Analysis of molecular biology of epilepsy

• Project/Area Number: 16109006
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Neurology
• Research Institution: Hirosaki University
• Principal Investigator: KANEKO Sunao Hirosaki University, 大学院・医学研究科, 教授 (40106852)
• Co-Investigator(Kenkyū-buntansha): WADA Kazumaru 弘前大学, 大学院・保健学研究科, 教授 (60241486) ; OKADA Motohiro 三重大学, 大学院・医学系研究科, 教授 (10281916) ; YASUI-FURUKORI Norio 弘前大学, 医学部附属病院, 講師 (20333734) ; SHIMIZU Toshio 弘前大学, 大学院・理工学研究科, 教授 (00110750) ; KOJIMA Toshio 理化学研究所, ゲノム情報比較解析研究チーム, チームリーダー (00311340) ; UENO Shinya 弘前大学, 大学院・医学研究科, 教授 (00312158) ; FUKUSAWA Masashi 弘前大学, 農学生命科学部, 准教授 (10231557) ; NAKAGAWA Kazuko 熊本大学, 大学院・医学薬学研究部, 教授 (20284747) ; HIROSE Shinichi 福岡大学, 医学部, 教授 (60248515) ; YAMAKAWA Kazuhiro 理化学研究所, 神経遺伝研究チーム, チームリーダー (30241235) ; 若林 孝一 弘前大学, 大学院・医学研究科, 教授 (50240768) ; 佐藤 敬 弘前大学, 医学部, 教授 (20125438)
• Co-Investigator(Renkei-kenkyūsha): SATOH Kei 弘前大学, 大学院・医学研究科, 教授 (20125438) ; TSUJI Shoji 東京大学, 医学部附属病院, 教授 (70150612) ; KUWANO Ryozo 新潟大学, 脳研究所, 准教授 (20111734) ; ARAKI Kimi 熊本大学, 発生医学研究センター, 准教授 (90211705) ; WAKABAYASHI Koichi 弘前大学, 大学院・医学研究科, 教授 (50240768)
• Project Period (FY): 2004 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥119,860,000 (Direct Cost: ¥92,200,000、Indirect Cost: ¥27,660,000); Fiscal Year 2008: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000); Fiscal Year 2007: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000); Fiscal Year 2006: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000); Fiscal Year 2005: ¥23,140,000 (Direct Cost: ¥17,800,000、Indirect Cost: ¥5,340,000); Fiscal Year 2004: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
• Keywords: ゲノム / シグナル伝達 / 神経科学 / 脳神経疾患 / 遺伝子 / 脳神経学 / 脳神経疾愚 / てんかん / 個別化治療 / Epilepsy / gene / polymorohism / CYP / ion channel / receptor / treatment / transporter

Research Abstract

(1)各種てんかん類型の責任遺伝子を同定し、モデル動物の基準を満たす世界初のヒトてんかん遺伝子導入モデル動物作出に成功した。このラットを用い、分子病態を解析し、病態補正の可能性、その臨界期の存在を明らかにし、根治療法開発への突破口を開いた。(2)遺伝情報から最適の抗てんかん薬(AED)の種類と至適量を選択する個別化治療開発の基本フレームを提案した。(3)てんかんの遺伝子診断用DNA chip(プロトタイプ)を世界に先駆けて開発した。

Research Products

• [Journal Article] Physico-chemical property changes of amino acid residue accompanied with missense mutations in SCN1A affect the epilepsy phenotype severity (2009)
  • Author(s): Kanai K, Yoshida S, Hirose S, Oguni H, Kuwabara S, Sawai S, Hiraga A, Fukuma G, Iwasa H, Kojima T, and Kaneko S.
  • Journal Title: JMG2009 (in press)
  • Peer Reviewed
• [Journal Article] Lack of potassium current in W309R mutant KCNQ3 channel causing benign familial neonatal convulsions (BFNC) (2009)
  • Author(s): Sugiura Y, Nakatsu F, Hiroyasu K, Ishii A, Hirose S, Okada M, Jibiki I, Ohno H, Kaneko S, Ugawa Y.
  • Journal Title: EpilepsyRes 84(1) Pages: 82-5
  • Peer Reviewed
• [Journal Article] Sequence Selection for Multiple Alignments of Transmembrane Proteins (2009)
  • Author(s): Nishio T, Ohta T, Kaneko S, and Shimizu T.
  • Journal Title: Information 12 Pages: 235-42
  • Peer Reviewed
• [Journal Article] Lack of potassium current in W309R mutant KCNQ3 channel causing benign familial neonatal convulsions (BFNC) (2009)
  • Author(s): Sugiura Y, Nakatsu F, Hiroyasu K, Ishii A, Hirose S, Okada M, Jibiki I, Ohno H, Kaneko S, Ugawa Y.
  • Journal Title: Epilepsy Res (in press)
  • Peer Reviewed
• [Journal Article] Topiramate and zonisamide prevent paradoxical intoxication induced by carbamazepine and phenytoin (2009)
  • Author(s): Yamamura S, Hamaguchi T, Ohoyama K, Sugiura Y, Suzuki D, Kanehara S, Nakagawa M, Motomura E, Matsumoto T, Tanii H, Shiroyama T, Okada. M.
  • Journal Title: Epilepsy Res (in press)
  • Peer Reviewed
• [Journal Article] Effects of zotepine on extracellular levels of monoamine, GABA and glutamate in rat prefrontal cortex (2009)
  • Author(s): Yamamura S, Ohoyama K, Hamaguchi T, Nakagawa M, Suzuki D, Matsumoto T, Motomura E, Tanii H, Shiroyama T, Okada M
  • Journal Title: Br J Pharmacol (in press)
  • Peer Reviewed
• [Journal Article] Effects of zonisamide on neurotransmitter release associated with inositol triphosphate receptors (2009)
  • Author(s): Yamamura S, Saito. H, Suzuki N, kashimoto S, Hamaguchi H, Ohoyama K, Suzuki D, Kanehara S, Nakagawa M, Shiroyama T, Okada M.
  • Journal Title: Neurosci Lett (In press)
  • Peer Reviewed
• [Journal Article] A de novo KCNQ2 mutation detected in non-familial benign neonatal convulsions (2009)
  • Author(s): Ishii A, Fukuma G, Uehara. A, Miyajima T, Makita Y, Hamachi A, Yasukochi M, Inoue T, Yasumoto S, Okada M, Kaneko S, Mitsudome A, Hirose S.
  • Journal Title: Brain Dev 31(1) Pages: 27-33
  • NAID: 10025578186
  • Peer Reviewed
• [Journal Article] DSCAM deficiency causes loss of pre-inspiratoru neuron synchroneity and perinatal death (2009)
  • Author(s): Amano K, Fujii M, Arata S, Tojima T, Ogawa M, Shimohata A, Furuichi T, Itohara S, Kamiguchi H, Korenberg J. R, Arata A, Yamakawa K.
  • Journal Title: J Neurosci 29(9) Pages: 2984-96
  • Peer Reviewed
• [Journal Article] Efhcl deficiency causes spontaneous myoclonus and increasedse izure susceptibility (2009)
  • Author(s): Suzuki T, Miyamoto H, Nakahari T, Inoue I, Suemoto T, Jiang B, Hirota Y, Itohara S, Saido TC, Tsumoto T, Sawamoto K, Hensch TK, Delgado-Escueta AV, and Yamakawa K.
  • Journal Title: Hum. Mol Genet 18(6) Pages: 1099-1109
  • Peer Reviewed
• [Journal Article] Novel de novo splice-site mutation of SCN1A in a patient with partial epilepsy with febrile seizures plus (2009)
  • Author(s): Kumakura A, Ito M, Hata D, Oh N, Kurahashi H, Wang JW, Hirose S.
  • Journal Title: Brain Dev 31(2) Pages: 179-82
  • NAID: 10025578995
  • Peer Reviewed
• [Journal Article] Two novel CYP2D6*10 haplotypes as possible causes of a poor metabolic phenotype in Japanese (2009)
  • Author(s): Matsunaga M, Yamazaki H, Kiyotani K, Iwano S, Saruwatari J, Nakagawa K, Soyama A, Ozawa S, Sawada J, Kashiyama E, Kinoshita M, Kamataki T.
  • Journal Title: Drug Metab Dispos 37(4) Pages: 699-701
  • Peer Reviewed
• [Journal Article] Sequence Sehection for Multiple Alignments of Transmembrane Proteins (2009)
  • Author(s): Nishio T, Ohta T, Kaneko S, and Shimizu T.
  • Journal Title: Information 12 Pages: 235-42
  • Peer Reviewed
• [Journal Article] Glutathione S-transferase Al polymorphism as a risk factor for smoking-related type 2 diabetes in Japanese (2009)
  • Author(s): Oniki K, Umemoto Y, Nagata R, Hori M, Mihara S, Marubayashi T, Nakagawa K.
  • Journal Title: Toxicol Lett 178 Pages: 143-5
  • Peer Reviewed
• [Journal Article] Association between SCN1A polymorphism and carbamazepine-resistant epilepsy (2008)
  • Author(s): Abe T, Seo T, Ishitsu T, Nakagawa T, Hori M, Nakagawa K.
  • Journal Title: Br J Clin Pharmacol 66 Pages: 304-307
  • Peer Reviewed
• [Journal Article] Population estimation of the effects of cytochrome P450 2C19 and 3A5 polymorphisms on zonisamide clearance (2008)
  • Author(s): Okada Y, Seo T, Wanibuchi A, HashimotoN, Higa Y, Ishitsu T, Nakagawa K.
  • Journal Title: Ther Drug Monit 30 Pages: 540-543
  • Peer Reviewed
• [Journal Article] Epilepsy Genetic Study Group Japan. Genome-wide identification of febrile seizure and releted epilepsy phenotype loci (2008)
  • Author(s): Yoshida S, Miyashita A, Kuwano R, Kojima T, Sasaki T, Zhu G, Kanai K,Fujita H, Hirosa S, Kaneko S.
  • Journal Title: Epilepsy & Seizure 1(1) Pages: 30-9
  • Peer Reviewed
• [Journal Article] Development of individualized medicine for epilepsy based on genetic information (2008)
  • Author(s): Kaneko S, Yoshida S, Kanai K, Yasui-Furukori N, & Iwasa H.
  • Journal Title: ExpertRevClin Pharmacol 1(5) Pages: 661-81
  • Peer Reviewed
• [Journal Article] Rats harboring S284L Chrna4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype (2008)
  • Author(s): Zhu G, Okada M, Yoshida S, Ueno S, Mori F, Takahata T, Saito R, Miura Y, Kishi A, Tomiyama M, Sato A, Kojima T, Fukuma G, Wakabayashi K, Hase K, Ohno H,Kijima H, Takano Y, Mitsudome A,Kaneko S, Hirose S.
  • Journal Title: J Neurosci 28(47) Pages: 12465-76
  • Peer Reviewed
• [Journal Article] Microchromosomal deletions involving SCN1A and adjacent genes ins evere myoclonic epilepsy in infancy (2008)
  • Author(s): Wang JW, Kurahashi H, Ishii A, Kojima T, Ohfu M, Inoue T, Ogawa A, Yasumoto S, Oguni H, Kure S, Fujii T, Ito M, Okuno T, Shirasaka Y, Natsume J, Hasegawa A, Konagaya A, Kaneko S, Hirose S.
  • Journal Title: Epilepsia 49(9) Pages: 1528-34
  • Peer Reviewed
• [Journal Article] Novel mutations in Myoclonin1/EFHC1 in sporadic and tamilial juvenile myoclonic epilepsy (2008)
  • Author(s): Medina MT, Suzuki T, Alonso ME, Duron RM, Matinaz IE, Bailey JN, Bai D, Inoue Y, Yoshimura I, Kaneko S, Montoya MC, Ochoa AJ, Tanaka M, Machado-Salas J, Fujimoto S, Ito M, Hamano S, Sugita K, Ueda Y, Osawa M, Oguni H, Rubio-Donnadieu F, Yamakawa K, and Deidacio-Escueta AV.
