Integrated Mechanism Regulating Phosphorylation- Dependent Signal Transduction

• Project/Area Number: 16083202
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tohoku University
• Principal Investigator: UCHIDA Takafumi Tohoku University, 大学院農学研究科, 教授 (80312239)
• Co-Investigator(Kenkyū-buntansha): HARADA Masahiko 東北大学, 大学院農学研究科, 准教授 (70218642) ; ITOU Tomohiko 名古屋大学, 大学院理学研究科, 教授 (30183742) ; UCHIDA Chiyoko 茨城大学, 保健管理センター, 准教授 (80312776) ; TAKAHASHI Katuhiko 昭和大学, 薬学部, 講師 (80307066)
• Project Period (FY): 2004 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥64,500,000 (Direct Cost: ¥64,500,000); Fiscal Year 2008: ¥12,900,000 (Direct Cost: ¥12,900,000); Fiscal Year 2007: ¥12,900,000 (Direct Cost: ¥12,900,000); Fiscal Year 2006: ¥12,900,000 (Direct Cost: ¥12,900,000); Fiscal Year 2005: ¥15,300,000 (Direct Cost: ¥15,300,000); Fiscal Year 2004: ¥10,500,000 (Direct Cost: ¥10,500,000)
• Keywords: Pin1 / Gas7 / 微小管 / アルツハイマー病 / アミロイド / タウ / STAT / Notch1 / Pinl / リン酸化 / TGβ / Smad / 癌 / high throughput screening / Alzheimer'sdlsease / プロリン異性化酵素 / stat3 / proteome / Alzheimer's disease / oligodendrocyte / spinal cord injury / リチウム / Tau / Arp / Myc

Research Abstract

タンパク質のリン酸化は、細胞周期、細胞内シグナル伝達、微小管重合など多様な細胞機能に関与する。我々は、Pin1 が癌やアルツハイマー病に関わる機構の解明を継続して行うとともに、これら以外の加齢疾患の発症にも関わることを明らかにした。またリン酸化タンパク質の機能を制御する分子としてGas7 を発見し、Gas7 が、リン酸化タウを介して微小管重合を促進する、脳特異的タンパク質であること、また、アルツハイマー病で激減していることを明らかにした。

Research Products

• [Journal Article] Dipentamethylene thiuram monosulfide is a novel inhibitor of Pin1 (2009)
  • Author(s): Tatara Y, Lin YC, Bamba Y, Mori T and Uchida T
  • Journal Title: Biochem Biophys Res Commun 384 Pages: 394-398
  • Peer Reviewed
• [Journal Article] Effect of Pin1 or microtubule binding on dephosphorylation of FTDP-17 mutant tau (2009)
  • Author(s): Yotsumoto K, Saito T, Asada A, Oikawa1 T, Kimura T, Uchida C, Ishiguro K, Uchida T, Hasegawa M and Hisanaga S
  • Journal Title: J Biol Chem, (doi/10.1074/jbc.M109.003277) in press
  • Peer Reviewed
• [Journal Article] Use of a Real-time Fluorescence Monitoring System for High-Throughput Screening for Prolyl Isomerase Inhibitors (2009)
  • Author(s): Mori T, Itami S, Yanagi T, Tatara Y, Takamiya M and Uchida T
  • Journal Title: J .Biomol Screen 14(4) Pages: 419-424
  • Peer Reviewed
• [Journal Article] Pin1 downregulates TGF-beta signaling by inducing degradation of Smad proteins (2009)
  • Author(s): Nakano A, Koinuma D, Miyazawa K, Uchida T, Saitoh M, Kawabata M, Hanai J, Akiyama H, Abe M, Miyazono K, Matsumoto T, Imamura T
  • Journal Title: J Biol Chem 284 Pages: 6109-6115
  • Peer Reviewed
• [Journal Article] The human actin-related protein hArp5 : Nucleo-cytoplasmic shuttling and involvement in DNA repair (2009)
  • Author(s): Kitayama K, Kamo M, Oma Y, Matsuda R, Uchida T, Ikura T, Tashiro S, Ohyama T, Winsor B, Harata M
  • Journal Title: Exp Cell Res 315(2) Pages: 206-217
  • Peer Reviewed
• [Journal Article] Use of a Real-time Fluorescence Monitoring System for High-Throughput Screening for Prolyl Isomerase Inhibitors. (2009)
  • Author(s): Mori T, et.al.
  • Journal Title: J. Biomol Screen (印刷中(ネットで閲覧可))
  • Peer Reviewed
• [Journal Article] Pinl downregulates TGF-13 signaling byinducing degradation of Smad proteins. (2009)
  • Author(s): Nakano A, et.al.
  • Journal Title: J Biol Chem 284 Pages: 6109-6115
  • Peer Reviewed
• [Journal Article] The human actin-related protein hArp5 : Nucleo-cytoplasmic shuttling and involvement in DNA repair (2009)
  • Author(s): Kitayama K, et.al.
