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Mechanisms of brain sex differentiation induced by neurosteroids

Research Project

Project/Area Number 16086206
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionWaseda University (2006-2008)
Hiroshima University (2004-2005)

Principal Investigator

TSUTSUI Kazuyoshi  Waseda University, 教育・総合科学学術院, 教授 (20163842)

Co-Investigator(Kenkyū-buntansha) SAKAGUCHI Hironobu  獨協医科大学, 医学部, 准教授 (30162291)
OKANOYA Kazuo  理化学研究所, 脳科学総合研究センター, 生物言語研究チームリーダー (30211121)
UKENA Kazuyishi  広島大学, 大学院・総合科学研究科, 准教授 (10304370)
Project Period (FY) 2004 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥84,000,000 (Direct Cost: ¥84,000,000)
Fiscal Year 2008: ¥16,800,000 (Direct Cost: ¥16,800,000)
Fiscal Year 2007: ¥16,800,000 (Direct Cost: ¥16,800,000)
Fiscal Year 2006: ¥16,800,000 (Direct Cost: ¥16,800,000)
Fiscal Year 2005: ¥16,800,000 (Direct Cost: ¥16,800,000)
Fiscal Year 2004: ¥16,800,000 (Direct Cost: ¥16,800,000)
Keywords脳の性分化 / 性的二型核 / ニューロステロイド / アポトーシス抑制因子 / Ad4BP / SF-1 / 鳥類 / エストラジオール / 7a-ヒドロキシプレグネノロン / P450 / cDNAマイクロアレイ / 7α-ヒドロキシプレグネノロン / 脳の性差 / CYP7b
Research Abstract

脳の性分化機構は未解明の重要課題である。本研究は、脳の自立的性分化機構の解明を目的として、脳の構造と行動に最も典型的な性差を示す鳥類のウズラを用い、脳が合成するニューロステロイドに着目して、ニューロステロイドによる脳の性分化誘導作用を解析した。その結果、脳の性分化に重要となる感受性期の間脳では、転写調節因子であるAd4BP/SF-1がニューロステロイド合成酵素の発現に性差を導くことでニューロステロイド合成に性差が生じて脳の性分化が誘導されることが見いだされた。

Report

(6 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (266 results)

All 2009 2008 2007 2006 2005 2004 Other

All Journal Article (186 results) (of which Peer Reviewed: 108 results) Presentation (39 results) Book (33 results) Remarks (6 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Molecular evolution of multiple forms of kisspeptins and GPR54 receptors in vertebrates2009

    • Author(s)
      Y. R. Lee(筆頭著者), K. Tsutsui(最終著者),et al(著者13名)
    • Journal Title

      Endocrinology doi:10.1210/en

      Pages: 2008-1679

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diurnal changes in the synthesis of 7α-hydroxypregnenolone stimulating locomotor activity in newts2009

    • Author(s)
      T. Koyama(筆頭著者), K. Tsutsui(最終著者), et al(著者4名)
    • Journal Title

      Ann. N. Y. Acad. Sci. (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Seasonal changes in the synthesis of 7α-hydroxypregnenolone stimulating locomotor activity in newts2009

    • Author(s)
      S. Haraguchi(筆頭著者), K. Tsutsui(最終著者),et al(著者4名)
    • Journal Title

      7α-hydroxypregnenolone stimulating locomotor activity in newts (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Neurosteroid biosynthesis : enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides2009

    • Author(s)
      J. L. DoRego(筆頭著者), K. Tsutsui(8番目), et al(著者9名)
    • Journal Title

      Front. Neuroendocrinol. (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Discovery of a novel avian neurosteroid, 7・-hydroxypregnenolone, and its role in the regulation of the diurnal rhythm of locomotor activity in Japanese quail2009

    • Author(s)
      K. Tsutsui(筆頭著者), et al(著者7名)
    • Journal Title

      Gen. Comp. Endocrinol. (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : A new key neurohormone controlling reproduction, gonadotropin-inhibitory hormone (GnIH) : Biosynthesis, mode of action and functional significance2009

    • Author(s)
      K. Tsutsui(単独著者)
    • Journal Title

      Prog. Neurobiol. 88

      Pages: 76-88

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Neurosteroid biosynthesis and action in the Purkinje cell2009

    • Author(s)
      K. Tsutsui(単独著者)
    • Journal Title

      cell. J. Exp. Neurosci. 2

      Pages: 1-12

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new key neurohormone controlling reproduction, gonadotropin-inhibitory hormone (GnIH) in birds : discovery, progress and prospect (review)2009

    • Author(s)
      K. Tsutsui(筆頭著者), K. Ukena(7番目), et al(著者10名)
    • Journal Title

      J. Neuroendocrinol. 21

      Pages: 271-275

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification, biosynthesis and function of 7・-hydroxypregnenolone, a new key neurosteroid controlling locomotor activity, in non-mammals (review)2009

    • Author(s)
      K. Tsutsui(筆頭著者), et al(著者9名)
    • Journal Title

      Ann. N.Y. Acad. Sci. (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular evolution of multiple forms of kisspeptins and GPR54 receptors in vertebrates2009

    • Author(s)
      Y. R. Lee, et.al.
    • Journal Title

      Endocrinology (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diurnal changes in the synthesis of 7alpha-hydroxypregnenolone stimulating locomotor activity in newts2009

    • Author(s)
      T. Koyama, et.al.
    • Journal Title

      Ann. N.Y. Acad. Sci. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Seasonal changes in the synthesis of 7alpha-hydroxypregnenolone stimulating locomotor activity in newts.2009

    • Author(s)
      S. Haraguchi, et.al.
    • Journal Title

      Ann. N.Y. Acad. Sci. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Neurosteroid biosynthesis : enzymatic pathways and neuroendocrine regulation by neurotransmitte rs and neuropeptides2009

    • Author(s)
      J. L. Do Rego, et.al.
    • Journal Title

      Front. Neuroendocrinol. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Discovery of a novel avian neurosteroid, 7alpha-hydroxypregnenolone, and its role in the regul ation of the diurnal rhythm of locomotor activity in Japanese quail2009

    • Author(s)
      K. Tsutsui, et.al.
    • Journal Title

      Gen. Comp. Endocrinol. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Proximate and ultimate mechanisms driving circadian control of neuroendocrine function : Lesson s from the young and old2009

    • Author(s)
      W. P. Williams III, et.al.
    • Journal Title

      Integr. Comp. Biol. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Gonadotropin-inhibitory hormone (GnIH) and its homologous peptides in vertebrates : discovery, mode of action and functional significance2009

    • Author(s)
      K. Tsutsui
    • Journal Title

      Prog. Neurobiol. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new key neurohormone controlling reproduction, gonadotropin-inhibitory hormone (GnIH) in birds : disc overy, progress and prospect (review)2009

    • Author(s)
      K. Tsutsui, et.al.
    • Journal Title

      J. Neuroendocrinol 21

      Pages: 271-275

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GnlH : A Multifunctional Neuropeptide2009

    • Author(s)
      G. E. Bentley, et.al.
    • Journal Title

      J. Neuroendocrinol 21(review)

      Pages: 276-281

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Octopus GnRH (oct-GnRH), a multifunctional peptide in the endocrine and nervous systems of the cephalo pod (review)2009

    • Author(s)
      H. Minakata, et.al.
    • Journal Title

      J. Neuroendocrinol 21

      Pages: 322-326

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evolutionary origin and divergence of GnIH and its homologous peptides (review)2009

    • Author(s)
      K. Tsutsui and T. Osugi
    • Journal Title

      Gen. Comp. Endocrinol 161

      Pages: 30-33

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification, biosynthesis and function of 7alpha-hydroxypregnenolone, a new key neurosteroid contro lling locomotor activity, in non-mammals (review)2009

    • Author(s)
      K. Tsutsui, et.al.
    • Journal Title

      Ann. N.Y. Acad. Sci. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hormone-mediated reproductive behavior in the red-bellied newt (review)2009

    • Author(s)
      S. Kikuyama, et.al.
    • Journal Title

      Ann. N.Y. Acad. Sci. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Steroid Biosynthesis within the frog brain : A model of neuroendocrine regulation (review)2009

    • Author(s)
      J. L. Do Rego, et.al.
    • Journal Title

      Ann. N. Y. Acad. Sci. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] メラトニンとGnIHの光周性2009

    • Author(s)
      筒井和義
    • Journal Title

      光周性の分子生物学海老原・井澤編 (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] メラトニンに関する最近の話題 : メラトニンとGnIH2009

    • Author(s)
      筒井和義
    • Journal Title

      糖尿病・代謝・内分泌2009中外医学社 5

      Pages: 190-195

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alterations in RFamide-related peptide expression are coordinated with the preovulatory luteinizing hormone surge2008

    • Author(s)
      M. Gibson(筆頭著者), K. Tsutsui(最終著者),et al(著者7名)
    • Journal Title

      Endocrinology 149

      Pages: 4958-4969

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potent action of RFRP-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion2008

    • Author(s)
      I. J. Clarke(筆頭著者), K. Tsutsui(12番目), et al(著者14名)
    • Journal Title

      Endocrinology 149

      Pages: 5811-5821

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypophysiotropic role of RFamide-related peptide-3 in the inhibition of LH secretion in female rats2008

    • Author(s)
      M. Murakami(筆頭著者), K. Tsutsui(最終著者), et al(著者7名)
    • Journal Title

