Molecular Properties of Nuclear Architecture and Centromere Function for Faithful Chromosome Segregation

• Project/Area Number: 16084207
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kurume University
• Principal Investigator: TAKAHASHI Kohta Kurume University, 分子生命科学研究所, 教授 (40303804)
• Co-Investigator(Kenkyū-buntansha): ISHII Kojiro 大阪大学, 生命機能研究科, 特任准教授 (40360276) ; FUKAGAWA Tatsuo 国立遺伝学研究所, 分子遺伝研究系, 教授 (60321600)
• Project Period (FY): 2004 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥153,100,000 (Direct Cost: ¥153,100,000); Fiscal Year 2008: ¥31,100,000 (Direct Cost: ¥31,100,000); Fiscal Year 2007: ¥31,100,000 (Direct Cost: ¥31,100,000); Fiscal Year 2006: ¥31,100,000 (Direct Cost: ¥31,100,000); Fiscal Year 2005: ¥31,100,000 (Direct Cost: ¥31,100,000); Fiscal Year 2004: ¥28,700,000 (Direct Cost: ¥28,700,000)
• Keywords: セントロメア / 染色体 / 細胞周期 / ヘテロクロマチン / がん / CENP-A / 分裂酵母 / Mad2 / siRNA

Research Abstract

遺伝情報をコードするDNAは、細胞核内の染色体に収納され、セントロメアを制御拠点として子孫細胞に伝達される。本研究では、分裂酵母および高等真核細胞をモデル系にして、進化的に保存されたセントロメア核内機能と染色体分配における新規制御機構を分子的に明らかにした。これらセントロメア機能の制御破綻が、細胞がん化などの病態にどのように関わるかを探ることで、新たな治療戦略の考案に資することが期待できよう。

Research Products

• [Journal Article] Cohesin associates with spindle poles in a mitosis-specific manner and functions in spindle assemble in vertebrate cells (2009)
  • Author(s): Xiangduo Kong, 他
  • Journal Title: Molecular Biology of the Cell 20 Pages: 1289-1301
  • Peer Reviewed
• [Journal Article] Heterochromatin integrity affects chromosome reorganization after centromere dysfunction (2008)
  • Author(s): Kojiro Ishii, Yuki Ogiyama, Yuji Chikashige, Saeko Soejima, Fumie Masuda, Tatsuyuki Kakuma, Yasushi Hiraoka, and Kohta Takahashi
  • Journal Title: Science 321 Pages: 1088-1091
  • Peer Reviewed
• [Journal Article] CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore (2008)
  • Author(s): Tetsuya Hori, Miho Amano, Aussie Suzuki, Chelsea Backer, Julie Welburn, Yimin Dong, Bruce F. McEwen, Emiko Suzuki, Katsuya Okawa, Iain M. Cheeseman, and Tatsuo Fukagawa
  • Journal Title: Cell 135 Pages: 1039-1052
  • Peer Reviewed
• [Journal Article] Dual regulation of Mad2 localization on kinetochores by Bub1 and Dam1/DASH that ensure proper spindle interaction (2008)
  • Author(s): Shigeaki Saitoh, Yasuyo Kobayashi, Yuki Ogiyama, and Kohta Takahashi
  • Journal Title: Mol. Biol. Cell 19 Pages: 3885-3897
  • Peer Reviewed
• [Journal Article] CENP-O-class proteins form a stable complex and are required for proper kinetochore function (2008)
  • Author(s): Tetsuya Hori, Masahiro Okada, Katsumi Maenaka, and Tatsuo Fukagawa
  • Journal Title: Mol. Biol. Cell 19 Pages: 843-854
  • Peer Reviewed
• [Journal Article] Biphasic incorporation of centromeric histone CENP-A in fission yeast (2008)
  • Author(s): Yuko Takayama, Hiroshi Sato, Shigeaki Saitoh, Yuki Ogiyama, Fumie Masuda, and Kohta Takahashi
  • Journal Title: Mol. Biol. Cell 19 Pages: 682-690
  • Peer Reviewed
• [Journal Article] Heterochromatin integrity affects chromosome reorganization after centromere dysfunction (2008)
  • Author(s): Kojiro Ishii, 他
  • Journal Title: Science 321 Pages: 1088-1091
  • Peer Reviewed
• [Journal Article] Dual regulation of Mad2 localization on kinetochores by Bubl and Datn1/DASH that ensure proper spindle interaction (2008)
  • Author(s): Shigeaki Saitoh, 他
  • Journal Title: Molecular Biology of the Cell 19 Pages: 3885-3897
