinje cell-specific gene targeting system (2009)
  • Author(s): Abe M
  • Organizer: 39^<th> Annual meeting of the Society for Neuroscience
  • Place of Presentation: アメリカ、シカゴ McCormick Place
  • Year and Date: 2009-10-18
• [Presentation] 発達期小脳における登上線維-プルキンエ細胞間シナプス除去への抑制性GABA作動性伝達の関与 (2009)
  • Author(s): 中山寿子
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 愛知県名古屋市名古屋国際会議場
  • Year and Date: 2009-09-17
• [Presentation] 成熟マウス小脳における2-アラキドノイルグリセロールによる逆行性シナプス伝達 (2009)
  • Author(s): 谷村あさみ
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 愛知県名古屋市名古屋国際会議場
  • Year and Date: 2009-09-17
• [Presentation] mGluR1は瞬目反射条件づけ記憶の獲得に必要であり、その発現や保持には必要ではない (2009)
  • Author(s): 中尾晴美
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 愛知県名古屋市名古屋国際会議場
  • Year and Date: 2009-09-17
• [Presentation] 小脳プルキンエ細胞のグルタミン酸感受性長期抑圧の制御機構としてのA1アデノシン受容体 (2009)
  • Author(s): 藤田洋介
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 愛知県名古屋市名古屋国際会議場
  • Year and Date: 2009-09-16
• [Presentation] 中枢神経系組織培養細胞への遺伝子導入方法 (2009)
  • Author(s): 上阪直史
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 愛知県名古屋市名古屋国際会議場
  • Year and Date: 2009-09-16
• [Presentation] Two-Photon Imaging of Population Activity in Cerebellar Purkinje Cells in GluR δ2 Knockout Mouse (2009)
  • Author(s): Hashizume M
  • Organizer: 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: 京都府国立京都国際会館
  • Year and Date: 2009-07-31
• [Presentation] Bi-directional regulation of cerebellar synaptic plasticity through inter-GPCR interplay (2009)
  • Author(s): Kamikubo Y
  • Organizer: 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: 京都府国立京都国際会館
  • Year and Date: 2009-07-28
• [Presentation] Analysis of climbing fiber inputs to Purkinje cells in the developing rat cerebellum in vivo (2009)
  • Author(s): Kawamura Y
  • Organizer: 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: 京都府国立京都国際会館
  • Year and Date: 2009-07-28
• [Presentation] Translocation of the strongest climbing fiber to Purkinje cell dendrites after synaptic competition on the soma in developing cerebellum (2009)
  • Author(s): Hashimoto K
  • Organizer: 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: 京都府国立京都国際会館
  • Year and Date: 2009-07-28
• [Presentation] Modulation of hippocampal inhibitory synaptic transmission through protease-activated receptor 1 (2009)
  • Author(s): Hashimotodani Y
  • Organizer: 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: 京都府国立京都国際会館
  • Year and Date: 2009-07-28
• [Presentation] Activity-dependent regulation of climbing fiber synapse elimination during postnatal cerebellar development. (2009)
  • Author(s): Kano, M
  • Organizer: Gordon Research Conference on Neural Circuits & Plasticity.
  • Place of Presentation: Newport, RI, USA.