  • Journal Title: Exp Cell Res 315(2) Pages: 206-217
  • Peer Reviewed
• [Journal Article] Acid activation of protyrosinase from Aspergillus oryzae : homo-tetrameric protyrosinase is converted to active dimmers with an essential intersubunit disulfide bond at acididic pH (2008)
  • Author(s): Tatara Y, Namba T, Yamagata, Y., Yoshida, T, Uchida, T. and Ichishima, E
  • Journal Title: Pigment Cell Melanoma Res 21 Pages: 89-96
  • Peer Reviewed
• [Journal Article] Pseudomonas fluorescens proliferates in a mouse organ homogenate at low temperature (2008)
  • Author(s): Tatara Y, Terakawa T, Yamagata, Y. and Uchida T
  • Journal Title: Int J Mol Med 21 Pages: 621-626
  • Peer Reviewed
• [Journal Article] Prolyl isomerase Pin1 : New findings on post-translational modifications and physiological substrates in cancer, Alzheimer's disease and asthma (2008)
  • Author(s): Takahashi K, Uchida C, Shin RW, Shimazaki,K and Uchida T
  • Journal Title: Cell and Mol Life Sci 65 Pages: 359-375
  • Peer Reviewed
• [Journal Article] Onco-suppressor p53 protein prevents an Alzheimer disease mouse model, Pin1-null mouse from the increase of presenilin-1 (2008)
  • Author(s): Takahashi K, Shimazaki K, Obama T, Kato R, Itabe H, Akiyama H. Uchida C, Shin RW, and Uchida T
  • Journal Title: New Frontiersin Lifestyle-Related Diseases, (Eds. Miyazaki, A and Imawari M), (Springer Japan, Doi : 10.1007/978-4-431-76428-1)
• [Journal Article] Novel Functions of Prolyl Isomerase Pin1 (2008)
  • Author(s): Akiyama H, Tatara Y and Uchida T
  • Journal Title: Tohoku J Agr Res 58 Pages: 147-156
• [Journal Article] The nuclear actin-related protein Act3p/Arp4 influences yeast cell shape and bulk chromatin organization (2008)
  • Author(s): Miloshev J, Harata M, and Georgieva M
  • Journal Title: Cell Bio chem 104 Pages: 59-67
  • Peer Reviewed
• [Journal Article] The actin-related protein hArp8 accumulates on the mitotic chromosomes and functions in chromosome alignment (2008)
  • Author(s): Aoyama N, Oka A, Kitayama K, Kurumizaka H, Harata M
  • Journal Title: Exp Cell Res 314 Pages: 859-868
  • Peer Reviewed
• [Journal Article] Ino80 Chromatin Remodeling Complex Promotes Recovery of Stalled Replication Forks (2008)
  • Author(s): Shimada K, Oma Y, Schleker T, Kugou K, Ohta K, Harata M, Gasser SM
  • Journal Title: Curr. Biol 18 Pages: 566-575
  • Peer Reviewed
• [Journal Article] Prolyl isomerase Pinl : New findings on post-translational modifications and physiological substrates in cancer, Alzheimer's disease and asthma (2008)
  • Author(s): Takahashi K, et.al.
  • Journal Title: Cell and Mol Life Sci 65 Pages: 359-375
  • Peer Reviewed
• [Journal Article] Acid activation of protyrosinase from Aspergillus oryzae : homo-tetrameric protyrosinase is converted to active dimmers with an essential intersubunit disulfide bond at acididic pH (2008)
  • Author(s): Tatara Y, et.al.
  • Journal Title: Pigment Cell Melanoma Res 21 Pages: 89-96
  • Peer Reviewed
• [Journal Article] Pseudomonas fluorescens proliferates in a mouse organ homoaenate at low temnerature (2008)
  • Author(s): Tatara Y, et.al.
  • Journal Title: Int J Mol Med 21 Pages: 621-626
  • Peer Reviewed
• [Journal Article] Novel Functions of Prolyl Isomerase Pinl (2008)
  • Author(s): Akiyama H, et.al.
  • Journal Title: Tohoku J Agr Res 58 Pages: 147-156
  • Peer Reviewed
• [Journal Article] The nuclear actin-related protein Act3p / Arp4 influences yeast cell shape and bulk chromatin organization (2008)
  • Author(s): Miloshev J, et.al.
  • Journal Title: J Cell Biochem 104 Pages: 59-67
  • Peer Reviewed
• [Journal Article] The actin-related protein hArp8 accumulates on the mitotic chromosomes and functions in chromosome alignment (2008)
  • Author(s): Aoyama N, et.al.
  • Journal Title: Exp Cell Res 314 Pages: 859-868
  • Peer Reviewed
• [Journal Article] Ino80 Chromatin Remodeling Complex Promotes Recovery of Stalled Replication Forks. (2008)
  • Author(s): Shimada K, et.al.
  • Journal Title: Curr. Biol 18 Pages: 566-575
  • Peer Reviewed
• [Journal Article] Involvement of the actin-related protein Arp6 in spatial organization of radial chromosome territories (2008)
  • Author(s): Harata M
  • Journal Title: Chromosome Science 11 Pages: 27-27
  • Peer Reviewed
• [Journal Article] Pseudomonas fluorescens proliferates in a mouse organ homogenate at low temperature. (2008)
  • Author(s): Tatara Y, et. al.
  • Journal Title: Int J Mol Med 21 Pages: 621-626
  • Peer Reviewed
• [Journal Article] Ino80 chromatin remodeling complex promotes recovery of stalled replicationforks. (2008)
  • Author(s): Shimada K, et. al.
