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glomerular sclerosis

Research Project

Project/Area Number 16109005
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Kidney internal medicine
Research InstitutionTokai University

Principal Investigator

ICHIKAWA Iekuni  Tokai University, 医学部, 教授 (80317768)

Co-Investigator(Kenkyū-buntansha) MATSUSAKA Taiji  東海大学, 医学部, 准教授 (50317749)
NIIMURA Fumio  東海大学, 医学部, 准教授 (30282750)
NAGATA Michio  筑波大学, 基礎医学系, 教授 (10192238)
Co-Investigator(Renkei-kenkyūsha) MOTOJIMA Masaru  東海大学, 医学部, 講師 (80468636)
Project Period (FY) 2004 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥107,380,000 (Direct Cost: ¥82,600,000、Indirect Cost: ¥24,780,000)
Fiscal Year 2008: ¥21,450,000 (Direct Cost: ¥16,500,000、Indirect Cost: ¥4,950,000)
Fiscal Year 2007: ¥21,450,000 (Direct Cost: ¥16,500,000、Indirect Cost: ¥4,950,000)
Fiscal Year 2006: ¥21,450,000 (Direct Cost: ¥16,500,000、Indirect Cost: ¥4,950,000)
Fiscal Year 2005: ¥20,930,000 (Direct Cost: ¥16,100,000、Indirect Cost: ¥4,830,000)
Fiscal Year 2004: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Keywordsポドサイト / 慢性腎不全 / 細胞周期 / レニン・アンギオテンシン / 糸球体硬化症 / 蛋白尿 / Angiotensin II / SV40 / megalin / トランスジェニックマウス / キメラマウス / GIV-1 / 糸球体上皮細胞 / ノックアウトマウス / Cre-loxPシステム / Megalin / VEGF / SV40T / コンディショナル・ターゲッティング
Research Abstract

慢性腎臓病は国民健康上の大きな問題であるが、腎臓のポドサイトという細胞の傷害が鍵になっている。ポドサイトは生後に増殖する事なく、一度失われると補充される事はない。我々は、ポドサイトの増加を新たな治療の方向性として、生体内でポドサイトの増殖を誘導させる実験を行った。その結果、ポドサイトの増殖は、脱分化とは不可分ではなく、可能である事を示した。また、多くの腎臓病において、ポドサイトの傷害の後、尿細管傷害が続発するが、その過程において、megalin によるタンパク質の再吸収が関与する事を明らかにした。さらに、Angiotensin II が腎臓病を増悪させるが、その機序を明らかにし、またAngiotensin の産生経路に新たな発見を得た。

Report

(6 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (65 results)

All 2009 2008 2007 2006 2005 2004 Other

All Journal Article (26 results) (of which Peer Reviewed: 17 results) Presentation (39 results)

  • [Journal Article] Genetic Podocyte Lineage Reveals Progressive Podocytopenia with Prietal Cell Hyperplasia in a Murine Model of Celluar/Collapsing Focal Segmental Glomerulosclerosis.2009

    • Author(s)
      Suzuki T, Matsusaka T, Nakayama M, Asano T, Watanabe T, Ichikawa I, Nagata M.
    • Journal Title

      Am J Pathol. 174(5) : (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fibrinogen That Appear in the Bowman's Space of Proteinuric Kidneys in vivo Activates Podocyte Toll-like Receptor 2 and 4 in vitro.2009

    • Author(s)
      Motojima M, Matsusaka T, Kon V, Ichikawa I.
    • Journal Title

      Nephron Experimental. (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] An essential role of the universal polarity protein, aPKClambda, on the maintenance of podocyte slit diaphragms2009

    • Author(s)
      Hirose T, Satoh D, Kurihara H, Kusaka C, Hirose H, Akimoto K, Matsusaka T, Ichikawa I, Noda T, Ohno s.
    • Journal Title

      PLoS ONE. 4(1)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic Podocyte Lineage Reveals Progressive Podocytopenia with Prietal Cell Hyperplasia in a Murine Model of Celluar/Collapsing Focal Segmental Glomerulosclerosis.2009

    • Author(s)
      Suzuki T, Matsusaka T, Nakayama M, Asano T, Watanabe T, Ichikawa I, Nagata M.
    • Journal Title

      Am J Pathol. 174(5)(in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibrinogen That Appear in the Bowman's Space of Proteinuric Kidneys in vivo Activates Podocyte Toll-like Receptor 2 and 4 in vitro.2009