  • Year and Date: 2009-06-08
• [Presentation] Activity-dependent regulation of climbing fiber synapse elimination during postnatal cerebellar development (2009)
  • Author(s): Kano M
  • Organizer: Gordon Research Conference on Neural Circuits & Plasticity
  • Place of Presentation: アメリカ Salve Regina 大学
  • Year and Date: 2009-06-07
• [Presentation] 2-Arachidonoylglycerol mediates short-term retrograde suppression of synaptic transmission in the cerebellum (2009)
  • Author(s): Kano M
  • Organizer: 4^<th> International Conference on Phospholipase A_2 and Lipid Mediators(PLM2009)
  • Place of Presentation: 東京都千代田区一ツ橋学術総合センター
  • Year and Date: 2009-05-25
• [Presentation] Strength of GABAa receptor-mediated transmission is crucial for the late phase of climbing fiber synapse elimination during postnatal cerebellar development (2008)
  • Author(s): Nakayama H
  • Organizer: Neuroscience 2008
  • Place of Presentation: ワシントンDC, アメリカ
  • Year and Date: 2008-11-18
• [Presentation] Developmental changes in climbing fiber responses of cerebellar Purkinje cells revealed by whole-cell patch-clamp recordings in vivo (2008)
  • Author(s): Kawamura Y
  • Organizer: Neuroscience 2008
  • Place of Presentation: ワシントンDC, アメリカ
  • Year and Date: 2008-11-16
• [Presentation] Functional coupling between mGluR1 and Cav3.1 T-type calcium channels enhances cerebellar Purkinje cell excitability and local signaling (2008)
  • Author(s): Hildebrand M E
  • Organizer: Neuroscience 2008
  • Place of Presentation: ワシントンDC, アメリカ
  • Year and Date: 2008-11-15
• [Presentation] Endocannabinoid-mediated retrograde synaptic modulation triggered by activation of group I mGluRs (2008)
  • Author(s): Kano M
  • Organizer: 6th International Meeting of Metabotropic Glutamate Receptors
  • Place of Presentation: シチリア島、イタリア
  • Year and Date: 2008-09-17
• [Presentation] Requirement of type 1 metabotropic glutamate receptor for activity-dependent synapse elimination in the lateral geniculate nucleus (2008)
  • Author(s): Narushima-Takahashi M
  • Organizer: 6th FENS (Forum of European Neuroscience)
  • Place of Presentation: ジュネーブ、スイス
  • Year and Date: 2008-07-15
• [Presentation] Gating of complex spike calcium transient by metabotropic glutamate recentors in cerebellar Purkinie cells (2008)
  • Author(s): Otsu Y
  • Organizer: 6th FENS (Forum of European Neuroscience)
  • Place of Presentation: ジュネーブ、スイス
  • Year and Date: 2008-07-15
• [Presentation] Functional coupling between mGluR1 and Cav3.1 T-Type calcium channels enhances cerebellar Purkinje cell excitability and local signaling (2008)
  • Author(s): Isope P
  • Organizer: 6th FENS (Forum of European Neuroscience)
  • Place of Presentation: ジュネーブ、スイス
  • Year and Date: 2008-07-15
• [Presentation] 成体期の小脳における代謝型グルタミン酸受容体1型の役割 (2008)
  • Author(s): 中尾晴美
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京都千代田区東京国際フオーラム
  • Year and Date: 2008-07-10
• [Presentation] ERKは発達期小脳におけるシナプス除去に必要である (2008)
  • Author(s): 原田武志
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京都千代田区東京国際フォーラム
  • Year and Date: 2008-07-10
• [Presentation] 代謝型グルタミン酸受容体1型による網膜-外側膝状体シナプス除去の調節集 (2008)
  • Author(s): 鳴島円
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京都千代田区東京国際フォーラム
  • Year and Date: 2008-07-10
• [Presentation] 発達期小脳プルキンエ細胞のin vivoパッチクランプ法による解析 (2008)
  • Author(s): 河村吉信
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京都千代田区東京国際フォーラム
  • Year and Date: 2008-07-09
