Researches on intra-nuclear architecture and regulation of chromatinfunction

• Project/Area Number: 16084201
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tohoku University
• Principal Investigator: HARATA Masahiko Tohoku University, 大学院・農学研究科, 准教授 (70218642)
• Co-Investigator(Kenkyū-buntansha): TSUTSUI Ken 岡山大学, 自然生命科学研究支援センター, 教授 (70108158)
• Project Period (FY): 2004 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥120,300,000 (Direct Cost: ¥120,300,000); Fiscal Year 2008: ¥22,900,000 (Direct Cost: ¥22,900,000); Fiscal Year 2007: ¥22,900,000 (Direct Cost: ¥22,900,000); Fiscal Year 2006: ¥22,900,000 (Direct Cost: ¥22,900,000); Fiscal Year 2005: ¥22,900,000 (Direct Cost: ¥22,900,000); Fiscal Year 2004: ¥28,700,000 (Direct Cost: ¥28,700,000)
• Keywords: 細胞核 / クロマチン / アクチン関連タンパク質 / ゲノム機能 / 遺伝子発現 / ゲノム機能制御 / トポイソメラーゼII / 転写誘導 / 神経細胞 / 細胞分化 / 核構造 / 核マトリックス / タンパク質複合体 / トポイソメラーゼ / 染色体分配 / 遺伝子発現制御

Research Abstract

真核生物ゲノムの機能制御には、クロマチンと細胞核が中心的な役割を果たしている。本研究では、細胞核に局在するアクチンファミリーであるアクチン関連タンパク質(actin-related protein ; Arp)に主に焦点を当て、細胞核の内部構造の分子構築がどのようにクロマチンやゲノムの機能に関与しているかを明らかにすることを目的として研究を進めた。その結果、クロマチンや細胞核の構築において、Arpが様々な分子機構で関与することを明らかにすることができた。

Research Products

• [Journal Article] Actin-related protein Arp6 influences H2AZ-dependent and -independent gene expression and links ribosomal protein genes to nuclear pores (2010)
  • Author(s): Yoshida, T., Shimada, K., Oma, Y., Kalck, V., Akimura, K., Taddei, A., Iwahashi, H., Kugou, K., Ohta, K., Gasser, S.M., Harata, M
  • Journal Title: PLoS Genet (in press)
  • Peer Reviewed
• [Journal Article] Identification and characterization of two isoforms of the vertebrate H2A. Z histone variant (2010)
  • Author(s): Matsuda, R., Hori, T., Kitamura, H., Takeuchi, K., Fukagawa, T., Harata, M
  • Journal Title: Nucleic Acids Res (in press)
  • Peer Reviewed
• [Journal Article] Molecular mechanisms underlying nucleocytoplasmic shuttling of actinin-4 (2010)
  • Author(s): Kumeta, M., Yoshimura, S.H., Harata, M., Takeyasu, K
  • Journal Title: J. Cell Sci (in press)
  • NAID: 120002561115
  • Peer Reviewed
• [Journal Article] Involvement of actin-related protein Arp6 in organization of chromosomes (2010)
  • Author(s): Ohfuchi Maruyama, E., Harata, M
  • Journal Title: Adv. Chromosome Sc (in press)
• [Journal Article] Molecular mechanisms underlying nucleocytoplasmic shuttling of actinin-4. (2010)
  • Author(s): Kumeta, et al
  • Journal Title: J.Cell Sci. (In press)
  • Peer Reviewed
• [Journal Article] Identification and characterization of two isoforms of the vertebrate H2 A.Z histone variant. (2010)
  • Author(s): Matsuda, et al.
  • Journal Title: Nucleic Acids Res. (In press)
  • Peer Reviewed
• [Journal Article] Actin-related protein Arp6 influences H2AZ-dependent and-independent gene expression and links ribosomal protein genes to nuclear pores. (2010)
  • Author(s): Yoshida, et al.
  • Journal Title: PLoS Genetics 6
  • Peer Reviewed
• [Journal Article] The human actin-related protein hArp5: nucleo-cytoplasmic shuttling and involvement in DNA repair (2009)
  • Author(s): Kitayama, K., Kamo, M., Oma, Y., Matsuda, R., Uchida, T., Ikura, T., Tashiro, S., Ohyama, T., Winsor, B., Harata, M
  • Journal Title: Exp. Cell Res 315 Pages: 206-217
  • Peer Reviewed
• [Journal Article] The human actin-related protein hArp5 : nucleo-cytoplasmic shuttling and involvement in DNA repair (2009)
  • Author(s): Kitayama, et al.