    • Author(s)
      Motojima M, Matsusaka T, Kon V, Ichikawa I.
    • Journal Title

      Nephron Experimental (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria.2008

    • Author(s)
      Motoyoshi Y, Matsusaka T, Saito A, Pastan I, Willnow TE, Mizutani S, Ichikawa I.
    • Journal Title

      Kidney Int. 74(10)

      Pages: 1262-1269

    • NAID

      10026412041

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bmp in podocytes is essential for normal glomerular capillary formation.2008

    • Author(s)
      Ueda H, Miyazaki Y, Matsusaka T, Utsunomiya Y, Kawamura T, Hosoya T, Ichikawa I.
    • Journal Title

      J Am Soc Nephrol. 19(4)

      Pages: 685-694

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bmp in Podocytes Is Essential for Normal Glomerular Capillary Formation.2008

    • Author(s)
      Ueda H, Miyazaki Y, Matsusaka T, Utsunomiya Y, Kawamura T, Hosoya T, Ichikawa I.
    • Journal Title

      J Am Soc Nephrol 19(4)

      Pages: 685-694

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria.2008

    • Author(s)
      Motoyoshi Y, Matsusaka T, Saito A, Pastan I, Willnow TE, Mizutani s, Ichikawa I.
    • Journal Title

      Kidney Int. 74(10)

      Pages: 1262-1269

    • NAID

      10026412041

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bmp in Podocytes Is Essential for Normal Glomerular Capillary Formation2008

    • Author(s)
      Ueda H, Miyazaki Y, Matsusaka T, Utsunomiya Y, Kawamura T, Hosoya T, Ichikawa I.
    • Journal Title

      J Am Soc Nephrol (Epub Feb.)(in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin inhibition decreases progression of advanced atherosclerosis and stabilizes established atherosclerotic plaques.2007

    • Author(s)
      Suganuma E, Babaev VR, Motojima M, Zuo Y, Ayabe N, Fogo AB, Ichikawa I, Linton MF, Fazio S, Kon V.
    • Journal Title

      J Am Soc Nephrol. 18(8)

      Pages: 2311-2319

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of podocyte injury on glomerular development2007

    • Author(s)
      Ma J, Rossini M, Yang HC, Zuo Y, Fogo AB, Ichikawa I.
    • Journal Title

      Pediatr Res 62(4)

      Pages: 417-421

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HIV-1 genes vpr and nef synergistically damage podocytes, leading to glomerulosclerosis.2006

    • Author(s)
      Zuo Y, Matsusaka T, Zhong J, Ma J, Ma LJ, Hanna Z, Jolicoeur P, Fogo AB, Ichikawa I.
    • Journal Title

      J Am Soc Nephrol. 17(10)

      Pages: 2832-2843

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The renin-angiotensin system in the development of the congenital anomalies of the kidney and urinary tract.2006

    • Author(s)
      Niimura F, Kon V, Ichikawa I.
    • Journal Title

      Curr Opin Pediatr. 18(2)

      Pages: 161-6

    • Related Report
      2008 Final Research Report
  • [Journal Article] Inhibition of endogenous BMP in the glomerulus leads to mesangial matrix expansion.2006

    • Author(s)
      Miyazaki Y, Ueda H, Yokoo T, Utsunomiya Y, Kawamura T, Matsusaka T, Ichikawa I, Hosoya T.
    • Journal Title

      Biochem Biophys Res Commun. 340(2)

      Pages: 681-688

    • Related Report
      2008 Final Research Report 2005 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HIV-1 genes vpr and nef synergistically damage podocytes, leading to glomerulosclerosis.2006

    • Author(s)
      Zuo Y, Matsusaka T, Zhong J, Ma J, Ma LJ, Hanna Z, Jolicoeur P, Fogo AB, Ichikawa I.
    • Journal Title

      J Am Soc Nephrol 17・10

      Pages: 2832-2843

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A role of BMP in the development of glomerular sclerosis.2005

    • Author(s)
      Ueda H, Miyazaki Y, Yokoo T, Utsunomiya Y, Kawamura T, Matsusaka T, Ichikawa I, Hosoya T.
    • Journal Title