  • Journal Title: Current Biology 18 Pages: 566-575
  • Peer Reviewed
• [Journal Article] The actin-related protein hArp8 accumulates on the mitotic chromosomes and functions in chromosome alignment (2008)
  • Author(s): Aoyama N, et. al.
  • Journal Title: Experimental Cell Research 314 Pages: 859-868
  • Peer Reviewed
• [Journal Article] Prolyl isomerase Pin1: New findings on post-translational modifications and physiological substrates in cancer, Alzheimer's disease and asthma. (2008)
  • Author(s): Takahashi K, et. al.
  • Journal Title: Cell and Molecular Life Science 65 Pages: 359-375
  • Peer Reviewed
• [Journal Article] Topology of AspT, the aspartate:alanine antiporter of Tetragenococcus halophilus, determined by site-directed fluorescence labeling (2007)
  • Author(s): Nanatani K, Fujiki T, Kanou K, Takeda-Shitaka M, Umeyama H, Ye L, Wang X, Nakajima T, Uchida T, Maloney PC, Abe K
  • Journal Title: J Bacteriol 189 Pages: 7089-7097
  • Peer Reviewed
• [Journal Article] Opposite regulation of oligodendrocyte apoptosis by JNK3 and Pin1 after spinal cord injury (2007)
  • Author(s): Li M, Tep C, Yune Y, Zhou Z, Uchida T, Lu P, Yoon SO
  • Journal Title: J Neurosci 27 Pages: 8395-8404
  • Peer Reviewed
• [Journal Article] Pin1 is required for the Ser727 phosphorylation- dependent Stat3 activity (2007)
  • Author(s): Lufei C, Koh TH, Uchida T and Cao X
  • Journal Title: Oncogene 26 Pages: 7656-7664
  • Peer Reviewed
• [Journal Article] Ablation of a peptidyl prolyl isomerase Pin1 from p53-null mice accelerated thymic hyperplasia by increasing the level of the intracellular form of Notch1 (2007)
  • Author(s): Takahashi K, Akiyama H, Shimazaki K, Uchida C, Akiyama OH, Tomita M, Fukumoto M, and Uchida T
  • Journal Title: Oncogene 26 Pages: 3835-3845
  • Peer Reviewed
• [Journal Article] Membrane Topology of Aspartate:Alanine Antiporter AspT from Comamonas testosteroni (2007)
  • Author(s): Fujiki T, Nanatani K, Nishitani K, Yagi K, Ohnishi F, Yoneyama H, Uchida T, Nakajima T, Abe K
  • Journal Title: J Biochem 141 Pages: 85-91
  • Peer Reviewed
• [Journal Article] Safe and Handy Fluorescent Stain Imager for Proteome Analysis (2007)
  • Author(s): Terakawa T, Keicho N, Uchida C and Uchida T
  • Journal Title: Current Proteomics 4 Pages: 115-120
  • Peer Reviewed
• [Journal Article] Opposite regulation of oligodendrocyte apoptosis by JNK3 and Pin1 after spinal cord injury (2007)
  • Author(s): Li M, et. al.
  • Journal Title: J Neuroscience 27 Pages: 8395-8404
  • Peer Reviewed
• [Journal Article] Pin1 is required for the Ser727 phosphorylation-dependent Stat3 activity (2007)
  • Author(s): Lufei C, et. al.
  • Journal Title: Oncogene 26 Pages: 7656-7664
  • Peer Reviewed
• [Journal Article] Acid activation of protyrosinase from Aspergillus oryzae: homo-tetrameric protyrosinase is converted to active dimmers with an essential intersubunit disulfide bond at acididic pH (2007)
  • Author(s): Tatara Y, et. al.
  • Journal Title: Pigment Cell Research 21 Pages: 89-96
  • Peer Reviewed
• [Journal Article] Safe and Handy Fluorescent Stain Imager for Proteome Analysis. (2007)
  • Author(s): Terakawa T, et. al.
  • Journal Title: Current Proteomics 4 Pages: 115-120
  • Peer Reviewed
• [Journal Article] Actin-related protein Arp4 functions in kinetochore assembly (2007)
  • Author(s): Ogiwara H, et. al.
  • Journal Title: Nucleic Acids Res. 35 Pages: 3109-3117
  • Peer Reviewed
• [Journal Article] The nuclear actin-related protein Act3p/Arp4 influences yeast cell shape and bulk chromatin organization (2007)
  • Author(s): Miloshev J, et. al.
  • Journal Title: J Cell Biochem 104 Pages: 59-67
  • Peer Reviewed
• [Journal Article] Membrane Topology of Aspartate : Alanine Antiporter AspT from Comamonas testosteroni (2007)
  • Author(s): Fujiki T et al.
  • Journal Title: J Biochem 141 Pages: 85-91
• [Journal Article] The INO80 complex is required for damage-induced recombination. (2007)
  • Author(s): Kawashima S et al.
