Molecular dynamics of nuclear pore complexes and regulation of nucleocytoplasmic protein transport

• Project/Area Number: 16084204
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Osaka University
• Principal Investigator: YONEDA Yoshihiro Osaka University, 生命機能研究科, 教授 (80191667)
• Project Period (FY): 2004 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥169,100,000 (Direct Cost: ¥169,100,000); Fiscal Year 2008: ¥32,300,000 (Direct Cost: ¥32,300,000); Fiscal Year 2007: ¥32,300,000 (Direct Cost: ¥32,300,000); Fiscal Year 2006: ¥32,300,000 (Direct Cost: ¥32,300,000); Fiscal Year 2005: ¥34,000,000 (Direct Cost: ¥34,000,000); Fiscal Year 2004: ¥38,200,000 (Direct Cost: ¥38,200,000)
• Keywords: 細胞核 / 核タンパク質輸送 / 細胞分化 / 核膜孔複合体 / ES 細胞 / 筋芽細胞 / ヌクレオポリン / 核蛋白質輸送 / 原子間力顕微鏡 / 筋細胞分化 / 筋分化 / 核外輸送シグナル / 分子イメージング / 核構造 / Ran / RanGAP / importin α / 核蛋白質輸 / SUMO化 / リン酸化

Research Abstract

細胞核の重要な構造体である核膜孔複合体に焦点を当て、その分子動態が複雑な生命現象とどのように深く関連しているのかを解析した。その結果、筋芽細胞から筋細胞への分化の過程で、核膜孔複合体構成因子の1つNUP358の発現量が分化に応じて変動し、その変動が筋分化に必須であることがわかった。また、核輸送因子importin・サブタイプ発現のスイッチングが細胞の分化・未分化決定機構に重要な役割を果たすことを、マウスES細胞を用いて明らかにした。

Research Products

• [Journal Article] Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA. (2009)
  • Author(s): Katahira, J., Inoue, H., Hurt, E. and Yoneda, Y.
  • Journal Title: EMBO J. 28 Pages: 556-567
  • Peer Reviewed
• [Journal Article] Infrared lager-Mediated gene induction in targeted single cells in vivo (2009)
  • Author(s): Kamei, Y., et.al.
  • Journal Title: Nature Methods 6 Pages: 79-81
  • Peer Reviewed
• [Journal Article] mDia2 shuttles between the nucleus and the cytoplasm throuigh the Importin-α/β- and CRM1-mediated nuclear transport meehanism (2009)
  • Author(s): Miki, T., et.al.
  • Journal Title: J. Biol. Chem 284 Pages: 99-104
  • Peer Reviewed
• [Journal Article] Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA (2009)
  • Author(s): Katahira, J., et.al.
  • Journal Title: EMBO J (in press)
  • Peer Reviewed
• [Journal Article] Selective localization of PCBP2 to cytoplasmic processing bodies (2009)
  • Author(s): Fujimura, K., et.al.
  • Journal Title: Biochim. Biophys. Acta-Molecular Cell Research (in press)
  • Peer Reviewed
• [Journal Article] Synergistic nuclear import of NeuroD1 and its partner transcription factor E47 via heterodimerization (2009)
  • Author(s): Mehmood, R., et.al.
  • Journal Title: Exp. Cell Res. (in press)
  • Peer Reviewed
• [Journal Article] Roles of the TREX complex in.nuclear export of mRNA (2009)
  • Author(s): Katahira, J. and Yoneda, Y
  • Journal Title: RNA Biol. (in press)
  • Peer Reviewed
• [Journal Article] The role of nuclear transport system in cell differentiation (2009)
  • Author(s): Yasuhara, N., et.al.
  • Journal Title: Seminars in Cell and Developmental Biology (in press)
  • Peer Reviewed
• [Journal Article] Localized regulation of axonal RanGTPase controls retrograde injury signaling in peripheral nerve. (2008)
  • Author(s): Yudin, D. ,Hanz, S., Yoo, S. avnilovitch, E., Willis, D., Gradus, T., Segal-Ruder, Y., Ben-Yaakov, K., Hieda, M., Yoneda, Y., Twiss, J. L. and Fainzilber, M
  • Journal Title: Neuron 59 Pages: 241-252
  • Peer Reviewed
• [Journal Article] Generation and characterization of a monoclonal antibody against NPI-1 subfamily of importin α (2008)
  • Author(s): Tachibana, T., et.al.