      Nephrology (Carlton). 10 Supple6

    • Related Report
      2008 Final Research Report 2005 Annual Research Report
  • [Journal Article] Podocyte damage damages podocytes : autonomous vicious cycle that drives local spread of glomerular sclerosis.2005

    • Author(s)
      Ichikawa I, Ma J, Motojima M, Matsusaka T.
    • Journal Title

      Curr Opin Nephrol Hypertens. 14(3)

      Pages: 205-210

    • Related Report
      2008 Final Research Report 2005 Annual Research Report
  • [Journal Article] Genetic engineering of glomerular sclerosis in the mouse via control of onset and severity of podocyte-specific injury.2005

    • Author(s)
      Matsusaka T, Xin J, Niwa S, Kobayashi K, Akatsuka A, Hashizume H, Wang QC, Pastan I, Fogo AB, Ichikawa I.
    • Journal Title

      J Am Soc Nephrol. 16(4)

      Pages: 1013-1023

    • Related Report
      2008 Final Research Report 2005 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Permanent genetic tagging of podocytes : fate of injured podocytes in a mouse model of glomerular sclerosis.2005

    • Author(s)
      Asano T, Niimura F, Pastan I, Fogo AB, Ichikawa I, Matsusaka T.
    • Journal Title

      J Am Soc Nephrol. 16(8)

      Pages: 2257-2262

    • Related Report
      2008 Final Research Report 2005 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of HIV-1 genes in podocytes alone can lead to the full spectrum of HIV-1-associated nephropathy.2005

    • Author(s)
      Zhong J, Zuo Y, Ma J, Fogo AB, Jolicoeur P, Ichikawa I, Matsusaka T.
    • Journal Title

      Kidney Int. 68(3)

      Pages: 1048-1060

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interruption of Glomerular Filtration Interrupts the Pathogenic Pathway from Podocyte Injury to Glomerular Sclerosis.2004

    • Author(s)
      Matsusaka T, Fogo A, Pastan I, Ichikawa I.
    • Journal Title

      J Am Soc Nephrol 15

    • Related Report
      2004 Annual Research Report
  • [Journal Article] HIV-1 Genes vpr and nef Synergistically Cause Podocyte Injury.2004

    • Author(s)
      Zuo Y, Zhong J, Ma J, Fogo A, Ichikawa I, Matsusaka T.
    • Journal Title

      J Am Soc Nephrol 15

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Identity of the Origin of Proliferating Visceral Epithelial Cells.2004

    • Author(s)
      Asano T, Matsusaka T, Fogo A, Ichikawa I.
    • Journal Title

      J Am Soc Nephrol 15

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The Role of BMP4 in Glomerulogenesis and Nephrogenesis.2004

    • Author(s)
      Ueda H, Miyazaki Y, Asano T, Matsusaka T, Utsunomiya Y, Kawamura T, Hosoya T, Ichikawa I.
    • Journal Title

      J Am Soc Nephrol 15

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Genetic engineering of glomerular sclerosis in the mouse via control of onset and of severity of podocyte-specific injury.

    • Author(s)
      Matsusaka T, Xin J, Niwa S, Kobayashi K, Akatsuka A, Hashizume H, Wang Q C, Pastan I, Fogo A, Ichikawa I.
    • Journal Title

      J Am Soc Nephrol (in press)

    • Related Report
      2004 Annual Research Report
  • [Presentation] Augmented Expression of Renal Angiotensinogen and Intrarenal Vascular Hypertrophy in Hypotensive Mice with Liver-Specific Inactivation of Angiotensinogen.2008

    • Author(s)
      Niimura F, Matsusaka T, Asano T, Ichikawa I, Nishiyama A.
    • Organizer
      American Society of Nephrology Renal Week 2008 Annual Meeting
    • Place of Presentation
      Philadelphia.
    • Related Report
      2008 Final Research Report
  • [Presentation] Nephrin Gene Expression in Podocytes Is Regulated by Histone Acetylation.2008

    • Author(s)
      Motojima M, Matsusaka T, Kon V, Ichikawa I.
    • Organizer
      American Society of Nephrology Renal Week 2008 Annual Meeting.
    • Place of Presentation
      Philadelphia.
    • Related Report
      2008 Final Research Report
  • [Presentation] Angiotensin II Receptor (ATI) Antagonist Protects Podocytes through Mechanism(s) Independent of AT1 on Podocytes.2008