  • Journal Title: Exp Cell Res 315 Pages: 206-217
  • Peer Reviewed
• [Journal Article] Ino80 Chromatin Remodeling Complex Promotes Recovery of Stalled Replication Forks (2008)
  • Author(s): Shimada, K., Om, a Y., Schleker, T., Kugou, K., Ohta, K., Harata, M., *Gasser SM
  • Journal Title: Curr. Biol 18 Pages: 566-575
  • Peer Reviewed
• [Journal Article] The actin-related protein hArp8 accumulates on the mitotic chromosomes and functions in chromosome alignment (2008)
  • Author(s): Aoyama, N., Oka, A., Kitayama, K., Kurumizaka, H., Harata, M
  • Journal Title: Exp. Cell Res 314 Pages: 859-868
  • Peer Reviewed
• [Journal Article] The nuclear actin-related protein Act3p/Arp4 influences yeast cell shape and bulk chromatin organization (2008)
  • Author(s): Miloshev, J., Harata, M., Georgieva, M
  • Journal Title: J. Cell Biochem 104 Pages: 59-67
  • Peer Reviewed
• [Journal Article] Topoisomerase IIb activates a subset of neuronal genes that are repressed in AT-rich genomic environment (2008)
  • Author(s): Sano, K., Miyaji-Yamaguchi, M., Tsutsui, KM., Tsutsui, K
  • Journal Title: PLoS ONE 3(12)
  • Peer Reviewed
• [Journal Article] Ino8O Chromatin Remodeling Complex Promotes Recovery of Stalled Replication Forks. (2008)
  • Author(s): Shimada, et al.
  • Journal Title: Current Biology Pages: 566-575
  • Peer Reviewed
• [Journal Article] The actin-related protein hArp8 accumulates on the mitotic chromosomes and functions in chromosome alignment. (2008)
  • Author(s): Aoyama, et al.
  • Journal Title: Experimental Cell Research 314 Pages: 859-868
  • Peer Reviewed
• [Journal Article] The nuclear actin-related protein Act3p/Arp4 influences yeast cell shape and bulk chromatin organization (2008)
  • Author(s): Miloshev, et al.
  • Journal Title: J.Cell.Biochem. 104 Pages: 59-67
  • Peer Reviewed
• [Journal Article] Ino80 Chromatin Remodeling Complex Promotes Recovery of Stalled Replication Forks (2008)
  • Author(s): Shimada, 他
  • Journal Title: Current Biology (In press)
  • Peer Reviewed
• [Journal Article] The actin-related protein hArp8 accumulates on the mitotic chromosomes and functions in chromosome alignment (2008)
  • Author(s): Aoyama, 他
  • Journal Title: Exp Cell Res 314 Pages: 859-868
  • Peer Reviewed
• [Journal Article] Actin-related protein Arp4 functions in kinetochore assembly (2007)
  • Author(s): Ogiwara, H., Ui, A., Kawashima, S., Kugou, K., Onoda, F., Iwahashi, H., Harata, M., Ohta, K., Enomoto, T., Seki M
  • Journal Title: Nucleic Acids Res 35 Pages: 3109-3117
  • Peer Reviewed
• [Journal Article] The INO80 complex is required for damage-induced recombination (2007)
  • Author(s): Kawashima, S., Ogiwara, H., Tada, S., Harata, M., Wintersberger, U., Enomoto, T., Seki, M
  • Journal Title: Biochem. Biophys. Res. Commun 355 Pages: 835-841
  • Peer Reviewed
• [Journal Article] Actin-related protein Arp4 functions in kinetochore assembly. (2007)
  • Author(s): Ogiwara, 他
  • Journal Title: Nucleic Acid Res 35 Pages: 3109-3117
  • Peer Reviewed
• [Journal Article] The INO80 complex is required for damage-induced recombination. (2007)
  • Author(s): Kawashima, 他
  • Journal Title: Biochem Biophys Res Commun 355 Pages: 835-841
  • Peer Reviewed
• [Journal Article] Cytotoxicity of lawsone and cytoprotective activity of antioxidants in catalase mutant. (2007)
  • Author(s): Sauriasari, R, 他
  • Journal Title: Escherichia coli 235 Pages: 103-111
  • Peer Reviewed
• [Journal Article] The INO80 complex is required for damage-induced recombination. (2007)
  • Author(s): Kawashima et al.
  • Journal Title: Biochem Biophys Res Commun 355 Pages: 835-841
• [Journal Article] Actin-related protein Arp4 functions in kinetochore assembly. (2007)
  • Author(s): Ogiwara et al.
