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Development of Sensory Genomics and Basic Analysis on Taste Bioinformation Technology

Research Project

Project/Area Number 16108004
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Applied molecular and cellular biology
Research InstitutionThe University of Tokyo

Principal Investigator

ABE Keiko  The University of Tokyo, Graduate School of Agricultural and Life Sciences, Professor (10151094)

Co-Investigator(Kenkyū-buntansha) NAKAGAWA Keiichi  The University of Tokyo, The University of Tokyo Hospital, Radiology and Biomedical Engineering, Associate professor (80188896)
MATSUMOTO Ichiro  The University of Tokyo, Graduate School of Agricultural and Life Sciences, Associate professor (00291328)
YOSHIHIRO Yoshihiko  RIKEN, Japan, Laboratory for Neurobiology of Synapse, Laboratory Head (20220717)
MISAKA Takumi  The University of Tokyo, Graduate School of Agricultural and Life Sciences, Associate professor (40373196)
Project Period (FY) 2004 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥101,530,000 (Direct Cost: ¥78,100,000、Indirect Cost: ¥23,430,000)
Fiscal Year 2007: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2006: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2005: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2004: ¥44,330,000 (Direct Cost: ¥34,100,000、Indirect Cost: ¥10,230,000)
KeywordsTaste system / Transgenic animals / DNA microarray / Taste signal transmission / Feeding behavior / トランスジェニックメダカ / 魚T1Rs / 魚T2R / 味覚受容体 / アミノ酸 / 魚T2Rs / 味覚 / 食品 / ゲノム / シグナル伝達 / 脳・神経 / ホスホリパーゼCβ2 / 味覚行動 / モデル魚
Research Abstract

Taste is an essential sensation for any animal to keep its appropriate feeding behavior. It has also had an indispensable motivation for us to construct our traditional food cultures and develop sophisticated food industries. To have clear insights into the molecular basis of this important sensation, we have conducted the studies using genomics on taste reception and signaling. In detail, the studies are comprised of 1) analysis of taste signal transmission pathways in model fish and 2) analysis of taste signal transduction pathways in mice, with the following results. (1) We investigates the GPCR→G-protein→PLCbeta2→TRPM5 pathway and found that the taste signal effector, PLCbeta2, was expressed in medaka and zebrafish as well as in mammals. We then revealed that the taste receptors, T1RGPCRs and T2R GPCRs, and TROM5 existed in these fish as well as in humans and other vertebrates. Interestingly enough, the fish received amino acid by T1R2/3 as well as by T1R1/3 and bitter tastants by T2Rs We also tried to ligate the dominant-negative G-protein to the PLC promoter and succeeded to construct a transgenic, taste-blind medaka mutant. (2) For taste transmission studies, we constructed transgenic mice by ligation of the lectin, wheat germ agglutinin (WGA) to the T1R3 promoter, and observed the WGA signaling events in the taste bud, primary neurons, GG, NPG and TG, as well as those in NST. The observation revealed that both the WGA mRNA and the protein were expressed just in the T1R3-positive cells, with no expression in other taste cells responding to bitterness and sourness. The WGA signal was also observed in parts of neurocytes with GG, NPG and even NST, and we thus succeeded to differentially identify the taste cell→taste neuron→NST neuron pathway for sweet and umami-taste transmission.

Report

(5 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (159 results)

All 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article (124 results) (of which Peer Reviewed: 52 results) Presentation (32 results) Book (3 results)

  • [Journal Article] Construction of a taste-blind medaka fish and quantitative assay of its preference-aversion behavior.2008

    • Author(s)
      Aihara, Y.
    • Journal Title

      Gene Brain Behav. 7

      Pages: 924-932

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Neoculin, a taste-modifying sweet protein, accumulates in ripening fruits of cultivated Curculigo latifolia.2008

    • Author(s)
      Okubo, S.
    • Journal Title

      J. Plant Physiol. 165

      Pages: 1964-1969

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Studies on taste : molecular biology and food science.2008

    • Author(s)
      Abe, K.
    • Journal Title

      Biosci. Biotechnol. Biochem. 72

      Pages: 1647-1656

    • NAID

      10027529260

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Distinct contributions of CXCR4b and CXCR7/RDC1 receptor systems in regulation of PGC migration revealed by medaka mutants kazura and yanagi.2008

    • Author(s)
      Sasado, T.
    • Journal Title

      Dev. Biol. 320

      Pages: 328-339

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Characterization of umami receptor and coupling G protein in mouse taste cells.2008

    • Author(s)
      Narukawa, M.
    • Journal Title

      Neuroreport 19

      Pages: 1169-1173

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Advanced method for high-throughput expression of mutated eukaryotic membrane proteins in Saccharomyces cerevisiae.2008

    • Author(s)
      Ito, K.
    • Journal Title

      Biochem. Biophys. Res. Commun. 371

      Pages: 841-845

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Genetic tracing of the gustatory and trigeminal neural pathways originating feom T1R3-expressing taste receptor cells and solitary chemoreceptor cells.2008

    • Author(s)
      Ohmoto, M.
    • Journal Title

      Mol. Cell Neurosci. 38

      Pages: 505-517

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Biochemical and Genomic Analysis of Neoculin Compared to Monocot Mannose-Binding Lectins.2008

    • Author(s)
      Shimizu-Ibuka, A.
    • Journal Title

      J. Agric. Food Chem. 56

      Pages: 5338-5344

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Acid-induced sweetness of neoculin is ascribed to its pH-dependent agonistic-antagonistic interaction with human sweet taste receptor.2008

    • Author(s)
      Nakajima, K.
    • Journal Title

      FASEB J. 22

      Pages: 2323-2330

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Applying an Aspergillus saitoi protease preparation to soybean curd for modification of its functional and rheoloeical properties.2008