      J. Endocrinol 199

      Pages: 105-112

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 7・-Hydroxypregnenolone mediates melatonin action underlying diurnal locomotor rhythms2008

    • Author(s)
      K. Tsutsui(筆頭著者), K. Inoue(2番目),et al(著者6名)
    • Journal Title

      Jneuroscience 28

      Pages: 2158-2167

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Melatonin stimulates the release of growth hormone and prolactin by inducing the expression of frog growth hormone-releasing peptide (fGRP) and its related peptide-2 (fGRP-RP-2) in the amphibian hypothalamus2008

    • Author(s)
      V. S. Chowdhury(筆頭著者), K. Tsutsui(最終著者),et al(著者6名)
    • Journal Title

      Endocrinology 149

      Pages: 962-970

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-inhibitory hormone neurons interact directly with gonadotropin- releasing hormone-I and -II neurons in European starling brain2008

    • Author(s)
      T. Ubuka(筆頭著者), K. Tsutsui(8番目) et al(著者9名)
    • Journal Title

      Endocrinology 149

      Pages: 268-278

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-inhibitory hormone and its receptor in the avian reproductive system2008

    • Author(s)
      G. Bentley(筆頭著者), K. Tsutsui(最終著者)et al(著者10名)
    • Journal Title

      Gen. Comp. Endocrinol. 156

      Pages: 34-43

    • NAID

      10020188345

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Auditory stimulation of reproductive function in male Rufous-winged Sparrows, Aimophila carpalis2008

    • Author(s)
      T. W. Small (筆頭著者), K. Tsutsui (5番目), et al(著者7名)
    • Journal Title

      Horm. Behav. 53

      Pages: 28-39

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review: Neurosteroids in the Purkinje cell : Biosynthesis, mode of action and functional significance2008

    • Author(s)
      K. Tsutsui(単独著者)
    • Journal Title

      Mol. Neurobiol. 37

      Pages: 116-125

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Recent advances in reproductive neuroendocrinology : A role for the RFamide peptides in seasonal reproduction?2008

    • Author(s)
      T. J. Greives(筆頭著者), K. Tsutsui(4番目),et al(著者5名)
    • Journal Title

      Proc. R. Soc. B 275

      Pages: 1943-1951

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Progesterone biosynthesis and action in the developing neuron2008

    • Author(s)
      K. Tsutsui(単独著者)
    • Journal Title

      Endocrinology 149

      Pages: 2757-2761

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Expression, localization and possible actions of 25-Dx, a membrane-associated putative progesterone-binding protein, in the developing Purkinje cell of the cerebellum : A new insight into the biosynthesis, metabolism and multiple actions of progesterone as a neurosteroid2008

    • Author(s)
      H. Sakamoto(筆頭著者), K. Ukena(2番目), K. Tsutsui(最終著者), et al(著者4名)
    • Journal Title

      Cerebellum 7

      Pages: 18-25

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in GnRH I, bradykinin and their receptors and GnIH in the ovary of Calotes versicolor during reproductive cycle2008

    • Author(s)
      P. Singh, et.al.
    • Journal Title

      Gen.Comp. Endocrinol. 159

      Pages: 158-169

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alterations in RFamide-related peptide expression are coordinated with the preovulatory luteinizing hormone surge2008

    • Author(s)
      E. M. Gibson, et.al.
    • Journal Title

      Endocrinology 149

      Pages: 4958-4969

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potent action of RFRP-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion2008

    • Author(s)
      I. J. Clarke, et.al.
    • Journal Title

      Endocrinology 149

      Pages: 5811-5821

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypophysiotropic role of RFamide-related peptide-3 in the inhibition of LH secretion in female rats2008

    • Author(s)
      M. Murakami, et.al.
    • Journal Title

      J. Endocrinol. 199

      Pages: 105-112

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical detection and biological activities of CYP17 (P450017) in the indifferent gonad of the frog Rana rugosa2008

    • Author(s)
      N. Sakurai, et.al.
    • Journal Title

      J. Steroid Biochem. Mol. Biol. 112

      Pages: 5-12

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 7alpha-Hydroxypregnenolone mediates melatonin action underlying diurnal locomotor rhythms2008

    • Author(s)
      K. Tsutsui, et.al.
    • Journal Title

      J. Neuroscience 28

      Pages: 2158-2167

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Melatonin stimulates the release of growth hormone and prolactin by inducing the expression of frog gr owth hormone-releasing peptide and its related peptide-2 in the amphibian hypothalamus2008

    • Author(s)
      V. S. Chowdhury, et.al.
    • Journal Title

      Endocrinology 149

      Pages: 962-970

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-inhibitory hormone neurons interact directly with gonadotropin-releasing hormone-I and-II neurons in European starling brain2008

    • Author(s)
      T. Ubuka, et.al.
    • Journal Title

      Endocrinology 149

      Pages: 268-278

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-inhibitory hormone and its receptor in the avian reproductive system2008

    • Author(s)
      G. Bentley, et.al.
    • Journal Title

      Gen. Comp. Endocrinol 156

      Pages: 34-43

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photoperiod-independent hypothalamic regulation of luteinizing hormone secretion in a free-living Sonoran desert bird, the Rufous-winged Sparrow (Aimophila carpalis)2008

    • Author(s)
      T. W. Small, et.al.
    • Journal Title

      Brain Behay. Evol. 71

      Pages: 127-142

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Auditory stimulation of reproductive function in male Rufous-winged Sparrows, Aimophila carpalis2008

    • Author(s)
      T. W. Small, et.al.
    • Journal Title

      Norm. Behay 53

      Pages: 28-39

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The orexigenic effect of GnIH is mediate by central opioid receptors in chicks2008

    • Author(s)
      T. Tachibana, et.al.
    • Journal Title

      Comp. Biochem. Physiol. A Mol. Integr. Physiol. 150

      Pages: 21-25

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebellum, a target for hormonal signaling2008

    • Author(s)
      N. Koibuchi, et.al.
    • Journal Title

      Cerebellum 7

      Pages: 499-504

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Gonadotropin-inhibitory hormone (GnIH) : biosynthesis, mode of action and functional significan ce in birds.2008

    • Author(s)
      K. Tsutsui and G. E. Bentley
    • Journal Title

      Avian Biol. Res. 1

      Pages: 175-186

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Neurosteroids in the Purkinje cell : Biosynthesis, mode of action and functional significance.2008

    • Author(s)
      K. Tsutsui
    • Journal Title

      Mol. Neurobiol 37

      Pages: 116-125

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Recent advances in reproductive neuroendocrinology : A role for the RFamide peptides in seasona I reproduction?2008

    • Author(s)
      T. J. Greives, et.al.
    • Journal Title

      Proc. R. Soc. B. 275

      Pages: 1943-1951

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Progesterone biosynthesis and action in the developing neuron.2008

    • Author(s)
      K. Tsutsui
    • Journal Title

      Endocrinology 149

      Pages: 2757-2761

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurosteroid synthesis and action in the cerebellum during development (Review).2008

    • Author(s)
      K. Tsutsui
    • Journal Title

      Cerebellum 7

      Pages: 502-504

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review : Expression, localization and possible actions of 25-Dx, a membrane-associated putative progest erone-binding protein, in the developing Purkinje cell of the cerebellum.2008

    • Author(s)
      H. Sakamoto, et.al.
    • Journal Title

      Cerebellum 7

      Pages: 18-25

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生殖神経内分泌学の新たな展開 : GnIHとキスペプチンの発見2008

    • Author(s)
      筒井和義
    • Journal Title

      増刊号「ホルモンの病態異常と臨床検査」臨床検査Journal of Medioal Technology(医学書院) 52

      Pages: 1207-1207

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GnlHと6niH同属ペプチド(LPXRFamideペプチド) : 構造と機能の普遍性と多様性2008

    • Author(s)
      筒井和義
    • Journal Title

      生化学 80

      Pages: 849-854

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 総説 : ステロイドのnon-genomic action特集 : 合成ステロイドホルモン-最新の基礎・臨床研究-2008

    • Author(s)
      徳元俊伸、筒井和義
    • Journal Title

      日本臨床 66

      Pages: 70-76

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 7alpha-Hydroxypregnenolone mediates melatonin action underlying diurnal locomotor rhythms.2008

    • Author(s)
      K. Tsutsui et al.
    • Journal Title

      J Neuroscience 28

      Pages: 2158-2167

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Melatonin stimulates the release of growth hormone and prolactin by inducing the expression of frog growth hormone-releasing peptide and its related peptide-2 in the amphibian hypothalamus.2008

    • Author(s)
      V. S. Chowdhury et al.
    • Journal Title

      Endocrinology 149

      Pages: 962-970

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-inhibitory hormone neurons interact directly with gonadotropin-reeasing hormone-l and-ll neurons in European starling brain.2008

    • Author(s)
      T. Ubuka et al.
    • Journal Title

      Endocrinology 149

      Pages: 268-278

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-inhibitory hormone and its receptor in the avian reproductive system.2008

    • Author(s)
      G. E. Bentley et al.
    • Journal Title

      Gen. Comp. Endocrinol. 156

      Pages: 34-43

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photoperiod-independent hypothalamic regulation of luteinizing hormone secretion in a free-living Sonoran desert bird, the Rufous-winged Sparrow (Aimophila carpalis).2008

    • Author(s)
      T. W. Small et al.
    • Journal Title

      Brain Behav. Evol. 71

      Pages: 127-142

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Auditory stimulation of reproductive function in male Rufous-wingde Sparrows, Aimophila carpalis.2008