• [Presentation] 成熟マウス小脳平行線維とプルキンエ細胞間の逆行性シナプス調節における内因性カンナビノイドの寄与 (2008)
  • Author(s): 谷村あさみ
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京都千代田区東京国際フォーラム
  • Year and Date: 2008-07-09
• [Presentation] 延髄と小脳の共培養による小脳プルキンエ細胞への機能的シナプス結合再構築 (2008)
  • Author(s): 上坂直史
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京都千代田区東京国際フォーラム
  • Year and Date: 2008-07-09
• [Presentation] 代謝型GABA受容体-代謝型グルタミン酸受容体クロストークによる小脳プルキンエ細胞LTDの増強 (2008)
  • Author(s): 上窪 裕二
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-26
• [Presentation] 逆行性シナプス伝達抑制における内因性カンナビノイドである2-アラキドノイルグリセロールの産生と分解 (2008)
  • Author(s): 橋本谷 裕樹
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-25
• [Presentation] Mechanisms of endocannabinoid-mediated retrograde modulation of synaptic transmission. (2007)
  • Author(s): Masanobu Kano
  • Organizer: The joint meeting of the 10th Southeast Asian Western Pacific Regional Meeting of Pharmacologists(SEAWP-RMP)and the 41st Annual Scientific Meeting of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists(ASCEPT)
  • Place of Presentation: Adelaide,Australia
  • Year and Date: 2007-12-04
• [Presentation] Protocadherin-alpha family in the olivo-cerebellar system; their isoform expression and loss of function analysis. (2007)
  • Author(s): You Kumode
  • Organizer: 37th Annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2007-11-07
• [Presentation] mGluR1 is essential for motor coordination in the adult cerebellum. (2007)
  • Author(s): Atsushi Aiba
  • Organizer: 37th Annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2007-11-06
• [Presentation] GABAΒ receptor signaling enhances mGluR1 signaling and LTD in cultured cerebellar Purkinje cells. (2007)
  • Author(s): Yuji Kamikubo
  • Organizer: 37th Annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2007-11-03
• [Presentation] Junctophilin-mediated functional crosstalk between ryanodine receptors and SK channels essential for cerebellar long-term depression. (2007)
  • Author(s): Sho Kakizawa
  • Organizer: 37th Annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2007-11-03
• [Presentation] Mechanisms of Ca^<2+>-driven endocannabinoid release: Apharmacological and genetic approach. (2007)
  • Author(s): Masanobu Kano
  • Organizer: 17th Neuropharmacology "Conference" Cannabinoid signaling in the nervous system"
  • Place of Presentation: San Diego, USA
  • Year and Date: 2007-11-01
• [Presentation] Mechanisms of Ca2+-driven endocannabinoid release: A pharmacological and genetic approach. (2007)
  • Author(s): Kano, M., Hashimotodani, Y., Ohno-Shosaku, T., Fukami, K.
  • Organizer: 17th Neuropharmacology Conference "Cannabinoid signaling in the nervous system. "
  • Place of Presentation: San Diego, USA
  • Year and Date: 2007-10-31
• [Presentation] 小脳神経回路形成におけるプロトカドヘリンアルファのアイソフォーム発現と機能解析 (2007)
  • Author(s): 雲出 佑
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-12
• [Presentation] 内因性カンナビノイド受容体および代謝型グルタミン酸受容体シグナリングの役割について (2007)
  • Author(s): 岸本 泰司
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-12
• [Presentation] 中枢神経系における内因性カンナビノイド放出と逆行性シナプス抑制のメカニズム (2007)
  • Author(s): 狩野 方伸
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-11
• [Presentation] 内因性カンナビノイド制御におけるモノアシルグリセロールリパーゼの役割 (2007)
  • Author(s): 橋本谷 祐輝
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-11
• [Presentation] 発達期小脳の神経回路形成過程における登上線維シナプス除去へのGABA作動性シナプス伝達の関与 (2007)
  • Author(s): 中山 寿子