  • Journal Title: Nucleic Acids Res. (In press)
• [Journal Article] Vertebrate Arp6, a novel nuclear actin-related protein, interacts with heterochromatin protein 1 (2006)
  • Author(s): Ohfuchi, E., Kato, M., Sasaki, M., Sugimoto, K., Oma, Y., Harata, M
  • Journal Title: Eur. J. Cell Biol 85 Pages: 411-421
  • Peer Reviewed
• [Journal Article] Assembly of staphylococcal leukocidin into a pore-forming oligomer on detergent-resistant membrane microdomains, lipid rafts, in human polymorphonuclear leukocytes (2006)
  • Author(s): Nishiyama, A., Kaneko, J., Harata, M., Kamio, Y
  • Journal Title: Biosci. Biotechnol. Biochem 70 Pages: 1300-1307
  • NAID: 10018529746
  • Peer Reviewed
• [Journal Article] Correlations between scaffold/matrix attachment region (S/MAR) binding activity and DNA duplex destabilization energy (2006)
  • Author(s): Bode, J., Winkelmann, S., Gotze, S., Spiker, S., Tsutsui, K., Bi, C., Prashanth, A.K., Benham, C
  • Journal Title: J. Mol. Biol 358 Pages: 597-613
  • Peer Reviewed
• [Journal Article] Expression dynamics and functional implications of DNA topoisomerase IIb in the brain (2006)
  • Author(s): Tsutsui, KM., Sano, K., Hosoya, O., Tsutsui, K
  • Journal Title: Anat. Sci. Int 81 Pages: 156-163
  • Peer Reviewed
• [Journal Article] Nulcear actin-related proteins involved in the organization of euchromatin and heterochromatin. DNA structure, chromatin, and gene expression (2006)
  • Author(s): Harata, M., Ohfuchi, E., Oma, Y
  • Journal Title: Transworld Research Network Inc(eds. Shimizu, M. and Kiyama, R. ) Pages: 181-112
• [Journal Article] Actin-related proteins involved in nuclear and chromatin dynamics (2006)
  • Author(s): Harata, M
  • Journal Title: Springer-Verlag Tokyo, Inc(Nuclear Dynamics: Approaches from Biochemistry, Molecular Cell Biology, and Visual Biology (eds. Nagata, S. and Takeyasu, K. )) Pages: 239-248
• [Journal Article] 核の構造とその分子基盤蛋白質核酸酵素 (2006)
  • Author(s): 原田昌彦、北山久美子、尾間由佳子
  • Journal Title: 51 Pages: 591-599
• [Journal Article] クロマチン蛋白質核酸酵素 (2006)
  • Author(s): 原田昌彦
  • Journal Title: 51 Pages: 1943-1949
• [Journal Article] Stilbenoids of Kobresia nepalensis (Cyperaceae) exhibiting DNA topoisomerase II inhibition. (2006)
  • Author(s): Yamada, M. et al.
  • Journal Title: Phytochemistry 67 Pages: 307-313
• [Journal Article] Nepalensinols D-G, new resveratrol oligomers from Kobresia nepalensis (Cyperaceae) as potent inhibitors of DNA topoisomerase II. (2006)
  • Author(s): Yamada, M. et al.
  • Journal Title: Chem Pham Bull (Tokyo) 54 Pages: 354-358
• [Journal Article] Inhibitory activity of plant stilbene oligomeres against DNA topoisomerase II. (2006)
  • Author(s): Yamada, M. et al.
  • Journal Title: Biol. Pharm. Bull 29 Pages: 1504-1507
• [Journal Article] Correlations between scaffold/matrix attachment region (S/MAR) binding activity and DNA duplex destabilization energy. (2006)
  • Author(s): Bode, J. et al.
  • Journal Title: J. Mol. Biol. 358 Pages: 597-613
• [Journal Article] Expression dynamics and functional implications of DNA topoisomerase IIβ in the brain. (Review) (2006)
  • Author(s): Tsutsui, K. et al.
  • Journal Title: Anatomical Science International 81 Pages: 156-163
• [Journal Article] 核マトリックスとRNAを結ぶもの (2006)
  • Author(s): 筒井 研, 河野真二
  • Journal Title: 蛋白質 核酸 酵素 51巻,14号 Pages: 1964-1969
• [Journal Article] Vertebrate Arp6, a novel nuclear actin-related protein, interacts with heterochromatin protein 1 (2006)
  • Author(s): Ohfuchi E et al.