  • Peer Reviewed
• [Journal Article] CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore (2008)
  • Author(s): Tetsuya Hori, 他
  • Journal Title: Cell 135 Pages: 1039-1052
  • Peer Reviewed
• [Journal Article] Biphasic incorporation of centromeric histone CENP-A in fission yeast (2008)
  • Author(s): Yuko Takayama, Hiroshi Sato, Shigeaki Saitoh, Yuki Ogiyama, Fumie Masuda, Kohta Takahashi
  • Journal Title: Molecular Biology of the Cell 19 Pages: 682-690
  • Peer Reviewed
• [Journal Article] CENP-O-class proteins form a stable complex and are required for proper kinetochore function. (2008)
  • Author(s): Tetsuya Hori, Masahiro Okada, Katsumi Maenaka, Tatsuo Fokagawa
  • Journal Title: Molecular Biology of the Cell 19 Pages: 843-854
  • Peer Reviewed
• [Journal Article] KNL1 and CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates. (2008)
  • Author(s): Iain M.cheeseman, Tetsuya Hori, Tatsuo Fukagawa, Arshad Desai
  • Journal Title: Molecular Biology of the Cell 19 Pages: 587-594
  • Peer Reviewed
• [Journal Article] The kinetochore and spindle checkpoint in vertebrate cells. (2008)
  • Author(s): Tatsuo Fukagawa
  • Journal Title: Frontiers in Bioscience 13 Pages: 2705-2713
  • Peer Reviewed
• [Journal Article] Differential regulation of repeated histone genes during the fission yeast cell cycle (2007)
  • Author(s): Yuko Takayama, and Kohta Takahashi
  • Journal Title: Nucleic Acids Res 35 Pages: 3223-3237
  • Peer Reviewed
• [Journal Article] The fission yeast DASH complex is essential for satisfying the spindle assembly checkpoint induced by defects in the inner-kinetochore proteins (2007)
  • Author(s): Yasuyo Kobayashi, Shigeaki Saitoh, Yuki Ogiyama, Saeko Soejima, and Kohta Takahashi
  • Journal Title: Genes Cells 12 Pages: 311-28
  • Peer Reviewed
• [Journal Article] Differential regulation of repeated histone genes during the fission yeast cell cycle (2007)
  • Author(s): Yuko Takayama, Kohta Takahashi
  • Journal Title: Nucleic Acids Research 35 Pages: 3223-3237
  • Peer Reviewed
• [Journal Article] Essential Role of CAF-1-mediated Rapid Nucleosome Assembly for DNA Replication and Cell Division in Vertebrate Cells. (2007)
  • Author(s): Yasunari Takami, Tatsuya Ono, Tatsuo Fukagawa, Kei-ichi Shibahara, Tatsuo Nakayama
  • Journal Title: Molecular Biology of the Cell 18 Pages: 129-141
  • Peer Reviewed
• [Journal Article] The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions. (2007)
  • Author(s): Michela Zuccolo, Annabelle Alves, Vincent Galy, Stephanie Bolhy, Etienne Formstecher, Victor Racine, Jean-Baptiste Sibarita, Tatsuo Fukagawa, Ramin Shiekhattar, Tim Yen, Valerie Doye
  • Journal Title: The EMBO Journal 26 Pages: 1854-1864
  • Peer Reviewed
• [Journal Article] CENP-C is involved in chromosome segregation, mitotic checkpoint function and kinetochore assembly. (2007)
  • Author(s): Mi-Sun Kwon, Tetsuya Hori, Masahiro Okada, Tatsuo Fukagawa
  • Journal Title: Molecular Biology of the Cell 18 Pages: 2155-2168
  • Peer Reviewed
• [Journal Article] Differential regulation of repeated histone genes during the fission yeast cell cycle (2007)
  • Author(s): Takayama Y, et al.
  • Journal Title: Nucleic Acids Research (in press)
• [Journal Article] CENP-C is involved in chromosome segregation, mitotic checkpoint function and kinetochore assembly (2007)
  • Author(s): Kwon M-S, et al.