  • Journal Title: Biochem Biophys Res Commun. 335 Pages: 835-841
• [Journal Article] Hydrophobic interactions between the secondary structures on the molecular surface reinforce the alkaline stability of serine protease (2006)
  • Author(s): Oguchi Y, Maeda H, Abe K, Nakajima T, Uchida T and Yamagata Y
  • Journal Title: Biotechnol Lett 28 Pages: 1383-1391
  • Peer Reviewed
• [Journal Article] Comparative analysis of enzyme activities and mRNA levels of peptidyl prolyl cis/trans isomerases in various organs of wild type and Pin1-/- mice (2006)
  • Author(s): Fanghanel J, Akiyama H, Uchida C and Uchida T
  • Journal Title: FEBS Lett 580 Pages: 3227-3245
  • Peer Reviewed
• [Journal Article] Follicle- stimulating hormone (FSH) stimulates the expression of Pin1, a peptidyl-prolyl isomerase, in the bovine granulosa cells (2006)
  • Author(s): Shimizu T, Tetsuka M, Miyamoto A and Uchida T
  • Journal Title: Domest Anim Endocrinol 32 Pages: 226-234
  • Peer Reviewed
• [Journal Article] Expression of Pin1, A Peptidyl Prolyl Isomerase, in the Ovaries of eCG/hCG-treated Immature Female Mice (2006)
  • Author(s): Shimizu T, Akiyama H, Abe Y, Sasada H, Sato E, Miyamoto A and Uchida T
  • Journal Title: J Reprod Dev 52 Pages: 287-291
  • NAID: 120006390132
  • Peer Reviewed
• [Journal Article] 認知症のメカニズムに迫る Pin1 とアルツハイマー病の病態 (2006)
  • Author(s): 辛龍雲、秋山弘匡、内田隆史
  • Journal Title: 化学と生物 44,7 Pages: 447-452
  • NAID: 10017994673
• [Journal Article] Ablation of a peptidyl prolyl isomerase Pin1 from p53-null mice accelerated thymic hyperplasia by increasing the level of the intracellular form of Notch1 (2006)
  • Author(s): Takahashi K et al.
  • Journal Title: Oncogene (advance online publication)
• [Journal Article] Comparative analysis of enzyme activities and mRNA levels of peptidyl prolyl cis/trans isomerases in various organs of wild type and Pin1-/- mice (2006)
  • Author(s): Fanghanel J et al.
  • Journal Title: FEBS Lett 580 Pages: 3227-3245
• [Journal Article] Follicle-stimulating hormone (FSH) stimulates the expression of Pin1, a peptidyl-prolyl isomerase, in the bovine granulosa cells. (2006)
  • Author(s): Shimizu T et al.
  • Journal Title: Domest Anim Endocrinol. 32 Pages: 226-234
• [Journal Article] Expression of Pin1, A Peptidyl Prolyl Isomerase, in the Ovaries of eCG/hCG-treated Immature Female Mice. (2006)
  • Author(s): Shimizu T et al.
  • Journal Title: J Reprod Dev. 52 Pages: 287-291
• [Journal Article] 認知症のメカニズムに迫る Pinlとアルツハイマー病の病態 (2006)
  • Author(s): 辛龍雲 et al.
  • Journal Title: 化学と生物 44 Pages: 447-452
• [Journal Article] Hydrophobic interactions between the secondary structures on the molecular surface reinforce the alkaline stability of serine protease (2006)
  • Author(s): Oguchi Y et al.
  • Journal Title: Biotechnol Lett 28 Pages: 1383-1391
• [Journal Article] Vertebrate Arp6, a novel nuclear actin-related protein, interacts with heterochromatin protein 1 (2006)
  • Author(s): Ohfuchi, E. et al.
  • Journal Title: Eur. J. Cell Biol. 85 Pages: 411-421
• [Journal Article] Assembly of staphylococcal leukocidin into a pore-forming oligomer on detergent-resistant membrane microdomains, lipid rafts, in human polymorphonuclear leukocytes. (2006)
  • Author(s): Nishiyama, A et al.
  • Journal Title: Biosci Biotechnol Biochem. 70 Pages: 1300-1307
• [Journal Article] 核の構造とその分子基盤 (2006)
  • Author(s): 原田昌彦 et el
  • Journal Title: PNE 51 Pages: 1943-1949
• [Journal Article] クロマチン (2006)
  • Author(s): 原田昌彦
  • Journal Title: PNE 51 Pages: 1943-1949
• [Journal Article] Expression of Pin1, A Peptidyl-Prolyl Isomerase, in the Ovaries of eCG/hCG-treated Immature Female Mice (2006)
  • Author(s): Shimizu, T. et al.
  • Journal Title: J.Reprod Dev. (印刷中)
• [Journal Article] Vertebrate Arp6, a novel nuclear actin-related protein, interacts with heterochromatin protein 1 (2006)
  • Author(s): Ohfuchi, E.et al.
  • Journal Title: Eur.J.Cell Biol. (印刷中)
• [Journal Article] 加齢疾患を抑制するプロリン異性化酵素Pin1 (2005)
  • Author(s): 内田隆史 Joerg Fanghaenel、 内田千代子、Linnaea Ostroff
  • Journal Title: タンパク核酸酵素, (共立出版) Vol50, No.11 Pages: 1413-1419
  • NAID: 40006927837
• [Journal Article] Prolyl isomerase Pin1 facilitates production of Alzheimer's amyloid beta from beta-cleaved amyloid precursor protein (2005)
  • Author(s): Akiyama H, Shin R, Uchida C, Kitamoto T and UchidaT
  • Journal Title: Biochem Biophys Res Commun, (Corrigendum ; Nature (2007)446, 342) 336 Pages: 521-529
  • Peer Reviewed
• [Journal Article] Pin1 promotes production or Alzheimer's amyloid beta from beta-cleaved amyloid. (2005)
  • Author(s): Akiyama, H. et al.