    • Author(s)
      T. W. Small et al.
    • Journal Title

      Horm. Behav. 53

      Pages: 28-39

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The orexigenic effect of GnlH is mediate by central opioid receptors in chicks.2008

    • Author(s)
      T. Tachibana et al.
    • Journal Title

      Comp. Biochem. Phvsiol. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review: Neurosteroids in the Purkinje cell: Biosynthesis, mode of action and functional significance.2008

    • Author(s)
      K. Tsutsui
    • Journal Title

      Mol. Neurobiol. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review: Recent advances in reproductive neuroendocrinology: A role for the RFamide peptides in seasonal reproduction?2008

    • Author(s)
      T. J, Greives et al.
    • Journal Title

      Proc. R. Soc. B (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review: Progesterone biosynthesis and action in the developing neuron.2008

    • Author(s)
      K. Tsutsui
    • Journal Title

      Endocrinology (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebellum, a target for hormonal signaling.2008

    • Author(s)
      N. Koibuchi et al.
    • Journal Title

      Cerebellum (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review: Expression, localization and possible actions of 25-Dx, a membrane-associated putative progesterone-binding protein, in the developing Purkinje cell of the cerebellum.2008

    • Author(s)
      H. Sakamoto et al.
    • Journal Title

      Cerebellum (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurosteroid synthesis and action in the cerebellum during development (Review).2008

    • Author(s)
      K.Tsutsui
    • Journal Title

      Cerebellum (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Variability in preference for conspecific songs with syntactical complexity in female Bengalese finches: towards an understanding of song evolution.2008

    • Author(s)
      T.Morisaka et al.
    • Journal Title

      Ornithol. Sci. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression analysis of cadherins in the songbird brain: relationship to vocalsystem develooment.2008

    • Author(s)
      E.Matsunaga et al.
    • Journal Title

      J.Comp. Neurol. 508

      Pages: 329-342

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sex differences in audiovisual discrimination learning by Bengalese finches (Lonchura striata var. domestics).2008

    • Author(s)
      Y.Seki et al.
    • Journal Title

      J.Comp. Psvchol. 122

      Pages: 25-34

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic and developmental effects, and morphological influences on the acoustic structure of individual distance calls in female Bengalese finches Lonchura striata var. domestica.2008

    • Author(s)
      M.Soma et al.
    • Journal Title

      J.Avian Biol. 39

      Pages: 101-107

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mode of action and functional significance of estrogen inducing dendritic growth, spinogenesis and synaptogenesis in the developing Purkinje cell2007

    • Author(s)
      K. Sasahara (筆頭著者), K. Tsutsui (最終著者), et al(著者7名)
    • Journal Title

      J Neuroscience 27

      Pages: 7408-7417

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cerebellum, a target for hormonal signaling2007

    • Author(s)
      N. Koibuchi(筆頭著者), K. Tsutsui(最終著者), et al(著者4名)
    • Journal Title

      Cerebellum 7

      Pages: 499-504

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mode of action and functional significance of estrogen inducing dendritic growth, spinogenesis and synaptogenesis in the developing Purkinje cell.2007

    • Author(s)
      K.Sasahara et al.
    • Journal Title

      J Neuroscience 27

      Pages: 7408-7417

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion, and has variable effects on sex behavior in the adult male rat.2007

    • Author(s)
      M. A. Johnson et al.
    • Journal Title

      Horm Behav. 51

      Pages: 171-180

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review: Discovery of gonadotropin-inhibitory hormone in a domesticated bird, its mode of action and functional significance.2007

    • Author(s)
      K. Tsutsui et al.
    • Journal Title

      J. Ornithol. 148

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review: Gonadotropin-inhibitory hormone in seasonally-breeding songbirds: Neuroanatomy and functional biology.2007

    • Author(s)
      G. E. Bentley et al.
    • Journal Title

      J. Ornithol. 148

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative reproductive neuroendocrinology.2007

    • Author(s)
      P. J. Sharp et al.
    • Journal Title

      Gen. Comp. Endocrinol. 153

      Pages: 344-345

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Review: The general and comparative biology of gonadotropin-inhibitory hormone(GnIH).2007

    • Author(s)
      K. Tsutsui et a1.
    • Journal Title

      Gen. Comp. Endocrinol. 153

      Pages: 365-370

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sex-specific maternal effect on egg mass, laying order, and sibling competition in the Bengalese finch (Lonchura striata var. domestica).2007

    • Author(s)
      M. Soma et al.
    • Journal Title

      Behav. Ecol. Sociobiol. 61

      Pages: 1695-1705

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebellum, a target for hormonal signaling.2007

    • Author(s)
      N.Koibuchi et al.
    • Journal Title

      Cerebellum (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion, and has variable effects on sex behavior in the adult male rat.2007

    • Author(s)
      M.A.Johnson et al.
    • Journal Title

      Horm Behav. 51

      Pages: 171-180

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Neurosteroid synthesis and action in the cerebellum during development (Review).2007

    • Author(s)
      K.Tsutsui
    • Journal Title

      Cerebellum (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Review : Discovery of gonadotropin-inhibitory hormone in a domesticated bird, and its mode of action and functional significance.2007

    • Author(s)
      K.Tsutsui et al.
    • Journal Title

      J. Ornithol. (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Review : Gonadotropin-inhibitory hormone in seasonally-breeding songbirds : Neuroanatomy and functional biology.2007

    • Author(s)
      G.E.Bentley et al.
    • Journal Title

      J. Ornithol. (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Review : The general and comparative biology of gonadotropin-inhibitory hormone (GnIH).2007

    • Author(s)
      K.Tsutsui et al.
    • Journal Title

      Gen. Comp. Endocrinol. Epub ahead of print

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Control of luteinizing hormone and testosterone secretion in a flexibly breeding male passerine, the Rufous-winged Sparrow, Aimophila carpalis2006

    • Author(s)
      P. J. Deviche (筆頭著者), K. Tsutsui (最終著者), et al(著者4名)
    • Journal Title

      Gen. Comp. Endocrinol. 149

      Pages: 226-235

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evolutionary origin and divergence of PQRFamide peptides and LPXRFamide peptides in the RFamide peptide family : Insights from novel lamprey RFamide peptides2006

    • Author(s)
      T. Osugi(筆頭著者), K. Ukena(2番目), K. Tsutsui(最終著者), et al(著者5名)
    • Journal Title

      FEBS Journal 273

      Pages: 1731-1743

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid inhibition of female sexual behavior by gonadotropin-inhibitory hormone (GnIH)2006

    • Author(s)
      G. E. Bentley(筆頭著者), K. Tsutsui(5番目), et al(著者6名)
    • Journal Title

      Horm. Behav. 49

      Pages: 550-555

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-inhibitory hormone inhibits gonadal development and maintenance by decreasing gonadotropin synthesis and release in male quail2006

    • Author(s)
      T. Ubuka(筆頭著者), K. Ukena(2番目), K. Tsutsui(最終著者), et al(著者5名)
    • Journal Title

      Endocrinology 147

      Pages: 1187-1194

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel hypothalamic neuropeptides stimulate the release of gonadotropins and growth hormone from the pituitary of sockeye salmon2006

    • Author(s)
      M. Amano(筆頭著), K. Ukena(7番目), K. Tsutsui(最終著者), et al(著者8名)
    • Journal Title

      J. Endocrinology 188

      Pages: 417-423

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals2006

    • Author(s)
      L. J. Kriegsfeld(筆頭著者), K. Ukena(7番目), K. Tsutsui(8番目), et al(著者9名)
    • Journal Title

      Proc. Natl. Acad. Sci. USA 103

      Pages: 103-103

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes2006

    • Author(s)
      O. Whitney(筆頭著者), S. Sakaguchi(8番目), et al(著者15名)
    • Journal Title

      Proc. Natl. Acad. Sci. USA 103

      Pages: 15212-15217

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lesions of an avian forebrain nucleus prevent changes in protein kinase C levels associated with deafening-induced vocal plasticity in adult songbirds2006

    • Author(s)
      A. Watanabe(筆頭著者), K. Okanoya(3番目), S. Sakaguchi(最終著者), et al(著者4名)
    • Journal Title

      Eur. J. Neurosci. 23

      Pages: 1460-9568

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Biosynthesis, mode of action and functional significance of neurosteroids in the developing Purkinje cell2006

    • Author(s)
      K. Tsutsui(単独著者)
    • Journal Title

      J. Steroid Biochem. Mol. Biol. 102

      Pages: 187-194

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Biosynthesis and organizing action of neurosteroids in the developing Purkinje cell2006

    • Author(s)
      K. Tsutsui(単独著者)
    • Journal Title

      Cerebellum 5

      Pages: 89-96

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Hypothalamic LPXRF-amide peptides in vertebrates : Identification, localization and hypophysiotropic activity2006

    • Author(s)
      K. Tsutsui(筆頭著者) and K. Ukena(最終著者)
    • Journal Title

      Peptides 27

      Pages: 1121-1129

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mode of action and functional significance of avian gonadotropin-inhibitory hormone (GnIH): A review.2006

    • Author(s)
      K. Tsutsui(筆頭著者), K. Ukena(5番目), et al(著者11名)
    • Journal Title

      J. Exp. Zool. 305A

      Pages: 801-806

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neurosteroidbiosynthesis in the quail brain : A review2006