  • Journal Title: Neurology 70(22) Pages: 2137-44
  • Peer Reviewed
• [Journal Article] Association between glutathione S-transferase A1, M1 and T1 polymorphisms and hypertension (2008)
  • Author(s): Oniki K, Hori M, Takata K, Yokoyama T, Mihara S, Marubayashi T. Nakagawa K.
  • Journal Title: Pharmacogenet Genomics 18 Pages: 275-7
  • Peer Reviewed
• [Journal Article] Glutathione-S-transferase (GST) M1 null genotype and combined GSTM1 and GSTT1 null genotypes are risk factors for elevated serum γ-glutamyltransferase in valproic acid-treated patients (2008)
  • Author(s): Fukushima Y, Seo T, Hashimoto N, Higa Y, Ishitsu T, Nakagawa K.
  • Journal Title: Clin Chim Acta 389 Pages: 98-102
  • Peer Reviewed
• [Journal Article] ABCC2 haplotype is not associated with drug-resistant epilepsy (2008)
  • Author(s): Seo T, Ishitsu T, Oniki K, Abe T, Shuto T, Nakagawa K.
  • Journal Title: J Pharm Pharmacol 60 Pages: 631-5
  • Peer Reviewed
• [Journal Article] Potential relationships between transaminase abnormality and valproic acid clearance or serum carnitine concentrations in Japanese epileptic patients (2008)
  • Author(s): Goto S, Seo T, Hagiwara T, Ueda K, Yamauchi T, Nagata S, Ando Y, Ishitsu T, Nakagawa K.
  • Journal Title: J Pharm Pharmacol 60 Pages: 267-72
  • Peer Reviewed
• [Journal Article] Interactive effect of smoking and paraoxonase-1 genotype on the lung function decline (2008)
  • Author(s): Seo T, Pahwa P, McDuffie HH, Y, Nakada N, Goto S, Ghosh S, Nakagawa K.
  • Journal Title: Ann Epidemiol 18 Pages: 330-4
  • Peer Reviewed
• [Journal Article] Cytochrome P450 2C19 polymorphisms have an impact on the efficacy of clobazam therapy (2008)
  • Author(s): Seo T, Nagata R, Ishitsu T, Takaishi C, Hori M, Nakagawa K.
  • Journal Title: Pharmacogenomics 9 Pages: 527-37
  • Peer Reviewed
• [Journal Article] Population estimation of the effects of cytochrome P450 2C19 and 3A5 polymorphisms on zonisamide clearance (2008)
  • Author(s): Okada Y, Seo T, Wanibuchi A, Hashimoto N, Higa Y, Ishitsu T, Nakagawa K.
  • Journal Title: Ther Drug Monit 30 Pages: 540-3
  • Peer Reviewed
• [Journal Article] Genome-wide identification of febrile seizure and related epilepsy phenotype loci (2008)
  • Author(s): Yoshida S, Miyashita A, Kuwano R, Kojima T, Sasaki T, Zhu G, Kanai K, Fujita H, Hirosa S, Kaneko S, & Epilepsy Genetic Study Group Japan.
  • Journal Title: Epilepsy & Seizure 1(1) Pages: 30-9
  • NAID: 130000061687
  • Peer Reviewed
• [Journal Article] Development of individualized medicine for epilepsy based on genetic information (2008)
  • Author(s): Kaneko S, Yoshida S, Kanai K, Yasui-Furukori N, & Iwasa H.
  • Journal Title: Expert Rev Clin Pharmacol 1(5) Pages: 661-81
  • Peer Reviewed
• [Journal Article] Rats harboring S284L Chrna4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype (2008)
  • Author(s): Zhu G, Okada M, Yoshida S, Ueno S, Mori F, Takahata T, Saito R, Miura Y, Kishi A, Tomiyama M, Sato A, Kojima T, Fukuma G, Wakabayashi K, Hase K, Ohno H, Kijima H, Takano Y, Mitsudome A, Kaneko S, Hirose S.
  • Journal Title: J Neurosci 28(49) Pages: 12465-76
  • Peer Reviewed
• [Journal Article] Bemegride lengthens seizure duration electric convulsive therepy in a schizophrenic patients with increased seizure threshold (2008)
  • Author(s): Katagai H, Yasui-Furukori N, Kikuchi A, Kaneko S.
  • Journal Title: J ECT (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Memory trace dependence onnumber of stimuli in magnetic mismatch negativity (2008)
  • Author(s): Matsuoka T, Yabe H, Asai R, Hara E, Kaneko S.
  • Journal Title: Neuroreport 19(10) Pages: 1003-7
  • Peer Reviewed
• [Journal Article] Comparative in vivo bioequivalence and in vitro dissolution of two valproic acid sustained-release formulation (2008)
  • Author(s): Fujii A, Yasui-Furukori N, Nakagami T, Niioka T, Saito M, Sato Y, and Kaneko S.
  • Journal Title: Design, Development & Therapy Drug 2 Pages: 139-44
  • Peer Reviewed
• [Journal Article] Dipole Source Analysis of Temporal Slow Waves in the Elderly (2008)
  • Author(s): Motomura E, Inui K, Ogawa H, Nakase S, Hamanaka K, Honda T, Shiroyama T, Matsumoto T, Komori T, Okada M, Kakigi R.
  • Journal Title: Neuropsychobiology 57 Pages: 9-13
  • Peer Reviewed
• [Journal Article] Associations between psychotic-like experiences and mental health status and other psychopathologies among Japanese early teens (2008)
  • Author(s): Nishida A, Tanii H, Nishimura Y, Kajiki N, Inoue K, Okada M, Sasaki T, Okazaki Y.
  • Journal Title: Schizophr Res 99 Pages: 125-33
  • Peer Reviewed
• [Journal Article] A functional near-infrared spectroscopy study on the basic word order in Japanese (2008)
  • Author(s): Nishimura Y, Sugisaki K, Hattori N, Inokuchi Y, Nishimura Y, Ogawa M, Okada M, Okazaki Y, Taki W, Yamamoto T, Yoshida E, Avano S.
  • Journal Title: Neuroreport 19 Pages: 915-19
  • Peer Reviewed
• [Journal Article] Caffeine-inducible ATP release is mediated by Ca^<2+>-signal trans ducins system from the endonlasmic reticulum to mitochondria (2008)
  • Author(s): Katsuragi T, Sato C, Ueho S, Segawa M, and Migita K.
  • Journal Title: Naunyn Schmiedebergs Arch Pharmac ol 387(1) Pages: 93-101
  • Peer Reviewed
• [Journal Article] Developmental changes in KCNQ2 and KCNQ3 expression in human brain : possible contribution to the age-dependent etiology of benign familial neonatal convulsions (2008)
  • Author(s): Kanaumi T, Takashima S, Iwasaki H, Itoh M, Mitsudome A, Hirose S.
  • Journal Title: Brain Dev 30(5) Pages: 362-9
  • NAID: 10025577003
  • Peer Reviewed
• [Journal Article] Altered KCNQ3 potassium channel function caused by the W309R pore-helix mutation found in human epilepsy (2008)
  • Author(s): Uehara A, Nakamura Y, Shioya T, Hirose S, Yasukochi M, Uehara K.
  • Journal Title: J Membr Biol 222(2) Pages: 55-63
  • Peer Reviewed
• [Journal Article] Microchromosomal deletions involving SCN1A and adjacent genes in severe myoclonic epilepsy in infancy (2008)
  • Author(s): Wang JW, Kurahashi H, Ishii A, Kojima T, Ohfu M, Inoue T, Ogawa A, Yasumoto S, Oguni H, Kure S, Fujii T, Ito M, Okuno T, Shirasaka Y, Natsume J, Hasegawa A, Konagaya A, Kaneko S, Hirose S.
  • Journal Title: Epilepsia 49(9) Pages: 1528-34
  • Peer Reviewed
• [Journal Article] A new family of transcription factors (2008)
  • Author(s): Yamada Y, Wang H. Y, Fukuzawa M, Barton G. J. and Williams, JG
  • Journal Title: Development 135 Pages: 3093-101
  • Peer Reviewed
• [Journal Article] Novel mutations in Myocloninl/EFHC1 in sporadic and tamilial juvenile myoclonic epilepsy (2008)
  • Author(s): Medina MT, Suzuki T, Alonso ME, Duron RM, Matinaz IE, Bailey JN, Bai D, Inoue Y, Yoshimura I, Kaneko S, Montoya MC, Ochoa AJ, Tanaka M, Machado-Salas J, Fujimoto S, Ito M, Hamano S, Sugita K, Ueda Y, Osawa M, Oguni H, Rubio-Donnadieu F, Yamakawa K, and Deidacio-Escueta AV.
  • Journal Title: Neurology 70(22 pt 2) Pages: 2137-44
  • Peer Reviewed
• [Journal Article] Monozygotic twins with severe myoclonic epilepsy in infancy discordant for clinical features (2008)
  • Author(s): Miyama S, Goto T, Inoue Y, Yamakawa K.
  • Journal Title: Pediat Neurol 39(2) Pages: 120-2
  • Peer Reviewed
• [Journal Article] Sequential expression of Efhcl/myocloninl in choroid plexus and ependymal cell cilia (2008)
  • Author(s): Suzuki T, Inoue I, Yamagata T, Morita N, Furuichi T, Yamakawa K.
  • Journal Title: Biochem Biophys Res Commun 367 Pages: 226-33
  • Peer Reviewed
• [Journal Article] Association study between the Down syndrome cell adhesion molecule (DSCAM) gene and bipolar disorder (2008)
  • Author(s): Amano K, Yamada K, Iwayama Y, Detera-Wadleigh SD, Hattori E, Toyota T, Tokunaga K, Yoshikawa T, Yamakawa K.
  • Journal Title: Psychiatr Genet 18 Pages: 1-10
  • Peer Reviewed
• [Journal Article] Performance Evaluation of Loop-Structured-Computer by Applying Pairwise Seauence Alignment (2008)
  • Author(s): Ichijo K, Kikuchi N, Yoshioka Y, and Shimizu T.
  • Journal Title: Information 11 Pages: 351-62
  • Peer Reviewed
• [Journal Article] Micro chromosomal deletions involving SCN1A and adjacent genes in severe myoclonic epilepsy in infancy. (2008)
  • Author(s): Wang, J., Kurahashi, H., Ishii, A., Kojima, T., Ohfu, T., Inoue, T., Ogawa, A., Yasumoto S., Oguni, H., Kure, T., Fujii, T., Ito, M., Okuno T., Shirasaka, Y., Nakatsu, J., Hasegawa, A., Konagaya, A., Kaneko, S. & Hirose S.
  • Journal Title: Epilepsia (in press)
  • Peer Reviewed
• [Journal Article] New-onset diabetic ketoacidosis in a schizophrenic patients with multiple autoimmune during treatment with risperidone. (2008)
  • Author(s): Sato, Y., Yasui-Furukori, N. & Kaneko, S.
  • Journal Title: Prog. Neuro-Psychopharmacol. Biol. 32 Pages: 577-578
  • Peer Reviewed
• [Journal Article] Carbamazepine prevents breakdown of neurotransmitter release induced by hyperactivation of ryanodine receptor (2007)
  • Author(s): Yoshida S, Okada M, Zhu G, Kaneko S.
  • Journal Title: Neuropharmacology 52(7) Pages: 1538-46
  • Peer Reviewed
• [Journal Article] Mutational analysis of CACNA1G in idiopathic generalized epilepsy. Mutation in brief #962.Online (2007)
  • Author(s): Singh B, Monteil A, Bidaud I, Sugimoto Y, Suzuki T, Hamano S, Oguni H, Osawa M, Alonso ME, Delgado-Escueta AV, Inoue Y, Yasui-Furukori N, Kaneko S, Lory P Yamakawa K.
  • Journal Title: Hum Mutat 28(5) Pages: 524-5
  • Peer Reviewed
• [Journal Article] Nav1.1 Localizes to Axons of Parvalbumin-Positive Inhibitory Interneurons : a Circuit Basis for Epileptic Seizures in Mice Carrying an Scn1a Gene Mutation (2007)
  • Author(s): Ogiwara I, Miyamoto H, Morita N, Atapour N, Mazaki E, Inoue I, Takeuchi T, Itohara S, Yanagawa Y, Obata K, Furuichi T, Hensch TK, Yamakawa K.