    • Author(s)
      Nishinoaki, M.
    • Journal Title

      Biosci. Biotechnol. Biochem. 72

      Pages: 587-590

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Muscle RING-Finger Protein MuRF1 as a Connector of Muscle Energy Metabolism and Protein Synthesis.2008

    • Author(s)
      Koyama, S.
    • Journal Title

      J. Mol. Biol. 376

      Pages: 1224-1236

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Signal peptide peptidase and its homologues in Arabidopsis thaliana : plant tissue-specific expression and distinct subcellular localization.2008

    • Author(s)
      Tamura, T.
    • Journal Title

      FEBS J. 275

      Pages: 34-43

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Functional food science and food for specified health use policy in Japan : state of the art.2008

    • Author(s)
      Arai, S.
    • Journal Title

      Curr. Opin. Lipidol. 19

      Pages: 69-73

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Up-regulation of Genes Related to the Ubiquitin-Proteasome System in the Brown Adipose Tissue of 24-h-fasted Rats.2008

    • Author(s)
      Nakai, Y.
    • Journal Title

      Biosci. Biotechnol. Biochem. 72

      Pages: 139-148

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Construction of a taste-blind medaka fish and quantitative assay of its preference-aversion behavior2008

    • Author(s)
      Aihara, Y., Yasuoka, A., Iwamoto, S., Yoshida, Y., Misaka, T., Abe, K.
    • Journal Title

      Gene Brain Behav. 7

      Pages: 924-932

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Neoculin, a taste-modifying sweet protein, accumulates in ripening fruits of cultivated Curculigo latifolia2008

    • Author(s)
      Okubo, S., Asakura, T., Okubo, K., Abe, K., Misaka, T., Akita, T., Abe, K.
    • Journal Title

      J.Plant Physiol. 165

      Pages: 1964-1969

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Aquaporin-11 knockout mice and polycystic kidney disease animals share a common mechanism of cyst formation2008

    • Author(s)
      Okada, S., Misaka, T., Tanaka, Y., Matsumoto, I., Ishibashi, K., Sasaki, S., Abe, K.
    • Journal Title

      FASEB J. 22

      Pages: 3672-3684

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Studies on taste : molecular biology and food science2008

    • Author(s)
      Abe, K.
    • Journal Title

      Biosci.Biotechnol.Biochem. 72

      Pages: 1647-1656

    • NAID

      10027529260

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Distinct contributions of CXCR4b and CXCR7/RDC1 receptor systems in regulation of PGC migration revealed by medaka mutants kazura and yanagi2008

    • Author(s)
      Sasado, T., Yasuoka, A., Abe, K., Mitani, H., Furutani-Seiki, M., Tanaka, M., Kondoh, H.
    • Journal Title

      Dev.Biol. 320

      Pages: 328-339

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Characterization of umami receptor and coupling Gprotein in mouse taste cells2008

    • Author(s)
      Narukawa, M., Kitagawa-Iseki, K, Oike, H., Abe, K., Mori, T., Hayashi, Y.
    • Journal Title

      Neuroreport 19

      Pages: 1169-1173

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Advanced method for high-throughput expression of mutated eukaryotic membrane proteins in Saccharomyces cerevisiae2008

    • Author(s)
      Ito, K., Sugawara, T., Shiroishi, M., Tokuda, N., Kurokawa, A., Misaka, T., Makyio, H., Yurugi-Kobayashi, T., Shimamura, T., Nomura, N., Murata, T., Abe, K., Iwata, S., Kobayashi.T.
    • Journal Title

      Biochem.Biophys.Res.Commun. 371

      Pages: 841-845

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Genetic tracing of the gustatory and trigeminal neural pathways originating from T1R3-expressing taste receptor cells and solitary chemoreceptor cells2008

    • Author(s)
      Ohmoto, M., Matsumoto, I., Yasuoka, A., Yoshihara, Y., Abe, K.
    • Journal Title

      Mol.Cell Neurosci. 38

      Pages: 505-517

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Biochemical and Genomic Analysis of Neoculin Compared to Monocot Mannose-Binding Lectins2008

    • Author(s)
      Shimizu-Ibuka, A., Nakai, Y., Nakamori, K., Morita, Y., Nakajima, K., Kadota, K., Watanabe, H., Okubo, S., Terada, T., Asakura, T., Misaka, T., Abe, K.
    • Journal Title

      J.Agric.Food Chem. 56

      Pages: 5338-5344

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Acid-induced sweetness of neoculin is ascribed to its pH-dependent agonistic-antagonistic interaction with human sweet taste receptor2008

    • Author(s)
      Nakajima, K., Morita, Y., Koizumi, A., Asakura, T., Terada, T., Ito, K., Shimizu-Ibuka, A., Maruyama, J., Kitamoto, K., Misaka, T., Abe, K.
    • Journal Title

      FASEB J. 22

      Pages: 2323-2330

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Applying an Aspergillus saitoi protease preparation to soybean curd for modification of its functional and rheological properties2008

    • Author(s)
      Nishinoaki, M., Asakura, T., Watanabe, T., Kunizaki, E., Matsumoto, M., Eto, W., Tamura, T., Minami, M., Obata, A., Abe, K., Funaki, J.
    • Journal Title

      Biosci.Biotechnol.Biochem. 72

      Pages: 587-590

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Muscle RING-Finger Protein MuRF1 as a Connector of Muscle Energy Metabolism and Protein Synthesis2008

    • Author(s)
      Koyama, S., Hata, S., Witt, C., Ono, Y., Lerche, S., Ojima, K., Chiba, T., Doi, N., Kitamura, F., Tanaka, K., Abe, K., Witt, S., Rybin, V., Gasch, A., Franz, T., Labeit, S., Sorimachi, H.
    • Journal Title