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-11
• [Presentation] 中枢ニューロンにおける高閾値型電位依存性Ca^<2+>チャネルの容量性Ca^<2+>流入への寄与 (2007)
  • Author(s): 田端 俊英
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] 線条体における2-アラキドノイルグリセロールを介した逆行性シグナル伝達に関与する分子の細胞内配置 (2007)
  • Author(s): 内ケ島 基政
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] 視床皮質軸索の枝分かれ形成における視床と大脳皮質細胞の神経活動の役割 (2007)
  • Author(s): 山田 成人
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] Phospholipase C beta as a neuronal coincidence detector. (2007)
  • Author(s): Masanobu Kano
  • Organizer: Life Science 2007
  • Place of Presentation: Glasgow, UK
  • Year and Date: 2007-07-10
• [Book] Handbook of Neurochemistry and Molecular Neurobiology 3rd Edition Neural Signaling Mechanisms (2009)
  • Author(s): Tabata, T., Kano M. Synaptic
  • Publisher: Springer Sciencet Business Media
• [Book] Handbook of Neurochemistry and Molecular Neurobiology 3rd Edition Neural Signaling Mechanisms (2009)
  • Author(s): Tabata T
  • Total Pages: 632
  • Publisher: Springer Science Business Media
• [Book] Synaptic plasticity in the cerebellum. In : Handbook of Neurochemistry an d Molecular Neurobiology (2009)
  • Author(s): Tabata T
  • Publisher: Springer Science Business Media(In pres)(発行確定)
• [Book] 分子・細胞・シナプスからみる脳 (2008)
  • Author(s): 田端俊英、狩野方伸
  • Publisher: 東京大学出版会
• [Book] シナプスの刈り込みと神経回路発達(脳を知る・創る・守る・育む : NPO法人脳の世紀推進会議/編) (2008)
  • Author(s): 狩野方伸
  • Total Pages: 159
  • Publisher: クバプロ
• [Book] 小脳におけるシナプス可塑性(シリーズ脳科学5、分子・細胞・シナプスからみる脳 : 甘利俊一/監修、古市貞一/編) (2008)
  • Author(s): 田端俊英
  • Total Pages: 284
  • Publisher: 東京大学出版会
• [Book] 長期抑圧(現代医学・生物学の仮説・学説2008)生体の科学59 : No.5 (2008)
  • Author(s): 由端俊英
  • Total Pages: 488
  • Publisher: 医学書院
• [Book] 感覚受容から認知、記憶・学習、行動までの脳機構研究の新展開 (2007)
  • Author(s): 狩野方伸, 高田昌彦, 伊佐正
  • Total Pages: 232
  • Publisher: 羊土社
• [Book] 生化学-神経生化学を中心に(クルズス基礎医学)(赤川 公朗・編) (2007)
  • Author(s): 五十嵐 道弘
  • Publisher: 星和書店(印刷中)
• [Book] Control of synaptic transmission in the CNS through endocannabinoid-mediated retrograde signaling. Dendritic Neurotransmitter Release(M.Ludwig(ed)) (2005)
  • Author(s): Ohno-Shosaku, T.
  • Total Pages: 12
  • Publisher: Springer, New York
• [Book] 経験を積み重ねて作られる神経回路(朝日選書771「脳はどこまでわかったか」)(井原康夫 編集) (2005)
  • Author(s): 狩野方伸
  • Total Pages: 19
  • Publisher: 朝日新聞社
• [Book] シンタキシンの新規結合蛋白質の機能解析.「ブレインサイエンスレビュー2004」 (2004)
  • Author(s): 五十嵐 道弘
  • Total Pages: 10
  • Publisher: 伊藤正男・川合述史編/クバプロ
• [Book] 海馬におけるシナプス伝達と可塑性・記憶の分子機構「(特集)記憶・学習の分子基盤に迫る」 Molecular Medicine41巻9号 (2004)
  • Author(s): 真鍋 俊也
  • Total Pages: 17
  • Publisher: 中山書店
• [Remarks] 東京大学大学院医学系研究科神経生理学教室
  • URL: http://plaza.umin.ac.jp/~neurophy/Kano%20lab/Top.html
• [Remarks]
  • URL: http://www.togo-nou.nips.ac.jp/
• [Remarks]
  • URL: http://plaza.umin.ac.jp/~neurophy/
• [Remarks] 東京大学大学院医学系研究科神経生理学教室
  • URL: http://plaza.umin.ac.jp/~neurophy/Kano%201ab/Top.html
• [Remarks] 東京大学大学院医学系研究科神経生理学教室
  • URL: http://plaza.umin.ac.jp/~neurophy/Kano%201ab/Top.html
• [Remarks]
  • URL: http://plaza.umin.ac.jp/~neurophy/
• [Patent(Industrial Property Rights)] polypeptide having intracellular calcium ion indicator function (2010)
  • Inventor(s): Ohmori H, Ishii T, Takatsuka K
  • Industrial Property Rights Holder: Kyoto University
  • Filing Date: 2010-01-12
• [Patent(Industrial Property Rights)] 細胞内カルシウムイオン指示機能を有するポリペプチド (2007)
  • Inventor(s): 大森治紀、石井孝広、高塚賢二
  • Industrial Property Rights Holder: 京都大学
  • Filing Date: 2007-03-01