  • Journal Title: Hybridoma 27 Pages: 285-289
  • Peer Reviewed
• [Journal Article] Localized regulation of axonal RanGTPase controls retrograde injury signaling in peripheral nerve (2008)
  • Author(s): Yudin, D., et.al.
  • Journal Title: Neuror 59 Pages: 241-252
  • Peer Reviewed
• [Journal Article] Individual binding pockets of importin β for FG-nucleoporins are diffierently regulated by RanGTP (2008)
  • Author(s): Otsuka, S., et.al.
  • Journal Title: Proc. Natl. Acad. Sci. USA 105 Pages: 16101-16106
  • Peer Reviewed
• [Journal Article] Characterization of human herpesvirus 6 U69 gene product and identification of its nuclear localization signal. (2008)
  • Author(s): Isegawa, Y., et. al.
  • Journal Title: J. Virol. 82 Pages: 710-718
  • Peer Reviewed
• [Journal Article] Nuclear RNA export factor 7 is localized in processing bodies and neuronal mRNA granules through interactions with shuttling hnRNPs. (2008)
  • Author(s): Katahira, J., et. al.
  • Journal Title: Nucl. Acids Res. 36 Pages: 616-628
  • Peer Reviewed
• [Journal Article] Triggering neural differentiation of ES cells by subtype switching of importin-α (2007)
  • Author(s): Yasuhara, N., shibazaki, N., Tanaka, S., Nagai , M., Kamikawa, Y., Oe, S., Kamachi, Y., K ondoh, H. and Yoneda, Y.
  • Journal Title: Nature Cell Biol. 9 Pages: 72-79
  • Peer Reviewed
• [Journal Article] Arx1 functions as an unorthodox nuclear export receptor for the 60S pre-ribosomal subunit. (2007)
  • Author(s): Bradatsch, B., Katahira, J., Kowalinski, E., Bange, G., Yao, W. ,Sekimoto, T., Baumgrtel, V, Boese, G., Bassler, J., Wild, K. ,Peters, R., Yoneda, Y., Sinning, I. and Hurt, E.
  • Journal Title: Mol. Cell 27 Pages: 767-779
  • Peer Reviewed
• [Journal Article] PGC7/Stella as a protector against DNA demethylation in early embryogenesis. (2007)
  • Author(s): Nakamura, T., Arai, Y., Umehara, H., Masuhara, M., Kimura, T., Taniguchi, H., Sekimoto, T., Ikawa, M., Yoneda, Y., Okabe, M., Tanaka, S., Shiota, K. and Nakano, T.
  • Journal Title: Nature Cell Biol. 9 Pages: 64-71
  • Peer Reviewed
• [Journal Article] NXF2 is involved in cytoplasmic mRNA dynamics through interactions with motor proteins. (2007)
  • Author(s): Takano, K., et. al.
  • Journal Title: Nucl. Acids Res. 35 Pages: 2513-2521
  • Peer Reviewed
• [Journal Article] A novel nuclear import of Vpr promoted by importin A ia crucial for HIV-1 replication in macrophages. (2007)
  • Author(s): Nitahara-Kasahara, Y., et. al.
  • Journal Title: J. Virol. 81 Pages: 5284-5293
  • Peer Reviewed
• [Journal Article] Arx1 functions as an unorthodox nuclear export receptor for the 60Spre-ribosomal subunit. (2007)
  • Author(s): Bradatsch, B., et. al.
  • Journal Title: Mol. Cell 27 Pages: 767-779
  • Peer Reviewed
• [Journal Article] Normal brain development in importin-A5 deficient-mice. (2007)
  • Author(s): Yasuhara, N., et. al.
  • Journal Title: Nature Cell Biol. 9 Pages: 1339-1339
  • Peer Reviewed
• [Journal Article] 細胞分化を制御する核送因子importin α (2007)
  • Author(s): 安原徳子、米田悦啓
  • Journal Title: 蛋白質核酸酵素 52 Pages: 427-433
  • Peer Reviewed
• [Journal Article] PGC7/Stella as a protector against DNA demethylation in early embryogenesis. (2007)
  • Author(s): Nakamura, T., et al.
  • Journal Title: Nature Cell Biol 9 Pages: 64-71
• [Journal Article] Triggering neural differentiation of ES cells by subtype switching of importin-α. (2007)
  • Author(s): Yasuhara, N., et al.