  • Journal Title: Molecular Biology of the Cell (in press)
• [Journal Article] The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions (2007)
  • Author(s): Zuccolo M, et al.
  • Journal Title: The EMBO Journal 26・7 Pages: 1853-1864
• [Journal Article] The fission yeast DASH complex is essential for satisfying the spindle assembly checkpoint induced by defects in the inner-kinetochore proteins (2007)
  • Author(s): Kobayashi Y, et al.
  • Journal Title: Genes Cells 12・3 Pages: 311-328
• [Journal Article] Essential Role of CAF-1-mediated Rapid Nucleosome Assembly for DNA Replication and Cell Division in Vertebrate Cells (2007)
  • Author(s): Takami Y, et al.
  • Journal Title: Molecular Biology of the Cell 18・1 Pages: 129-141
• [Journal Article] The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres (2006)
  • Author(s): Masahiro Okada, Iain M. Cheeseman, Tetsuya Hori, Katsuya Okawa, Ian X. McLeod, John R. Yates III, Arshad Desai, and Tatsuo Fukagawa
  • Journal Title: Nature Cell Biol. 8 Pages: 446-457
  • Peer Reviewed
• [Journal Article] Purification of a protein complex that associates with chromatin (2006)
  • Author(s): Okada M et al.
  • Journal Title: Nature Protocols DOI:10.1038/nprot.2006.417
• [Journal Article] A novel histone-exchange factor, protein phosphatase 2Cγ, mediates the exchange and dephosphorylation of H2A/H2B (2006)
  • Author(s): Kimura H, et al.
  • Journal Title: Journal of Cell Biology 175・3 Pages: 389-400
• [Journal Article] The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres (2006)
  • Author(s): Okada M, et al.
  • Journal Title: Nature Cell Biology 8・5 Pages: 446-457
• [Journal Article] The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation (2006)
  • Author(s): Kline S, et al.
  • Journal Title: Journal of Cell Biology 173・1 Pages: 9-17
• [Journal Article] Asf1 is required for viability and chromatin assembly during DNA replication in vertebrate cells (2006)
  • Author(s): Sanematsu F, et al.
  • Journal Title: Journal of Biological Chemistry 281・19 Pages: 13817-13827
• [Journal Article] Spindle checkpoint signaling requires the Mis6 kinetochore subcomplex, which interacts with Mad2 and mitotic spindles (2005)
  • Author(s): Shigeaki Saitoh, Kojiro Ishii, Yasuyo Kobayashi, and Kohta Takahashi
  • Journal Title: Mol. Biol. Cell 16 Pages: 3666-3677
  • Peer Reviewed
• [Journal Article] Spindle checkpoint signaling requires the mis6 kinetochore subcomplex, which interacts with mad2 and mitotic spindles. (2005)
  • Author(s): Saitoh S, et al.
  • Journal Title: Molecular Biology of the Cell 16・8 Pages: 3666-3677
• [Journal Article] Functional region of CENP-H interacts with Nuf2 complex, which functions as a connector between the inner and outer kinetochores. (2005)
  • Author(s): Mikami Y, et al.
  • Journal Title: Molecular Cellular Biology 25・5 Pages: 1958-1970
• [Journal Article] CENP-A depletion leads to impaired mitotic checkpoint maintenace in vertebrate cells. (2005)
  • Author(s): Regnier V, et al.
  • Journal Title: Molecular Cellular Biology 25・10 Pages: 3967-3981
• [Journal Article] The Constitutive Centromere Component CENP-50 is Required for Recovery from Spindle damage. (2005)
  • Author(s): Minoshima Y, et al.