  • Journal Title: Eur. J. Cell Biol. 85 Pages: 411-421
• [Journal Article] Assembly of staphylococcal leukocidin into a pore-forming oligomer on detergent-resistant membrane microdomains, lipid rafts, in human polymorphonuclear leukocytes. (2006)
  • Author(s): Nishiyama et al.
  • Journal Title: Biosci Biotechnol Biochem. 70 Pages: 1300-1307
• [Journal Article] 核の構造とその分子基盤 (2006)
  • Author(s): 原田昌彦
  • Journal Title: 蛋白質核酸酵素 51 Pages: 591-599
• [Journal Article] クロマチン (2006)
  • Author(s): 原田昌彦
  • Journal Title: 蛋白質核酸酵素 51 Pages: 1943-1949
• [Journal Article] Vertebrate Arp6, a novel nuclear actin-related protein, interacts with heterochromatin protein 1 (2006)
  • Author(s): Ohfuchi E 他
  • Journal Title: Eur.J.Cell Biol. (in press)
• [Journal Article] 核の構造とその分子基盤 (2006)
  • Author(s): 原田 昌彦 他
  • Journal Title: 蛋白質核酸酵素 (印刷中)
• [Journal Article] Stilbenoids of Kobresia nepalensis (Cyperaceae) exhibiting DNA topoisomerase II inhibition (2006)
  • Author(s): Yamada M 他
  • Journal Title: Phytochemistry 67 Pages: 307-313
• [Journal Article] Nepalensinols D-G, new resveratrol oligomers from Kobresia Nepalensis(Cyperaceae) as potent inhibitors of DNA topoisomerase II (2006)
  • Author(s): Yamada M 他
  • Journal Title: Chem.Pham.Bull.(Tokyo) 54 Pages: 354-358
• [Journal Article] Expression dynamics and functional implications for DNA topoisomerase II β in the brain (2006)
  • Author(s): Tsutsui K他
  • Journal Title: Anat.Sci.Int. (In press)
• [Journal Article] The nuclear actin-related protein Act3p/Arp4p is involved in the dynamics of chromatin modulating complexes (2005)
  • Author(s): Sunada, R., Goerzer, I., Oma, Y., Yoshida, T., Suka, N., Wintersberger, U., Harata, M
  • Journal Title: Yeast 22 Pages: 753-768
  • Peer Reviewed
• [Journal Article] The nuclear actin-related protein Act3p/Arp4p is involved in the dynamics of chromatin modulating complexes (2005)
  • Author(s): Sunada R 他
  • Journal Title: Yeast 22 Pages: 753-768
• [Journal Article] ヘテロクロマチン研究:DNAからクロマチンへ、そして核構造へ (2005)
  • Author(s): 原田 昌彦
  • Journal Title: 生物と化学 43 Pages: 682-687
• [Journal Article] Dynamic view of the nuclear matrix (2005)
  • Author(s): Tsutsui K 他
  • Journal Title: Acta Med.Okayama 59 Pages: 113-120
  • NAID: 120002312554
• [Journal Article] Involvement of oxidative stress in hydroquinone-induced cytotoxicity in catalase-deficient Escherichia coli mutants (2005)
  • Author(s): Horita M 他
  • Journal Title: Free Radical Res 39 Pages: 1035-1041
• [Journal Article] Dynamic view of the nuclear matrix (2005)
  • Author(s): Tsutsui K. et al.
  • Journal Title: Acta Med.Okayama (in press)
  • NAID: 120002312554
• [Journal Article] Large-scale identification and mapping of nuclear matrix-attachment regions in the distal imprinted domain of mouse chromosome 7 (2004)
  • Author(s): Purbowasito, W., Suda, C., Yokomine, T., Zuair, M., Sado, T., Tsutsui, K., Sasaki, H
  • Journal Title: DNA Res 11 Pages: 391-407
  • Peer Reviewed
• [Journal Article] Fission yeast Arp6 is required for telomere silencing but functions independently of Swi6 (2004)
  • Author(s): Ueno, M. et al.
  • Journal Title: Nucleic Acids Res. 32 Pages: 736-741
• [Journal Article] Molecular cloning and expression analysis of vitellogenin in scallop, Patinopecten yessoensis (Bivalvia, Mollusca) (2004)
  • Author(s): Osada, M. et al.