  • Journal Title: Nature Cell Biol 9 Pages: 72-79
• [Journal Article] NXF2 is involved in cytoplasmic mRNA dynamics through interactions with motor proteins. (2007)
  • Author(s): Takano, K., et al.
  • Journal Title: Nucl. Acids Res. (In Press)
• [Journal Article] A novel nuclear import of Vpr promoted by importin α is crucial for HIV-1 replication in macrophages. (2007)
  • Author(s): Nitahara-Kasahara, Y., et al.
  • Journal Title: J. Virol. (In Press)
• [Journal Article] Exportin-5 orthologues are functionally divergent among species. (2006)
  • Author(s): Shibata, S., Sasaki, M., Miki, T., Shimamoto, A., Furuichi, Y., Katahira, J., and Yoneda, Y.
  • Journal Title: Nucl. Acids Res. 34 Pages: 4711-47211
• [Journal Article] The nuclear import of RNA helicase A is mediated by importin-α3. (2006)
  • Author(s): Aratani, S., et al.
  • Journal Title: Biochem. Biophys. Res. Commun. 340 Pages: 125-133
• [Journal Article] Impaired expression of the importin/karyopherin β1. leads to post-implantation lethality. (2006)
  • Author(s): Miura, K., et al.
  • Journal Title: Biochem. Biophys. Res. Commun. 341 Pages: 132-138
• [Journal Article] Mechanism of the stress-induced collapse of the Ran distribution. (2006)
  • Author(s): Yasuda, Y., et al.
  • Journal Title: Exp. Cell Res. 312 Pages: 512-520
• [Journal Article] Nuclear import of Epstein-Barr virus nuclear antigen-1 mediated by NPI-1 (importin α5) is up- and down regulated by phosphorylation of the nuclear localization signal for which 379Lys and Arg380 are essential. (2006)
  • Author(s): Kitamura, R., et al.
  • Journal Title: J. Virol. 80 Pages: 1979-1991
• [Journal Article] The mechanism of nuclear export of Smad3 involves exportin 4 and Ran. (2006)
  • Author(s): Kurisaki, A., et al.
  • Journal Title: Mol. Cell. Biol. 26 Pages: 1318-1332
• [Journal Article] Functional analysis of nuclear pore complex protein Nup62/p62 using monoclonal antibodies. (2006)
  • Author(s): Fukuhara, T., et al.
  • Journal Title: Hybridoma 25 Pages: 51-59
• [Journal Article] Exportin-5 orthologues are functionally divergent among species. (2006)
  • Author(s): Shibata, S., et al.
  • Journal Title: Nucl. Acids Res. 34 Pages: 4711-4721
• [Journal Article] Aberrant localization of importin α1 in hippocampal neurons in Alzheimer disease. (2006)
  • Author(s): Lee, H.-g., et al.
  • Journal Title: Brain Res. 1124 Pages: 1-4
• [Journal Article] The nuclear import of RNA helicase A is mediated by importin-α3. (2006)
  • Author(s): Aratani, S., et al.
  • Journal Title: Biochem.Biophys.Res.Commun. 340 Pages: 125-133
• [Journal Article] Impaired expression of the importin/karyopherin β1 leads to post-implantation lethality. (2006)
  • Author(s): Miura, K., et al.
  • Journal Title: Biochem.Biophys.Res.Commun. 341 Pages: 132-138
• [Journal Article] Mechanism of the stress-induced collapse of the Ran distribution. (2006)
  • Author(s): Yasuda, Y., et al.
  • Journal Title: Exp.Cell Res. 312 Pages: 512-520
• [Journal Article] Nuclear import of Epstein-Barr virus nuclear antigen-1 mediated by NPI-1 (importin α5) is up- and down regulated by phosphorylation of the nuclear localization signal for which 379Lys and Arg380 are essential. (2006)
  • Author(s): Kitamura, R., et al.
  • Journal Title: J.Virol. 80 Pages: 1979-1991
• [Journal Article] The mechanism of nuclear export of Smad3 involves exportin 4 and Ran. (2006)
  • Author(s): Kurisaki, A., et al.
  • Journal Title: Mol.Cell.Biol. 26 Pages: 1318-1332
• [Journal Article] Functional analysis of nuclear pore complex protein Nup62/p62 using monoclonal antibodies. (2006)
  • Author(s): Fukuhara, T., et al.