    • Author(s)
      K. Tsutsui(筆頭著者), K. Ukena(最終著者) et al(著者4名)
    • Journal Title

      J. Exp. Zool. 305A

      Pages: 733-742

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : Neurosteroids in the brain neuron : Biosynthesis, action and medicinal impact on neurodegenerative disease2006

    • Author(s)
      K. Tsutsui(筆頭著者) and S. H. Mellon(最終著者)
    • Journal Title

      Central Nerv. Syst. Agents Med. Chem. 6

      Pages: 73-82

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 総説:鳥類における脳の性分化機構ホルモンと臨床2006

    • Author(s)
      筒井和義(筆頭著者)・加藤真樹・岡ノ谷一夫(最終著者)
    • Journal Title

      54

      Pages: 13-20

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 総説:脳が合成するニューロステロイドと脳の自立的性分化機構2006

    • Author(s)
      筒井和義(単独著者)
    • Journal Title

      特集♂と♀のバイオロジー:生物の多様な性分化の仕組み細胞工学 25

      Pages: 388-392

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-inhibitory hormone inhibits gonadal development and maintenance by decreasing gonadotropin synthesis and release in male quail.2006

    • Author(s)
      T.Ubuka et al.
    • Journal Title

      Endocrinology 147

      Pages: 1187-1194

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals.2006

    • Author(s)
      L.J.Kriegsfeld et al.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 103

      Pages: 2410-2415

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Novel fish hypothalamic neuropeptides stimulate the release of gonadotropins and growth hormone from the pituitary of sockeye salmon.2006

    • Author(s)
      M.Amano et al.
    • Journal Title

      J. Endocrinology 188

      Pages: 417-423

    • Related Report
      2006 Annual Research Report
  • [Journal Article] peptides in the RFamide peptide family : Insights from novel lamprey RFamide peptides.2006

    • Author(s)
      T.Osugi et al.
    • Journal Title

      FEBS Journal 273

      Pages: 1731-1743

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Molecular cloning and functional characterization of a prolactin-releasing peptide homolog from Xenopus laevis.2006

    • Author(s)
      T.Sakamoto et al.
    • Journal Title

      Peptides 27

      Pages: 3347-3351

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Rapid inhibition of female sexual behavior by gonadotropin-inhibitory hormone (GnIH)2006

    • Author(s)
      G.E.Bentley et al.
    • Journal Title

      Horm. Behav. 49

      Pages: 550-555

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Control of luteinizing hormone and testosterone secretion in a flexibly breeding male passerine, the Rufous-winged Sparrow, Aimophila carpalis.2006

    • Author(s)
      P.J.Deviche et al.
    • Journal Title

      Gen. Comp. Endocrinol. 149

      Pages: 226-235

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Gonadotropin-inhibitory hormone in birds : possible mode of action.2006

    • Author(s)
      G.E.Bentley et al.
    • Journal Title

      Acta Zool Sinica. 52

      Pages: 178-182

    • Related Report
      2006 Annual Research Report
  • [Journal Article] and the suprachiasmatic nucleus with the paraventricular organ in the Japanese grass lizard (Takydromus tachydromoides).2006

    • Author(s)
      E.Kawano et al.
    • Journal Title

      Zool Sci. 23

      Pages: 277-287

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Review : Biosynthesis, mode of action and functional significance of neurosteroids in the developing Purkinje cell.2006

    • Author(s)
      K.Tsutsui
    • Journal Title

      J. Steroid Biochem. Mol. Biol. 102

      Pages: 187-194

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Review : Biosynthesis and organizing action of neurosteroids in the developing Purkinje cell.2006

    • Author(s)
      K.Tsutsui
    • Journal Title

      Cerebellum 5

      Pages: 89-96

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Review : Hypothalamic LPXRF-amide peptides in vertebrates : Identification, localization and hypophysiotropic activity.2006

    • Author(s)
      K.Tsutsui et al.
    • Journal Title

      Peptides 27

      Pages: 1121-1129

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Review : Gonadotropin-Inhibitory Hormone (GnIH) : Discovery, Progress and Perspective.2006

    • Author(s)
      K.Tsutsui
    • Journal Title

      J. Poult. Sci. 43

      Pages: 191-198

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Mode of action and functional significance of avian gonadotropin-inhibitory hormone (GnIH) : A review.2006

    • Author(s)
      K.Tsutsui et al.
    • Journal Title

      J. Exp. Zool. 305A

      Pages: 801-806

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Review : Interactions of gonadotropin-releasing hormone (GnRH) and onadotropin-inhibitory hormone (GnIH) in birds and mammals.2006

    • Author(s)
      G.E.Bentley et al.
    • Journal Title

      J. Exp. Zool. 305A

      Pages: 807-814

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Structures and diverse functions of frog growth hormone-releasing peptide (fGRP) and its related peptides (fGRP-RPs) : A review.2006

    • Author(s)
      K.Ukena et al.
    • Journal Title

      J. Exp. Zool. 305A

      Pages: 815-821

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Neurosteroid biosynthesis in the quail brain : A review.2006

    • Author(s)
      K.Tsutsui et al.
    • Journal Title

      J. Exp. Zool. 305A

      Pages: 733-742

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Review : Neurosteroids in the brain neuron : Biosynthesis, action and medicinal impact on neurodegenerative disease.2006

    • Author(s)
      K.Tsutsui et al.
    • Journal Title

      Central Nervous System Agents in Medicinal Chemistry 6

      Pages: 73-82

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Lesions of an avian forebrain nucleus prevent changes in protein kinase C levels associated with deafening-induced vocal plasticity in adult songbirds.2006

    • Author(s)
      A.Watanabe et al.
    • Journal Title

      Eur J Neurosci 23

      Pages: 1460-9568

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Differential localization of protein kinase C isoforms in the song system of the zebra finch forebrain.2006

    • Author(s)
      H.Sakaguchi
    • Journal Title

      Orthonological Sci 5

      Pages: 31-37

    • NAID

      130004935008

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes.2006

    • Author(s)
      O.Whitney et al.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 103

      Pages: 15212-15217

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Early rearing conditions affect the development of body size and song in Bengalese finches.2006

    • Author(s)
      M.Soma et al.
    • Journal Title

      Ethology 112

      Pages: 1071-1078

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Non-singing female Bengalese finches (Lonchura striata var. domestica) possess neuronal projections connecting a song learning region to a song motor region.2006

    • Author(s)
      Y.Tobari et al.
    • Journal Title

      Ornithological Science 5

      Pages: 47-55

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Trade-offs and correlations among multiple song traits in Bengalese finches.2006

    • Author(s)
      M.Soma et al.
    • Journal Title

      Ornithological Science 5

      Pages: 77-84

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 総説 : 鳥類における脳の性分化機構2006

    • Author(s)
      筒井和義 et al.
    • Journal Title

      ホルモンと臨床 54

      Pages: 13-20

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 総説 : 脳が合成するニューロステロイドと脳の自立的性分化機構 特集♂と♀のバイオロジー : 生物の多様な性分化の仕組み2006

    • Author(s)
      筒井和義
    • Journal Title

      細胞工学 25

      Pages: 388-392

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 小鳥のさえずりの維持と可塑性-成鳥における聴覚フィードバックの役割について-2006

    • Author(s)
      渡辺愛子 et al.
    • Journal Title

      比較生理生化学 23(1)

      Pages: 20-31

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Evolutionary origin and divergence of PQRFamide peptides and LPXRFamide peptides in the RFamide peptide family : Insights from novel lamprey RFamide peptides.2006

    • Author(s)
      T.Osugi
    • Journal Title

      FEBS Journal (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Lesions of an avian forebrain nucleus prevent changes in protein kinase C levels associated with deafening-induced vocal plasticity in adult songbirds.2006

    • Author(s)
      A.Watanabe
    • Journal Title

      Eur.J.Neurosci. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Neural interaction of gonadotropin-regulating hormone immunoreactive neurons and the suprachiasmatic nucleus with the paraventricular organ in the Japanese grass lizard (Takydromus tachydromoides).2006

    • Author(s)
      E.Kawano
    • Journal Title

      Zool Sci. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Review : Hypothalamic LPXRF-amide peptides in vertebrates : Identification, localization and hypophysiotropic activity.2006

    • Author(s)
      K.Tsutsui
    • Journal Title

      Peptides (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Mode of action and functional significance of avian gonadotropin-inhibitory hormone (GnIH) : A review.2006

    • Author(s)
      K.Tsutsui
    • Journal Title

      J.Exp.Zool. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Review : Interactions of gonadotropin-releasing hormone (GnRH) and gonadotropin-inhibitory hormone (GnIH) in birds and mammals.2006

    • Author(s)
      G.E.Bentley
    • Journal Title

      J.Exp.Zool. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Structures and diverse functions of frog growth hormone-releasing peptide (fGRP) and its related peptides (fGRP-RPs) : A review.2006

    • Author(s)
      K.Ukena
    • Journal Title

      J.Exp.Zool. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Neurosteroid biosynthesis in the quail brain : A review.2006

    • Author(s)
      K.Tsutsui
    • Journal Title

      J.Exp.Zool. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Review : Gonadotropin-Inhibitory Hormone (GnIH) : Discovery, Progress and Perspective.2006

    • Author(s)
      K.Tsutsui
    • Journal Title

      J.Poult.Sci. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Rapid inhibition of female sexual behavior by gonadotropin-inhibitory hormone (GnIH).2006