  • Journal Title: Mol.Reprod.Dev. 67 Pages: 273-281
• [Journal Article] 細胞核におけるアクチンファミリーの多様な機能 (2004)
  • Author(s): 原田昌彦
  • Journal Title: 蛋白質 核酸 酵素 49 Pages: 543-552
  • NAID: 40006120055
• [Journal Article] クロマチン構造変換複合体によるゲノム機能の制御:アクチン関連タンパク質(Arp)からのアプローチ (2004)
  • Author(s): 原田昌彦, 吉田貴人, 大渕恵理
  • Journal Title: 日本農芸化学会誌 49 Pages: 2061-2063
  • NAID: 10013286117
• [Journal Article] 核内アクチンファミリーの分子機能 (2004)
  • Author(s): 原田昌彦, 尾間由倖子
  • Journal Title: 細胞核のダイナミクス(竹安邦夫、米田悦啓(編)) Pages: 177-186
• [Journal Article] Localized expression of amphiphysin Ir, a retina-specific variant of amphiphysin I, in the ribbon synapse and its functional implication. (2004)
  • Author(s): Hosoya, O. et al.
  • Journal Title: Eur.J.Neurosci. 19 Pages: 2179-2187
• [Journal Article] 核マトリックスのダイナミズム (2004)
  • Author(s): 箇井 研, 佐野訓明, 筒井公子
  • Journal Title: 細胞核のダイナミクス(シュプリンガー・フェアラーク東京) Pages: 169-176
• [Journal Article] Large-scale identification and mapping of nuclear matrix-attachment regions in the distal imprinted domain of mouse chromosome 7 (2004)
  • Author(s): Purbowasito, W et al.
  • Journal Title: DNA Research 11 Pages: 391-407
• [Presentation] 遺伝子ノックアウト細胞を用いたヒトアクチン関連タンパク質hArp5およびhArp8の機能解析 (2010)
  • Author(s): 高橋裕一朗
  • Organizer: 日本農芸化学会2010年度大会
  • Place of Presentation: 東京
  • Year and Date: 2010-03-28
• [Presentation] ヒストンバリアントH2A.Zアイソフォームのクロマチンにおける機能解析 (2010)
  • Author(s): 松田涼
  • Organizer: 第27回染色体ワークショップ
  • Place of Presentation: 御殿場
  • Year and Date: 2010-01-21
• [Presentation] Roles of actin-related proteins in nuclear architecture and genome function (2009)
  • Author(s): Masahiko Harata
  • Organizer: 第32回日本分子生物学会年会シンポジウム「細胞核アーキテクチャーに基づくゲノム機能制御:そのコンセプトの最新像」
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-10
• [Presentation] 細胞核アーキテクチャーにおけるアクチン関連タンパク質の役割 (2009)
  • Author(s): 原田昌彦
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-10
• [Presentation] クロマチンリモデリングおよびヒストンバリアントによるゲノム機能制御 (2009)
  • Author(s): 原田昌彦
  • Organizer: 平成21年度国立遺伝学研究所研究会
  • Place of Presentation: 三島
  • Year and Date: 2009-11-12
• [Presentation] Actin-related proteins and chromatin organization in the nucleus (2009)
  • Author(s): Masahiko Harata
  • Organizer: International Symposium on Chromosome Cycle and Genome Dynamics
  • Place of Presentation: 那須
  • Year and Date: 2009-11-11
• [Presentation] The actin-related protein Arp6 is required for H2AZ deposition and the radial positioning of chromosome territories. (2009)
  • Author(s): Masahiko Harata
  • Organizer: EMBO Conference on Nuclear Structure and Dynamics
  • Place of Presentation: France, Avignon
  • Year and Date: 2009-10-30
• [Presentation] ヒストンバリアントH2A.Zにおけるアイソフォームの存在とその機能解析 (2009)
  • Author(s): 松田涼
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-22
• [Presentation] 脊椎動物のアクチン関連タンパク質による染色体・細胞核機能構造の形成 (2009)
  • Author(s): 原田昌彦
  • Organizer: 日本遺伝学会第81回大会ワークショップ「核ダイナミクス研究の新展開」
  • Place of Presentation: 松本
  • Year and Date: 2009-09-17
• [Presentation] 脊椎動物のアクチン関連タンパク質による染色体・細胞核機能構造の形成 (2009)
  • Author(s): 原田昌彦
  • Organizer: 日本遺伝学会第81回大会