  • Journal Title: Hrybridoma in press
• [Journal Article] Importin transports Ca^<2+>/calmodulin-dependent protein kinase type IV (CaMKIV) to the nucleus without utilizing importin (2005)
  • Author(s): Kotera, I., Sekimoto, T., Miyamoto, Y., Saiwaki, T., Nagoshi, E., Sakagami, H., Kondo, H. and Yoneda, Y.
  • Journal Title: EMBO J., 24 Pages: 942-951
  • Peer Reviewed
• [Journal Article] The 70 kDa heat shock cognate protein (hsc70) facilitates the nuclear export of the import receptors. (2005)
  • Author(s): Kose, S., Furuta, M. ,Koike, M., Yoneda, Y. and Imamoto, N.
  • Journal Title: J.Cell Biol. 171 Pages: 19-25
  • Peer Reviewed
• [Journal Article] Extracellular signal-dependent nuclear import of STAT3 is mediated by various importin α. (2005)
  • Author(s): Ushijima, R., et al.
  • Journal Title: Biochem.Biophys.Res.Commun. 330 Pages: 880-886
• [Journal Article] In vivo dynamics and kinetics of pKi-67:transition from a mobile to an immobile form at the onset of anaphase. (2005)
  • Author(s): Saiwaki, T., et al.
  • Journal Title: Exp.Cell Res. 308 Pages: 123-134
• [Journal Article] Nuclear-cytoplasmic shuttling of a RING-IBR protein RBCK1 and its functional interaction with nuclear body proteins. (2005)
  • Author(s): Tatematsu, K., et al.
  • Journal Title: J.Biol.Chem. 280 Pages: 22937-22944
• [Journal Article] β-Catenin can act as a nuclear import receptor for its partner transcription factor, lef-1. (2005)
  • Author(s): Asally, M., Yoneda, Y.
  • Journal Title: Exp.Cell Res. 308 Pages: 357-363
• [Journal Article] The 70 kDa heat shock cognate protein (hsc70) facilitates the nuclear export of the import receptors. (2005)
  • Author(s): Kose, S., et al.
  • Journal Title: J.Cell Biol. 171 Pages: 19-25
• [Journal Article] Specific monoclonal antibody against the nuclear pore complex protein, Nup98. (2005)
  • Author(s): Fukuhara, T., et al.
  • Journal Title: Hybridoma 24 Pages: 244-247
• [Journal Article] Importin 4 is responsible for ligand-independent nuclear translocation of vitamin D receptor. (2005)
  • Author(s): Miyauchi, Y., et al.
  • Journal Title: J.Biol.Chem. 280 Pages: 40901-40908
• [Journal Article] The phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1. (2005)
  • Author(s): Takeda, E., et al.
  • Journal Title: Cell Struct.Funct. 30 Pages: 69-80
• [Journal Article] The role of mammalian staufen on mRNA traffic : a view from its nucleocytoplasmic shuttling function. (2005)
  • Author(s): Miki, T., Takano, K., Yoneda Y.
  • Journal Title: Cell Struct.Funct. 30 Pages: 51-56
  • NAID: 130004137498
• [Journal Article] Importin-α promotes passage through the nuclear pore complex of human immunodeficiency virus type 1 Vpr. (2005)
  • Author(s): Kamata, M., Nitahira-Kasahara, Y., Miyamoto, Y., Yoneda, Y., Aida, Y.
  • Journal Title: J.Virol. (印刷中)
• [Journal Article] Altered protein expression in endometrial carcinogenesis. (2005)
  • Author(s): Yoshizaki, T., Enomoto, T., Nakashima, R., Ueda, Y., Kanao, H., Yoshino, K., Fukumoto, M., Yoneda, Y., Buzard, G.S., Murata, Y.
  • Journal Title: Cancer Lett (印刷中)
• [Journal Article] Molecular cloning and functional characterization of mouse NXF family gene products. (2005)
  • Author(s): Sasaki, M., Takeda, E., Takano, K., Yomogida, K., Katahira, J., Yoneda, Y.
  • Journal Title: Genomics (印刷中)
• [Journal Article] Importin α transports Ca^<2+>/calmodulin-dependent protein kinase type IV (CaMKIV) to the nucleus without utilizing importin β. (2005)
  • Author(s): Kotera, I., Sekimoto, T., Miyamoto, Y., Saiwaki, T., Nagoshi, E., Sakagami, H., Kondo, H., Yoneda, Y.