  • Journal Title: J Neurosc 27(22) Pages: 5903-14
  • Peer Reviewed
• [Journal Article] Patients with a sodium channel alpha 1 gene mutation show wide phenotypic variation. (2007)
  • Author(s): Osaka, H., Ogiwara, I. Mazaki, F., Okamura, N., Yamashita, S., Iai, M., Yamada, M., Kurosawa, K., Iwamoto, H., Yasui-Furukori, N., Kaneko. S., Fujisawa, T., Inoue, Y. & Yamakawa, K.
  • Journal Title: Epilepsy Res 75(1) Pages: 46-51
  • Peer Reviewed
• [Journal Article] Mutational analysis of CACNA1G in idiopathic generalized epilepsy. Mutation in beief #962. Online. (2007)
  • Author(s): Singh, B., Monteil, A., Bidaud, I., Sugimoto, Y., Suzuki, T., Hamano, S., Oguni, H., Osawa, M., Alonso, ME., Delgada-Escueta, AV., Inoue, Y., Yasui-Furukori, N., Kaneko, S., Lory, P. & Yamakawa, K.
  • Journal Title: Hum Mutat 28(5) Pages: 524-525
  • Peer Reviewed
• [Journal Article] Terbinafine increases the plasma concentration of paroxetine after a single oral administration of paroxetine in healthy subjects. (2007)
  • Author(s): Yasui-Furukori, N., Saito, M., Inoue, Y., Niioka, T., Sato, Y., Tsuchimine, S. % Kaneko, S.
  • Journal Title: Eur. J. Clin. Pharmacol. 63 Pages: 51-56
  • Peer Reviewed
• [Journal Article] Carbamazepine prevents breakdown of neurotransmitter release induced by hyperactivation of ryanodine receptor. (2007)
  • Author(s): Yoshida, S., Okada, M., Zhu, G. & Kaneko, S.
  • Journal Title: Neuropharmacol. 52(7) Pages: 1538-1546
  • Peer Reviewed
• [Journal Article] Effects of itraconazole on pharmacokinetics of paroxetine: The role of gut transporters. (2007)
  • Author(s): Yasui-Furukori, N., Saito, M., Niioka, T., Inoue, Y., Sato, Y. & Kaneko, S.
  • Journal Title: Ther: Drug Monit., 29(1) Pages: 45-48
  • Peer Reviewed
• [Journal Article] Different serum concentrations of steady-state valproic acid in two sustained-release formulation. (2007)
  • Author(s): Yasui-Furukori, N., Saito, M., Niioka, T., Inoue, Y., Sato, Y. Fuiji, A. & Kaneko, S.
  • Journal Title: Psychiat. Clin. Neurosci., 61 Pages: 308-312
  • Peer Reviewed
• [Journal Article] No association between CYP2D6 polymorphisms and personality trait in Japanese. (2007)
  • Author(s): Iwashima, K., Yasui-Furukori, N., Kaneda, A., Saito, M., Nakagami, T., Sato, Y. & Kaneko, S.
  • Journal Title: Brit. J. Clin. Pharmacol. 64(1) Pages: 96-99
  • Peer Reviewed
• [Journal Article] Personality types and coping style in hemodislysis patients. (2007)
  • Author(s): Kidachi, R., Kikuchi, A, Nishizawa, Y., Hiruma, T. & Kaneko, S.
  • Journal Title: Psychiat & Clin. Neurosci., 61 Pages: 339-347
  • Peer Reviewed
• [Journal Article] Staphylococcal enterotoxin induceces emesis though increasing serotonin release in intestine is downregulated by cannbinoid receptor 1. (2007)
  • Author(s): Hu, DL., Zhu, G, Mori, F., Omoe, K., Okada, M., Wakabayashi, K., Kaneko, S., Shinagawa, K. & Nakane A.
  • Journal Title: Cell. Microbiol., 9(9) Pages: 2267-2277
  • Peer Reviewed
• [Journal Article] Mutation screening of AP3M2 in Japanese epilepsy patients. (2007)
  • Author(s): Huang, M., Okada, M., Nakatsu, F., Oguni, H., Ito, m M., Morita, K., Nakafuji, H., Hirose, S., Sakaki, Y., Kaneko, S., Ohno, H. & Kojima, T.
  • Journal Title: Brain & development, 29 Pages: 462-467
  • NAID: 10024136602
  • Peer Reviewed
• [Journal Article] ssociation between cytochrome P450(CYP)2C19 polymorphisms and harm avoidance in Japanese. (2007)
  • Author(s): Yasui-Furukori, N., Kaneda, A., Iwashima, K., Saito, M., Nakagami, T., Tsuchimine, S. & Kaneko, S. A,
  • Journal Title: Am. J. Med. Genet. Part B 144B
  • Peer Reviewed
• [Journal Article] Effective electroconvulsive therapy in a 92-year-old dementic patients with psychotic feature. (2007)
  • Author(s): Katagai, H., Yasui-Furukori, N., Kikuchi, A., & Kaneko, S.
  • Journal Title: Psychiat & Clin. Neurosci. 61 Pages: 61-61
  • Peer Reviewed
• [Journal Article] Association between major multidrug resistance 1(MDR1)gene polymorphisms and plasma concentration of prolactin during risperidone treatment in schizophrenic patients. (2007)
  • Author(s): Yasui-Furukori, N, Tsuchimine, S., Saito, M., Nakagami, T., Sato, Y. & Kaneko, S.
  • Journal Title: Prog. Neuro-Psychopharmacol. Biol. 31 Pages: 1230-1234
  • Peer Reviewed
• [Journal Article] ミオクロニー発作. (2007)
  • Author(s): 岩佐博人, 兼子直.
  • Journal Title: Clin. Neurosci. 25(3), Pages: 303-305
• [Journal Article] てんかんの分子病態解明への展望. (2007)
  • Author(s): 兼子直.
  • Journal Title: Medical Science Digest 33(4) Pages: 782-783
• [Journal Article] てんかんの遺伝子研究かん見えてくる個別化治療の可能性. (2007)
  • Author(s): 兼子直, 藤井学, 吉田秀一.
  • Journal Title: 臨床精神薬理 10(4) Pages: 617-623
• [Journal Article] 非定型抗精神病薬の副作用に関する薬理遺伝学研究. (2007)
  • Author(s): 兼子直.
  • Journal Title: 厚生労働省科学研究費補助金(こころの健康科学研究事業)分担研究報告書 Pages: 13-16
• [Journal Article] ヒトてんかんと遺伝子導入モデル動物を用いたてんかんの病態解明. (2007)
  • Author(s): 廣瀬伸一, 岡田元宏, 朱剛, 上野伸哉, 吉田淑子, 福間五龍, 斎藤亮, 高野行夫, 兼子直, 満留昭久.
  • Journal Title: てんかん治療研究振興財団研究年報 18 Pages: 49-54
• [Journal Article] Chrna 4に異常を持つ遺伝子改変モデル動物の神経科学的解析. (2007)
  • Author(s): 廣瀬伸一, 岡田元宏, 朱剛, 上野伸哉, 吉田淑子, 福間五龍, 斎藤亮, 高野行夫, 兼子直, 満留昭久.
  • Journal Title: 厚生労働省精神・神経疾患研究委託費(16指-3)研究報告書 Pages: 81-86
• [Journal Article] てんかんの責任遺伝子探索と遺伝子多型に基づいた個別化治療の開発. (2007)
  • Author(s): 兼子直, 岩佐博人, 古郡規雄, 岡田元宏, 土嶺章子, 佐々木智美, 藤井学, 吉田秀一, 廣瀬伸一, 伊藤正利, 小国弘量, 大澤真木子, 前澤真理子, 小島俊男, 金井数明, 和田一丸.
  • Journal Title: 厚生労働省精神・神経疾患研究委託費(16指-3)研究報告書 Pages: 87-93
• [Journal Article] てんかん部分発作に対するgabapentinの長期投与試験-多施設共同非肓検試験-. (2007)
  • Author(s): 山内俊雄, 兼子直, 八木和一, 荒川明雄.
  • Journal Title: 臨床精神薬理 10(10) Pages: 1893-1908
• [Journal Article] 徐放性バルプロ酸ナトリウム製剤の体内薬物動態の比較検討. (2007)
  • Author(s): 古郡規雄, 兼子直.
  • Journal Title: Pharma Medica 25(11) Pages: 127-131
• [Journal Article] 青森県の精神医療の現状と課題. (2007)
  • Author(s): 兼子直, 朱剛.
  • Journal Title: 精神科 11(3) Pages: 224-227
• [Journal Article] ミスマッチ陰性電位研究における二つの重要課題. (2007)
  • Author(s): 矢部博興, 松岡貴志, 朝井廉, 兼子直.
  • Journal Title: 臨床脳波 49(12) Pages: 735-739
• [Journal Article] てんかん. (2007)
  • Author(s): 兼子直, 和田一丸.
  • Journal Title: 臨床と研究 84(2) Pages: 57-61
• [Journal Article] 妊娠中の向精神薬治療. (2007)
  • Author(s): 藤井学, 古郡規雄, 兼子直.
  • Journal Title: 臨床精神医学 36(増刊号) Pages: 299-303
• [Journal Article] Association of gene polymorphisms with myocardial infarction in individuals with or without conventional coronary risk factors. (2007)
  • Author(s): Nishihara K, Satoh K, et al.
  • Journal Title: Int J Mol Med 19(1) Pages: 129-141
• [Journal Article] Differential regulation of CREB and ERK phosphorylation through corticotrophin-releasing factor receptors type 1 and 2 in AtT-20 and A7r5 cells. (2007)
  • Author(s): Kageyama K, Satoh K, et al.
  • Journal Title: Mol Cell Endocrinol 263(1, 2) Pages: 90-102
• [Journal Article] Cytokine modulation of retinoic acid-inducible gene-I (RIG-I) expression in human epidermal kerationocytes. (2007)
  • Author(s): Kitamura H, Satoh K, et al.
  • Journal Title: J Dermatol Sci 45(2) Pages: 127-134
• [Journal Article] LGR4 Regulates the Postnatal Development and Integrity of Male Reproductive Tracts in Mice. (2007)
  • Author(s): Hoshii T, Takeo T, Nakagata N, Takeya M, Araki K, et al.
  • Journal Title: Biology of Reproduction 76 Pages: 303-313
• [Journal Article] Severe hypokinesis caused by paraneoplastic anti-Ma2 encephalitis associated with bilateral intratubular germ-cell neoplasia. (2007)
  • Author(s): Tsuji S, et al.
  • Journal Title: Movement Disord (in press)
• [Journal Article] Multiple families with multiple system atrophy. (2007)
  • Author(s): Tsuji S, et al.
  • Journal Title: (in press)
• [Journal Article] Novel locus for benign hereditary chorea with adult-onset maps to chromosome 8q21.3-q23.3. (2007)
  • Author(s): Shimohata K, Kuwano R, et al.
  • Journal Title: Brain (in press)
• [Journal Article] Mutation screening of AP3M2 in Japanese epilepsy patients. (2007)
  • Author(s): Hung MC, Okada M, Nakatsu F, Oguni H, Ito M, Morita K, Nagafuji H, Hirose S, Sakaki Y, Kaneko S, Ohno H, Kojima T
  • Journal Title: Brain Dev-Jpn (in press)
  • NAID: 10024136602
• [Journal Article] Mutation analysis of CACNA1G in idiopathic generalized epilepsy. (2007)
  • Author(s): Singh B, Monteil A, Bidaud I, Sugomoto Y, Suzuki T, Hamano S, Oguni H, Osawa M, Alonso ME, Eseueta AD, Inoue Y, Yasui=Furukori N, Kaneko S, Lory K, Yamakawa K
  • Journal Title: Hum Mutat (in press)
• [Journal Article] Insertion of {alpha} 7 nictinic receptors at neocortical layer V GABAergic synapses is induced by a Benzodiazepine. Midazolam. (2007)
  • Author(s): Yamamoto S, Ueno S, et al.
  • Journal Title: Cereb Cortex (in press)
• [Journal Article] Molecular basis for the GABAA receptor-mediated tonic inhibition in rat somatosensory cortex. (2007)
  • Author(s): Yamada J, Ueno S, et al.