      J.Mol.Biol. 376

      Pages: 1224-1236

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Signal peptide peptidase and its homologues in Arabidopsis thaliana : plant tissue-specific expression and distinct subcellular localization2008

    • Author(s)
      Tamura, T., Asakura, T., Uemura, T., Ueda, T., Terauchi, T., Misaka, T., Abe, K.
    • Journal Title

      FEBS J. 275

      Pages: 34-43

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Functional food science and food for specified health use policy in Japan : state of the art2008

    • Author(s)
      Arai, S., Yasuoka, A., Abe, K.
    • Journal Title

      Curr.Opin.Lipidol. 19

      Pages: 69-73

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Up-regulation of Genes Related to the Ubiquitin-Proteasome System in the Brown Adipose Tissue of 24-h-fasted Rats2008

    • Author(s)
      Nakai, Y., Hashida, H., Kadota, K., Minami, M., Shimizu, K., Matsumoto, I., Kato, H., Abe, K.
    • Journal Title

      Biosci.Biotechnol.Biochem. 72

      Pages: 139-148

    • NAID

      10027523175

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Acid-induced sweetness of neoculin is ascribed to its pH-dependentaonistic-antaonistic interaction with human sweet taste receptor2008

    • Author(s)
      Nakajima, K., et. al.
    • Journal Title

      FASEB J (掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] QuantifYing abnormal feeding behaviors of taste-numbed medaka fishby a novel reference-aversion assay sytem2008

    • Author(s)
      Aihara, Y., et. al.
    • Journal Title

      Genes Brain Behav (掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional food science and food for specified health use poIicy in Jaan:state of the art2008

    • Author(s)
      Arai, S., et. al.
    • Journal Title

      Current Opinion in Lipidology 19

      Pages: 69-73

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transient receptor potential channel M5 and phosphohpaseC-β2colocalizin in zebrafish taste recetor cells2008

    • Author(s)
      Yoshida, Y., et. al.
    • Journal Title

      Neuroreport 18

      Pages: 1517-1520

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transient receptor potential channel M5 and phospholipaseC-b2 colocalizing in zebrafish taste receptor cells.2007

    • Author(s)
      Yoshida, Y.
    • Journal Title

      Neuroreport 18

      Pages: 1517-1520

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Microbial production of sensory-active miraculin.2007

    • Author(s)
      Ito, K.
    • Journal Title

      Biochem. Biophys. Res. Commun. 360

      Pages: 407-411

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Characterization of Ligands for Fish Taste Receptors.2007

    • Author(s)
      Oike, H.
    • Journal Title

      J. Neurosci. 27

      Pages: 5584-5592

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Taste-modifying sweet protein, neoculin, is received at human T1R3 amino terminal domain.2007

    • Author(s)
      Koizumi, A.
    • Journal Title

      Biochem. Biophys. Res. Commun. 358

      Pages: 585-589

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Transgenic labeling of taste receptor cells in model fish under the control of the 5'-upstream region of medaka phospholipase C-beta 2 gene.2007

    • Author(s)
      Aihara, Y.
    • Journal Title

      Gene Expr. Patterns 7

      Pages: 149-157

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A transcriptional enhancer that directs telencephalon- specific transgene expression in mouse brain.2007

    • Author(s)
      Mitsui S
    • Journal Title

      Cerebral Cortex 17

      Pages: 522-30

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Transient receptor potential channel M5 and phospholipaseC-b2 colocalizing in zebrafish taste receptor cells2007

    • Author(s)
      Yoshida, Y.Saito, K., Aihara, Y.Okada, S.Misaka, T., Abe.K.
    • Journal Title

      Neuroreport 18

      Pages: 1517-1520

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Microbial production of sensory-active miraculin2007

    • Author(s)
      Ito, K., Asakura, T., Morita, Y., Nakajima, K., Koizumi, A., Shimizu-Ibuka, A., Masuda, K., Ishiguro, M., Terada, T., Maruyama, J., Kitamoto, K., Misaka, T., Abe.K.
    • Journal Title

      Biochem.Biophys.Res.Commun. 360

      Pages: 407-411

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Characterization of Ligands for Fish Taste Receptors2007

    • Author(s)
      Oike, H., Nagai, T., Furuyama, A., Okada, S., Aihara, Y., Ishimaru, Y., Marui, T., Misaka, T., Abe.K.
    • Journal Title

      J.Neurosci. 27

      Pages: 5584-5592

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Taste-modifying sweet protein, neoculin, is received at human T1R3 amino terminal domain2007

    • Author(s)
      Koizumi, A., Nakajima, K., Asakura, T., Morita, Y., Ito, K., Shimizu-Ibuka, A., Misaka, T., Abe.K.
    • Journal Title

      Biochem.Biophys.Res.Commun. 358

      Pages: 585-589

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Trans-genic labeling of taste receptor cells in model fish under the control of the 5'-upstream region of medaka phospholipase C-beta 2 gene2007

    • Author(s)
      Aihara, Y., Yasuoka, A., Yoshida, Y, Ohmoto, M., Shimizu-Ibuka, A., Misaka, T., Furutani-Seiki, M., Matsumoto I., Abe.K.
    • Journal Title

      Gene Expr.Patterns 7

      Pages: 149-157

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A transcriptional enhancer that directs telencephalon-specific transgene expression in mouse brain2007

    • Author(s)
      Mitsui S, Saito M, Mori K, Yoshihara Y
    • Journal Title

      Cerebral Cortex 17

      Pages: 522-30

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Characterization of ligands for fish taste receptors2007

    • Author(s)
      Oike, H., Nagai, T., Furuyama, A., Okada, S., Aihara, Y., Ishimaru, Y., Marui, T., Matsumoto, I., Misaka, T., Abe, K.
    • Journal Title