  • Journal Title: Biochem Biophys Res Commun 36(2) Pages: 521-529
• [Journal Article] 加齢疾患を制御するプロリン異性化酵素Pin1 (2005)
  • Author(s): 内田隆史 等
  • Journal Title: PNE 50(11) Pages: 1413-1419
• [Journal Article] The nuclear actin-related protein Act3p/Arp4p is involved in the dynamics of chromatin modulating complexes (2005)
  • Author(s): Sunada, R. et al.
  • Journal Title: Yeast 22 Pages: 753-768
• [Journal Article] Comparative analysis of ATP-binding cassette (ABC) transporter gene expression levels in peripheral blood leukocytes and in liver with hepatocellular carcinoma (2004)
  • Author(s): Moustafa, MA., Ogino, D., Nishimura, M., Ueda, N., Naito, S., Furukawa, M., Uchida, T., Ikai, I., Sawada, H., Fukumoto, M
  • Journal Title: Cancer Sci 95(6) Pages: 530-536
  • NAID: 10013723669
  • Peer Reviewed
• [Journal Article] Cytochrome P450 gene expression levels in peripheral blood mononuclear cells in comparison with the liver (2004)
  • Author(s): Furukawa, M., Nishimura, M., Ogino, D., Chiba, R., Ikai, I., Ueda, N., Naito, S., Kuribayashi, S., Moustafa, MA, Uchida, T., Sawada, H., Kamataki, T., Funae, Y., Fukumoto, M
  • Journal Title: Cancer Sci 95(6) Pages: 520-529
  • NAID: 10013723642
  • Peer Reviewed
• [Journal Article] A signaling pathway controlling myc degradation that impacts oncogenic transformation of human cells (2004)
  • Author(s): Yeh, E, Cunnigham, M., Arnold, H., Chasse, D., Monteith, T., Ivaldi, G., Hahn, WC., Stukenberg, T., Shenolikar, S., Uchida, T., Counter, CM., Nevins, JR., Means, AR. And Sears, R
  • Journal Title: Nature Cell Biol 6(4) Pages: 308-318
  • Peer Reviewed
• [Journal Article] 微小管の重合・脱重合 : 原子から細胞そして個体へ癌・アルツハイマー病とリン酸化調節因子Pin1 (2004)
  • Author(s): 内田隆史
  • Journal Title: 生物物理,44巻,(Suppl.1)
• [Journal Article] Overview リン酸化タンパク質の構造と機能を制御する因子の生物活性, 特集「タンパク質リン酸化調節異常と疾患」 (2004)
  • Author(s): 内田隆史
  • Journal Title: Molecular Medicine, (内田隆史 編) 41(5) Pages: 518-521
  • NAID: 40006185283
• [Journal Article] リン酸化タンパク質調節因子Pin1 による癌およびアルツハイマー病の制御, 特集「タンパク質リン酸化調節異常と疾患」 (2004)
  • Author(s): 内田隆史
  • Journal Title: Molecular Medicine, (内田隆史 編) 41(5)
  • NAID: 40006185286
• [Journal Article] Cytochrome P450 gene expression levels in peripheral blood mononuclear cells in comparison with the liver (2004)
  • Author(s): Furukawa M, et al.
  • Journal Title: Cancer Science 95(6) Pages: 520-529
• [Journal Article] Comparative analysis of ATP-binding cassette (ABC) transporter gene expression levels in peripheral blood leukocytes and in liver with hepatocellular carcinoma (2004)
  • Author(s): Moustafa MA, et al.
  • Journal Title: Cancer Science 95(6) Pages: 530-536
• [Journal Article] A Signaling Pathway Controlling Myc Degradation That Impacts Oncogenic Transformation of Human Cells (2004)
  • Author(s): Yeh E, et al.
  • Journal Title: Nature Cell Biology 6 Pages: 308-318
• [Journal Article] リン酸化タンパク質調節因子Pin1による癌およびアルツハイマー病の制御 (2004)
  • Author(s): 内田 隆史
  • Journal Title: Molecular Medicine 41(5) Pages: 538-543
• [Journal Article] リン酸化タンパク質の構造と機能を制御する因子の生物活性 (2004)
  • Author(s): 内田 隆史
  • Journal Title: Molecular Medicine 41(5) Pages: 518-521
• [Journal Article] Fission yeast Arp6 is required for telomere silencing but functions independently of Swi6 (2004)
  • Author(s): Ueno, M. et al.
  • Journal Title: Nucleic Acids Res. 32 Pages: 736-741
• [Journal Article] Molecular cloning and expression analysis of vitellogenin in scallop, Patinopecten yessoensis (Bivalvia, Mollusca) (2004)
  • Author(s): Osada, M. et al.