  • Place of Presentation: 松本
  • Year and Date: 2009-09-17
• [Presentation] INO80クロマチンリモデリング複合体のヒト染色体安定性維持への関与 (2009)
  • Author(s): 若林一陽
  • Organizer: 酵母遺伝学フォーラム第42回研究報告会
  • Place of Presentation: つくば
  • Year and Date: 2009-07-29
• [Presentation] ヒストンバリアントH2A.Zにおけるアイソフォームの存在とその機能解析 (2009)
  • Author(s): 松田涼
  • Organizer: 第8回核ダイナミクス研究会
  • Place of Presentation: 修善寺
  • Year and Date: 2009-06-19
• [Presentation] アクチン関連タンパク質Arp6の核膜との機能的相互作用およびクロマチン核内配置への関与 (2009)
  • Author(s): 吉田貴人、島田健士、尾間由佳子、秋村和美、岩橋均、久郷和人、太田邦史、Susan Gasser、原田昌彦
  • Organizer: 第61回日本細胞生物学会大会ミニシンポジウム-細胞骨格、核膜と核機能の連係
  • Place of Presentation: 名古屋
  • Year and Date: 2009-06-03
• [Presentation] アクチン関連タンパク質Arp6の核膜との機能的相互作用およびクロマチン核内配置への関与 (2009)
  • Author(s): 原田昌彦
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-06-03
• [Presentation] Actin-related proteins functional organization of chromatin (2009)
  • Author(s): Masahiko Harata
  • Organizer: Chromosome Dynamics and Genome Stability
  • Place of Presentation: Switzerland, Villars
  • Year and Date: 2009-05-15
• [Presentation] クロマチンリモデリングおよびヒストンバリアントによるゲノム機能制御 (2009)
  • Author(s): 原田昌彦
  • Organizer: 平成21年度国立遺伝学研究所研究会-クロマチン・染色体の分子構築と機能制御
  • Place of Presentation: 三島
• [Presentation] Actin-related proteins functional organization of chromatin (2009)
  • Author(s): Yoshida T, Shimada K, Oma Y, Kugou K, Ohta K, Hori T, Fukagawa T, Gasser S, Harata M
  • Organizer: Switzerland-Japan Joint Meeting on the Molecular Mechanisms regulating "Chromosome Dynamics and Genome Stability"
  • Place of Presentation: Villars, Switzerland
• [Presentation] Multiple functions of actin-related proteins in chromatin and nuclear organization (2008)
  • Author(s): Harata, M
  • Organizer: Nuclear Signaling Network -Epigenetics and Development-
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2008-12-12
• [Presentation] Multiple functions of actin-related proteins in chromatin and nuclear or ganization (2008)
  • Author(s): Masahiko Harata
  • Organizer: Nuclear Signaling Network-Epigenetics and Deve lopment-
  • Place of Presentation: 仙台
  • Year and Date: 2008-12-12
• [Presentation] Involvement of the actin-related protein Arp6 in spatial organization of radial chromosome territories (2008)
  • Author(s): Masahiko Harata
  • Organizer: The 3^<rd> Asian Chromosome Colloquium
  • Place of Presentation: 大阪
  • Year and Date: 2008-12-03
• [Presentation] ゲノム機能制御におけるクロマチンリモデリング複合体の多様な機能 (2008)
  • Author(s): 原田昌彦
  • Organizer: 国立遺伝学研究所研究会 クロマチン研究会-細胞核・染色体・クロマチンの機能構造構築と動態-
  • Place of Presentation: 三島
  • Year and Date: 2008-10-22
• [Presentation] コンフォーカルレーザー顕微鏡などによるバイオイメージングに基づく細胞機能解析 (2008)
  • Author(s): 原田昌彦
  • Organizer: 第62回日本栄養・食糧学会大会(女子栄養大学)イブニングセミナー「若手研究者のための栄養・食糧学技術セミナー」
  • Place of Presentation: 板戸
  • Year and Date: 2008-05-03
• [Presentation] コンフォーカルレーザー顕微鏡などによるバイオイメージングに基づく細胞機能解析 (2008)
  • Author(s): 原田昌彦
  • Organizer: 第62回日本栄養・食糧学会大会
  • Place of Presentation: 板戸
  • Year and Date: 2008-05-03
• [Presentation] クロマチンおよび細胞核の機能構造形成における出芽酵母Arp6の関与 (2008)
  • Author(s): 原田 昌彦, 他
  • Organizer: 第25回染色体ワークショップ