      J.Neurosci. 27

      Pages: 5584-5592

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Taste-modifying sweet protein, neoculin, is received at human T1R3 amino terminal domain2007

    • Author(s)
      Koizumi, A., Nakajima, K., Asakura, T., Morita, Y., Ito, K., Shmizu-Ibuka, A., Misaka, T., Abe, K.
    • Journal Title

      Biochem.Biophys.Res.Commun. 358

      Pages: 585-589

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Transgenic labeling of taste receptor cells in model fish under the control of the 5'-upstream region of medaka phospholipase C-beta 2 gene2007

    • Author(s)
      Aihara, Y., Yasuoka, A., Yoshida, Y, Ohmoto, M., Shimizu-Ibuka, A., Misaka, T., Furutani-Seiki, M., Matsumoto, I., Abe, K.
    • Journal Title

      Gene Expr.Patterns 7

      Pages: 149-157

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Microbial production of sensory-active miraculin2007

    • Author(s)
      Ito, K., et. al.
    • Journal Title

      Biochem.Biophys.Res.Commun 360

      Pages: 407-411

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Ligands for Fish Taste Receptors2007

    • Author(s)
      Oike, H., et. al.
    • Journal Title

      J.Neurosci 27

      Pages: 5584-5592

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Taste-modifying sweet protein,neoculin,is received at human TIR3amino temlinal domain2007

    • Author(s)
      Koizumi, A., et. al.
    • Journal Title

      Biochem.Biophys.Res.Commun 358

      Pages: 585-589

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transgenic labelillg of taste receptor cells inmodel fish under the control of the 5'-upstream region of medaka phospholipase C-beta 2gene2007

    • Author(s)
      Aihara, Y., et. al.
    • Journal Title

      Gene Expr.Patterns 7

      Pages: 149-157

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Ligands for Fish Taste Receptors.2007

    • Author(s)
      Oike, H., et al.
    • Journal Title

      J. Neurosci. (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Transgenic labeling of taste receptor cells in model fish under the control of the 5'-upstream region of medaka phospholipase C-beta 2 gene.2007

    • Author(s)
      Aihara, Y., et al.
    • Journal Title

      Gene Expr. Patterns 7

      Pages: 149-149

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Taste receptor cells express voltage-dependent potassium channels in a cell age-specific manner.2006

    • Author(s)
      Ohmoto, M.
    • Journal Title

      Chem. Senses 31

      Pages: 739-746

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Relation between acute & late irradiation impairment of four basic tastes and irradiated tongue volume in patients with head and neck cancer.2006

    • Author(s)
      Yamashita, H.
    • Journal Title

      Int. J. of Radiat. Oncol. Biol. Phys. 66

      Pages: 1422-1429

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Arachidonic acid can function as a signaling modulator by activating the TRPMS cation channel in taste receptor cells.2006

    • Author(s)
      Oike, H.
    • Journal Title

      Biochim. Biophys. Acta 1761

      Pages: 1078-1084

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Neoculin, a taste-modifying protein, is recognized by human sweet taste receptor.2006

    • Author(s)
      Nakajima, K.
    • Journal Title

      Neuroreport 17

      Pages: 1241-1244

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Crystal structure of neoculin : insights into its sweetness and taste-modifying activity.2006

    • Author(s)
      Shimizu-Ibuka, A.
    • Journal Title

      J. Mol. Biol. 359

      Pages: 148-158

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Extracellular production of a heterodimetric protein, neoculin, with sweet-tasting and taste-modifying activities by Aspergillus oryzae.2006

    • Author(s)
      Nakajima, K.
    • Journal Title

      Appl. Environ. Microbiol. 72

      Pages: 3716-3723

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Group IIA phospholipase A2 is co-expressed with SNAP-25 in mature taste recentor cells of rat circumvallate papillae.2006

    • Author(s)
      Oike, H.
    • Journal Title

      J. Comp. Neurol. 494

      Pages: 876-886

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Taste dysfunction in patients receiving radiotherapy.2006

    • Author(s)
      Yamashita, H.
    • Journal Title

      Head Neck. 28

      Pages: 508-16

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Srctyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation.2006

    • Author(s)
      Li, Z.
    • Journal Title

      Biochem and Biophys Res Commun. 341

      Pages: 363-368

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Zinc-finger gene Fez in the olfactory sensory neurons regulates development of the olfactory bulb non-cell-autonomously.2006

    • Author(s)
      Hirata T
    • Journal Title

      Development 133

      Pages: 1433-43

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The dynamin-related mouse mitochondrial GTPase OPA1 alters the structure of the mitochondrial inner membrane when exogenously introduced into COS-7 cells.2006

    • Author(s)
      Misaka, T.
    • Journal Title

      Neurosci. Res. 55

      Pages: 123-133

    • NAID

      10020615716

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Taste receptor cells express voltage-dependent potassium channels in a cell age-specific manner2006

    • Author(s)
      Ohmoto, M., Matsumoto, I., Misaka, T., Abe.K.
    • Journal Title

      Chem.Senses 31

      Pages: 739-746

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Relation between acute & late irradiation impairment of four basic tastes and irradiated tongue volume in patients with head and neck cancer2006

    • Author(s)
      Yamashita, H., Nakamura, N., Abe.K., Asakage, T., Ohmoto, M., Okada, S., Matsumoto, I., Hosoi, M., Sasano, N., Yamakawa, S., Ohtomo, K., Nakagawa, K.
    • Journal Title

      Int.J.of Radiat.Oncol.Biol.Phys. 66

      Pages: 1422-1429

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Arachidonic acid can function as a signaling modulator by activating the TRPM5 cation channel in taste receptor cells2006