  • Journal Title: Cereb Cortex (in press)
• [Journal Article] Determination of genomic breakpoints in an epileptic patient using genotyping array (2006)
  • Author(s): Kojima T, Mukai W, Fuma D, Ueda Y, Okada M, Sakaki Y, Kaneko S.
  • Journal Title: BiochemBiophys Res Commun 341 Pages: 792-796
  • Peer Reviewed
• [Journal Article] Effects of interleukin-1beta on hippocampal glutamate and GABA releasesassociated with Ca^<2+>-induced Ca^<2+>releasing systems (2006)
  • Author(s): Zhu G, Okada M, Yoshida S, Mori F, Ueno S, Wakabayashi K, Kaneko S.
  • Journal Title: Epilepsy Res. 71(2-3) Pages: 107-16
  • Peer Reviewed
• [Journal Article] Involvement of Ca^<2+>-induced Ca^<2+>releasing system in interlerkin-1beta-associatedadenosine release (2006)
  • Author(s): Zhu G, Okada M, Yoshida S, Mori F, Hirose S, Wakabayashi K, Kaneko S.
  • Journal Title: Eur J Pharmacol 532(3) Pages: 246-52
  • Peer Reviewed
• [Journal Article] Brain-type creatine kinase activates neuron-specific K^+-Clco-transporter KCC2 (2006)
  • Author(s): Inoue K, Yamada J, Ueno S, Fukuda A.
  • Journal Title: J Neurochem 96(2) Pages: 598-608
  • Peer Reviewed
• [Journal Article] Involvement of Ca^<2+>-induced Ca^<2-> releasing system in interleukin-1 β-associated adenosine release. (2006)
  • Author(s): Zhu G, Okada M, Yoshida S, Mori F, Hirose S, Wakabayashi K, Kaneko S
  • Journal Title: Eur J Pharmacol 532 Pages: 246-252
• [Journal Article] Autho's reply : Hydroxylation of lansoprazole in poor metabolizers of CYP2C19. (2006)
  • Author(s): Yasui-Furukori N, Uno T, Kaneko S, Tateishi T
  • Journal Title: Brit J Clin Pharmacol 61(3) Pages: 361-362
• [Journal Article] Determination of genomic breakpoints in an epileptic patient using genotyping array. (2006)
  • Author(s): Kojima T, Mukai W, Fuma D, Ueda Y, Okada M, Sakaki Y, Kaneko S
  • Journal Title: Biochem Bioph Res Co 341(3) Pages: 792-796
• [Journal Article] Digitalis intoxiction induced by paroxetine co-administration. (2006)
  • Author(s): Yasui-Furukori N, Kaneko S
  • Journal Title: Lancet 367 Pages: 788-788
• [Journal Article] Association between multidrug resistance 1 (MDR1) gene polymorphisms and therapeutic response to bromperidol in schizophrenic patients : A preliminary study. (2006)
  • Author(s): Yasui-Furukori N, Saito M, Nakagami T, Kaneda A, Tateishi T, Kaneko S
  • Journal Title: ProgNeuro-Psychoph ＆ Biol Psychiat 30 Pages: 286-291
• [Journal Article] Co-localization of β-peptide and phosphorylated tau in astrocytes in a patient with corticobasal degeneration. (2006)
  • Author(s): Wakabayashi K, Mori F, Hasegawa M, Kusumi T, Yoshimura I, Takahashi H, Kaneko S
  • Journal Title: Neuropathology 26 Pages: 66-71
  • NAID: 10020387387
• [Journal Article] Treatment of partial seizure with gabapentin : Double-blind, placebo-controlled, parallel-group study. (2006)
  • Author(s): Yamauchi T, Kaneko S, Yagi K, Sase S
  • Journal Title: Psychiat Clin Neurosci 60 Pages: 507-515
• [Journal Article] Effects of interleukin-1 β on hippocampal glutamate and GABA releases associated wuth Ca^<2+>-induced Ca^<2+> releasing systems. (2006)
  • Author(s): Zhu G, Okada M, Yoshida S, Mori F, Ueno S, Wakabayashi K, Kaneko S
  • Journal Title: Epilepsy Res 71(2-3) Pages: 107-116
• [Journal Article] Identification of a shingle time-point for plasma lansoprazole measurement that adequately reflects area under the concentration-time corve. (2006)
  • Author(s): Niioka T, Yasui-Furukori N, Uno T, Sugawara K, Kaneko S, Tateishi T
  • Journal Title: Ther Drug Monit 28(3) Pages: 321-325
• [Journal Article] Phenotypes and genotypes in epilepsy with febrile seizures plus. (2006)
  • Author(s): Ito M, Yamakawa K, Sugawara T, Hirose S, Fukuma G, Kaneko S
  • Journal Title: Epilepsy Res 28(3) Pages: 308-311
• [Journal Article] Regeneration of megakaryocytopoiesis and thrombopoiesis stem cells. (2006)
  • Author(s): Kashiwakura I, SatohK, et al.
  • Journal Title: Radiat Res 166(8) Pages: 345-351
• [Journal Article] Genetic risk for atheromobotic cerebral infarction in indivividuals stratified by sex or conventional risk factors for atherosclerosis. (2006)
  • Author(s): Yamaguchi S, Satoh K
  • Journal Title: Int J Mol Med 18(5) Pages: 871-883
• [Journal Article] Assessment of genetic component of hypertension. (2006)
  • Author(s): Yamada Y, Satoh K, et al.
  • Journal Title: Am J Hypertens 19(11) Pages: 1158-1165
• [Journal Article] Retinoic acid-inducible gene-I is induced in gingival fibroblasts by LPS or poly IC : possible roles in interleukin-1 β, -6 and -8 expression. (2006)
  • Author(s): Kubota K, Satoh K, et al.
  • Journal Title: Oral Misrobio Immunol 21(6) Pages: 399-406
• [Journal Article] Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease. (2006)
  • Author(s): Kuwano R, et al.
  • Journal Title: Hum Mol Genet 15 Pages: 2170-2182
  • NAID: 40015443849
• [Journal Article] Propofol, an anesthetic possessing neuroprotective action against oxidative stress, promotes the process of cell death induced by H202 in rat thymocytes. (2006)
  • Author(s): Chikutei K, Ueno S, et al.
  • Journal Title: Eur J Pharmacol 540(1-3) Pages: 18-23
• [Journal Article] Cytometic analysis of lidocaine-induced cytotoxicity : a model expriment using rat thymocytes. (2006)
  • Author(s): Nishimura Y, Ueno S, et al.
  • Journal Title: Toxicology 218(1) Pages: 48-57
• [Journal Article] Brain-type creatine kinase activates neuron-specific K^+-Cl-co-transporter KCC2. (2006)
  • Author(s): Inoue K, Ueno S, et al.
  • Journal Title: J Neurochem 96(2) Pages: 598-608
• [Journal Article] Hypoglycemic encephalopathy with extensive lesions in the cerebral white matter. (2006)
  • Author(s): Mori F, Nishie M, Houzen H, Yamaguchi J, Wakabayashi K
  • Journal Title: Neuropathology 26(2) Pages: 147-152
  • NAID: 10020387084
• [Journal Article] Progression patterns of neuronal loss and Lewy body pathology in the substantia nigra in Parkinson's disease. (2006)
  • Author(s): Wakabayashi K, et al.
  • Journal Title: Parkinsonism Relat Disord 12(Suppl 2)
• [Journal Article] Cardiac sympathetic denervation in Lewy body disease. (2006)
  • Author(s): Orimo S, Amino T, Takahashi A, Kojo T, Uchihara T, Mori F, Wakabayashi K, et al.
  • Journal Title: Parkinsonism Relat Disord 12(Suppl 2)
• [Journal Article] NUB1 suppresses the formation of Lewy body-like inclusions by proteasomal degradation of synphilin-1. (2006)
  • Author(s): Tanji K, Tanaka T, Mori F, Kito K, Takahashi H, Wakabayashi K, et al.
  • Journal Title: Am J Pathol 169(2) Pages: 553-565
• [Journal Article] Relationship among α -synuclein accumulation, dopamine synthesis, and neurodegeneration in Parkinson disease substantia nigra. (2006)
  • Author(s): Mori F, Nishie M, Kakita A, Yoshimoto M, Takahashi H, Wakabayashi K
  • Journal Title: J Neuropathol Exp Neurol 65(8) Pages: 808-815
• [Journal Article] Cellular pathology in multiple system atrophy. (2006)
  • Author(s): Wakabayashi K, et al.
  • Journal Title: Neuropathology 26(4) Pages: 338-345
  • NAID: 10018059103
• [Journal Article] Listeria monocytogenes induces the expression of retinoic acid-inducible gene-I. (2006)
  • Author(s): Imaizumi T, Sashinami H, Mori F, Matsumiya T, Yoshida H, Nakane A, Wakabayashi K, et al.
  • Journal Title: Microbiol Immunol 50(10) Pages: 811-815
  • NAID: 10020554990
• [Journal Article] Degeneration of cardiac sympathetic nerve can occur in multiple system atrophy. (2006)
  • Author(s): Orimo S, Kanazawa T, Nakamura A, Uchihara T, Mori F, Kakita A, Wakabayashi K, et al.
  • Journal Title: Acta Neuropathol 113(1) Pages: 81-86
• [Journal Article] Upregulation of vascular endothelial growth factor by heat-killed Listeria monocytogenes in macrophages. (2006)
  • Author(s): Sato F, Imaizumi T, Sashinami H, Yoshida H, Kusumi T, Mori F, Wakabayashi K, et al.
  • Journal Title: Biochem Biophys Res Commun 354(2) Pages: 608-612
• [Journal Article] An infant with a mitochondrial A3243G mutation demonstrating the MELAS phenotype. (2006)
  • Author(s): Kanaumi T, Hirose S, et al.
  • Journal Title: Pediatr Neurol 34(3) Pages: 235-238
• [Journal Article] A new paradigm of channelopathy in epilepsy syndrome : Intracellular trafficking abnormality of channel molecules. (2006)
  • Author(s): Hirose S
  • Journal Title: Epilepsy Res 70S
• [Journal Article] Neuropathology of methylmalonic acidemia in a child. (2006)
  • Author(s): Kanaumi T, Takashima S, Hirose S, et al.
  • Journal Title: Pediatr Neurol 34(2) Pages: 156-159
• [Journal Article] Developmental changes in the expression of GABA_A receptor alpha 1 and gamma 2 subunts in human temporal lobe, hippocampus and basal ganglia; An implication for consideration on age-related epilepsy. (2006)
  • Author(s): Kanaumi T, Takashima S, Iwasaki H, Mitsudime S, Hirose S
  • Journal Title: Epileps Res 71 Pages: 47-53
• [Journal Article] A novel murine gene, Sickle tail (Skt), linked to the Danforth's short tail (Sd) locus, is required for normal development of the intervertebral disc. (2006)
  • Author(s): Semba K, Araki K, et al.
  • Journal Title: Genetics 172 Pages: 445-456
• [Journal Article] Impaired expression of Importin/karyopherin 1 leads to post-implantation lethality. (2006)
  • Author(s): Miura K, Yoshinobu K, Imaizumi T, Haruna K, Miyamoto Y, Yoneda, Y, Nakagata N, Araki M, Miyakawa T, Yamamura K, Araki K
  • Journal Title: Biochem Biophys Res Commun 341 Pages: 132-138
• [Journal Article] Enhanced trypsin activity in pancreatic acinar cells deficient for serine protease inhibitor kazal type 3. (2006)
  • Author(s): Ohmuraya M, Hirota M, Araki K, et al.
  • Journal Title: Pancreas 33 Pages: 104-106
• [Journal Article] Smooth muscle-specific dystrophin expression improves aberrant vasoregulation in mdx mice. (2006)
  • Author(s): Ito K, Kimura S, Ozasa S, Matsukura M, Ikezawa M, Yoshioka K, Ueno H, Suzuki M, Araki K, et al.
  • Journal Title: Hum Mol Genet 15 Pages: 2266-2275
• [Journal Article] Negative Selection with the Diphtheria toxin A fragment Gene Improves Frequency of Cre-Mediated Cassette Exchange in ES Cells. (2006)
  • Author(s): Araki K, et al.