  • Place of Presentation: 湯河原
  • Year and Date: 2008-02-01
• [Presentation] アクチンファミリーと細胞核・クロマチンの機能構造文部科学省科学研究費助成金「特定領域究」2領域合同 (2008)
  • Author(s): 原田昌彦
  • Organizer: 公開シンポジウム「クロマチンシグナリングの分子機構」
  • Place of Presentation: 東京
  • Year and Date: 2008-01-08
• [Presentation] アクチンファミリーと細胞核・クロマチンの機能構造 (2008)
  • Author(s): 原田 昌彦
  • Organizer: 文部科学省科学研究費助成金「特定領域研究」2領域合同 公開シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-01-08
• [Presentation] Involvement of the actin-related protein Arp6 in spatial organization of radial chromosome territories (2008)
  • Author(s): Harata, M
  • Organizer: The 3rd Asian Chromosome Colloquium
  • Place of Presentation: Osaka, Japan
• [Presentation] クロマチンの核内配置とアクチン関連タンパク質:クロマチン工学への応用 (2007)
  • Author(s): 原田昌彦, 他
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-15
• [Presentation] クロマチン高次構造による遺伝子制御 (2007)
  • Author(s): 筒井 研, 他
  • Organizer: 第30回日本分子生物学会年会第80回日本生化学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-15
• [Presentation] 細胞核に局在するアクチン関連タンパク質の染色体機能への関与 (2007)
  • Author(s): 原田 昌彦, 他
  • Organizer: 第58回染色体学会・第17回染色体コロキウム合同年会
  • Place of Presentation: 葉山
  • Year and Date: 2007-11-27
• [Presentation] DNA複製へのINO80クロマチンリモデリング複合体の関与 (2007)
  • Author(s): 尾間 由佳子, 他
  • Organizer: 日本農芸化学会東北支部 第142回大会
  • Place of Presentation: 仙台
  • Year and Date: 2007-11-10
• [Presentation] アクチン関連タンパク質による核構築とゲノム機能制御 (2007)
  • Author(s): 原田 昌彦
  • Organizer: 平成19年度 国立遺伝学研究所研究会「クロマチン研究会 -ゲノム・細胞核から個体発生まで-」
  • Place of Presentation: 三島
  • Year and Date: 2007-10-26
• [Presentation] ヒストンバリアントH2AZアイソフォームの機能解析 (2007)
  • Author(s): 松田 涼, 他
  • Organizer: 第7回 核ダイナミクス研究会
  • Place of Presentation: 札幌
  • Year and Date: 2007-09-26
• [Presentation] INO80 CHROMATIN REMODELING COMPLEX PROMOTES THE RESTART OF DNA REPLICATION (2007)
  • Author(s): Shimada Kenji, 他
  • Organizer: Cold Spring Harbor Symposium
  • Place of Presentation: Cold Spring Harbor, USA
  • Year and Date: 2007-09-05
• [Presentation] Evolutionarily conserved function of the nuclear actin-related protein Arp5 in the INO80 chromatin remodeling complex (2007)
  • Author(s): Oma Yukako, 他
  • Organizer: 32nd FEBS Congress -Molecular Machines-
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2007-07-10
• [Presentation] Actin-related proteins involved in chromatin and nuclear organization (2007)
  • Author(s): Yoshida T, Shimada K, Kugo K, Ohta K, Gasser S, Harata M
  • Organizer: 第59回日本細胞生物学会シンポジウム「細胞核構造構築のダイナミクス」
  • Place of Presentation: 博多
  • Year and Date: 2007-05-28
• [Presentation] Actin-related proteins involved in chromatin and nuclear organization (2007)
  • Author(s): Harata Masahiko, 他
  • Organizer: 第59回日本細胞生物学会シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 2007-05-28
• [Presentation] 遺伝子発現制御とクロマチンドメイン核内配置における出芽酵母Arp6の機能解析 (2007)
  • Author(s): 秋村 和美, 他
  • Organizer: 日本農芸化学会2008年度(平成20年度)大会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-03-28
• [Presentation] 細胞核のアクチンファミリーによるゲノムダイナミクス制御 (2007)
  • Author(s): 原田昌彦、吉田貴人、大渕恵理、尾間由佳子、久郷和人、太田邦史、Susan Gasser、島田健士