  • Journal Title: EMBO J. (印刷中)
• [Journal Article] Zinc finger domain of Snail functions as a nuclear localization signal for importin β-mediated nuclear import pathway. (2005)
  • Author(s): Yamasaki, H., Sekimoto, T., Ohkubo, T., Douchi, T., Nagata, Y., Ozawa, M., Yoneda, Y.
  • Journal Title: Genes Cells (印刷中)
• [Journal Article] Importin α/β mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal. (2005)
  • Author(s): Sakakida, Y., Miyamoto, Y., Nagoshi, E., Akashi, M., Nakamura, T.J., Mamine, T., Kasahara, M., Minami, Y., Yoneda, Y., Takumi, T.
  • Journal Title: J.Biol.Chem. (印刷中)
• [Journal Article] Cellular stresses induce the nuclear accumulation of importin α and cause a conventional nuclear import block. (2004)
  • Author(s): Miyamoto, Y., Saiwaki, T., Yamashita, J., Yasuda, Y. ,Kotera, I., Shibata, S., Shigeta, M., Hiraoka, Y., Haraguchi, T., and Yoneda, Y.
  • Journal Title: J.Cell Biol. 165 Pages: 617-623
  • Peer Reviewed
• [Journal Article] 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27^<Kip1>. (2004)
  • Author(s): Sekimoto, T., Fukumoto, M., and Yoneda, Y.
  • Journal Title: EMBO J. 23 Pages: 1934-1942
  • Peer Reviewed
• [Journal Article] Heat-shock induced nuclear retention and recycling inhibition of importin α. (2004)
  • Author(s): Furuta, M., Kose, S., Koike, M., Shimi, T., Hiraoka, Y., Yoneda, Y., Haraguchi, T., Imamoto, N.
  • Journal Title: Genes Cells 9 Pages: 429-441
• [Journal Article] Importin α/β-mediated nuclear protein import is regulated in a cell cycle-dependent manner. (2004)
  • Author(s): Yasuhara, N., Takeda, E., Inoue, H., Kotera, I., Yoneda, Y.
  • Journal Title: Exp.Cell Res. 297 Pages: 285-293
• [Journal Article] 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27^<Kip1> (2004)
  • Author(s): Sekimoto, T., Fukumoto, M., Yoneda, Y.
  • Journal Title: EMBO J. 23 Pages: 1934-1942
• [Journal Article] Cellular stresses induce the nuclear accumulation of importin α and cause a conventional nuclear import block. (2004)
  • Author(s): Miyamoto, Y., Saiwaki, T., Yamashita, J., Yasuda, Y., Kotera, I., Shibata, S., Shigeta, M., Hiraoka, Y., Haraguchi, T., Yoneda, Y.
  • Journal Title: J.Cell Biol. 165 Pages: 617-623
• [Journal Article] β-Catenin shows an overlapping sequence requirement but distinct molecular interactions for its bi-directional passage through nuclear pores. (2004)
  • Author(s): Koike, M., Kose, S., Furuta, M., Taniguchi, M., Yokoya, F., Yoneda, Y., Imamoto, N.
  • Journal Title: J.Biol.Chem. 279 Pages: 34038-34047
• [Journal Article] An ATP-dependent activity that releases RanGDP from NTF2. (2004)
  • Author(s): Yamada, M., Mattaj, I., Yoneda, Y.
  • Journal Title: J.Biol.Chem. 279 Pages: 36228-36234
• [Journal Article] Specific monoclonal antibody against nuclear import factor, importin alpha1/Rch1. (2004)
  • Author(s): Kamikubo, Y., Sakaguchi, N., Shikata, K., Furuta, M., Miyamoto, Y., Imamoto, N., Yoneda, Y., Ogino, K., Tachibana, T.
  • Journal Title: Hybridoma and Hybridomics 23 Pages: 301-304
• [Journal Article] Alternative splicing of Staufen2 creates the nuclear export signal for CRM1(exportin1) (2004)
  • Author(s): Miki, T., Yoneda Y.
  • Journal Title: J.Biol.Chem 279 Pages: 47473-47479
• [Presentation] C2C12細胞の筋分化における核膜孔複合体リモデリング (2009)
  • Author(s): Asally,M., Yasuda,Y., Oka, M., Otsuka, S., Yoshimura, S. H., Yorted_a, Y.