    • Author(s)
      G.E.Bentley
    • Journal Title

      Horm.Behav 49

      Pages: 550-555

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Gonadotropin-inhibitory hormone inhibits gonadal development and maintenance by decreasing gonadotropin synthesis and release in male quail.2006

    • Author(s)
      T.Ubuka
    • Journal Title

      Endocrinology 147

      Pages: 1187-1194

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Novel fish hypothalamic neuropeptides stimulate the release of gonadotropins and growth hormone from the pituitary of sockeye salmon.2006

    • Author(s)
      M.Amano
    • Journal Title

      J.Endocrinology 188

      Pages: 417-423

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Identification and characterization of a gonadotropin-inhibitory system in the brain of mammals.2006

    • Author(s)
      L.J.Kriegsfeld
    • Journal Title

      Proc.Natl.Acad.Sci.USA 103

      Pages: 2410-2415

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Review : Neurosteroids in the brain neuron : Biosynthesis, action and medicinal impact on neurodegenerative disease.2006

    • Author(s)
      K.Tsutsui
    • Journal Title

      Central Nervous System Agents in Medicinal Chemistry 6

      Pages: 73-82

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 総説:脳が合成するニューロステロイドと脳の自立的性分化機構 特集 ♂と♀のバイオロジー:生物の多様な性分化の仕組み2006

    • Author(s)
      筒井和義
    • Journal Title

      細胞工学 25

      Pages: 388-392

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Melatonin induces the expression of gonadotropin-inhibitory hormone in the avian brain,Nature Reviews Highlight2005

    • Author(s)
      T. Ubuka(筆頭著者), K. Ukena(3番目), K. Tsutsui(最終著者), et al(著者5名)
    • Journal Title

      Proc. Natl. Acad. Sci. USA, Nat. Rev. Neurosci. 102,6

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel G protein-coupled receptor for gonadotropin- inhibitory hormone in the Japanese quail (Coturnix japonica) : identification, expression and binding activity2005

    • Author(s)
      H. Yin(筆頭著者), K. Ukena(2番目), K. Tsutsui(最終著者), et al(著者4名)
    • Journal Title

      J. Endocrinology 184

      Pages: 257-266

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Review : A new member of the hypothalamic RF-amide peptide family, LPXRF-amide peptides : Structure, localization and function2005

    • Author(s)
      K. Ukena(筆頭著者) and K. Tsutsui(最終著者)
    • Journal Title

      Spectrom. Rev. 24

      Pages: 469-486

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-inhibiting hormone stimulates feeding behavior in chicks.2005

    • Author(s)
      T.Tachibana
    • Journal Title

      Brain Res. 1050

      Pages: 94-100

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Expression of aromatase mRNA in the abdominal gland of the newt, Cynops pyrrhogaster.2005

    • Author(s)
      Y.Ito
    • Journal Title

      Ann.N.Y.Acad.Sci. 1040

      Pages: 348-350

    • Related Report
      2005 Annual Research Report 2004 Annual Research Report
  • [Journal Article] Melatonin induces the expression of gonadotropin-inhibitory hormone in the avian brain.2005

    • Author(s)
      T.Ubuka
    • Journal Title

      Proc.Natl.Acad.Sci.USA [Nature Reviews Highlight] 102

      Pages: 3052-3057

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A novel G protein-coupled receptor for gonadotropin-inhibitory hormone in the Japanese quail (Coturnix japonica) : identification, expression and binding activity.2005

    • Author(s)
      H.Yin
    • Journal Title

      J.Endocrinology 184

      Pages: 257-266

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Review : Gonadotropin-inhibitory hormone (GnIH).2005

    • Author(s)
      K.Tsutsui
    • Journal Title

      Jpn.J.Reprod.Endocrinol. 10

      Pages: 49-53

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Review : A new member of the hypothalamic RF-amide peptide family, LPXRF-amide peptides : Structure, localization and function.2005

    • Author(s)
      K.Ukena
    • Journal Title

      Mass Spectrometry Reviews 24

      Pages: 469-486

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 総説:発達期の小脳プルキンエ細胞における25-Dxの発現-プルキンエ細胞が合成するプロゲステロンの作用機構-特集:脳の遺伝子-どこでどのように働いているのか2005

    • Author(s)
      筒井和義
    • Journal Title

      生体の科学 56

      Pages: 296-302

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Sex differences in the telencephalic song control circuitry in Bengalese finches (Lonchura striata var.domestica).2005

    • Author(s)
      Y.Tobari
    • Journal Title

      Zool.Sci. 22

      Pages: 1089-1094

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Review : Hypothalamic LPXRF-amide peptides in vertebrates : Identification, localization and hypophysiotropic activity.2005

    • Author(s)
      K.Tsutsui
    • Journal Title

      Peptides In press(印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Review : A new member of the hypothalamic RF-amide peptide family, LPXRF-amide peptides : Structure, localization and function.2005

    • Author(s)
      K.Ukena
    • Journal Title

      Mass Spectrometry Reviews In press(印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Review : Organizing actions of neurosteroids in the Purkinje neuron.2005

    • Author(s)
      K.Tsutsui
    • Journal Title

      Neurosci.Res. 49

      Pages: 273-279

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Melatonin induces the expression of gonadotropin-inhibitory hormone in the avian brain.2005

    • Author(s)
      T.Ubuka
    • Journal Title

      Proc.Natl.Acad.Sci.USA(プレスリリース:米国のThe Scientist, Reuters, Health Magazine,読売新聞,日経新聞、共同通信,NHK) 102

      Pages: 3052-3057

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A novel G protein-coupled receptor for gonadotropin-inhibitory hormone in the Japanese quail (Coturnix japonica):identification, expression and binding activity.2005

    • Author(s)
      H.Yin
    • Journal Title

      J.Endocrinology 184

      Pages: 257-266

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 7・-Hydroxypregnenolone acts as a neuronal activator to stimulate locomotor activity of breeding newts by means of the dopaminergic system2004

    • Author(s)
      M. Matsunaga(筆頭著者), K. Ukena(2番目), K. Tsutsui(最終著者), et al(著者4名)
    • Journal Title

      Proc. Natl. Acad. Sci. USA 101

      Pages: 17282-17287

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotropin-inhibitory hormone in Gambel's white-crowned sparrow : cDNA identification, transcript localization and functional effects in laboratory and field experiments2004

    • Author(s)
      T. Osugi(筆頭著者), K. Ukena(2番目), K. Tsutsui(最終著者), et al(著者7名)
    • Journal Title

      J. Endocrinology 182

      Pages: 33-42

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression and localization of 25-Dx, a membrane-associated putative progesterone- binding protein, in the developing Purkinje cell2004

    • Author(s)
      H. Sakamoto(筆頭著者), K. Ukena(2番目), K. Tsutsui(最終著者), et al(著者6名)
    • Journal Title

      Neuroscience 126

      Pages: 325-334

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of 3・, 5・-tetrahydroprogesterone,a progesterone metabolite, and its stimulatory action on preoptic neurons in the avian brain2004

    • Author(s)
      M. Matsunaga(筆頭著者), K. Ukena(3番目) K. Tsutsui(最終著者), et al(著者4名)
    • Journal Title

      Brain Res. 1007

      Pages: 160-166

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential expression of glutamate receptors in avian neural pathways for learned vocalization.2004

    • Author(s)
      K.Wada
    • Journal Title

      J.Comp.Neurol. 476

      Pages: 44-64

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effect of social factors on the development of PKC expression in songbird brain.2004

    • Author(s)
      H.Sakaguchi
    • Journal Title

      NeuroReport 15

      Pages: 2819-2823

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Gonadotrophin inhibitory hormone depresses gonadotrophin α and follicle-stimulating hormone β subunit expression in the pituitary of the domestic chicken.2004

    • Author(s)
      N.A.Ciccone
    • Journal Title

      J.Neuroendocrinology 16

      Pages: 999-1006

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 7α-Hydroxypregnenolone acts as a neuronal activator to stimulate locomotor activity of breeding newts by means of the dopaminergic system.2004

    • Author(s)
      M.Matsunaga
    • Journal Title

      Proc.Natl.Acad.Sci.USA(プレスリリース:読売新聞、NHKなど) 101

      Pages: 17282-17287

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Does gonadotrophin inhibiting hormone (GnIH) play a functional role in avian reproduction?2004

    • Author(s)
      N.A.Ciccone
    • Journal Title

      Br.Poult.Sci. 45

      Pages: 28-29

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Gonadotropin-inhibitory hormone in Gambel's white-crowned sparrow : cDNA identification, transcript localization and functional effects in laboratory and field experiments.2004

    • Author(s)
      T.Osugi
    • Journal Title

      J.Endocrinology 182

      Pages: 33-42

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Expression and localization of 25-Dx, a membrane-associated putative progesterone-binding protein, in the developing Purkinje cell.2004

    • Author(s)
      H.Sakamoto
    • Journal Title

      Neuroscience 126

      Pages: 325-334

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Dendritic growthin response to environmental estrogens in the developing Purkinje cell.2004

    • Author(s)
      H.Shikimi
    • Journal Title

      Neurosci.Lett. 364

      Pages: 114-118

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Expression and distribution of octopus GnRH in the central nervous system and peripheral organs of the octopus (Octopus vulgaris) by in situ hybridization and immunohistochemistry.2004