  • Journal Title: Molecular Cellular Biology 25・23 Pages: 10315-10328
• [Journal Article] Two distinct pathways responsible for the loading of CENP-A to centromeres in the fission yeast cell cycle. (2005)
  • Author(s): Kohta Takahashi
  • Journal Title: Philos. Trans. R. Soc. Lond. B. Biol. Sci. in press
• [Journal Article] Functional region of CENP-H interacts with Nuf2 complex, which functions as a connector between the inner and outer kinetochores. (2005)
  • Author(s): Yoshikazu Mikami
  • Journal Title: Mol Cell Biol. 25・5 Pages: 1958-1970
• [Journal Article] BAF53/Arp4 homolog Alp5 in fission yeast is required for histone H4 acetylation, kinetochore-spindle attachment, and gene silencing at centromere. (2005)
  • Author(s): Aki Minoda
  • Journal Title: Mol Biol Cell 16・1 Pages: 316-327
• [Journal Article] Dicer is essential for formetion of the heterochromatin structure in vertebrate cells (2004)
  • Author(s): Tatsuo Fukagawa (他7名1番目)
  • Journal Title: Nature Cell Biol. 6
  • Peer Reviewed
• [Journal Article] Centromere DNA, proteins and kinetochore assembly in vertebrate cells. (2004)
  • Author(s): Tatsuo Fukagawa
  • Journal Title: Chromosome Res. 12・6 Pages: 557-556
• [Journal Article] "Dicer is essential for formetion of the heterochromatin structure in vertebrate cells." (2004)
  • Author(s): Tatsuo Fukagawa
  • Journal Title: Nat Cell Biol. 6・8 Pages: 784-791
• [Journal Article] Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres. (2004)
  • Author(s): Takeshi Hayashi
  • Journal Title: Cell 118・6 Pages: 715-729
• [Presentation] ネオセントロメア形成機構の分裂酵母を用いた解析 (2009)
  • Author(s): 石井浩二郎
  • Organizer: 日本農芸化学会2009年度大会シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 2009-03-28
• [Presentation] 染色体再編成の分子機構 (2008)
  • Author(s): 石井浩二郎
  • Organizer: 第31会日本分子生物学会シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] セントロメア特異的クロマチン構造の構築 (2008)
  • Author(s): 深川竜郎
  • Organizer: BMB2008(第31会日本分子生物学会シンポジウム)
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] Heterochromatin integrity affects chromosome reorganization after centromere dysfunction (2008)
  • Author(s): Ishii K
  • Organizer: The 3rd Asim Chromosome Colloquiumシンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2008-12-03
• [Presentation] 小分子RNAによる染色体機能制御 (2008)
  • Author(s): 石井浩二郎
  • Organizer: 千里ライフサイエンスセミナー「機能性non-coding RNA古典的なセントラルドグマへの挑戦」
  • Place of Presentation: 大阪
  • Year and Date: 2008-11-11
• [Presentation] Molecular Mechanism on Chromosome Reorganization (2008)
  • Author(s): 高橋考太
  • Organizer: 大阪大学蛋白質研究所シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2008-10-31
• [Presentation] Chromosome reorganization after centromere dysfunction (2008)
  • Author(s): Takahashi K
  • Organizer: EMBO workshop "Chromosome Segregation : Centromere & Kinetochore"
  • Place of Presentation: Bordeaux
  • Year and Date: 2008-09-29
• [Presentation] Molecular architecture of the vertebrate constitutive centromere associated network (2008)
  • Author(s): Fukagawa T
  • Organizer: EMBO workshop on Chromosome Segregation : Centromers and Kinetochores
  • Place of Presentation: Bordeaux
  • Year and Date: 2008-09-29
• [Presentation] Heterochromatin Integrity Affects Chromosome Reorganisation after Centromere Dysfunction (2008)
  • Author(s): Takahashi K
  • Organizer: 33rd FEBS Congress & 11th IUBMB Conference "Chromosome Structure, Movements and Insulators"
  • Place of Presentation: Athens
  • Year and Date: 2008-06-29