    • Author(s)
      Matsusaka T, Niimura F, Asano T, Fogo A, Ichikawa I.
    • Organizer
      American Society of Nephrology Renal Week 2008 Annual Meeting.
    • Place of Presentation
      Philadelphia.
    • Related Report
      2008 Final Research Report
  • [Presentation] p21欠損実験腎炎マウスにおける上皮増殖病変ポドサイトタグ付け遺伝子改変マウスによる解析~壁側上皮由来の増殖.2008

    • Author(s)
      鈴木大成、松阪泰二、浅野貴子、市川家國、長田道夫.
    • Organizer
      第51回日本腎臓学会学術総会.
    • Place of Presentation
      福岡.
    • Related Report
      2008 Final Research Report
  • [Presentation] ポドサイトの修復と再生の可能性を求めて2008

    • Author(s)
      松阪泰二、市川家國.
    • Organizer
      第51回日本腎臓学会学術総会.
    • Place of Presentation
      福岡
    • Related Report
      2008 Final Research Report
  • [Presentation] p21欠損実験腎炎マウスにおける上皮増殖病変ポドサイトタグ付け遺伝子改変マウスによる解析〜壁側上皮由来の増殖2008

    • Author(s)
      鈴木大成, 松阪泰二, 浅野貴子, 市川家國, 長田道夫
    • Organizer
      第51回日本腎臓学会学術総会
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2008 Annual Research Report
  • [Presentation] Augmented Expression of Renal Angiotensinogen and Intrarenal Vascular Hypertrophy in Hypotensive Mice with Liver-Specific Inactivation of Angiotensinogen.2008

    • Author(s)
      Niimura F, Matsusaka T, Asano T, Ichikawa I, Nishiyama A
    • Organizer
      ASN Annual Meeting2008
    • Place of Presentation
      米国・フィラデルフィア
    • Related Report
      2008 Annual Research Report
  • [Presentation] Nephrin Gene Expression in Podocytes Is Regulated by Histone Acetylation.2008

    • Author(s)
      Motojima M, Matsusaka T, Kon V, Ichikawa l
    • Organizer
      ASN Annual Meeting2008
    • Place of Presentation
      米国・フィラデルフィア
    • Related Report
      2008 Annual Research Report
  • [Presentation] Podocyte-Derived VEGF Serves as Their Own Protective and Survival Factor In Vitro.2008

    • Author(s)
      Ma J, Yang H, Matsusaka T, Zuo Y, Fogo A, Ichikawa l
    • Organizer
      ASN Annual Meeting2008
    • Place of Presentation
      米国・フィラデルフィア
    • Related Report
      2008 Annual Research Report
  • [Presentation] Angiotensin II Receptor (ATI) Antagonist Protects Podocytes through Mechanism (s) Independent of AT1 on Podocytes2008

    • Author(s)
      Matsusaka T, Niimura F, Asano T, Fogo A, Ichikawa l
    • Organizer
      ASN Annual Meeting2008
    • Place of Presentation
      米国・フィラデルフィア
    • Related Report
      2008 Annual Research Report
  • [Presentation] Megalin Mediates Tubule Injury Induced by Proteinuria.2007

    • Author(s)
      Motoyoshi Y, Matsusaka T, Saito A, Willnow TE, Ichikawa I.
    • Organizer
      American Society of Nephrology Renal Week 2007 Annual Meeting
    • Place of Presentation
      San Francisco.
    • Related Report
      2008 Final Research Report
  • [Presentation] Nphs1-Cre/ROSA26-loxP Genetic Podocyte Tagging Revealed Parietal Cell Proliferation in p21 Deficient Mice with Experimental Glomerulonephritis.2007

    • Author(s)
      Suzuki S, Matsusaka T, Asano T, Ichikawa I, Nagata M.
    • Organizer
      American Society of Nephrology Renal Week 2007 Annual Meeting.
    • Place of Presentation
      San Francisco.
    • Related Report
      2008 Final Research Report
  • [Presentation] Identification of Activators of Nephrin Gene Promoter.2007

    • Author(s)
      Motojima M, Matsusaka T, Kon V, Ichikawa I.
    • Organizer
      American Society of Nephrology Renal Week 2007 Annual Meeting.
    • Place of Presentation
      San Francisco.
    • Related Report
      2008 Final Research Report
  • [Presentation] Megalin Mediates Tubular Injury Secondary to Glomerular Diseases.2007

