Regulation of nuclear domain localization and dynamics
| Project/Area Number |
16084205
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Hiroshima University |
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Principal Investigator |
TASHIRO Satoshi Hiroshima University, 原爆放射線医科学研究所, 教授 (20243610)
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| Research Collaborator |
CREMER Thomas ミュンヘン大学, 生物学部II, 教授
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| Project Period (FY) |
2004 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥62,400,000 (Direct Cost: ¥62,400,000)
Fiscal Year 2008: ¥11,700,000 (Direct Cost: ¥11,700,000)
Fiscal Year 2007: ¥11,700,000 (Direct Cost: ¥11,700,000)
Fiscal Year 2006: ¥11,700,000 (Direct Cost: ¥11,700,000)
Fiscal Year 2005: ¥11,700,000 (Direct Cost: ¥11,700,000)
Fiscal Year 2004: ¥15,600,000 (Direct Cost: ¥15,600,000)
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| Keywords | 細胞核 / バイオイメージング / 核内ドメイン / イメージング |
|---|
| Research Abstract |
DNA代謝制御に関わる核内ドメインの局在と動態の制御機構の解明に取り組んだ。その結果、転写因子Bach2が形成する核内ドメインの動態制御には蛋白質翻訳後修飾SUMO化修飾が重要であること、ヒストンH2AXのゲノム損傷依存的なアセチル化がゲノム修復関連核内ドメインRAD51フォーカスの形成制御に係わっていることが明らかになった。これらの研究から得られた知見から、核内ドメイン形成制御機構の一端が明らかになり、今後様々な疾患の新しい診断法、治療法の開発に結びつくことが期待される。
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Report
(6 results)
Research Products
(65 results)
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[Journal Article] FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway2008
Author(s)
Ishiai M, Kitao H, Smogorzewska A,Tomida J, Kinomura A, Uchida E, Saberi A,Kinoshita E, Kinoshita-Kikuta E, Koike T,Tashiro S, Elledge SJ, Takata M.
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Journal Title
Nat Struct Mol Biol 15(11)
Pages: 1138-1146
Related Report
Peer Reviewed
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[Journal Article] DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics2008
Author(s)
Ikura T*, Tashiro S*, Kakino A, Shima H, Jacob N, Amunugama R, Yoder K, Izumi S, Kuraoka I, Tanaka K, Kimura H, Ikura M, Nishikubo S, Ito T, Muto A, Miyagawa K, Takeda S, Fishel R, Igarashi K, Kamiya K
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Journal Title
Mol Cell Biol 27
Pages: 7028-7040
Related Report
Peer Reviewed
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[Journal Article] Non-SCN5A related Brugada syndromes: verification of normal splicing and trafficking of SCN5A without exonic mutations2007
Author(s)
Nakano Y, Tashiro S, Kinoshita E, Kinoshita-Kikuta E, Takenaka S, Miyoshi M, Ogi H, Sakoda E, Oda N, Suenari K, Tonouchi Y, Okimoto T, Hirai Y, Miura F, Yamaoka K, Koike T, Chayama K
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Journal Title
Ann Hum Genet 71
Pages: 8-17
Related Report
Peer Reviewed
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[Journal Article] Polycomb group gene mel-18 regulates early T progenitor expansion by maintaining the expression of Hes-12005
Author(s)
Miyazaki M, Kawamoto H, Kato Y, Itoi M, Miyazaki K, Masuda K, Tashiro S, Ishihara H, Igarashi K, Amagai T, Kanno R, Kanno M
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Journal Title
a target of the notch pathway.J Immunol. 174 174
Pages: 2507-2516
Related Report
Peer Reviewed
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