  • Journal Title: J Biochem. 140 Pages: 793-798
  • NAID: 10018840450
• [Journal Article] Analysis of tandem repeats found in 44 prokaryotic genomes. (2006)
  • Author(s): Mizuta S, Munakata H, Aimaiti A, Oya I., Oosawa K., Shimizu T.
  • Journal Title: In Silico Bio 16 Pages: 147-159
• [Journal Article] How to obtain multiple alignments in which transmembrane segment regions are well aligned without inserted (2006)
  • Author(s): Kimura T, Ohta T, Nishio T, Shimizu T
  • Journal Title: Chem-Bio Informatics Journal, under revision. (in press)
• [Journal Article] Analysis of tandem repeats found in 44 prokaryotic genomes (2006)
  • Author(s): Mizuta S, Munakata H, Aimaiti A, Oya I, Oosawa K, Shimizu T
  • Journal Title: In Silico Biology (in press) (accepted.)
• [Journal Article] Brain-type creatine kinase activates neuron-apecific K^+-Cl^-co-transporter KCC2. (2006)
  • Author(s): Inoue K, Yamada J, Ueno S, Fukuda A
  • Journal Title: J Neurochem 96 Pages: 598-608
• [Journal Article] Cytometric analysis of lidocaine-induced cytotoxicity : A model experiment using rat thymocytes. (2006)
  • Author(s): Nishimura Y, Kanada A, Yamaguchi J, Horimoto K, Kobayashi M, Tatsuishi T, Kanemura K, Ueno S, Oyama Y
  • Journal Title: Toxicology 218 Pages: 48-57
• [Journal Article] Oligodendrocytes within astrocytes ("emperipolesis") in the cerebral white matter in hepatic and hypoglycemic encephalopathy. (2006)
  • Author(s): Nishie M, Mori F, Houzen H, Yamaguchi J, Jensen PH, Wakabayashi K.
  • Journal Title: Neuropathology 26 Pages: 62-65
  • NAID: 10020387365
• [Journal Article] Co-localization of β-peptide and phosphorylated tau in astrocytes in a patient with corticobasal degeneration. (2006)
  • Author(s): Wakabayashi K, Mori F, Hasegawa M, Kusumi T, Yoshimura I, Takahashi H, Kaneko S.
  • Journal Title: Neuropathology 26 Pages: 66-71
  • NAID: 10020387387
• [Journal Article] Involvement of Ca^<2+>-induced Ca^<2+> releasing system in interleukin-1 β-associated adenosine release. (2006)
  • Author(s): Zhu G, Okada M, Yoshida S, Mori F, Hirose S, Wakabayashi K, Kaneko S.
  • Journal Title: Eur J Pharmacol 532 Pages: 246-252
• [Journal Article] Effect of vasoconstricotr coupling factor 6 on gene expression profile in human vascular endothelial cells : enhanced release of asymmetric dimethylarginine. (2006)
  • Author(s): Tanaka M, Osanai T, Murakami R, Sasaki S, Tomita H, Maeda N, Satoh K, Magota K, Okumura K
  • Journal Title: J Hypertens 24 Pages: 489-497
• [Journal Article] Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-bgeo cassette. (2006)
  • Author(s): Taniwaki, T., Haruna, K., Nakamura, H., Sekimoto, T., Oike, Y., Imaizumi, T., Saito, F., Muta, M., Soejima, Y., Utoh, A., Nakagata, N., Araki, M., Yamamura, K., Araki, K.
  • Journal Title: Develop Growth Differ 47 Pages: 163-172
• [Journal Article] A novel murine gene, Sickle tail (Skt), linked to the Danforth's short tail (Sd) locus, is required for normal development of the intervertebral disc (2006)
  • Author(s): Semba, K., Araki, K., Li, Z., Matsumoto, K., Suzuki, M., Nakagata, N., Takagi, K., Takeya, M., Yoshinobu, K., Araki, M., Imai, K., Abe, K., Yamamura, K.
  • Journal Title: Genetics 172 Pages: 445-456
• [Journal Article] Impaired expression of Importin/karyopherin beta1 leads to post-implantation lethality. (2006)
  • Author(s): Miura, K., Yoshinobu, K., Imaizumi, T., Haruna, K., Miyamoto, Y., Yoneda, Y., Nakagata, N., Araki, M., Miyakawa, T., Yamamura, K., Araki, K.
  • Journal Title: Biochem.Biophys.Res.Commun. 341 Pages: 132-138
• [Journal Article] Effects of zonisamide on neurotransmitter exocytosis associated with ryanodine receptors (2005)
  • Author(s): Yoshida S, Okada M, Zhu G, Kaneko S
  • Journal Title: Epilepsy Res. 67(3) Pages: 153-62
  • Peer Reviewed
• [Journal Article] Effects of ryanodine receptor activation on neurotransmitter release and neruronal cell death following kainic acid-induced status epilepticus (2005)
  • Author(s): Mori F, Okada M, Tomiyama M, Kaneko S, Wakabayshi K.
  • Journal Title: Epilepsy Res 65(1-2) Pages: 59-70
  • Peer Reviewed
• [Journal Article] Biphasic actions of topiramete on monamine exocytosis associated with both soluble N-ethylmateimide-sensitive factor attachment protein receptors and Ca^<2+>-induced Ca^<2+>-releasing systems (2005)
  • Author(s): Okada M, Yoshida S, Zhu G, Hirose S, Kaneko S.
  • Journal Title: Neuroscience 134(1) Pages: 233-46
  • Peer Reviewed
• [Journal Article] Zonisamide at clinically relevant concentrations inhibits field EPSP but not presynaptic fiber volley in rat frontal cortex (2005)
  • Author(s): Huang CW, Ueno S, Okada M, Kaneko S.
  • Journal Title: Epilepsy Res 67 Pages: 51-60
  • Peer Reviewed
• [Journal Article] Biphasic action of topiramate on monoamine exocytosis associated with both soluble N-ethylmaleimide-sensitive factor attachment protein receptors and Ca^<2+>-induced Ca^<2+>-releasing systems. (2005)
  • Author(s): Okada M, Yoshida S, Zhu G, Hirose S, Kaneko S
  • Journal Title: Neuroscience 134 Pages: 233-246
• [Journal Article] Genetics of idiopathic epilepsies. (2005)
  • Author(s): Hirose S, Mitsudome A, Okada M, Kaneko S, on behalf of The Epilepsy Study Group, Japan
  • Journal Title: Epilepsia 46(Suppl 1) Pages: 38-43
  • NAID: 10016481115
• [Journal Article] Effects of ryanodine receptor activation on neurotransmitter release and neuronal cell death following kainic acid-induced status epilepticus. (2005)
  • Author(s): Mori F, Okada M, Tomiyama M, Kaneko S, Wakabayashi K
  • Journal Title: Epilepsy Res 65(1-2) Pages: 59-70
• [Journal Article] Effects of zonisamide on neurotransmitter exocytosis associated with ryanodine receptors. (2005)
  • Author(s): Yoshida S, Okada M, Zhu G, Kaneko S
  • Journal Title: Epilepsy Res 67(3) Pages: 153-162
• [Journal Article] Localisation of missense mutations in SCN1A affects epilepsy phenotype severity. (2005)
  • Author(s): Kanai K, Hirose S, Oguni H, Fukuma G, Shirasaka Y, Miyajima T, Kuwabara S, Wada K, Iwasa H, Yasumoto S, Ito M, Hattori T, Mitsudome A, Kaneko S
  • Journal Title: Neurology Asia 9(Suppl 1) Pages: 144-144
• [Journal Article] Mutations of KCNQ2 and KCNQ3 identified in benign neonatal convulsions cause channel dysfunction despite proper expression on the cell membrane. (2005)
  • Author(s): Ishii A, Fukuma G, Yasukochi M, Uehara A, Miyajima T, Hamachi A, Yonetani M, Kaneko S, Mitsudome A, Hirose S
  • Journal Title: Neurology Asia 9(Suppl 1) Pages: 146-146
• [Journal Article] Possible pathogenesis of severe myoclonic epilepsy in infancy : A novel nonsense mutation of GABRG2 leading to aggregation of GABA receptors in neurons. (2005)
  • Author(s): Kanaumi T, Fukuma G, Ueno S, Ishii A, Haga Y, Hamachi A, Yonetani M, Itoh M, Takashima S, Kaneko S, Mitsudome A, Hirose S
  • Journal Title: Neurology Asia 9(Suppl 1) Pages: 151-151
• [Journal Article] Down-regulation of CICR gene expression by carbamazepine, via stimulation of CICR associated monoamine exocytosis. (2005)
  • Author(s): Okada M, Yoshida S, Zhu G, Ueno S, Kaneko S
  • Journal Title: J Pharmacol Sci 97(Suppl 1) Pages: 78-78
• [Journal Article] Zonisamido at clinically relevant concentrations inhibits evoked EPSP but not presynaptic fiber volley in rat frontal cortex. (2005)
  • Author(s): Huang CW, Ueno S, Okada M, Kaneko S
  • Journal Title: J Pharmacol Sci 97(Suppl 1) Pages: 268-268
• [Journal Article] Age-Dependent impaiement of GABAergic transmission in μ3B knockout mice. (2005)
  • Author(s): Zhu G, Okada M, Mori F, Nakatsu F, Yoshida S, Wakabayashi K, Ohno H, Kaneko S
  • Journal Title: Epilepsia 46(Suppl 2) Pages: 2-2
• [Journal Article] A novel de novo KCNQ2 mutation in a sporadic case of benign neomatal convulsions. (2005)
  • Author(s): Ishii Ai, Fukuma G, Uehara A, Miyajima T, Makita Y, Hamachi A, Yasukochi M, Inoue T, Okada M, Kaneko S, Akihisa M, Hirose S
  • Journal Title: Epilepsia 46(Suppl 2) Pages: 3-4
• [Journal Article] Effects of carbamazepine on mechanism of Ca2+-induced Ca2+ releasing system-associated exocytosis. (2005)
  • Author(s): Okada M, Zhu Gang, Yoshida S, Mori F, Wakabayashi K, Kaneko S
  • Journal Title: Epilepsia 46(Suppl 2) Pages: 15-16
• [Journal Article] Epileptic seizure in mice deficient in μ3B subunit of AP-3B complex. (2005)
  • Author(s): Nakatsu F, Okada M, Mori F, Kumazawa N, Iwasa H, Zhu G, Kasagi Y, Kamiya H, Harada A, Nishimura K, Takeuchi A, Miyazaki T, Watanabe M, Yasa D, Manabe T, Wakabayashi K, Kaneko S, Saito T, Ohno H
  • Journal Title: Epilepsia 46(Suppl 2) Pages: 67-68
• [Journal Article] Impairment of monoaminergic transmission in μ3B knockout mice. (2005)
  • Author(s): Zhu G, Okada M, Nakatsu F, Mori F, Yoshida S, Wakabayashi K, Ohno H, Kaneko S
  • Journal Title: Epilepsia 46(Suppl 3) Pages: 11-12
• [Journal Article] Identification of the gene responsible for juvenile myoclonic epilepsy. (2005)
  • Author(s): Suzuki T, Delgado-Escueta VA, Aguan K, Shi J, Hara Y, Nishida M, Numata T, Takeuchi T, Bai D, Inoue Y, Osawa M, Kaneko S, Oguni H, Mori Y, Yamakawa K
  • Journal Title: Epilepsia 46(Suppl 3) Pages: 15-16
• [Journal Article] てんかん -責任遺伝子解明の進展とその後の課題- (2005)
  • Author(s): 兼子 直, 金井数明, 岡田元宏, 桑原聡, 廣瀬伸一
  • Journal Title: 実験医学 23(5) Pages: 776-781
• [Journal Article] ヒトてんかんと同じ遺伝子異常をもつ組換え動物の作出 (2005)
  • Author(s): 岡田元宏, 朱 剛, 上野伸哉, 吉田淑子, 福間五龍, 廣瀬伸一, 兼子 直
  • Journal Title: 精神薬療研究年報 37 Pages: 160-164
• [Journal Article] てんかんにおける認知障害とその分子基盤-遺伝子異常との関連を含めて- (2005)
  • Author(s): 岩佐博人, 兼子 直
  • Journal Title: 分子精神医学 5(3) Pages: 284-290
• [Journal Article] てんかんの分子遺伝学研究のUp to date (2005)