    • Author(s)
      E.Iwakoshi-Ukena
    • Journal Title

      J.Comp.Neurol. 477

      Pages: 310-323

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Photoperiodic response of serotonin- and galanin-immunoreactive neurons of the paraventricular organ and infundibular nucleus in Japanese quail, Coturnix coturnix japonica.2004

    • Author(s)
      Y.Haida
    • Journal Title

      Zool.Sci. 21

      Pages: 575-582

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Identification of 3β,5β-tetrahydroprogesterone, a progesterone metabolite, and its stimulatory action on preoptic neurons in the avian brain.2004

    • Author(s)
      M.Matsunaga
    • Journal Title

      Brain Res. 1007

      Pages: 160-166

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Neural correlates of song complexity in Bengalese finch high vocal center.2004

    • Author(s)
      K.Z.Nakamura
    • Journal Title

      NeuroReport 15

      Pages: 1359-1363

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Song syntax in Bengalese finches : proximate and ulitimate analyses.2004

    • Author(s)
      K.Okanoya
    • Journal Title

      Adva.Stud.Behavior 34

      Pages: 297-341

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The Bengalese finch : a window on the behavioral neurobiology of bird song syntax.2004

    • Author(s)
      K.Okanoya
    • Journal Title

      Ann.N.Y.Acad.Sci. 1016

      Pages: 724-735

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Functional and structural pre-adaptations to language : insight from comparative cognitive science into the study of language origin.2004

    • Author(s)
      K.Okanoya
    • Journal Title

      Jpn.Psychol.Research 46

      Pages: 207-215

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Spontaneous construction of "Chinese boxes" by Degus(Octodon degu):A rudiment of recursive intelligence?2004

    • Author(s)
      N.Tokimoto
    • Journal Title

      Jpn.Psychol.Research 46

      Pages: 255-261

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Estimation of hearing range in raptors using unconditioned responses.2004

    • Author(s)
      Y.Yamazaki
    • Journal Title

      Ornithol.Science 3

      Pages: 85-92

    • Related Report
      2004 Annual Research Report
  • [Presentation] Gonadotropin-inhibitory hormone (GnIH) : discovery, progress and prospect2008

    • Author(s)
      K. Tsutsui
    • Organizer
      prospectThe 5th International Symposium on Molecular Endocrinology
    • Place of Presentation
      Gwangju, Korea(基調講演)
    • Year and Date
      2008-04-04
    • Related Report
      2008 Final Research Report
  • [Presentation] Gonadotropin-inhibitory hormone (GnIH) : discovery, progress and prospect2008

    • Author(s)
      K. Tsutsui
    • Organizer
      The 5th International Symposium on Molecular Endocrinology
    • Place of Presentation
      Gwangju, Korea.
    • Year and Date
      2008-04-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] The novel neurosteroid 7alpha-hydroxypregnenolone is a key factor inducing sex-dependent locomotor activity2008

    • Author(s)
      K. Tsutsui
    • Organizer
      第85日本生理学会シンポジウム「性差の分子メカニズム Moiecular Mechanisms of Sexual Differences」
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] GnlHとGnlH同族ペプチドの多様性と分子進化2008

    • Author(s)
      筒井和義
    • Organizer
      基礎生物学研究所研究会「生殖生物学の歴史と展望」
    • Place of Presentation
      岡崎力ンファレンス
    • Year and Date
      2008-03-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] Novel molecular mechanism inducing sex difference in locomotor activity by 7・-hydroxypregnenolone, a newly discovered neurosteroid2008

    • Author(s)
      K. Tsutsui
    • Organizer
      International Symposium for Gonad and Brain Sex Differentiation
    • Place of Presentation
      Fukuoka, Japan(招待講演)
    • Related Report
      2008 Final Research Report
  • [Presentation] Discovery of gonadotropin-inhibitory hormone (GnIH), and its mode of action and functional significance2008

    • Author(s)
      K.Tsutsui
    • Organizer
      US/Japan International Symposium on Neurosteroids
    • Place of Presentation
      Gifu, Japan(招待講演)
    • Related Report
      2008 Final Research Report
  • [Presentation] Identification, biosynthesis and function of 7・-hydroxypregnenolone, a new key neurosteroid controlling locomotor activity2008

    • Author(s)
      K. Tsutsui
    • Organizer
      The 24th Conference European Comparative Endocrinologists
    • Place of Presentation
      Genova, Italy(招待講演)
    • Related Report
      2008 Final Research Report
  • [Presentation] Evolutionary origin and divergence of GnIH and its homologous peptides2008

    • Author(s)
      K. Tsutsui
    • Organizer
      The 6th International Symposium on Fish Endocrinology and Neuroendocrinology
    • Place of Presentation
      Calgary, Canada(基調講演)
    • Related Report
      2008 Final Research Report
  • [Presentation] Novel molecular mechanism inducing sex difference in locomotor activity by 7alpha-hydroxypregnenolone, a newly discovered neurosteroid.2008

    • Author(s)
      K. Tsutsui
    • Organizer
      International Symposium for Gonad and Brain Sex Differentiation
    • Place of Presentation
      Fukuoka, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] Discovery of gonadotropin-inhibitory hormone(GnIH), and its mode of action and functional significance.2008

    • Author(s)
      K. Tsutsui
    • Organizer
      US/Japan International Symposium on Neurosteroids
    • Place of Presentation
      Gifu, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] Rapid stimulation of locomotor activity by 7alpha-hydroxypregnenolone identified as a novel neuronal a ctivator.2008

    • Author(s)
      S. Haraguchi and K. Tsutsui
    • Organizer
      US/Japan International Symposium on Neurosteroids
    • Place of Presentation
      Gifu, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] Identification, biosynthesis and function of 7alpha-hydroxypregnenolone, a new key neurosteroid contro fling locomotor activity.2008

    • Author(s)
      K. Tsutsui.
    • Organizer
      The 24th Conference European Comparative Endocrinologists
    • Place of Presentation
      Genova, Italy
    • Related Report
      2008 Annual Research Report
  • [Presentation] Hormone-mediated reproductive behavior in the newt2008

    • Author(s)
      S. Kikuyama and K. Tsutsui
    • Organizer
      The 24th Conference European Comparative Endocrinologists
    • Place of Presentation
      Genova, Italy
    • Related Report
      2008 Annual Research Report
  • [Presentation] The novel avian neurosteroid 7alpha-hydroxypregnenolone mediates melatonin action underlying diurnal I ocomotor rhythms.2008

    • Author(s)
      K. Tsutsui
    • Organizer
      The 9th International Symposium on Avian Endocrinology
    • Place of Presentation
      Leuven, Belgium
    • Related Report
      2008 Annual Research Report
  • [Presentation] Evolutionary origin and divergence of GnIH and its homologous peptides2008

    • Author(s)
      K. Tsutsui
    • Organizer
      The 6th International Symposium on Fish Endocrinology and Neuroendocrinology
    • Place of Presentation
      Calgary, Canada
    • Related Report
      2008 Annual Research Report
  • [Presentation] Neurosteroid synthesis and action in the cerebellar Purkinje cell2007

    • Author(s)
      K.Tsutsui
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会シンポジウム「局所ステロイドの合成と機能」
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-12-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] イモリから同定した新規ニューロステロイドの生理作用2007

    • Author(s)
      筒井和義
    • Organizer
      日本動物学会第78回大会シンポジウム「両生類はワンダーランド」
    • Place of Presentation
      弘前大学
    • Year and Date
      2007-09-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] ニューロステロイド合成の日周性とメラトニンによる調節2007

    • Author(s)
      筒井和義
    • Organizer
      第29回日本比較生理生化学会シンポジウム「生体リズムにおける振動制御機構と出力機構〜研究の現状と新展開〜」
    • Place of Presentation
      岡山大学
    • Year and Date
      2007-07-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] 鳥類から発見された生殖腺刺激ホルモン放出抑制ホルモン(GnlH)とその受容体2007

    • Author(s)
      筒井和義
    • Organizer
      第4回GPCR研究会シンポジウム「GPCRと内分泌・生殖機能」
    • Place of Presentation
      日本科学未来館
    • Year and Date
      2007-05-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] The novel avian neurosteroid 7・-hydroxypregnenolone mediates melatonin action underlying diurnal locomotor rhythms2007

    • Author(s)
      K. Tsutsui
    • Organizer
      The 9th International Symposium on Avian Endocrinology
    • Place of Presentation
      Leuven, Belgium(Farner Medal受賞講演)
    • Related Report
      2008 Final Research Report
  • [Presentation] Gonadotropin-inhibitory hormone (GnIH) in a new reproductive axis2007

    • Author(s)
      K. Tsutsui
    • Organizer
      The 6th Congress of the Asia and Oceania Society for Comparative Endocrinology
    • Place of Presentation
      Siliguri, India(基調講演)
    • Related Report
      2008 Final Research Report
  • [Presentation] Gonadotropin-inhibitory hormone (GnIH) : discovery, mode of action, functional significance and prospective application to reproductive dysfunction2007

    • Author(s)
      K. Tsutsui
    • Organizer
      The 5th Anniversary Congress of International Drug Discovery Science and Technology (IDDST)-2007
    • Place of Presentation
      Xi'an, China(招待講演)
    • Related Report
      2008 Final Research Report
  • [Presentation] Melatonin regulates the production of 7・-hydroxypregnenolone identified as an active neurosteroid stimulating locomotor activity in vertebrates2007