• [Presentation] インナーキネトコアの分子構築 (2008)
  • Author(s): 深川竜郎
  • Organizer: 第60回日本細胞生物学会シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2008-06-29
• [Presentation] Targeting mechanisms of fission yeast non-coding RNAs by the RNA interference machinery (2008)
  • Author(s): Ishii K
  • Organizer: 第21回内藤カンフアレンス「細胞核ダイナミクスとRNA[I]」
  • Place of Presentation: 八ヶ岳
  • Year and Date: 2008-06-25
• [Presentation] Heterochromatin integrity affects chromosome reorganization after chentromere dysfunction (2008)
  • Author(s): Takahashi K
  • Organizer: International Symposium on Chromosome Dynamics in Ise
  • Place of Presentation: Ise
  • Year and Date: 2008-05-28
• [Presentation] Molecular architecture of the vertebrate constitutive centromere associated network (2008)
  • Author(s): Fukagawa T
  • Organizer: International Symposium on chromosome dynamics in Ise
  • Place of Presentation: Ise
  • Year and Date: 2008-05-28
• [Presentation] カリオタイプ変動の分子機構 (2008)
  • Author(s): 高橋考太
  • Organizer: 大阪大学蛋白質研究所セミナー"染色体機能とその病態"
  • Place of Presentation: 大阪府吹田市
  • Year and Date: 2008-03-14
• [Presentation] CENP-H/1複合体のサブ複合体であるCENP-0クラスの性質 (2008)
  • Author(s): 深川竜郎
  • Organizer: 第25回染色体ワークショップ
  • Place of Presentation: 静岡県熱海市
  • Year and Date: 2008-02-01
• [Presentation] セントロメア破壊に起因するカリオタイプ変動の制御機構 (2008)
  • Author(s): 高橋考太
  • Organizer: 第25回染色体ワークショップ
  • Place of Presentation: 静岡県熱海市
  • Year and Date: 2008-01-31
• [Presentation] CENP-Aの低下はヒト正常細胞を老化させる (2008)
  • Author(s): 前原佳代子
  • Organizer: 第25回染色体ワークショップ
  • Place of Presentation: 静岡県熱海市
  • Year and Date: 2008-01-31
• [Presentation] Chromosome reorganization after centromere dysfunction (2008)
  • Author(s): Kohta Takahashi
  • Organizer: EMBO workshop, Chromosome Segregation: Centromere & Kinetochore
  • Place of Presentation: Bordeaux
• [Presentation] Molecular architecture of the vertebrate constitutive centromere associated network (2008)
  • Author(s): Tatsuo Fukagawa
  • Organizer: EMBO workshop, Chromosome Segregation: Centromere & Kinetochore
  • Place of Presentation: Bordeaux
• [Presentation] Heterochromatin integrity affects chromosome reorganization after centromere dysfunction (2008)
  • Author(s): Kojiro Ishii
  • Organizer: The 3rd Asian Chromosome Colloquium
  • Place of Presentation: Osaka
• [Presentation] Functional role of CENP-H/I complex in the kinetochore (2007)
  • Author(s): T.Fukagawa
  • Organizer: 第30回日本分子生物学会年会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2007-12-12
• [Presentation] クロマチン工学への応用に向けたキネトコアタンパク質複合体の再構成 (2007)
  • Author(s): 堀哲也、深川竜郎
  • Organizer: 第30回日本分子生物学会年会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2007-12-12
• [Presentation] 分裂酵母セントロメア破壊株の分離 (2007)
  • Author(s): 高橋考太
  • Organizer: 染色体学会・染色体コロキウム合同年会
  • Place of Presentation: 神奈川県葉山
  • Year and Date: 2007-11-27
• [Presentation] コアヒストン遺伝子の転写制御と染色体動態の機能連関 (2007)
  • Author(s): 高山優子
  • Organizer: 染色体学会・染色体コロキウム合同年会
  • Place of Presentation: 神奈川県葉山
  • Year and Date: 2007-11-27
• [Presentation] コアヒストン遺伝子の転写制御と染色体動態の機能連関 (2007)
  • Author(s): 高山優子
  • Organizer: 第七回核ダイナミクス研究会
  • Place of Presentation: 北海道札幌
  • Year and Date: 2007-09-26
• [Presentation] セントロメア除去による染色体高次構築の変化 (2007)
  • Author(s): 荻山友貴
  • Organizer: 第七回核ダイナミクス研究会
  • Place of Presentation: 北海道札幌
  • Year and Date: 2007-09-25
• [Presentation] CENP-50ノックアウトマウスの染色体動態 (2007)
  • Author(s): 堀哲也、佐渡敬、深川竜郎
  • Organizer: 日本遺伝学会第79回大会
  • Place of Presentation: 岡山市