  • Author(s): 兼子 直, 金井数明, 福間五龍, 岡田元宏, 桑原 聡, 廣瀬伸一
  • Journal Title: ゲノム医学 5(3) Pages: 241-245
• [Journal Article] てんかんの薬物療法における新たな視点-オーダーメイド治療の可能性と課題- (2005)
  • Author(s): 岩佐博人, 兼子 直
  • Journal Title: 神経進歩 49(5) Pages: 745-756
• [Journal Article] メンデル型遺伝を示すてんかん症候群 -チャネル病を中心に- (2005)
  • Author(s): 兼子 直, 和田一丸
  • Journal Title: 精神科治療学 20(Suppl) Pages: 364-366
• [Journal Article] 徐放性バルプロ酸ナトリウム製剤(セレニカ【○!R】R錠200mg,デパケン【○!R】R錠R200)の体内薬物動態と生物学的同等性の比較検討 (2005)
  • Author(s): 古郡規雄, 近藤 毅, 兼子 直
  • Journal Title: Pharma Medica 23(12) Pages: 71-75
• [Journal Article] How accurately G-protein-coupled receptors can be discriminated as 7-tms TM protein sequences from others? (2005)
  • Author(s): Inoue Y, Yamazaki Y, Shimizu T
  • Journal Title: Biochem.Biophys.Res.Commun 338 Pages: 1542-1546
• [Journal Article] A proteome-wide analysis of domain architectures of prokaryotic single-spanning transmembrane proteins (2005)
  • Author(s): Arai M, Fukushi T, Satake M, Shimizu T
  • Journal Title: Comput.Biol.Chem 29 Pages: 379-387
• [Journal Article] Model analysis of surfactant-polymer interaction as cooperative ligand binding to linear lattice (2005)
  • Author(s): Nishio T, Shimizu T
  • Journal Title: Biophysical Chemistry 117 Pages: 19-25
• [Journal Article] Characterization of newly cloned variant of rat glycine receptor α1 subunit. (2005)
  • Author(s): Inoue K, Ueno S, Yamada J, Fukuda A
  • Journal Title: Biochem Biophy Rea Comm 327 Pages: 300-305
• [Journal Article] Zonisamide at clinically relevant concentrations inhibits field EPSP but not presynaptic fiber volley in rat frontal cortex. (2005)
  • Author(s): Huang CW, Ueno S, Okada M, Kaneko S
  • Journal Title: Epilepsy Res 67 Pages: 51-60
• [Journal Article] Differential functional expression of cation-C1^- cotransporter mRNAs (KCC1, KCC2, and NKCC1) in rat trigeminal nervous system. (2005)
  • Author(s): Toyoda H, Yamada J, Ueno S., Okabe A, Kato H, Sato K, Hashimoto K, Fukuda A
  • Journal Title: Molecular Brain Res 133 Pages: 12-18
• [Journal Article] Accumulation of NEDD8 in neuronal and glial inclusions of neurodegenerative disorders. (2005)
  • Author(s): Mori F, Nishie M, Piao Y-S, Kito K, Kamitani T, Takahashi H, Wakabayashi K
  • Journal Title: Neuropathol Appl Neurobiol 31 Pages: 53-61
• [Journal Article] Peculiar venous lesions in fatal hyponatremic brain edema (2005)
  • Author(s): Nishie M, Mori F, Tomita T, Nishijima M, Kaimori M, Wakabayashi K
  • Journal Title: Neuropathology 25 Pages: 95-98
  • NAID: 10017018923
• [Journal Article] Frontotemporal dementia with co-occurrence of astrocytic plaques and tufted astrocytes, and severe degeneration of the cerebral white matter : a variant of corticobasal degeneration? (2005)
  • Author(s): Tan C-F, Piao Y-S, Kakita A, Yamada M, Takano H, Tanaka M, Mano A, Makino K, Nishizawa M, Wakabayashi K, Takahashi H
  • Journal Title: Acta Neuropathol 109 Pages: 329-338
• [Journal Article] Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease. (2005)
  • Author(s): Orimo S, Amino T, Itoh Y, Takahashi A, Kojo T, Uchihara T, Tsuchiya K, Mori F, Wakabayashi K, Takahashi H.
  • Journal Title: Acta Neuropathol 109 Pages: 583-588
• [Journal Article] An autopsy case of early ("minimal change") olivopontocerebellar atrophy (multiple system atrophy-cerebellar). (2005)
  • Author(s): Wakabayashi K, Mori F, Nishie M, Oyama Y, Kurihara A, Yoshimoto M, Kuroda N.
  • Journal Title: Acta Neuropathol 110 Pages: 185-190
• [Journal Article] Rhabdoid cystic papillary meningioma with diffuse subarachnoid dissemination. (2005)
  • Author(s): Wakabayashi K, Suzuki N, Mori F, Kamada M, Hatanaka M.
  • Journal Title: Acta Neuropathol 110 Pages: 196-198
• [Journal Article] Double-stranded RNA induces the synthesis of retinoic acid-inducible gene-I in vascular endothelial cells. (2005)
  • Author(s): Imaizumi T, Hatakeyama M, Yamashita K, Ishikawa A, Yoshida H, Satoh K, Taima K, Mori F, Wakabayashi K.
  • Journal Title: Endothelium 12 Pages: 133-137
• [Journal Article] Disseminated intraparenchymal microgranulomas in the brainstem in a case of CNS sarcoidosis ("sarcoid brainstem encephalitis"). (2005)
  • Author(s): Nishie M, Mori F, Suzuki C, Ogawa M, Kurahashi K, Kaimori M, Wakabayashi K.
  • Journal Title: Neuropathology 25 Pages: 361-364
• [Journal Article] Double-stranded RNA stimulates the expression of monocyte chemoattractant protein-1 in BEAS-2B bronchial epithelial cells. (2005)
  • Author(s): Taima K, Takanashi S, Okumura K, Imaizumi T, Kumagai M, Ishikawa A, Yoshida H, Satoh K, Fujita T
  • Journal Title: Exp Lung Res 31(3) Pages: 361-375
• [Journal Article] Involvement of RIG-I in IFN-γ/STAT1 signaling pathway in BEAS-2B cells (2005)
  • Author(s): Imaizumi T, Kumagai M, Taima K, Fujita T, Yoshida H, Satoh K
  • Journal Title: Eur Resp J 25(6) Pages: 1077-1083
• [Journal Article] Double-stranded RNA induces the synthesis of retinoic acid-inducible gene-I in vascular endothelial cells. (2005)
  • Author(s): Imaizumi T, Mori F, Hatakeyama M, Yamashita K, Ishikawa A, Taima K, Yoshida H, Wakabayashi K, Satoh K
  • Journal Title: Endothelium 12(3) Pages: 133-137
• [Journal Article] Effect of peroxisome proliferator-activated receptor-γ ligands on the expression of retinoic acid-inducible gene-I in endothelial cells stimulated with lipopolysaccharide. (2005)
  • Author(s): Imaizumi T, Yamashita K, Taima K, Ishikawa A, Yoshida H, Satoh K
  • Journal Title: Prostaglandins Other Lipid Mediat 78(1-4) Pages: 46-54
• [Journal Article] Genetics of idiopathic epilepsies. (2005)
  • Author(s): Hirose S, Mitsudome A, Okada M, Kaneko S
  • Journal Title: Epilepsia 46(1) Pages: 38-43
  • NAID: 10016481115
• [Journal Article] Mutation in the NHLRC1 gene are the common causefor Lafora disease in the Japanese population. (2005)
  • Author(s): Singh S, Suzuki T, Uchiyama A, Kumada S, Moriyama N, Hirose S, Takahashi Y, Sugie H, Mizoguchi K, Inoue Y, Kimura K, Sawaishi Y, Yamakawa K, Ganesh S
  • Journal Title: J Hum Genet 50 Pages: 347-352
• [Journal Article] Screening method for organic aciduria by spectrofluorometric measurement of total dicarboxyloc acids in human urine based on intramolecular excimer-forming fluroscence derivatization. (2005)
  • Author(s): Yoshida H, Araki J, Sonoda J, Nohta H, Ishida J, Hirose S, Yamaguchi M
  • Journal Title: Anal Chimica Acta 534 Pages: 177-183
• [Journal Article] Carnitine palmitoyltransferase II deficiency due to a novel gene variant a patient with phabdomyolysis and ARF. (2005)
  • Author(s): Kaneko H, Uesugi N, Moriguchi A, Hirose S, Takayanagi M, Yamaguchi S, Shigematsu Y, Yasuno T, Sasatomi Y, Sait T
  • Journal Title: Am J Kidney Dis 45 Pages: 596-602
• [Journal Article] Seven myoclonic epilepsy in infants -clinical analysis and relation to SCN1A, mutations. (2005)
  • Author(s): Oguni H, Hayashi K, Osawa M, Awaya Y, Fukuyama Y, Fukuma G, Hirose S, Mitsudome A, Kaneko S
  • Journal Title: Adv Neurol 95 Pages: 103-117
• [Journal Article] Neuropathological findings in a child with methymalonic academia. (2005)
  • Author(s): Kanaumi T, Takahashi S, Hirose S, Kodama T, Iwasaki H, Mitsudome A
  • Journal Title: Pediatr Neurol (in press)
• [Journal Article] An infant with a mitochondrial A3243G mutation demonstrating the MELAS phenotype running title : An infant of MELAS phenotype. (2005)
  • Author(s): Kanaumi T, Hirose S, Goto Y, Naitou E, Mitsudome A
  • Journal Title: Pediatr Neurol (in press)
• [Journal Article] An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family. (2005)
  • Author(s): Funayama M, Hasegawa K, Ohta E, Kawashima N, Komiyama M, Kowa H, Tsuji S, Obata F
  • Journal Title: Ann Neurol 57(6) Pages: 918-921
• [Journal Article] Interference of CREB-dependent transcriptional activation by expanded polyglutamine stretches - Augmentation of transcriptional activation as a potential therapeutic strategy for polyglutamine diseases (2005)
  • Author(s): Shimohata, M, Shimohata, T, Igarashi, S, Naruse, S, Tsuji, S
  • Journal Title: J.Neurochem 93 Pages: 654-663
• [Journal Article] Interference with activity-dependent transcriptional activation of BDNF gene depending upon the expanded polyglutamines in neurons. (2005)
  • Author(s): Miyashita T, Tabuchi A, Fukuchi M, Hara D, Kisukeda T, Shimohata T, Tsuji S, Tsuda M
  • Journal Title: Biochem Biophys Res Commun 333(4) Pages: 1241-1248
• [Journal Article] Determination of genomic breakpoints in an epileptic patient using genotyping array. (2005)
  • Author(s): Kojima T, Mukai W, Fuma D, Ueda Y, Okada M, Sakai Y, Kaneko S
  • Journal Title: Biochem Biophys Res Commun 341(3) Pages: 792-796
• [Journal Article] Microarray analysis of the genes induced by tetracycline-regulated expression of NDRF/NeuroD2 inP19 cells. (2005)
  • Author(s): Oda, H., Fushimi, F., Kato, M., Kitagawa, M., Araki, K., Seki, N., Ohkubo, H.
  • Journal Title: Biochem Biophys Res Commun 335 Pages: 458-468
• [Journal Article] Severe myoclonic epilepsy in infancy : clinical analysis and relation to SCN1A mutation in a Japanese cohort. (2005)
  • Author(s): Oguni H, Kaneko S, et al.
  • Journal Title: Adv Neurol 95 Pages: 103-107
• [Journal Article] Role of α7-nicotinic acetylcholine receptors in titanic stimulation-induced γ oscillations in rat hippocampal slices. (2005)
  • Author(s): Wu J, Wakui M, et al.
  • Journal Title: Neuropharmacol (in press)
• [Journal Article] Platelet-activating factor enhances the expression of nerve growth factors in normal human astrocytes under hypoxia. (2005)
  • Author(s): Yoshida H, Satoh K, et al.