    • Author(s)
      K. Tsutsui
    • Organizer
      The 2nd World Congress of Chronobiology
    • Place of Presentation
      Tokyo, Japan(招待講演)
    • Related Report
      2008 Final Research Report
  • [Presentation] Structures, diverse actions and functional significance of frog growth hormone-releasing peptide (fGRP) and its related peptides (fGRP-RPs)2007

    • Author(s)
      K. Tsutsui
    • Organizer
      International Symposium on Amphibian and Reptile Endocrinology and Neurobiology
    • Place of Presentation
      Berkeley, California, USA(基調講演)
    • Related Report
      2008 Final Research Report
  • [Presentation] Gonadotropin-inhibitory hormone (GnIH) in a new reproductive axis2007

    • Author(s)
      K. Tsutsui
    • Organizer
      The 6th Congress of the Asia and Oceania Society for Comparative Endocrinology
    • Place of Presentation
      Siliguri, India
    • Related Report
      2007 Annual Research Report
  • [Presentation] Gonadotropin-inhibitory hormone (GnIH): discovery, mode of action, functional significance and prospective application to reproductive dysfunction2007

    • Author(s)
      K. Tsutsui
    • Organizer
      The 5th Anniversary Congress of International Drug Discovery Science and Technology (IDDST)-2007
    • Place of Presentation
      Xi'an, China
    • Related Report
      2007 Annual Research Report
  • [Presentation] Melatonin regulates the production of 7alpha-hydroxypregnenolone identified as an active neurosteroid stimulating locomotor activity in vertebrates2007

    • Author(s)
      K. Tsutsui
    • Organizer
      The 2nd World Congress of Chronobiology
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2007 Annual Research Report
  • [Presentation] The comparative biology of gonadotrophin-inhibitory hormone (GnIH) and its homologous peptides2006

    • Author(s)
      K. Tsutsui
    • Organizer
      The23rdConference of European Comparative Endocrinologists
    • Place of Presentation
      Manchester, UK(基調講演)
    • Related Report
      2008 Final Research Report
  • [Presentation] Discovery of gonadotropin-inhibitory hormone in a domesticated bird, its mode of action and functional significance2006

    • Author(s)
      K. Tsutsui
    • Organizer
      The24thInternational Ornithological Congress
    • Place of Presentation
      Hamburg, Germany(基調講演)
    • Related Report
      2008 Final Research Report
  • [Presentation] Dendritic growth, spinogenesis and synaptogenesis in response to neurosteroids in the developing Purkinje cell2006

    • Author(s)
      K. Tsutsui
    • Organizer
      InternationalSymposium on Hormonal Regulation on Neurons and Network : Synaptogenesis to Behavior, The 29th Annual Meeting(Neuroscience 2006) of the Japan Neuroscience Society
    • Place of Presentation
      Kyoto, Japan(招待講演)
    • Related Report
      2008 Final Research Report
  • [Presentation] Biosynthesis, mode of action and functional significance of neurosteroids in the developing Purkinje cell2006

    • Author(s)
      K. Tsutsui
    • Organizer
      The 17th International Symposium of the Journal of Steroid Biochemistry and Molecular Biology
    • Place of Presentation
      Seefeld, Tyrol, Austria(招待講演)
    • Related Report
      2008 Final Research Report
  • [Presentation] Neurosteroid biosynthesis and function in the quail brain2005

    • Author(s)
      K. Tsutsui
    • Organizer
      The15thInternationalCongressofComparative Endocrinology
    • Place of Presentation
      Boston, Massachusetts, USA(招待講演)
    • Related Report
      2008 Final Research Report
  • [Presentation] Mode of action and functional significance of avian gonadotropin-inhibitory hormone(GnIH)2005

    • Author(s)
      K. Tsutsui
    • Organizer
      The 15thInternationalCongressofComparative Endocrinology
    • Place of Presentation
      Boston, Massachusetts, USA(招待講演)
    • Related Report
      2008 Final Research Report
  • [Presentation] Molecular evolution of the RF-amide peptide family2005

    • Author(s)
      K. Tsutsui
    • Organizer
      Satellite Workshop on Reproductive Endocrine System in Agnathans and Protochordates of the 15th International Congress of Comparative Endocrinology
    • Place of Presentation
      Boston, Massachusetts, USA(招待講演)
    • Related Report
      2008 Final Research Report
  • [Presentation] Discovery of gonadotropin-inhibitory hormone (GnIH) and its mode of action and functional significance2005

    • Author(s)
      K.Tsutsui
    • Organizer
      ISCE Symposium on "Comparative Endocrinology and Reproductive Physiology: Retrospect and Prospect"
    • Place of Presentation
      New Delhi, India(特別講演)
    • Related Report
      2008 Final Research Report
  • [Presentation] Synapse formation in response to neurosteroids in the Purkinje neuron2004

    • Author(s)
      K. Tsutsui
    • Organizer
      The 7th International Symposium on Molecular Medicine
    • Place of Presentation
      Crete, Greece(招待講演)
    • Related Report
      2008 Final Research Report
  • [Presentation] Probing neurosteroids and novel neuropeptides in the avian brain : discovery, progress and perspective2004

    • Author(s)
      K. Tsutsui
    • Organizer
      The8thInternational Symposium on Avian Endocrinology
    • Place of Presentation
      Phoenix, Arizona, USA(基調講演)
    • Related Report
      2008 Final Research Report
  • [Presentation] GnIH and its related peptides in the quail brain : Identification, localization and function2004

    • Author(s)
      K. Ukena and K. Tsutsui
    • Organizer
      The8thInternationalSymposiumonAvianEndocrinology
    • Place of Presentation
      Phoenix, Arizona, USA(基調講演)
    • Related Report
      2008 Final Research Report
  • [Presentation] Classical and novel neurosteroids in vertebrate brains2004

    • Author(s)
      K. Tsutsui
    • Organizer
      The 5th Congress of the Asia and Oceania Society for Comparative Endocrinology
    • Place of Presentation
      Nara, Japan(招待講演)
    • Related Report
      2008 Final Research Report
  • [Book] Melatonin action on neuropeptide induction through receptor-mediated mechanisms in the brain2007

    • Author(s)
      K. Tsutsui, T. Ubukaand G.E.Bentley
    • Total Pages
      14
    • Publisher
      In : Melatonin : From Molecules to Therapy, (S. R. Pandi-PerumalandD. P. Cardinali (eds) NovaScience Publishers, New York)
    • Related Report
      2008 Final Research Report
  • [Book] Gonadotropin-inhibitory hormone (GnIH) in the avian brain2007

    • Author(s)
      K. Tsutsui
    • Total Pages
      7
    • Publisher
      In : Hormone Biotechnology(S. K. Maitra (ed), Daya Publishing House, Delhi)
    • Related Report
      2008 Final Research Report
  • [Book] Neuronal neurosteroidogenesis and organizing actions of neurosteroids during cerebellar development2007

    • Author(s)
      K.Tsutsui
    • Total Pages
      18
    • Publisher
      In : Evolutionary Molecular Strategies and Plasticity(M. Canonaco and R. M. Facciolo (eds) Research SignpostPublishers,Trivandrum)
    • Related Report
      2008 Final Research Report
  • [Book] Melatonin action on neuropeptide induction through receptor-mediated mechanisms in the brain. In: Melatonin: From Molecules to TheraPy.2007

    • Author(s)
      K. Tsutsui et al.
    • Total Pages
      14
    • Publisher
      Nova Science Publishers, New York
    • Related Report
      2007 Annual Research Report
  • [Book] Gonadotropin-inhibitory hormone (GnIH) in the avian brain. In: Hormone Biotechnology.2007

    • Author(s)
      K. Tsutsui
    • Total Pages
      7
    • Publisher
      Daya Publishing House, Delhi
    • Related Report
      2007 Annual Research Report
  • [Book] Neuronal neurosteroidogenesis and organizing actions of neurosteroids during cerebellar development. In: Evolutionary Molecular Strategies and Plasticity.2007

    • Author(s)
      K. Tsutsui
    • Total Pages
      18
    • Publisher
      Research Signpost Publishers, Trivandrum
    • Related Report
      2007 Annual Research Report
  • [Book] 脳ホルモン新領域シリーズ21世紀の動物科学10内分泌と生命現象第5章脳ホルモンの新領域長濱嘉孝・井口泰泉共編2007

    • Author(s)
      筒井和義, et. al.
    • Total Pages
      39
    • Publisher
      培風館
    • Related Report
      2007 Annual Research Report
  • [Book] ホルモンハンドブック新訂eBook版脂溶性情報分子(細胞内受容体結合分子ファミリー)日本比較内分泌学会編2007

    • Author(s)
      筒井和義
    • Total Pages
      130
    • Publisher
      南江堂
    • Related Report
      2007 Annual Research Report
  • [Book] Melatonin action on neuropeptide induction through receptor-mediated mechanisms in the brain.2007

    • Author(s)
      K.Tsutsui et al.
    • Publisher
      In : Melatonin : From Molecules to Therapy, S.R. Pandi-Perumal and D. P. Cardinali (eds) Nova Science Publishers, New York(in press)
    • Related Report
      2006 Annual Research Report
  • [Book] Gonadotropin-inhibitory hormone (GnIH) in the avian brain.2007

    • Author(s)
      K.Tsutsui
    • Total Pages
      7
    • Publisher
      In : Hormone Biotechnology, S.K. Maitra (ed), Daya Publishing House, Delhi
    • Related Report
      2006 Annual Research Report
  • [Book] Neuronal neurosteroidogenesis and organizing actions of neurosteroids during cerebellar development.2007