    • Author(s)
      Oike, H., Wakamori, M., Mori, Y., Nakanishi, H., Taguchi, R, Misaka, T., Matsumoto, I., Abe.K.
    • Journal Title

      Biochim.Biophys.Acta 1761

      Pages: 1078-1084

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Neoculin, a taste-modifying protein, is recognized by human sweet taste receptor2006

    • Author(s)
      Nakajima, K., Asakura, T., Oike, H., Morita, Y., Shimizu-Ibuka, A., Misaka, T., Sorimachi, H., Arai, S., Abe.K.
    • Journal Title

      Neuroreport 17

      Pages: 1241-1244

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Crystal structure of neoculin : insights into its sweetness and taste-modifying activity2006

    • Author(s)
      Shimizu-Ibuka, A., Morita, Y., Terada, T., Asakura, T., Nakajima, K., Iwata, S., Misaka, T., Sorimachi, H., Arai, S., Abe.K.
    • Journal Title

      J.Mol.Biol. 359

      Pages: 148-158

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Extracellular production of a heterodimetric protein, neoculin, with sweet-tasting and taste-modifying activities by Aspergillus oryzae2006

    • Author(s)
      Nakajima, K, Asakura, T., Maruyama, J., Morita, Y., Oike, H., Shimizu-Ibuka, A., Misaka, T., Sorimachi, H., Arai, S., Kitamoto, K, Abe.K.
    • Journal Title

      Appl.Environ.Microbial. 72

      Pages: 3716-3723

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Group IIA phospholipase A2 is co-expressed with SNAP-25 in mature taste receptor cells of rat circumvallate papillae2006

    • Author(s)
      Oike, H., Matsumoto, I., Abe.K.
    • Journal Title

      J.Comp.Neurol. 494

      Pages: 876-886

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Taste dysfunction in patients receiving radiotherapy2006

    • Author(s)
      Yamashita, H., Nakagawa, K, Tago, M., Nakamura, N., Shiraishi, K., Eda, M., Nakata, H., Nagamatsu, N., Yokoyama, R., Onimura, M., Ohtomo, K.
    • Journal Title

      Head Neck. 28

      Pages: 508-16

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation2006

    • Author(s)
      Li, Z., Hosoi, Y., Cai, K., Tanno, Y., Matsumoto, Y., Enomoto, A., Morita, A., Nakagawa, K, Miyagawa, K.
    • Journal Title

      Biochem and Biophys Res Commun. 341

      Pages: 363-368

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Group IIA phospholipase A2 is co-expressed with SNAP-25 in mature taste receptor cells of rat circumvallate papillae2006

    • Author(s)
      Oike, H., Matsumoto, I., Abe, K.
    • Journal Title

      J.Comp.Neurol. 494

      Pages: 876-886

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Zinc-finger gene Fez in the olfactory sensory neurons regulates development of the olfactory bulb non-cell-autonomously2006

    • Author(s)
      Hirata T, Nakazawa M, Yoshihara S, Miyachi H, Kitamura K, Yoshihara Y, Hibi M
    • Journal Title

      Development 133

      Pages: 1433-43

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Taste Receptor Cells Express Voltage- Dependent Potassium Channels in a Cell Age-Specific Manner2006

    • Author(s)
      Ohmoto, M., Matsumoto, I., Misaka, T., Abe, K.
    • Journal Title

      Chem.Senses 31

      Pages: 739-746

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Arachidonic acid can function as a signaling modulator by activating the TRPM5 cation channel in taste receptor cells2006

    • Author(s)
      Oike, H., Wakamori, M., Mori, Y., Nakanishi, H., Taguchi, R., Misaka, T., Matsumoto, I., Abe K.
    • Journal Title

      Biochim.Biophys.Acta 1761

      Pages: 1078-1084

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Crystal structure of neoculin : insights into its sweetness and taste-modifying activity2006

    • Author(s)
      Shimizu-Ibuka, A., Morita, Y., Terada, T., Asakura, T., Nakajima, K., Iwata, S., Misaka, T., Sorimachi, H., Arai, S., Abe, K.
    • Journal Title

      J.Mol.Biol. 359

      Pages: 148-158

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The dynamin-related mouse mitochondrial GTPase OPA1 alters the structure of the mitochondrial inner membrane when exogenously introduced into COS-7 cells2006

    • Author(s)
      Misaka, T, Murate, M., Fujimoto, K., Kubo, Y.
    • Journal Title

      Neurosci.Res. 55

      Pages: 123-133

    • NAID

      10020615716

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Taste receptor cells express voltage-dependent potassium channels in a cell age-specific manner.2006

    • Author(s)
      Ohmoto, M., et al.
    • Journal Title

      Chem. Senses 31

      Pages: 739-739

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Arachidonic acid can function as a signaling modulator by activating the TRPM5 cation channel in taste receptor cells.2006

    • Author(s)
      Oike, H., et al.
    • Journal Title

      Biochim. Biophys. Acta 1761

      Pages: 1078-1078

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Crystal structure of neoculin : insights into its sweetness and taste-modifying activity.2006

    • Author(s)
      Shimizu-Ibuka, A., et al.
    • Journal Title

      J.Mol.Biol. 359

      Pages: 148-148

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Group IIA phospholipase A2 is co-expressed with SNAP-25 in mature taste receptor cells of rat circumvallate papillae.2006

    • Author(s)
      Oike, H., et al.
    • Journal Title

      J. Comp. Neurol. 494

      Pages: 876-876

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Group IIA phospholipase A2 is co-expressed with SNAP-25 in mature taste receptor cells of rat circumvallate papillae.2006

    • Author(s)
      Ooike, H.
    • Journal Title

      J.Comp.Neurol. 494

      Pages: 876-886

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Two families of candidate taste receptors in fishes.2005