  • Journal Title: Mol.Reprod.Dev. 67 Pages: 273-281
• [Journal Article] 細胞核におけるアクチンファミリーの多様な機能 (2004)
  • Author(s): 原田昌彦
  • Journal Title: 蛋白質 核酸 酵素 49 Pages: 543-552
  • NAID: 40006120055
• [Journal Article] クロマチン構造変換複合体によるゲノム機能の制御:アクチン関連タンパク質(Arp)からのアプローチ (2004)
  • Author(s): 原田昌彦等
  • Journal Title: 日本農芸化学会誌 49 Pages: 2061-2063
  • NAID: 10013286117
• [Journal Article] 核内アクチンファミリーの分子機能 (2004)
  • Author(s): 原田昌彦, 尾間由佳子
  • Journal Title: 細胞核のダイナミクス(竹安邦夫、米田悦啓(編)) Pages: 177-186
• [Presentation] ナノ解析技術の微小管関連因子探索への応用 (2009)
  • Author(s): 甲賀友恵, 他
  • Organizer: 日本農芸化学会2009年度大会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2009-03-27
• [Presentation] リン酸基特異的なプロリン異性化酵素Pin1のターゲットタンパク質のプロテオーム解析 (2009)
  • Author(s): 大橋翼, 他
  • Organizer: 日本農芸化学会2009年度大会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2009-03-27
• [Presentation] Pinlp53ダブルーKOマウスの胸腺および脳の解析 (2009)
  • Author(s): 坂場義正, 他
  • Organizer: 日本農芸化学会2009年度大会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2009-03-27
• [Presentation] 微小管重合を調節するタンパク質および化学物質の探索 (2009)
  • Author(s): 坂本渉, 他
  • Organizer: 日本農芸化学会2009年度大会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2009-03-27
• [Presentation] プロリン異性化酵素PinlによるLpsシグナルの制御 (2009)
  • Author(s): 三澤拓馬, 他
  • Organizer: 日本農芸化学会2009年度大会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2009-03-27
• [Presentation] 細胞増殖抑制タンパク質Gas7による微小管重合制御 (2009)
  • Author(s): 後藤愛那、甲賀友恵、坂本渉、秋山弘匡、内田 隆史
  • Organizer: 日本農芸化学会2009年度大会
  • Place of Presentation: 福岡国際会議場
• [Presentation] 微小管重合調節因子Gas7と微小管の直接結合の可能性 (2009)
  • Author(s): 甲賀友恵、坂本渉、秋山弘匡、Nguyen Anh Hoa,樋口秀男、内田隆史
  • Organizer: 生体運動研究合同班会議2009 in TOKYO
  • Place of Presentation: 東京大学駒場
• [Presentation] アルツハイマー病患脳で減少しているGas7はリン酸化Tauに結合し微小管シート構造を安定化させる (2008)
  • Author(s): 秋山弘匡, 他
  • Organizer: BMB2008(第31回日本分子生物学会年会第81回日本生化学会大会合同大会)
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-09
• [Presentation] 膜透過ペプチドを用いたプロリン異性化酵素Pin1の細胞内輸送と分子治療への応用検討 (2008)
  • Author(s): 手島澄人, 他
  • Organizer: BMB2008(第31回日本分子生物学会年会第81回日本生化学会大会合同大会)
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-09
• [Presentation] 血小板分化におけるプロリン異性化酵素Pin1の機能解析 (2008)
  • Author(s): 鈴木伸幸, 他
  • Organizer: BMB2008(第31回日本分子生物学会年会第81回日本生化学会大会合同大会)
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-09
• [Presentation] リン酸基特異的なプロリン異性化酵素Pin1のターゲットタンパク質のプロテオーム解析 (2008)
  • Author(s): 多田羅洋太, 他
  • Organizer: BMB2008(第31回日本分1子生物学会年会第81回日本生化学会大会合同大会)
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-09
• [Presentation] Tally Naveh-Many The prolyl isomerase Pin1 determines PTH expression in vitro, in Pin1 knockout mice and in secondary hyperparathyroidism (2008)
  • Author(s): Morris Nechama, Takafumi Uchida, Justin Silver
  • Organizer: American Society of Nephorology
  • Place of Presentation: Philaderphia, USA
  • Year and Date: 2008-11-20
• [Presentation] The prolyl isomerase Pinl determines PTH expression in vitro, in Pinl knockout mice and in secondary hyperparathyroidism (2008)
  • Author(s): Morris Nechama, et.al.
  • Organizer: American Society of Nephorology
  • Place of Presentation: Philaderphia, USA
  • Year and Date: 2008-11-20
• [Presentation] hGas7b that controls microtubule dynamics is degraded in Alzheimer's brain (2008)
  • Author(s): Hirotada Akiyama, et.al.
  • Organizer: 2008 nano
  • Place of Presentation: 東京大学
  • Year and Date: 2008-10-31
• [Presentation] Tally Naveh-Many The peptidyl-prolyl isomerase Pin1 determines parathyroid hormone mRNA stability in vitro, in Pin1 knockout mice and in rats with experimental kidney disease (2008)
  • Author(s): Morris Nechama, Hirotada Akiyama, Takafumi Uchida, Justin Silver
  • Organizer: RNA TURNOVER
  • Place of Presentation: Asheville, USA
  • Year and Date: 2008-10-19
• [Presentation] The prolyl-isomerase Pinl determines paratyloid hormone mRNA stability in vitro (2008)
  • Author(s): Morris Nechama, et.al.