  • Organizer: 日本農芸化学会シンポジウム「ゲノムダイナミクスの理解とその応用展開」
  • Place of Presentation: 東京
  • Year and Date: 2007-03-27
• [Presentation] Actin-related proteins involved in dynamics organization of chromatin and cell nucleus (2007)
  • Author(s): Harata, M
  • Organizer: International Symposium -Functional Organization of the nucleus-
  • Place of Presentation: Awaji, Hyogo, Japan
  • Year and Date: 2007-01-09
• [Presentation] クロマチンの核内配置とアクチン関連タンパク質:クロマチン工学への応用 (2007)
  • Author(s): 吉田貴人、島田健士、秋村和美、久郷和人、太田邦史、岩橋均、Susan Gasser、原田昌彦
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会ワークショップ「クロマチン工学の開拓」
  • Place of Presentation: 横浜
• [Presentation] アクチン関連タンパク質による核構築とゲノム機能制御 (2007)
  • Author(s): 原田昌彦
  • Organizer: 平成19年度国立遺伝学研究所研究会「クロマチン研究会-ゲノム・細胞核から個体発生まで-」
  • Place of Presentation: 三島
• [Presentation] 細胞核・クロマチンのダイナミクスとアクチン関連タンパク質Arp6 (2006)
  • Author(s): 原田昌彦
  • Organizer: 国立遺伝学研究所研究会「クロマチンダイナミクスとゲノム機能制御」
  • Place of Presentation: 三島
  • Year and Date: 2006-10-15
• [Presentation] ヒトhArp5とhIno80の細胞核・ゲノム機能への関与 (2005)
  • Author(s): 北山久美子、松田涼、原田昌彦
  • Organizer: 遺伝研研究会「クロマチンダイナミクスとゲノム機能制御」
  • Place of Presentation: 三島
  • Year and Date: 2005-10-07
• [Presentation] 細胞核内構造-クロマチン相互作用とゲノム機能制御 (2005)
  • Author(s): 原田昌彦
  • Organizer: 日本農芸化学会東北支部シンポジウム「クロマチンの化学-ゲノム機能の鍵を握るタンパク質複合体の驚異-」
  • Place of Presentation: 仙台
  • Year and Date: 2005-07-02
• [Presentation] 細胞核・染色体・クロマチンの機能構造とアクチン関連タンパク質 (2004)
  • Author(s): 原田昌彦
  • Organizer: 国立遺伝学研究所研究会「DNAの高次構造とクロマチンに印された情報の理解に向けて」
  • Place of Presentation: 三島
  • Year and Date: 2004-09-10
• [Book] 実験医学増刊号「細胞核-遺伝情報制御と疾患」 (2009)
  • Author(s): 平岡泰、原田昌彦、木村宏、田代聡
  • Total Pages: 233
  • Publisher: 羊土社
• [Book] 実験医学増刊号「細胞核-遺伝情報制御と疾患」(平岡泰、原田昌彦、木村宏、田代聡:編) (2009)
  • Author(s): 尾間由佳子、松田涼、北村大志、原田昌彦
• [Book] 細胞核-遺伝情報制御と疾患 (2009)
  • Author(s): 平岡泰, 他
  • Publisher: 羊土社
• [Book] DNA複製と遺伝子発現ベーシックマスター生化学(大山隆:監修) (2008)
  • Author(s): 原田昌彦、大山隆
  • Publisher: オーム社
• [Book] ベーシックマスター生化学 (2008)
  • Author(s): 原田昌彦, 他
  • Publisher: オーム社(印刷中)
• [Book] ベーシックマスター分子生物学(東中川徹、大山隆、清水光弘:編) (2006)
  • Author(s): 原田昌彦
  • Publisher: オーム社
• [Book] DNA structure, chromatin, and gene expression (eds. Shimizu M and Kiyama R) (2006)
  • Author(s): Harata et al.
  • Total Pages: 252
  • Publisher: Transworld Research Network
• [Book] ベーシックマスター 分子生物学(東中川徹、大山隆、清水光弘(編)) (2006)
  • Author(s): 原田昌彦
  • Total Pages: 384
  • Publisher: オーム社
• [Book] Nuclear Dynamics : Approaches from Biochemistry, Molecular Cell Biology, and Visual Biology (Nagata, S. and Takeyasu, K. (ed)) (2006)
  • Author(s): Harata M
  • Total Pages: 260
  • Publisher: Springer-Verlag Tokyo, Inc., Tokyo
• [Book] 細胞核の分子生物学(水野重樹:編) (2005)
  • Author(s): 原田昌彦
  • Publisher: 朝倉書店
• [Book] 細胞核の分子生物学「クロマチンレベルの転写制御機構」(分担執筆) (2005)
  • Author(s): 水野 重樹(編)
  • Total Pages: 203
  • Publisher: 朝倉書店
• [Book] 細胞核の分子生物学(水野重樹(編)) (2005)
  • Author(s): 原田昌彦
  • Publisher: 朝倉書店(印刷中)
• [Patent(Industrial Property Rights)] 負の超らせんDNA結合ドメイン (2007)
  • Inventor(s): 筒井 研,他3名
  • Industrial Property Rights Holder: 岡山大学
  • Industrial Property Number: 2007-190612
  • Filing Date: 2007-07-23