    • Author(s)
      Ishimaru Y.
    • Journal Title

      Mech. Dev. 122

      Pages: 1310-1321

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Identification of 24 genes and 2 pseudo genes coding for olfactory receptors in Japanese_loach, classified into 4 subfamilies : A putative evolutionary process for fish olfactory receptor genes by comprehensive phylogenetic analysis.2005

    • Author(s)
      Irie-Kushiyama, S.
    • Journal Title

      Gene 325

      Pages: 123-135

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Mutually exclusive glomerular innervation by two distinct types of olfactory sensory neurons revealed in transgenic zebrafish.2005

    • Author(s)
      Sato Y
    • Journal Title

      J. Neurosci. 25

      Pages: 4889-4897

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Arx homeobox gene is essential for development of mouse olfactory system.2005

    • Author(s)
      Yoshihara S
    • Journal Title

      Development 132

      Pages: 751-762

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] OPA1 expression in the normal rat retina and optic nerve.2005

    • Author(s)
      Ju, W.K.
    • Journal Title

      J. Comp. Neurol. 488

      Pages: 1-10

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Two families of candidate taste receptors in fishes2005

    • Author(s)
      Ishimaru Y., Okada S., Naito H., Yasuoka A., Matsumoto I., Abe.K.
    • Journal Title

      Mech.Dev. 122

      Pages: 1310-1321

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Two families of candidate taste receptors in fishes2005

    • Author(s)
      Ishimaru Y., Okada S., Naito H., Yasuoka A., Matsumoto I., Abe K.
    • Journal Title

      Mech.Dev. 122

      Pages: 1310-1321

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Mutually exclusive glomerular innervation by two distinct types of olfactory sensory neurons revealed in transgenic zebrafish2005

    • Author(s)
      Sato Y, Miyasaka N, Yoshihara Y
    • Journal Title

      J.Neurosci. 25

      Pages: 4889-4897

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Arxhomeobox gene is essential for development of mouse olfactory system2005

    • Author(s)
      Yoshihara S, Omichi K, Yanazawa M, Kitamura K, Yoshihara Y
    • Journal Title

      Development 132

      Pages: 751-762

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] OPA1 expression in the normal rat retina and optic nerve2005

    • Author(s)
      Ju, W.K., Misaka, T., Kushnareva, Y., Nakagomi, S., Agarwal, N., Kubo, Y., Lipton, S.A., Bossy-Wetzel, E.
    • Journal Title

      J.Comp.Neurol. 488

      Pages: 1-10

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Two families of candidate taste receptors in fishes.2005

    • Author(s)
      Ishimaru Y.
    • Journal Title

      Mech.Dev. 122

      Pages: 1310-1321

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Mutations_affecting the formation ot posterior lateral line system in Medaka, Oryzias latipes.2004

    • Author(s)
      Yasuoka, A.
    • Journal Title

      Mech. Dev. 121

      Pages: 729-738

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Phospholipase C-beta 2 as a mammalian taste signaling marker is expressed in the mutiple gustatory tissues of medaka fish, Oryzias latipes.2004

    • Author(s)
      Yasuoka, A.
    • Journal Title

      Mech. Dev. 121

      Pages: 985-989

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Neoculin as a new taste-moditying protein occurring in the fruit of Curculigo latifolia.2004

    • Author(s)
      Shirasuka, Y.
    • Journal Title

      Biosci. Biotechnol. Biochem. 68

      Pages: 1403-1407

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Gene expression profiling of cranial sensory ganglia that transmit food intake stimuli.2004

    • Author(s)
      Matsumoto, I.
    • Journal Title

      BioFactors 21

      Pages: 15-18

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2004 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of candidate genes involved in somatosensory functions of cranial sensory ganglia.2004

    • Author(s)
      Matsumoto, I.
    • Journal Title

      Mol. Brain Res. 126

      Pages: 98-102

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Analysis of the expression and localization of a LAP protein, human Scribble, in the normal and neoplatic epithelium of uterine cervix.2004

    • Author(s)
      Nakagawa, S.
    • Journal Title

      British Journal of Cancer 90

      Pages: 194-199

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Laminar organization of the developing lateral olfactory tract revealed by differential expression of cell recognition molecules.2004

    • Author(s)
      Inaki K
    • Journal Title

      J. Comp. Neurol. 479

      Pages: 243-256

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Mutations affecting the formation of posterior lateral line system in Medaka, Oryzias latipes2004

    • Author(s)
      Yasuoka, A., Hirose, Y, Yoda, H., Aihara, Y., Suwa, H., Niwa, K., Sasado, T., Morinaga, C., Deguchi, T., Henrich, T., Iwanami, N., Kunimatsu, S., Abe.K., Kondoh, H., Furutani-Seiki, M.
    • Journal Title

      Mech.Dev. 121

      Pages: 729-738

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Phospholipase C-beta 2 as a mammalian taste signaling marker is expressed in the mutiple gustatory tissues of medaka fish, Oryzias latipes2004

    • Author(s)
      Yasuoka, A., Aihara, Y., Matsumoto, I., Abe.K.
    • Journal Title

      Mech.Dev. 121

      Pages: 985-989

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Neoculin as a new taste-modifying protein occurring in the fruit of Curculigo latifolia2004

    • Author(s)
      Shirasuka, Y., Nakajima, K., Asakura, T., Yamashita H., Yamamoto, A., Hata, S., Nagata, S., Abo, M., Sorimachi, H., Abe.K.
    • Journal Title

      Biosci.Biotechnol.Biochem. 68

      Pages: 1403-1407

    • NAID

      10013287069

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Gene expression profiling of cranial sensory ganglia that transmit food intake stimuli2004

    • Author(s)
      Matsumoto, I., Nakamura, S., Emori, Y., Arai, S., Abe.K.
    • Journal Title