    • Author(s)
      Motoyoshi Y, Matsusaka T, Ichikawa I.
    • Organizer
      14th Congress of the International Pediatric Nephrology Association.
    • Place of Presentation
      Budapest
    • Related Report
      2008 Final Research Report
  • [Presentation] 慢性腎臓病の非免疫学的進行機序に関する研究の流れと未来展望.2007

    • Author(s)
      市川家國
    • Organizer
      第50回日本腎臓学会学術総会.
    • Place of Presentation
      浜松.
    • Related Report
      2008 Final Research Report
  • [Presentation] 糸球体傷害に続発する尿細管傷害にはmegalinによる蛋白質再吸収が関与する2007

    • Author(s)
      元吉八重子、松阪泰二、市川家國.
    • Organizer
      第50回日本腎臓学会学術総会
    • Place of Presentation
      浜松.
    • Related Report
      2008 Final Research Report
  • [Presentation] 正常なポドサイトの数を増加させる事が可能である.2007

    • Author(s)
      松阪泰二、市川家國
    • Organizer
      第50回日本腎臓学会学術総会.
    • Place of Presentation
      浜松.
    • Related Report
      2008 Final Research Report
  • [Presentation] 慢性腎臓病の非免疫学的進行機序に関する研究の流れと未来展望2007

    • Author(s)
      市川 家國
    • Organizer
      第50回日本腎臓学会学術総会
    • Place of Presentation
      静岡県浜松市
    • Related Report
      2007 Annual Research Report
  • [Presentation] 糸球体傷害に続発する尿細管傷害にはmeaglinによる蛋白質再吸収が関与する2007

    • Author(s)
      元吉 八重子、松阪 泰二、市川 家國
    • Organizer
      第50回日本腎臓学会学術総会
    • Place of Presentation
      静岡県浜松市
    • Related Report
      2007 Annual Research Report
  • [Presentation] Megalin Mediates Tubular Injury Secondary to Glomerular Diseases.2007

    • Author(s)
      Motoyoshi Y, Matsusaka T, Ichikawa I.
    • Organizer
      14th Congress of the International Pediatric Nephrology Association
    • Place of Presentation
      ハンガリー・ブダペスト
    • Related Report
      2007 Annual Research Report
  • [Presentation] Megalin Mediates Tubule Injury Induced by Proteinuria2007

    • Author(s)
      Motoyosh i Y, Matsusaka T, Saito A, Willnow TE, Ichikawa I.
    • Organizer
      ASN Annual Meeting 2007
    • Place of Presentation
      米国・サンフランシスコ
    • Related Report
      2007 Annual Research Report
  • [Presentation] Inducible Podocyte-Specific Overexpression of VEGF in Mice2007

    • Author(s)
      Ma J, Matsusaka T, Fogo AB, Ichikawa I
    • Organizer
      ASN Annual Meeting 2007
    • Place of Presentation
      米国・サンフランシスコ
    • Related Report
      2007 Annual Research Report
  • [Presentation] Nphs1-Cre/ROSA26-loxP Genetic Podocyte Tagging Revealed Parietal Cell Proliferation in p21 Deficient Mice with Experimental Glomerulonephritis.2007

    • Author(s)
      Suzuki S, Matsusaka T, Asano T, Ichikawa I, Nagata M
    • Organizer
      ASN Annual Meeting 2007
    • Place of Presentation
      米国・サンフランシスコ
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of Activators of Nephrin Gene Promoter.2007

    • Author(s)
      Motojima M, Matsusaka T, Kon V, Ichikawa I
    • Organizer
      ASN Annual Meeting 2007
    • Place of Presentation
      米国・サンフランシスコ
    • Related Report
      2007 Annual Research Report
  • [Presentation] Experimental attempt to increase podocyte number in vivo.2006

    • Author(s)
      Matsusaka T, Ichikawa I, Kopp J.
    • Organizer
      American Society of Nephrology Renal Week 2006 Annual Meeting.
    • Place of Presentation
      San Diego.
    • Related Report
      2008 Final Research Report
  • [Presentation] Toll-like receptors in podocytes modulate response to injury.2006

    • Author(s)
      Motojima M, Matsusaka T, Ichikawa I.
    • Organizer
      American Society of Nephrology Renal Week 2006 Annual Meeting.
    • Place of Presentation
      San Diego.
    • Related Report
      2008 Final Research Report
  • [Presentation] ポドサイトにおけるアンジオテンシンの役割2006