  • Organizer: Pinl knck out mice and in rats with experimental kidney disease RNA meeting
  • Place of Presentation: USA Ashexille Noreh Carolong
  • Year and Date: 2008-10-19
• [Presentation] Harmful increase of astrocytic Ca2+ trigger reactive oxygen species production (2008)
  • Author(s): Morito R, Miyazaki K, Kadji HG, Uchida T, Kawashima R, Riera JJ
  • Organizer: Gordon Research Conferences on Brain Energy Metabolism & Blood Flow
  • Place of Presentation: Andover, USA
  • Year and Date: 2008-08-08
• [Presentation] Harmful increase of astrocytic Ca2+ trigger reactive oxygen sp cies production (2008)
  • Author(s): Rieko Morito, et.al.
  • Organizer: Gordon Research Conferences on Brain Energy Metabolism & Blood Flow
  • Place of Presentation: Andover, USA
  • Year and Date: 2008-08-08
• [Presentation] 前頭側頭葉認知症(FTDP-17)変異型タウの脱リン酸化 (2008)
  • Author(s): 浅田明子、四本健介、斎藤太郎、笈川貴之、石黒幸一、内田隆史、長谷川成人、久永真市
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-11
• [Presentation] 前頭側頭葉認知症(FTDP-17)変異型タウの脱リン酸化 (2008)
  • Author(s): 浅田明子, 他
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-11
• [Presentation] アルツハイマーモデルPin1欠損マウスの行動学的解析 (2008)
  • Author(s): 大野春香, 他
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-10
• [Presentation] アストロサイト内Ca2+上昇による活性酸素種の産生 (2008)
  • Author(s): 森戸里衣子, 他
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-10
• [Presentation] Harmful increase of astrocytic Ca2+ trigger reactive oxygen species production (2008)
  • Author(s): Rieko Morito, Kenichi Miyazaki, Herve Germain Enjieu Kadji, Takafumi Uchida, Ryuta Kawashima, Jorge Riera
  • Organizer: The 3rd International Society for Neurochemistry Special Neurochemistry Conference
  • Place of Presentation: Chaina/Beijin
  • Year and Date: 2008-06-29
• [Presentation] Harmful increase of astrocytic Ca2+ trigger reactive oxygen species production (2008)
  • Author(s): Rieko Morito, et.al.
  • Organizer: The 3rd International Society for Neurochemistry Special Neurochemistry Conference
  • Place of Presentation: 中国(北京)
  • Year and Date: 2008-06-29
• [Presentation] 暗視野顕微鏡による微小管重合調節剤の探索 (2008)
  • Author(s): 坂本渉・奥田徹・山下まり・山口高弘・渡邊康一・内田隆史
  • Organizer: 第5回東北大学バイオサイエンスシンポジウム(ポスターセッション)
  • Place of Presentation: 仙台
  • Year and Date: 2008-05-19
• [Presentation] プロリン異性化酵素Pin1の分子生物学-ライフサイエンスの応用を目指して- (2008)
  • Author(s): 内田隆史
  • Organizer: 第5回東北大学ライフサイエンスセミナー シンポジウム
  • Place of Presentation: Sendai
  • Year and Date: 2008-05-19
• [Presentation] 暗視野顕微鏡による微小管重合調節剤の探索 (2008)
  • Author(s): 坂本渉, 他
  • Organizer: 第5回東北大学バイオサイエンスシンポジウム
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2008-05-19
• [Presentation] 血小板分化におけるプロリン異性化酵素Ph11の機能解析 (2008)
  • Author(s): 鈴木伸幸, 他
  • Organizer: 第5回東北大学バイオサイエンスシンポジウム
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2008-05-19
• [Presentation] リン酸基特異的なプロリン異性化酵素Pin1のターゲットタンパク質の網羅的解析 (2008)
  • Author(s): 多田羅洋太, 他
  • Organizer: 第5回東北大学バイオサイエンスシンポジウム
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2008-05-19
• [Presentation] プロリン異性化酵素Pin1の分子生物学-ライフサイエンスの応用を目指して- (2008)
  • Author(s): 内田隆史
  • Organizer: 東北大学ライフサイエンスセミナーシンポジウム
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2008-05-19
• [Presentation] Novel microtubule regulatory proteins, Pin1 and Gas7 (2008)
  • Author(s): Takafumi Uchida
  • Organizer: 12th Akabori Conference
  • Place of Presentation: Kyoto
  • Year and Date: 2008-05-16
• [Presentation] アルツハイマー病患脳で減少しているGas7はリン酸化Tau に結合し微小管シート構造を安定化させる (2008)
  • Author(s): 秋山弘匡、伊藤知彦、辛龍雲、東誉人、後藤愛那、原田彰宏、内田隆史
  • Organizer: BMB2008(第31回日本分子生物学会年会第81回日本生化学会大会 合同大会)
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] hGas7b that controls microtubule dynamics is degraded in Alzheimer's brain (2008)
  • Author(s): Hirotada Akiyama, Tomohiko J. Itoh, Takahito Higashi, Ryong-Woon Shin, Keiko Hirose, Akihiro Harada, Chiyoko Uchida and Takafumi Uchida
  • Organizer: 2008nano学会
  • Place of Presentation: Tokyo
• [Presentation] 天然物由来のリン酸化蛋白質特異的プロリン異性化酵素機能調節剤の探索 (2008)
  • Author(s): 内田隆史
  • Organizer: 2008年度大会日本農芸化学会 産学官学術交流委員会フォーラム・企画賞中間報告
  • Place of Presentation: 名古屋名城大学
• [Presentation] 脳特異的に発現するGas7はリン酸化Tauに結合し微小管シート構造を安定化させた (2007)
  • Author(s): 東誉人, et. al.