      BioFactors 21

      Pages: 15-18

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Identification of 24 genes and 2 pseudo genes coding for olfactory receptors in Japanese loach, classified into 4 subfamilies : A putative evolutionary process for fish olfactory receptor genes by comprehensive phylogenetic analysis2004

    • Author(s)
      Irie-Kushiyama, S., Asano-Miyoshi, M., Suda, T., Abe.K., Emori, Y.
    • Journal Title

      Gene 325

      Pages: 123-135

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Identification of candidate genes involved in somatosensory functions of cranial sensory ganglia2004

    • Author(s)
      Matsumoto, I., Nagamatsu, N., Arai, S., Emori, Y., Abe.K.
    • Journal Title

      Mol.Brain Res. 126

      Pages: 98-102

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Analysis of the expression and localization of a LAP protein, human Scribble, in the normal and neoplatic epithelium of uterine cervix2004

    • Author(s)
      Nakagawa, S., Yano, T., Nakagawa, K., Tanizawa, S., Suzuki, Y., Yasugi, T., Huibregtse, J.M., Taketani, Y.
    • Journal Title

      British Journal of Cancer 90

      Pages: 194-199

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Identification of candidate genes involved in somatosensory functions of cranial sensory ganglia2004

    • Author(s)
      Matsumoto, I., Nagamatsu, N., Arai, S., Emori, Y., Abe, K.
    • Journal Title

      Mol.Brain Res. 126

      Pages: 98-102

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Gene expression profiling of cranial sensory ganglia that transmit food intake stimuli2004

    • Author(s)
      Matsumoto, I., Nakamura, S., Emori, Y., Arai, S., Abe, K.
    • Journal Title

      BioFactors 21

      Pages: 15-18

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Phospholipase C-beta 2 as a mammalian taste signaling marker is expressed in the mutiple gustatory tissues of medaka fish, Oryzias latipes2004

    • Author(s)
      Yasuoka, A., Aihara, Y., Matsumoto, I., Abe, K.
    • Journal Title

      Mech.Dev. 121

      Pages: 985-989

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Laminar organization of the developing lateral olfactory tract revealed by differential expression of cell recognition molecules2004

    • Author(s)
      Inaki K, Nishimura S, Nakashiba T, Itohara S, Yoshihara Y
    • Journal Title

      J.Comp.Neurol. 479

      Pages: 243-256

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Phospholipase C-beta 2 as mammalian taste signaling marker is expressed in the mutiple gustatory tissues of medaka fish, Oryzias latipes.2004

    • Author(s)
      Yasuoka, A.
    • Journal Title

      Mech.Dev. 121

      Pages: 985-989

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Mutations affecting the formation of posterior lateral line system in Medaka, Oryzias latipes.2004

    • Author(s)
      Yasuoka, A.
    • Journal Title

      Mech.Dev. 121

      Pages: 729-738

    • Related Report
      2004 Annual Research Report
  • [Journal Article] DNA microarray analyses of the effects of dietary proteins.2004

    • Author(s)
      Kato, H.
    • Journal Title

      BioFactors 21

      Pages: 11-13

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Aquaporin-11 knockout mice and polycystic kidney disease animals share a common mechanism of cyst formation.2003

    • Author(s)
      Okada, S.
    • Journal Title

      FASEB J. 22

      Pages: 3672-3684

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Crystal structure of neoculin : insights into its sweetness and taste-modifying activity.

    • Author(s)
      Shimizu-Ibuka
    • Journal Title

      J.Mol.Biol. (in press.)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Extracellular production of a heterodimetric protein, neoculin, with sweet-tasting and taste-modifying activities by Aspergillus oryzae.

    • Author(s)
      Nakajima, K.
    • Journal Title

      Appl.Environ.Microbiol. (in press.)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyses the β-subunit of coatomer complex, β-cop.

    • Author(s)
      Hata, S.
    • Journal Title

      J.Biol.Chem. (in press.)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Plant-specific insertions in the soybean aspartic proteinases, soyAP1 and soyAP2, perform different functions of vacuolar targeting.

    • Author(s)
      Terauchi, K.
    • Journal Title

      J.Plant Physiol. (in press.)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Group IIA phospholipase A2 is co-expressed with SNAP-25 in mature taste receptor cells of rat circumvallate papillae.

    • Author(s)
      Ooike, H.
    • Journal Title

      J.Comp.Neurol. (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Intake of soy protein isolate alters hepatic gene expression in rats.

    • Author(s)
      Tachibana, N.
    • Journal Title

      J.Agric.Food Chem. (in press)

    • Related Report
      2004 Annual Research Report
  • [Presentation] Taste Molecular Biology and New Food Chemistry2009

    • Author(s)
      Keiko Abe
    • Organizer
      Achems 2009 31st Annual Meeting
    • Place of Presentation
      Florida, USA
    • Year and Date
      2009-04-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Taste Molecular Biology and New Food Chemistry2009

    • Author(s)
      Keiko Abe
    • Organizer
      Achems 2009 31st Annual Meeting
    • Place of Presentation
      Sarasota, Florida, USA.
    • Year and Date
      2009-04-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Antioxidant Effect of Canadian Maple Syrup-Verification by Nutrigenomics2008

    • Author(s)
      Keiko Abe
    • Organizer
      カナダ農務省
    • Place of Presentation
      Canada
    • Year and Date
      2008-09-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 味覚修飾タンパク質はなぜ酸味を甘味に変えるのか一構造化学と分子生物学からのアプローチ2008

    • Author(s)
      阿部 啓子
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] モデル魚類の酸味受容機構の解析2008

    • Author(s)
      高木 陽介
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] PLCB2プロモーター誘導によるテタヌストキシン発現メダカの作出と摂食行動解析2008

    • Author(s)
      齋藤 佳奈
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 分子マーカーを用いたメダカの味神経中継核の探索2008