  • Organizer: 第26回染色体ワークショップ
  • Place of Presentation: 姫路
• [Presentation] 核蛋白質輸送と生命機能 (2008)
  • Author(s): 米田悦啓
  • Organizer: BMB2008第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] Nuclear pore dynamics during skeletal myogenesis. (2008)
  • Author(s): Asally,M., Yasuda,Y., Oka,M.,Otsuka,S., Yoshimura,S.H., Yoneda,Y.
  • Organizer: Cold Spring Harbor Laboratory Meeting on Dynamic Organization of Nuclear Function
  • Place of Presentation: N.Y./USA
• [Presentation] Nuclear protein import and its significance to cell function (2008)
  • Author(s): Yoneda, Y.
  • Organizer: 2nd International SOX Meeting
  • Place of Presentation: 兵庫
• [Presentation] Nucleocytoplasmic transport of proteins and RNAs and its significance, to cell function (2008)
  • Author(s): Yoneda, Katahira, J., S ekimoto, T., Yasuhara, N., and Oka, M
  • Organizer: 第60回日本細胞生物学会大会
  • Place of Presentation: 横浜
• [Presentation] Functional differences between, two isoforms of Npap60(Nup50)in nuclear impiort (2008)
  • Author(s): Ogawa, Y., Oka, M., Asally, M. and Yoneda, Y.
  • Organizer: 第60回日本細胞生物学会大会
  • Place of Presentation: 横浜
• [Presentation] Nuclear accumulation of importin a suppresses DNA repliation (2008)
  • Author(s): Mizuguchi, C., Yasuda, Y. and Yoneda, Y.
  • Organizer: 第60回日本細胞生物学会大会
  • Place of Presentation: 横浜
• [Presentation] Analysis of potential roles of Nup98 FG repeat region in oncogenesis (2008)
  • Author(s): Masahiro Oka, Munehiro Asally, Yoshinori Yasuda, Yoshihiro Yoneda
  • Organizer: 第60回日本細胞生物学会大会
  • Place of Presentation: 横浜
• [Presentation] Identification of a cis-acting dendritic targeting element in the brain-derived neurotrophic factor mRNA (2008)
  • Author(s): Souiehi Oe, Yoshihiro Yoneda
  • Organizer: 第60回日本細胞生物学会大会
  • Place of Presentation: 横浜
• [Presentation] Regulation of importin alphal expression (2008)
  • Author(s): Yasunao Katnikawa, Noriko Yasiahara, Yoshihiro Yoneda
  • Organizer: 2nd International SOX Meeting
  • Place of Presentation: 兵庫
• [Presentation] As novel regulatory system to maintain ES cells through nuclear-cytoplasmic transport (2008)
  • Author(s): Yasuhara, N, Memood, R., Kamikawa, Y., Touma, K. and Yoneda, Y
  • Organizer: 2nd International SOX Meeting
  • Place of Presentation: 兵庫
• [Presentation] Nuclear-cytoplasmic transport regulation of transcription factors (2008)
  • Author(s): Memood, R., Yoshikawa, K., Shibazaki, N., Kaneko, A., Yasuhara, N., Kondoh, H. and Yoneda, Y
  • Organizer: 2nd International SOX Meeting
  • Place of Presentation: 兵庫
• [Presentation] Nuclear import mechanism of Nanog (2008)
  • Author(s): Gibo, R., Okada, M., Yasuhara, and Yoneda, Y.
  • Organizer: 2nd International SOX Meeting
  • Place of Presentation: 兵庫
• [Presentation] Selective localization of PCBP2 to P-bodies -An implication for functional diversity among P-hodies (2008)
  • Author(s): Ken Fujimura, Jun Katahira, Fumi Kano, Yoshihiro Yoneda, Masayuki Murata
  • Organizer: Cold Spring Harbor Laboratory Meeting on Dynamic Organization of Nuclear Function
  • Place of Presentation: N. Y. /USA
• [Presentation] Nuclear pore dynamics during skeletal myogenesis (2008)
  • Author(s): Asally, M., Yasuda, Y., Oka, M., Otsuka, S., Yoshimura, S. H., Yoneda, Y.