  • Year and Date: 2007-09-19
• [Presentation] 分裂酵母におけるコアヒストン転写制御 (2007)
  • Author(s): 高山優子
  • Organizer: 第40回酵母遺伝学フォーラム
  • Place of Presentation: 大阪府吹田市
  • Year and Date: 2007-09-12
• [Presentation] Functional role of CENP-Q-class proteins in the kinetochore. (2007)
  • Author(s): T.Fukagawa
  • Organizer: 16th International Chromosome Conference
  • Place of Presentation: アムステルダム
  • Year and Date: 2007-08-28
• [Presentation] Neocentromere formation and telomere fusion: Two modes of survivors from centromere disruption (2007)
  • Author(s): Kohta Takahashi
  • Organizer: The 4th International Fission Yeast Meeting
  • Place of Presentation: Copenhagen
• [Presentation] Neocentromere formation and telomere fusion:Two modes of survivors from centromere disruption (2007)
  • Author(s): Kohta Takahashi
  • Organizer: 4th International Fission Yeast Meeting
  • Place of Presentation: Copenhagen
• [Presentation] Sequence-specific recognition of centromeric transcripts by the RNA interference machinery (2007)
  • Author(s): Kojiro Ishii
  • Organizer: 4th International Fission Yeast Meeting
  • Place of Presentation: Copenhagen
• [Presentation] The bubl checkpoint pathway and the DASH complex regulate the kinetochore localization of Mad2 (2007)
  • Author(s): Shigeaki Saitoh
  • Organizer: 4th International Fission Yeast Meeting
  • Place of Presentation: Copenhagen
• [Presentation] Two distinct cell cycle phases responsible for centromere localization of CENP-A in fission yeast (2004)
  • Author(s): Kohta Takahashi
  • Organizer: The Royal Society discussion meeting on chromosome segregation
  • Place of Presentation: London
• [Book] 動原体.酵母のすべて系統、細胞から分子まで(大隈良典・下田親編) (2007)
  • Author(s): 高橋考太
  • Publisher: シュプリンガー・ジャパン
• [Book] Breaking and tessellating the contiguous nuclear genome in "Nuclear Dynamics : Molecular biology and visualization of the nucleus" (2007)
  • Author(s): Ishii, K.
  • Total Pages: 7
  • Publisher: Springer-Verlag Inc.
• [Book] チェックポイント-細胞周期の監視点、細胞周期集中マスター(北側雅敏 編) (2006)
  • Author(s): 齋藤 成昭, 高橋 考太
  • Total Pages: 11
  • Publisher: 羊土社
• [Book] 細胞核の世界(M 期染色体動態の制御機構、蛋白質核酸酵素増刊) (2006)
  • Author(s): 高橋 考太
  • Total Pages: 9
  • Publisher: 共立出版株式会社
• [Book] The Molecular Biology in Fission Yeast (Egel R., Ed.) (2004)
  • Author(s): Kohta Takahashi, and Mitsuhiro Yanagida. Chromosome cohesion and segregation
  • Publisher: Springer-Verlag Inc.
• [Book] Chromosome cohesion and segregation. in "The molecular biology in fission yeast" (2003)
  • Author(s): Kohta Takahaehi
  • Total Pages: 450
  • Publisher: Egel R., Ed., Springer-Verlag
• [Remarks] 研究成果は、複数の新聞等のメディアに紹介された。
• [Patent(Industrial Property Rights)] セントロメア局在タンパク質 (2008)
  • Inventor(s): 深川竜郎、天野美保、堀哲也
  • Industrial Property Rights Holder: 情報システム研究機構
  • Filing Date: 2008-02-21
• [Patent(Industrial Property Rights)] RNA interference induction element and use thereof (2006)
  • Inventor(s): 石井浩二郎, 高橋考太
  • Industrial Property Rights Holder: 久留米大学, 科学技術振興機構
  • Filing Date: 2006-05-15
• [Patent(Industrial Property Rights)] 小分子RNAの検出方法および小分子RNA検出用試薬 (2005)
  • Inventor(s): 石井浩二郎
  • Industrial Property Rights Holder: 久留米大学、科学技術振興機構
  • Industrial Property Number: 2005-013338
  • Filing Date: 2005-01-20
• [Patent(Industrial Property Rights)] RNA干渉誘導エレメント及びその用途 (2005)
  • Inventor(s): 石井浩二郎、高橋考太
  • Industrial Property Rights Holder: 久留米大学、科学技術振興機構
  • Industrial Property Number: 2005-145876
  • Filing Date: 2005-05-18