    • Author(s)
      藍原 祥子
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 単離味蕾細胞を用いた非TIR、非T2R発現細胞の分子マーカーの探索2008

    • Author(s)
      黒川 あずさ
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] ゼブラフィッシュ味覚受容体の細胞外ループへの変異導入による機能差異2008

    • Author(s)
      永井 俊匡
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヒト苦味受容体hTAS2R16のリガンド認識に及ぼす酸性物質添加効果2008

    • Author(s)
      櫻井 敬展
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヒト味覚受容体(hTIRs)細胞外領域の昆虫細胞発現系を用いた発現生産2008

    • Author(s)
      三坂 巧
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 酸味受容体候補PKDIL3/PKD2L1の発見とその解析2008

    • Author(s)
      石丸 喜朗
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 孤立化学感覚細胞における味覚関連遺伝子の発現プロフィール2008

    • Author(s)
      磨本 真
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] Pichia pastortsを用いた味覚修飾タンパク質ミラクリンの発現2008

    • Author(s)
      菅原 大嗣
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] ミラクリンの味覚修飾活性に関与するアミノ酸残基の特定とシミュレーションモデリング2008

    • Author(s)
      伊藤 圭祐
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] ネオクリンのpH依存的な味覚修飾活性の解析2008

    • Author(s)
      中島 健一朗
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] 橋結合腕傍核ニューロンの分子特性2008

    • Author(s)
      前田 尚廣
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Functional food science and genomics- Looking back and ahead-2008

    • Author(s)
      Keiko Abe
    • Organizer
      5th Nestle International Nutrition Symposium
    • Place of Presentation
      Lausanne, Switzerland
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Genomics for food functionality and Palatability2007

    • Author(s)
      Keiko Abe
    • Organizer
      5th Nestle International Nutrition Symposium
    • Place of Presentation
      Lausanne, Switzerland
    • Year and Date
      2007-10-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Genomics for food functionality and Palatability2007

    • Author(s)
      Keiko Abe
    • Organizer
      4th International Nutrition Symposium 2007
    • Place of Presentation
      Lausanne, Switzerland
    • Year and Date
      2007-10-23
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Nutrigenomics-Food functionality evaluation2007

    • Author(s)
      Keiko Abe
    • Organizer
      Recent Progress in Food Science and Engineering 2007
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2007-06-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Nutrigenomics -Food functionality evaluation2007

    • Author(s)
      Keiko Abe
    • Organizer
      Recent Progress in Food Science and Engineering 2007
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-06-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Genomics for Food Functionality and Palatability2007

    • Author(s)
      Keiko Abe
    • Organizer
      International Conference on Food Factors for Health Promotion
    • Place of Presentation
      Kyoto, Japan
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structural analysis of neoculin-Insights into its sweetness and tastemodifying activity2006

    • Author(s)
      Keiko Abe
    • Organizer
      3rd International Nutrition Symposium
    • Place of Presentation
      Lausanne, Switzerland
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Two families of candidate taste receptors in fishes2006

    • Author(s)
      Keiko Abe
    • Organizer
      4th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
    • Place of Presentation
      Fukuoka, Japan
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Neoculin as a new sweet protein with taste-modifying activity-Purification and X-ray crystallography2006

    • Author(s)
      Shimizu-Ibuka, A
    • Organizer
      231st ACS National Meeting of Sweetness and Sweeteners
    • Place of Presentation
      Atlanta, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structural analysis of neoculin-Insights into its sweetness and taste-modifying activity2006

    • Author(s)
      Keiko Abe
    • Organizer
      3rd International Nutrition Symposium
    • Place of Presentation
      Lausanne, Switzerland
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Neoculin as a new sweet protein with taste-modifying activity-Purification and X-ray crystallography2006

    • Author(s)
      Shimizu-Ibuka, A.
    • Organizer
      231st ACS National Meeting of Sweetness and Sweeteners
    • Place of Presentation
      Atlanta, USA.
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Developing Functional Foods through Nutrigenomics2005

    • Author(s)
      Keiko Abe
    • Organizer
      ILSI's 1st International Conference on Nutrigenomics
    • Place of Presentation
      Singapore, Singapore
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Aquaporin-9 is expressed in a subset of mucus-secreting goblet cells of the intestinal tract2005

    • Author(s)
      Okada, S.
    • Organizer
      Aquaporins 2005
    • Place of Presentation
      Brussels, Belgium
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Group IIA Phospholipase A2 is co-expressed with SNAP-25 in older taste receptor cells of rat circumvallate papillae2005

    • Author(s)
      Matsumoto, I.
    • Organizer
      the 25th Blankenese Conference on Signalling in Sensory Systems
    • Place of Presentation
      Hamburg, Germany
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DNA microarray analysis of cranial sensory ganglia identifies genes involved in somatosensation in craniofacial structures including orophalynx related to food intake2004

    • Author(s)
      Matsumoto, I.
    • Organizer
      ISOT/JASTS 2004 14th International Symposium on Olfaction and Taste
    • Place of Presentation
      Kyoto, Japan
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Sweetness and Sweeteners2007

    • Author(s)
      Shimizu-Ibuka, A., et. al.
    • Total Pages
      4
    • Publisher
      Amer.Chem.Soc.
    • Related Report
      2007 Annual Research Report
  • [Book] 化学と生物2007

    • Author(s)
      阿部 啓子, 松本 一朗
    • Total Pages
      6
    • Publisher
      学会出版センター
    • Related Report
      2007 Annual Research Report
  • [Book] 日本味と匂学会誌2007

    • Author(s)
      森田 悠治, 阿部 啓子
    • Total Pages
      6
    • Publisher
      日本味と匂学会
    • Related Report
      2007 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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