  • Journal Title: Mol Brain Res 133 Pages: 95-101
• [Journal Article] Menatetrenone and vitamin D2 with calcium aupplements prevent nonverbral fracture in elderly women with Alzheimer's disease. (2005)
  • Author(s): Sato Y, Satoh K, et al.
  • Journal Title: Bone 36 Pages: 61-68
• [Journal Article] Mutations in EFHC1 cause juvenile myoclonic epilepsy (2004)
  • Author(s): Suzuki T, Delgado-Escueta AV, Aguan K, Alonso ME, Shi J, Hara Y, Nishida M, Numata T, Medina MT, Takeuchi T, Morita R, Bai D, Ganesh S, Sugimoto Y, Inazawa J, Bailey JN, OchoaA, Jara-Prado A, Rasmussen A, Ramos-Peek J, Cordova S, Rubio-Donnadieu F, Inoue Y, Osawa M, Kaneko S, Oguni H, Mori Y, and Yamakawa K.
  • Journal Title: Nat Genet 36(8) Pages: 842-9
  • Peer Reviewed
• [Journal Article] Mutation in EFHC1 cause juvenile myoclonic epilepsy. (2004)
  • Author(s): Suzuki T, Yamakawa K, Kaneko S, et al.
  • Journal Title: Nature Genet 36/8 Pages: 842-849
• [Journal Article] Seizure phenotypes of a family with missense mutations in SCN2A. (2004)
  • Author(s): Ito M, Hirose S, et al.
  • Journal Title: Pediatr Neurol 31/2 Pages: 150-152
• [Journal Article] Mutation of neuronal voltage-gated Na^+ channel alpha 1 subunit gene SCN1A in core severe myoclonic epilepsy in infancy (SMEI) and in borderline SMEI (SMEB). (2004)
  • Author(s): Fukuma G, Kaneko S, et al.
  • Journal Title: Epilepsia 45/2 Pages: 140-148
• [Journal Article] Defective function of GABA-containing synaptic vesicles in mice lacking the AP-3B clathrin adaptor. (2004)
  • Author(s): Nakatsu F, et al.
  • Journal Title: J Cell Biol 167/2 Pages: 293-302
• [Journal Article] Protein kinase associated with gating and closing transmission mechanisms in temporoammonic patyway. (2004)
  • Author(s): Okada M, et al.
  • Journal Title: Neuropharmacol 47/4 Pages: 485-504
• [Journal Article] Effect of localization of missense mutations in SCN1A on epilepsy phenotype severity. (2004)
  • Author(s): Kanai K, et al.
  • Journal Title: Neurology 63/2 Pages: 329-334
• [Journal Article] Evaluation of the color-coding method for searching tanden repeats in prokaryotic genomes. (2004)
  • Author(s): Mizuta S, Shimizu T, et al.
  • Journal Title: Chem-Bio Informatics J 4/4 Pages: 133-141
• [Journal Article] Proteome-wide functional classification and identification of Prokaryotic transmembrane proteins by transmembrane topology similarity comparison. (2004)
  • Author(s): Arai M, Shimizu T, et al.
  • Journal Title: Protein Sci 13 Pages: 2170-2183
• [Journal Article] ConPred II : a consensus prediction method for obtaining transmembrane topology models with high reliability. (2004)
  • Author(s): Arai M, Shimizu T, et al.
  • Journal Title: Nucleic Acids Res 32 Pages: 390-393
• [Journal Article] Internal gene duplication in the evolution of prokaryotic transmembrane proteins. (2004)
  • Author(s): Shimizu T, et al.
  • Journal Title: J Mol Biol 339 Pages: 1-15
• [Journal Article] Loss of PGC-specific expression of the orphan nusleara receptor ERR-β results in reduction of germ cell number in mouse embryos. (2004)
  • Author(s): Mitsunaga K, Araki K, et al.
  • Journal Title: Mechanisms Development 121 Pages: 237-246
• [Journal Article] Serine-arginine-rich muclear protein Luc71 regulates myogenesis in mice. (2004)
  • Author(s): Kimura E, Araki K, et al.
  • Journal Title: Gene 341 Pages: 41-47
• [Journal Article] Both 3, 4-dihydroxyphenylalanine and dopamine release are regulated by Ca^<2+>-induced Ca^<2+> releasing system in rat stritum. (2004)
  • Author(s): Zhu G, et al.
  • Journal Title: Neurosci Lett 362/3 Pages: 244-248
• [Journal Article] Pharmacological discrimination of protein kinase associated exocytosis mechanisms between dopamine and 3, 4-dihydroxyphenylalanine in rat using in vivo. (2004)
  • Author(s): Zhu G, et al.
  • Journal Title: Neurosci Lett 363/2 Pages: 120-124
• [Journal Article] Determination of exocytosis mechanisms DOPA in rat striatum using in vivo microdialysis. (2004)
  • Author(s): Zhu G, et al.
  • Journal Title: Neurosci Lett 367 Pages: 241-245
• [Journal Article] Marital status of patients with epilepsy with special reference to the influence of epileptic seizures on the patient's married life. (2004)
  • Author(s): Wada K, et al.
  • Journal Title: Epilepsia 45(Suppl.(8) Pages: 33-36
• [Journal Article] Physical and psychomotor development in the offspring born to mothers with epilepsy. (2004)
  • Author(s): Hirano, T, et al.
  • Journal Title: Epilepsia 45(Suppl.8) Pages: 53-57
• [Journal Article] Contribution of Asian mouse subspecies Mus musculus molossinus to genomic constitution of strain C57BL/6J, as defined by BAC-end sequences-SNP analysis. (2004)
  • Author(s): Abe K, Kojima T, et al.
  • Journal Title: Genome Res 14/12 Pages: 2439-2447
• [Journal Article] Association analysis between longevity in the Japanese population land polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways. (2004)
  • Author(s): Kojima T, et al.
  • Journal Title: Exp Gerontol 39/11-12 Pages: 1595-1598
• [Journal Article] Japanese SCA families with an unusual phenotype linked to a locus overlapping with SCA15 locus. (2004)
  • Author(s): Hara K, Kuwano R, Tsuji S, et al.
  • Journal Title: Neurology 62/4 Pages: 648-651
• [Journal Article] A rare case of hypohidrotic ectodermal dysplasia by compound heterozygous mutations in the EDAR gene. (2004)
  • Author(s): Shimomura Y, Kuwano R, et al.
  • Journal Title: J Invest Dermatol 123/4 Pages: 649-655
• [Journal Article] Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization. (2004)
  • Author(s): Angeli V, Satoh K, et al.
  • Journal Title: Immunity 21 Pages: 561-574
• [Journal Article] Double-stranded RNA enhances the expression of galectin-9 in vascular endothelial cells. (2004)
  • Author(s): Ishikawa A, Satoh K, et al.
  • Journal Title: Immunol Cell Biol 82 Pages: 410-414
• [Journal Article] Retinoic acid-inducible gene-I is induced by interferon-γ and regulates the expression of interferon-γ stimulated gene 15 in MCF-7 cells. (2004)
  • Author(s): Cui XE, Satoh K, et al.
  • Journal Title: Biochem Cell Biol 82 Pages: 401-405
• [Journal Article] Heparin inhibits IFN-γ induced fractalkine/CX3CL1 expression in human endothelial cells. (2004)
  • Author(s): Hatakeyama M, Satoh K, et al.
  • Journal Title: Inflammation 28/1 Pages: 7-13
• [Journal Article] Regulation of CX3CL1/fractalkine expression in endothelial cells. (2004)
  • Author(s): Imaizumi T, Satoh K, et al.
  • Journal Title: J Atherosclerosis Thrombosis 11/1 Pages: 15-21
• [Journal Article] 15-deoxy- ^<12,14>-prostaglandin J_2 inhibits the IL-1β-induced expression of granulocyte-macrophage colony-stimulating factor in BEAS-2B bronchial epithelial cells. (2004)
  • Author(s): Kumagai M, Satoh K, et al.
  • Journal Title: Tohoku J Exp Med 202 Pages: 69-76
• [Journal Article] Different inhibitory effect of fluvoxamine on omeprazole metabolism between CYP2C19 genotype. (2004)
  • Author(s): Yasui-Furukori N, et al.
  • Journal Title: Br J Clin Pahrmacol 57/4 Pages: 487-494
• [Journal Article] The effects of ginkgo biloba extracts on the pharmacokinetics and pharmacodynamics of donepezil. (2004)
  • Author(s): Yasui-Furukori N, et al.
  • Journal Title: J Clin Pharmacol 44/5 Pages: 538-542
• [Journal Article] Effects of various factors on steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone : lack of impact of MDR-1 genotypes. (2004)
  • Author(s): Yasui-Furukori N, et al.
  • Journal Title: Br J Clin Pharmacol 57/5 Pages: 569-575
• [Journal Article] Hyperactivity of endoplasmic reticulum associated exocytosis mechanism contributes to acute phencyclidine intoxication. (2004)
  • Author(s): Zhu G, et al.
  • Journal Title: J Pharmacol Sci 95 Pages: 214-227
• [Journal Article] Establishment of new cloned enzyme donor immuassays (CEDIA【○!R】) for haloperidol and bromperidol. (2004)
  • Author(s): Yasui-Furukori N, et al.
  • Journal Title: Ther Drug Monit 26/3 Pages: 336-341
• [Journal Article] Pertussis toxin-sensitive pathway inhibits glucose-stimulated Ca^<2+> signals of rat islet β-cells by affecting L-type Ca^<2+> channels and voltage-dependent K^+ channels (2004)
  • Author(s): Suga S, Wakui M, et al.
  • Journal Title: Cell Calcium 36 Pages: 469-477
• [Journal Article] 2-aminoethoxydiphenyl borate inhibits agonist-induced Ca^<2+> signals by blocking inositol trisphosphate formation in acutely dissociated mouse pancreatic acinar cells. (2004)
  • Author(s): Wu J, Wakui M, et al.
  • Journal Title: Pflugers Arch-Eur J Physiol 448 Pages: 592-595
• [Journal Article] Expression of retinoic acid-inducible gene-I in vascular smooth muscle cells stimulated with interferon-γ. (2004)
  • Author(s): Imaizumi T, Satoh K, et al.
  • Journal Title: Life Sci 75 Pages: 1171-1180
• [Journal Article] Interferon-γ induces retinoic acid-inducible gene-I in endothelia cells. (2004)
  • Author(s): Imaizumi T, Satoh K, et al.
  • Journal Title: Endothelium 11 Pages: 169-173
• [Journal Article] Risk factors for hip fracture among elderly patients with Alzheimer's disease. (2004)
  • Author(s): Sato Y, Satoh K, et al.
  • Journal Title: J Neurol Sci 223 Pages: 107-112
• [Journal Article] Upregulation of retinoic acid-inducible gene-I in T24 urinary blander carcinoma cells stimulated with interferon-γ. (2004)
  • Author(s): Imaizumi T, Satoh K, et al.
  • Journal Title: Tohoku J Exp Med 203 Pages: 313-318
• [Journal Article] Abnormal calcium homeostasis in disabled stroke patients with low 25-hydroxyvitamin D. (2004)
  • Author(s): Sato Y, Satoh K, et al.
  • Journal Title: Bone 34 Pages: 710-715
• [Journal Article] Interleukin-I β induces matrix metalloproteinase-I expression in cultured human gingival fibroblasts : role of cyclooxygenase-2 and prostaglandin E_2. (2004)
  • Author(s): Sasaki H, Satoh K, et al.
  • Journal Title: Oral Diseases 10 Pages: 87-93
• [Journal Article] Myopathy phenotype in transgenic mice expressing mutated PABPN1 as a model of oculopharyngeal muscular dystrophy. (2004)
  • Author(s): Hino H, Araki K, et al.