  • Organizer: 第30回日本分子生物学会(ワークショップ)
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
• [Presentation] リン酸化タンパク質の構造と機能を変化させるタンパク質。生体システムの制御の基盤となる蛋白質の構造変化 (2007)
  • Author(s): 内田隆史
  • Organizer: 第7回日本蛋白質学会(ワークショップ)
  • Place of Presentation: 仙台
  • Year and Date: 2007-05-26
• [Presentation] 脳特異的に発現するGas7はリン酸化Tauに結合し微小管シート構造を安定化させた (2007)
  • Author(s): 東誉人、辛龍雲、原田彰宏、秋山弘匡、内田隆史
  • Organizer: 第30回日本分子生物学会(ワークショップ)
  • Place of Presentation: パシフィコ横浜
• [Book] New Frontiers in Lifestyle Related Diseases (2008)
  • Author(s): Takahashi K, et.al.
  • Total Pages: 320
  • Publisher: Onco-suppressor p53 protein prevents an Alzheimer disease mouse model, Pinl-null mouse from the increase of presenilin-1
• [Book] 分子細胞生物学辞典 (2008)
  • Author(s): 原田昌彦
  • Total Pages: 450
  • Publisher: 東京化学同人
• [Book] DNA複製と遺伝子発現 (2008)
  • Author(s): 原田昌彦
  • Total Pages: 280
  • Publisher: オーム社
• [Book] "Nulcear actin-related proteins involved in the organization of euchromatin and heterochromatin" in DNA structure, chromatin, and gene expression (eds. Shimizu M and Kiyama R.) (2006)
  • Author(s): Harata M et al.
  • Total Pages: 252
  • Publisher: Springer-Verlag Tokyo, Inc., Tokyo
• [Book] 「翻訳の調節」ベーシックマスター 分子生物学(東中川徹、大山隆、清水光弘(編)) (2006)
  • Author(s): 原田昌彦
  • Total Pages: 384
  • Publisher: オーム社
• [Book] Actin-related proteins involved in nuclear and chromatin dynamics (Nuclear Dynamics : Approaches from Biochemistry, Molecular Cell Biology, and Visual Biology)(In : Nagata, S. and Takeyasu, K. (ed)) (2006)
  • Author(s): Harata M
  • Total Pages: 260
  • Publisher: Springer-Verlag Tokyo, Inc., Tokyo
• [Book] Actin-related proteins involved in nuclear and chromatin dynamics In : Nuclear Dynamics : Approaches from Biochemistry, Molecular Cell Biology, and Visual Biology,(Nagata, S.and Takeyasu, K.(ed)) (2006)
  • Author(s): Harata M.
  • Publisher: Springer-Verlag Tokyo, Inc., Tokyo(印刷中)
• [Book] 細胞核の分子生物学(水野重樹(編)) (2005)
  • Author(s): 原田昌彦(分担執筆)
  • Total Pages: 20
  • Publisher: 朝倉書店
• [Remarks]
  • URL: http://www.agri.tohoku.ac.jp/enzyme/index-j.html
• [Remarks] プロリン異性化酵素Pin1の分子生物学-ライフサイエンスの応用を目指して-東北大学ライフサイエンスセミナー部局推薦講演 (2008年5月19日 仙台)
• [Remarks] プロリン異性化酵素Pin1の生化学的および細胞生物学的機能 -加齢疾患との関連。生活習慣病研究会 (2008年2月22日東京)
• [Remarks] Phosphorylated Tau- Binding Proteins, Pin1 and Gas7 Are Implicated in Alzheimer's Disease. The Fourth Lyon-Tohoku Engineering and Science Forum (2007 年12月13日 仙台)
• [Remarks] ミラクル酵素。 せんだいコーディネータ協議会 BT 分科会 (2007年1月24日 仙台)
• [Remarks] 癌や神経変性疾患に関係するプロリルイソメラーゼPin1。 新潟大学 医学部(2005 年9月1日 新潟)
• [Remarks] 癌や神経変性疾患の発症とプロリルイソメラーゼPin1。 生体膜トランスポーター研究会 大阪大学 産業科学研究所(2004 年11 月15 日 大阪)
• [Remarks] 癌や神経変性疾患でのプロリルイソメラーゼPin1の役割,北海道大学医学部(講演)(2004.11.5 札幌)
• [Remarks] 加齢疾患分野でのプロテオーム解析の応用,東北大学プロテインチップバイオマーカーセミナー(講演)(2004.7.10)[仙台]
• [Remarks] 加齢疾患におけるプロテオーム解析の重要性,北海道大学学術交流会館プロテインチップバイオマーカーセミナー(講演)(2004.6.21)[北海道]
• [Remarks] 癌や神経変性疾患の発症を制御するプロリルイソメラーゼPin1,三菱化学総合研究所(2004.4.4)[東京]
• [Remarks]
  • URL: http://www.agri.tohoku.ac.jp/enzyme/index-j.html