    • Author(s)
      K Tsutsui
    • Total Pages
      18
    • Publisher
      In : Evolutionary Molecular Strategies and Plasticity, M. Canonaco and R. M. Facciolo (eds) Research Signpost Publishers, Trivandrum, India
    • Related Report
      2006 Annual Research Report
  • [Book] Endocrinology of reproduction2006

    • Author(s)
      G. E. Bentley, K. Tsutsuiand J. C. Wingfield
    • Total Pages
      62
    • Publisher
      In : ReproductiveBiologyandPhylogeny of Birds(Barrie G. M. Jamieson (ed) Science Publishers, Enfield, USA)
    • Related Report
      2008 Final Research Report
  • [Book] The Rfamide-related peptides2006

    • Author(s)
      N. Chartrel, K. Tsutsui, J. Costentin and H. Vaudry
    • Total Pages
      8
    • Publisher
      In : The Handbook of Biologically Active Peptides(In : The Handbook of Biologically Active Peptides)
    • Related Report
      2008 Final Research Report
  • [Book] Endocrinology of reproduction.2006

    • Author(s)
      G.E.Bentley et al.
    • Total Pages
      62
    • Publisher
      In : Reproductive Biology and Phylogeny of Birds, Barrie G.M. Jamieson (ed) Science Publishers, Enfield, USA
    • Related Report
      2006 Annual Research Report
  • [Book] Avian gonadotropin-inhibitory hormone (GnIH) : Identification, mode of action and functional significance.2006

    • Author(s)
      K.Tsutsui
    • Total Pages
      5
    • Publisher
      In : Comparative Endocrinology and Biodiversity in Asia and Oceania, P. Tangpraprutgul et al. (eds) Chulalongkorn University Press, Bangkok
    • Related Report
      2006 Annual Research Report
  • [Book] Melatonin action on the induction of gonadotropin-inhibitory hormone in the avian brain.2006

    • Author(s)
      V.S.Chowdhurv et al.
    • Total Pages
      4
    • Publisher
      In : Comparative Endocrinology and Biodiversity in Asia and Oceania, P. Tangpraprutgul et al. (eds) Chulalongkorn University Press, Bangkok
    • Related Report
      2006 Annual Research Report
  • [Book] The RFamide-related peptides2006

    • Author(s)
      N.Chartrel et al.
    • Total Pages
      8
    • Publisher
      In : The Handbook of Biologically Active Peptides, A. J. Kastin (ed) Elsevier publisher
    • Related Report
      2006 Annual Research Report
  • [Book] Melatonin action on neuropeptide induction through receptor-mediated mechanisms in the brain. (In : MELATONIN : from Molecules to Therapy)(S.R.Pandi-Perumal and D.P.Cardinali (eds))2006

    • Author(s)
      K.Tsutsui
    • Publisher
      Nova Science Publishers, New York(in press)
    • Related Report
      2005 Annual Research Report
  • [Book] Gonadotropin-inhibitory hormone (GnIH) in the avian brain. (In : Hormone Biotechnology)(S.K.Maitra (ed))2006

    • Author(s)
      K.Tsutsui
    • Publisher
      M/S Daya Publishing House, Delhi(in press)
    • Related Report
      2005 Annual Research Report
  • [Book] The RFamide-related peptides (In : The Handbook of Biologically Active Peptides)(A.J.Kastin (ed))2006

    • Author(s)
      N.Chartrel
    • Total Pages
      8
    • Publisher
      Elsevier publisher
    • Related Report
      2005 Annual Research Report
  • [Book] Avian gonadotropin-inhibitory hormone (GnIH) : Identification, mode of action and functional significance.(In : Comparative Endocrinology and Biodiversity in Asia and Oceania)(P.Tangpraprutgul et al. (eds))2006

    • Author(s)
      K.Tsutsui
    • Total Pages
      5
    • Publisher
      Chulalongkorn University Press, Bangkok, Thailand
    • Related Report
      2005 Annual Research Report
  • [Book] Melatonin action on the induction of gonadotropin-inhibitory hormone in the avian brain.(In : Comparative Endocrinology and Biodiversity in Asia and Oceania)(P.Tangpraprutgul et al. (eds))2006

    • Author(s)
      V.S.Chowdhury
    • Total Pages
      4
    • Publisher
      Chulalongkorn University Press, Bangkok, Thailand
    • Related Report
      2005 Annual Research Report
  • [Book] Structure, action and functional significance of GnIH2005

    • Author(s)
      K. Tsutsui, G. Bentley and N. Ciccone
    • Total Pages
      10
    • Publisher
      In : Functional Avian Endocrinology(A. Dawson and P. J. Sharp (eds) Narosa Publishing House, New Delhi)
    • Related Report
      2008 Final Research Report
  • [Book] Structure, action and functional significance of GnIH.(In : Functional Avian Endocrinology)(A.Dawson and P.J.Sharp (eds))2005

    • Author(s)
      K Tsutsui
    • Total Pages
      10
    • Publisher
      Narosa Publishing House, New Delhi
    • Related Report
      2005 Annual Research Report
  • [Book] Trends in Comparative Endocrinology2004

    • Author(s)
      T. Oishi, K. Tsutsui, S. Tanaka and S. Kikuyama
    • Total Pages
      593
    • Publisher
      AOSCE
    • Related Report
      2008 Final Research Report
  • [Book] Treads in Comparative Endocrinology2004

    • Author(s)
      K.Tsutsui
    • Total Pages
      593
    • Publisher
      Asia and Oceania Society for Comparative Endocrinology
    • Related Report
      2004 Annual Research Report
  • [Book] Classical and novel neurosteroids in vertebrate brains. Trends in Comparative Endocrinology (T.oishi, K.Tsutsui, S.Tanaka and S.Kikuyama (eds))2004

    • Author(s)
      K.Tsutsui
    • Total Pages
      3
    • Publisher
      AOSCE
    • Related Report
      2004 Annual Research Report
  • [Book] Synapse formation in response to estrogen synthesized de novo in the developing Purkinje cell. Trends in Comparative Endocrinology (T.Oishi, K.Tsutsui, S.Tanaka and S.Kikuyama (eds))2004

    • Author(s)
      H.Shikimi
    • Total Pages
      3
    • Publisher
      AOSCE
    • Related Report
      2004 Annual Research Report
  • [Book] A novel amphibian neurosteroid stimulating locomotor activity. Trends in Comparative Endocrinology (T.Oishi, K.Tsutsui, S.Tanaka and S.Kikuyama (eds))2004

    • Author(s)
      M.Matsunaga
    • Total Pages
      3
    • Publisher
      AOSCE
    • Related Report
      2004 Annual Research Report
  • [Book] Comparative aspects of novel hypothalamic LPXRF-amide peptides in the vertebrate brain : Structure, localization and function. Trends in Comparative Endocrinology (T.Oishi, K.Tsutsui, S.Tanaka and S.Kikuyama (eds))2004

    • Author(s)
      K.Ukena
    • Total Pages
      3
    • Publisher
      AOSCE
    • Related Report
      2004 Annual Research Report
  • [Book] Novel avian neurosteroid : Identification of 7a-hydroxypregnenolone in the quail brain. Trends in Comparative Endocrinology (T.Oishi, K.Tsutsui, and S.Kikuyama (eds))2004

    • Author(s)
      H.Miyabara
    • Total Pages
      3
    • Publisher
      AOSCE
    • Related Report
      2004 Annual Research Report
  • [Book] Identification and localization of a novel lamprey hypothalamic neuropeptide of the RF-amide peptide family. Trends in Comparative Endocrinology (T.Oishi, K.Tsutsui, S.Tanaka and S.Kikuyama (eds))2004

    • Author(s)
      T.Osugi
    • Total Pages
      3
    • Publisher
      AOSCE
    • Related Report
      2004 Annual Research Report
  • [Book] Effects of RF-amide peptides on the release of TSH from the bullfrog pituitary. Trends in Comparative Endocrinology (T.Oishi, K.Tsutsui, S.Tanaka and S.Kikuyama (eds))2004

    • Author(s)
      K.Yamamoto
    • Total Pages
      3
    • Publisher
      AOSCE
    • Related Report
      2004 Annual Research Report
  • [Remarks] 2008年3月2日読売新聞掲載

    • Related Report
      2008 Final Research Report
  • [Remarks] 2008年3月2日YOMIURI ONLINE掲載

    • Related Report
      2008 Final Research Report
  • [Remarks] 2008年7月15日Farner Medal受賞(International Society for Avian Endocrinology)

    • Related Report
      2008 Final Research Report
  • [Remarks] 2007年9月10日asahi.com OPINION(朝日新聞社報)掲載

    • URL

      http://www.f.waseda.jp/k-tsutsui/

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://vnwi.f.waseda.jp/k-tsutsui/fworks.htmI

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.f.waseda.jp/k-tsutsui/

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 新規メタスチン同族体およびその用途2009

    • Inventor(s)
      筒井和義
    • Industrial Property Rights Holder
      筒井和義
    • Industrial Property Number
      2008-253859
    • Acquisition Date
      2009-09-30
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 新規メタスチン同族体およびその用途2008

    • Inventor(s)
      筒井和義
    • Industrial Property Rights Holder
      筒井和義
    • Industrial Property Number
      2008-253859
    • Filing Date
      2008-09-30
    • Related Report
      2008 Annual Research Report

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Published: 2004-04-01   Modified: 2018-03-28  

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