    • Author(s)
      浅野貴子、市川家國、新村文男、松阪泰二.
    • Organizer
      第41回日本小児腎臓病学会学術集会
    • Place of Presentation
      名古屋.
    • Related Report
      2008 Final Research Report
  • [Presentation] BMP4の糸球体血管係蹄発生に対する調節機構.2006

    • Author(s)
      上田裕之、宮崎陽一、松阪泰二、宇都宮保典、川村哲也、細谷龍男、市川家國.
    • Organizer
      第49回日本腎臓学会学術総会.
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] ポドサイト再生の試み.2006

    • Author(s)
      松阪泰二、市川家國.
    • Organizer
      第49 回日本腎臓学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Dual Effect of an α-Actinin-4 Gene Mutation on Podocyte Injury.2005

    • Author(s)
      Matsusaka T, Fogo A, Ichikawa I.
    • Organizer
      American Society of Nephrology Renal Week 2005 Annual Meeting.
    • Place of Presentation
      Philadelphia
    • Related Report
      2008 Final Research Report
  • [Presentation] 糸球体病変が進行性に転じる際の上皮障害の役割.2005

    • Author(s)
      市川家國.
    • Organizer
      第35 回日本腎臓学会東部学術集会.
    • Place of Presentation
      新潟.
    • Related Report
      2008 Final Research Report
  • [Presentation] Interruption of Glomerular Filtration Interrupts the Pathogenic Pathway from Podocyte Injury to Glomerular Sclerosis.2004

    • Author(s)
      Matsusaka T, Fogo A, Pastan I, Ichikawa I.
    • Organizer
      American Society of Nephrology Renal Week 2004 Annual Meeting.
    • Place of Presentation
      Saint Louis.
    • Related Report
      2008 Final Research Report
  • [Presentation] Identity of the Origin of Proliferating Visceral Epithelial Cells2004

    • Author(s)
      Asano T, Matsusaka T, Fogo A, Ichikawa I.
    • Organizer
      American Society of Nephrology Renal Week 2004 Annual Meeting
    • Place of Presentation
      Saint Louis.
    • Related Report
      2008 Final Research Report
  • [Presentation] The Role of BMP4 in Glomerulogenesis and Nephrogenesis2004

    • Author(s)
      Ueda H, Miyazaki Y, Asano T, Matsusaka T, Utsunomiya Y, Kawamura T, Hosoya T, Ichikawa I.
    • Organizer
      American Society of Nephrology Renal Week 2004 Annual Meeting.
    • Place of Presentation
      Saint Louis
    • Related Report
      2008 Final Research Report
  • [Presentation] Analysis of Podocyte Injury Using Genetically Altered Mice2004

    • Author(s)
      Ichikawa I.
    • Organizer
      American Society of Nephrology Renal Week 2004 Annual Meeting
    • Place of Presentation
      Saint Louis.
    • Related Report
      2008 Final Research Report
  • [Presentation] HIV-1 genes vpr and nef synergistically cause podocyte injury.2004

    • Author(s)
      Zuo Y, Zhong J, Ma J, Fogo AB, Ichikawa I, Matsusaka T.
    • Organizer
      American Society of Nephrology Renal Week 2004 Annual Meeting
    • Place of Presentation
      Saint Louis.
    • Related Report
      2008 Final Research Report
  • [Presentation] Podocyte傷害と腎硬化2004

    • Author(s)
      松阪泰二、市川家國
    • Organizer
      第47回日本腎臓学会学術総会.
    • Place of Presentation
      宇都宮.
    • Related Report
      2008 Final Research Report
  • [Presentation] 傷害を受けたpodocyteの運命の追跡2004

    • Author(s)
      浅野貴子、松阪泰二、新村文男、市川家國.
    • Organizer
      第47回日本腎臓学会学術総会
    • Place of Presentation
      宇都宮.
    • Related Report
      2008 Final Research Report
  • [Presentation] BMP4による糸球体形態形成の調節機構2004

    • Author(s)
      上田裕之、宮崎陽一、浅野貴子、松阪泰二、宇都宮保典、川村哲也、細谷龍男、市川家國
    • Organizer
      第47回日本腎臓学会学術総会
    • Place of Presentation
      宇都宮
    • Related Report
      2008 Final Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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