  • Organizer: Cold Spring Harbor Laboratory Meeting on Dynamic Organization of Nuclear Function
  • Place of Presentation: N. Y. /USA
• [Presentation] Nuclear import mechanism of neuroD1, E47 and their heterodimeric complex (2008)
  • Author(s): Mehmood, R., Yasuhara, N., Oe, S., Nagai, M., Yoneda, Y
  • Organizer: Cold Spring Harbor Laboratory Meeting on Dynamic Organization of Nuclear Function
  • Place of Presentation: N. Y. /USA
• [Presentation] The role of Nup98 in a Crml-mediated nuclear export (2008)
  • Author(s): Oka, M., Asally, M., Yasuda, Y., Yoneda, Y.
  • Organizer: Cold Spring Harbor Laboratory Meeting on Dynamic Organization of Nuclear Function
  • Place of Presentation: N. Y. /USA
• [Presentation] Functional analysis of nuclear importin α accumulating in response to the stress (2008)
  • Author(s): Yasuda, Y., Miyainoto, Y., Yoneda, Y.
  • Organizer: Cold Spring Harbor Laboratory Meeting on Dynamic Organization of Nuclear Function
  • Place of Presentation: N. Y. /USA
• [Presentation] Nucleo-cytoplasmic transport and the assembly of stress granules (2008)
  • Author(s): Ken Fujimura, Jun Katahira, Fumi Kano, Yoshihiro Yoneda, Masayuki Murata
  • Organizer: Cold Spring Harbor Laboratory Meeting on Dynamic Organization of Nuclear Function
  • Place of Presentation: N. Y. /USA
• [Presentation] 精子細胞形成過程におけるimportin alphaの核内機能 (2008)
  • Author(s): 宮本洋一、安田善也、山城朋子、永井理博、米田悦啓、David Jans、Kate Loveland
  • Organizer: BMB2008第31回日本分r子生物学会年会・第81回日本生化学会太会合同大会
  • Place of Presentation: 神戸
• [Presentation] 核-細胞質間分子流通機構と生命機能の調節 (2007)
  • Author(s): 米田悦啓
  • Organizer: 第71 回日本生化学会中部支部会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-05-19
• [Presentation] 核-細胞質間分子流通機構と生命機能の調節 (2007)
  • Author(s): 米田悦啓
  • Organizer: 第71回日本生化学会中部支部会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-05-19
• [Presentation] Importin alpha has multiple functionsEMBO (2007)
  • Author(s): Yoneda, Y.
  • Organizer: Workshop on Mechanisms of Nucleocytoplasmic Transport
  • Place of Presentation: Italy
• [Presentation] Importin alpha has multiple functions (2007)
  • Author(s): Yoneda, Y.
  • Organizer: EMBO Workshop on Mechanisms of Nucleocytoplasmic Transport
  • Place of Presentation: Italy
• [Book] 分子生物学イラストレイテッド第3版 (2009)
  • Author(s): 浅利宗弘、米田悦啓
  • Total Pages: 348
  • Publisher: 羊土社
• [Book] 標準細胞生物学 (2008)
  • Author(s): 片平じゅん、米田悦啓
  • Total Pages: 358
  • Publisher: 医学書院
• [Book] 標準細胞生物学 (2008)
  • Author(s): 片平じゅん、米田税啓
  • Total Pages: 358
  • Publisher: 医学書院
• [Book] Nuclear Dynamics (2007)
  • Author(s): Saiwaki,T. and Yoneda,Y
  • Total Pages: 279
  • Publisher: Springer-Verlag Inc
• [Book] 細胞核の世界-ダイナミクスから病態まで (2007)
  • Author(s): 米田悦啓、他
  • Total Pages: 383
  • Publisher: 共立出版
• [Book] Nuclear Dynamics (2007)
  • Author(s): Saiwaki, T.・Yoneda, Y.
  • Total Pages: 279
  • Publisher: Springer-Verlag Inc.
• [Book] Nuclear Dynamics (2007)
  • Author(s): Saiwaki, T., Yoneda.Y.
  • Total Pages: 279
  • Publisher: Springer-Verlag Inc.
• [Remarks] ホームページ等
  • URL: http://www.anat3.med.osaka-u.ac.jp/
• [Remarks]
  • URL: http://www.anat3.med.osaka-u.ac.ip/
• [Remarks]
  • URL: http://www.anat3.med.osaka-u.ac.jp/