  • Journal Title: Human Mol Genet 13/2 Pages: 181-190
• [Journal Article] チャネロパチー (2004)
  • Author(s): 兼子直
  • Journal Title: 分子精神医学 4/2 Pages: 162-163
• [Journal Article] 抗てんかん薬の分類とその特徴 (2004)
  • Author(s): 和田一丸, 他
  • Journal Title: 日本医師会雑誌 131/12 Pages: 97-98
• [Journal Article] てんかんの遺伝子診断の可能性 (2004)
  • Author(s): 兼子直, 他
  • Journal Title: 精神経誌 106/5 Pages: 660-670
  • NAID: 10014249833
• [Journal Article] 熱性けいれん,熱性けいれんプラス,及び乳児重症ミオクロニーてんかんの遺伝子解析と遺伝子診断の設定 (2004)
  • Author(s): 兼子直, 他
  • Journal Title: てんかん治療研究振興財団研究年報 16 Pages: 91-100
  • NAID: 120001197367
• [Journal Article] てんかんの遺伝子 (2004)
  • Author(s): 兼子直, 他
  • Journal Title: 神経進歩 48/6 Pages: 889-898
• [Journal Article] 特発性てんかんの分子生物学 (2004)
  • Author(s): 廣瀬伸一
  • Journal Title: 小児神経学の進歩 33 Pages: 60-67
• [Journal Article] GABA受容体,Kチャネル異常を示すてんかん (2004)
  • Author(s): 廣瀬伸一, 他
  • Journal Title: てんかん研究 22/3 Pages: 160-170
  • NAID: 10016244179
• [Journal Article] イオンチャネルとてんかん (2004)
  • Author(s): 廣瀬伸一
  • Journal Title: 神経進歩 48/6 Pages: 899-905
• [Journal Article] てんかんの病態へ分子生物学で迫る (2004)
  • Author(s): 廣瀬伸一
  • Journal Title: 臨床神経学 44/11 Pages: 975-978
  • NAID: 10014115075
• [Journal Article] リバースゲノミクス的研究手法を用いた中枢系機能性疾患におけるERストレス仮説の構築 (2004)
  • Author(s): 岡田元宏, 他
  • Journal Title: 精神薬療基金研究年報 36 Pages: 74-82
• [Journal Article] マイクロダイアリーシスを用いた神経伝達物質開口分泌機構の解明 (2004)
  • Author(s): 岡田元宏, 他
  • Journal Title: 日本神経精神薬理学雑誌 24 Pages: 165-170
  • NAID: 10015423137
• [Journal Article] Child neurology in asia (2004)
  • Author(s): 廣瀬伸一, 他
  • Journal Title: 脳と発達 36/2 Pages: 141-142
  • NAID: 10012951581
• [Journal Article] 抗精神病薬の薬物動態と遺伝子多型 (2004)
  • Author(s): 古郡規雄, 他
  • Journal Title: 分子精神医学 4/3 Pages: 1-5
• [Journal Article] DNA variants in coding region of EFHC1 : SNPs do not associate with juvenile myoclonic epilepsy
  • Author(s): Bai D, Bailey JN, Duron RM, Alonso ME, Medina MT, Martinez-Juarez IE, Suzuki T, Machado-Salas J, Ramos-Ramirez R, Tanaka M, Ortega RH, Lopez-Ruiz M, Rasmussen A, Ochoa A, Jara-Prado A, Yamakawa K, Delgado-Escueta AV.
  • Journal Title: Epilepsia (Epub ahead of print)(掲載確定)
  • Peer Reviewed
• [Presentation] 部分てんかん治療におけるトピラマートの意義. (2008)
  • Author(s): 兼子直.
  • Organizer: 第35回東北てんかん談話会
  • Place of Presentation: 盛岡
  • Year and Date: 2008-03-08
• [Presentation] てんかん責任遺伝子変異データベースー. (2008)
  • Author(s): 吉田秀一, 金井数明, 小島俊男, 山崎祥拓, 清水俊夫, 兼子直, Epilepsy Genetic Study Group Japan.
  • Organizer: 第35回東北てんかん談話会
  • Place of Presentation: 盛岡
  • Year and Date: 2008-03-08
• [Presentation] Epilepsy and Pregnancy. (2008)
  • Author(s): Kaneko S.
  • Organizer: International CME on Emerging Trends in Management of Epilepsy
  • Place of Presentation: Mumbai, INDIA
  • Year and Date: 2008-01-12
• [Presentation] Epilepsy and Pregnancy. (2008)
  • Author(s): Kaneko S.
  • Organizer: International CME on Emerging Trends in Management of Epilepsy
  • Place of Presentation: Bengalore, INDIA
  • Year and Date: 2008-01-11
• [Presentation] Epilepsy and Pregnancy. (2008)
  • Author(s): Kaneko S.
  • Organizer: International CME on Emerging Trends in Management of Epilepsy
  • Place of Presentation: Kolkata, INDIA
  • Year and Date: 2008-01-10
• [Presentation] Epilepsy and Pregnancy. (2008)
  • Author(s): Kaneko S.
  • Organizer: International CME on Emerging Trends in Management of Epilepsy
  • Place of Presentation: Delhi, INDIA
  • Year and Date: 2008-01-09
• [Presentation] Epilepsy Genetic Study Group Japan.Development of individualizedmedicine for epilepsy based upongenetic polymorphisms (2008)
  • Author(s): Kaneko S, Yoshida S, Kanai K, Iwasa H, Yasui-Furukori N
  • Organizer: 2008International Conference onPharmacogenomics (Joint Conferencewith the 14th Annual Meeting of thePRACP)
  • Place of Presentation: Busan, KOREA
• [Presentation] S6 : Pharmacogenomics based personalized pharmacotherapy : Development of individualized medicine for epilepsy based upon gene tic polymorphisms : Potential in the combination of various res earch approaches (2008)
  • Author(s): Kaneko S, Yoshida S, Kanai K, Iwasa H, Yasui-Furukori N, and Epilepsy Genetic Study Group Japan
  • Organizer: 2008 International Conference on Pharmacogenomics (Joint Conference with the 14^<th> Annual Meeting of the PRACP)
  • Place of Presentation: Busan, KOREA
• [Presentation] Allele frequencies of CYP2C19 and CYP2D6 in a Japanese population (2008)
  • Author(s): Yasui-Furukori N, Uemichi T, Nobori T, Mizuno M, Shirahama S, Miyoshi Y, and Kaneko S.
  • Organizer: 2008 International Conference on Pharmacoge nomics (Joint Conference with the 14^<th> Annual Meeting of the PRACP)
  • Place of Presentation: Busan, KOREA
• [Presentation] Genomo-waide identification of febrile seizure and related epilepsy phenotype loci (2008)
  • Author(s): Yoshida S, Miyashita A, Kuwano R, Kojima T, Zhu G, Kanai K, Fujita K, Hirano S, and Kaneko S.
  • Organizer: 7^<th> Asian & Oceanian Epilepsy Congress
  • Place of Presentation: Xiamen. CHINA
• [Presentation] Determination of neurotransmitter release in a novel spontaneous epilepsy model, Prip-1 knockout mice (2008)
  • Author(s): Zhu G, Okada M, Yoshida S, Ueno S, Wakabayashi K, and Kaneko S.
  • Organizer: 7^<th> Asian & Oceanian Epilepsy Congress
  • Place of Presentation: Xiamen, CHINA
• [Presentation] Applicability of new spin trap agent, 2-diphenylphosphinoyl-2-methyl-3, 4-dihydro-2H-pyrrole N-oxide, in biological system (2008)
  • Author(s): Karakawa T, Muramoto Y, Mitani Y, Kitamado M, Iwanaga T, Nabeshima T, Maruyama K, Nakagawa K, Ishida K, Sasamoto K, Sato K.
  • Organizer: A Joint Conference of the 13th In Vivo ESR/EPR Spectroscopy & Imaging and the 10th International EPR Spin Trapping/Spin Labeling : Biomedical Redox Navigation (EPR2008)
  • Place of Presentation: Fukuoka, JAPAN
• [Presentation] Superoxide scavenging activity of pirfenidone-iron complex (2008)
  • Author(s): Mitani Y, Muramoto Y, Karakawa T, Kitamado M, Iwanaga T, Nabeshima T, Maruyama K, Nakagawa K, Ishida K, Sasamoto K, Sato K.
  • Organizer: A Joint Conference of the 13th In Vivo ESR/EPR Spectroscopy & Imaging and the 10th Inte rnational EPR Spin Trapping/Spin Labeling : Biomedical Redox Navigation (EPR2008)
  • Place of Presentation: Fukuoka, JAPAN
• [Presentation] Effects of Genetic Polymorphisms And Occupational Exposure to Canary Seed Dust on Longitudinal decline in pulmonary function (2008)
  • Author(s): Pahwa P, Nakagawa K, Koehncke N, McDuffie HH.
  • Organizer: The Sixth International Symposium : Public health and the agricultural rural ecosystem
  • Place of Presentation: Saskatoon, Canada
• [Presentation] Association between high-risk genotypes of glutathione S-trans ferases and type 2 diabetes mellitus, non-alcoholic fatty liver disease and hypertension (2008)
  • Author(s): Nakagawa K, Fujimura Y, Umemoto Y, Oniki K, Seo T, Mihara S, Marubavashi T.
  • Organizer: The Sixth International Symposium : Public health and the agricultural rural ecosystem
  • Place of Presentation: Saskatoon, Canada
• [Presentation] A De Novo KCNQ2 Mutation Detected in Benign Neonatal Convulsions : Possible Involvement Of Genes responsible for Rare Inherited Epilepsy in Idiopathic Epilepsy (2008)
  • Author(s): Ishii A, Fukuma G, Uehara A, Yasukochi M, Miyajima T, Makita Y, Hamachi A, Yonetani M, Inoue T, Okada M, Kaneko S, and Hirose S.
  • Organizer: The 4^<th> Congress of Asian Society for Pediatric Research
  • Place of Presentation: Hawaii, USA
• [Presentation] Perinatal Characteristics of Early-Onset Sepsis in Neonatal Intensive Care Unit in Recent Years (2008)
  • Author(s): Tsutsumi M, Ohta E, Inoue T, Kinoshita R, Nakamura M, Mori T. Hirose S.
  • Organizer: The 4^<th> Congress of Asian Society for Pediatric Research
  • Place of Presentation: Hawaii, USA
• [Presentation] The Application of Genetic Tests for Epilepsy-are there Guidelines for Clinicians? (2008)
  • Author(s): Hirose S
  • Organizer: 7^<th> Asian & Oceanian Epilepsy Congress Xiamen
  • Place of Presentation: Xiamen, CHINA
• [Presentation] EEG Findings on Headache with MELAS (2008)
  • Author(s): Ihara Y, Fujita T, Inoue T, Yasumoto S, Mitsudome A, Hirose S.
  • Organizer: 7^<th> Asian & Oceanian Epilepsy Congress Xiamen
  • Place of Presentation: Xiamen, CHINA
• [Presentation] Myoclonic-Astatic Epilepsy with Focal Spike Discharge may have Unfavourable Prognosis (2008)
  • Author(s): Ideguchi H, Inoue T, Ninomiya S, Fujita T, Nakamura N, Yasumoto S, Hirose S.
  • Organizer: 7^<th> Asian & Oceanian Epilepsy Congress Xiamen
  • Place of Presentation: Xiamen, CHINA
• [Presentation] Non-convulsive Status Epilepticuso of Temporal Lobe Epilepsy Misdiagnosed as a Psychosomatic Disease (2008)
  • Author(s): Fujita T, Nakamura N, Inoue T, Ninomiya S, Ihara Y, Tomonou Y, Ideguchi H, Yasumoto S. Mitsudome A. Hirose S.
  • Organizer: 7^<th> Asian & Oceanian Epilepsy Congress Xiamen
  • Place of Presentation: Xiamen, CHINA
• [Presentation] Psychomotor Retardation Aggravated by Infantile Non-convpislve Status Epileptics in Angelman Syndrome (2008)
  • Author(s): Ninomiya S, Nakamura N, Fujita T, Ideguchi H, Inoue T., Yasumoto S, Hirose S.
  • Organizer: 7^<th> Asian & Oceanian Epilepsy Congress Xiamen
  • Place of Presentation: Xiamen, CHINA
• [Presentation] The present Status and Problem of Plenatal Screening of Congenital Heart Defects ; 4 Major Refernal Centers in Kyusyu, Japan (2008)
  • Author(s): Yoshikane Y, Yoshizato T, Maeno Y, Nishibatake M, Kam N, Fusazaki N, Hirose S.
  • Organizer: The 2^<nd> Asia-Pacific Congress of Pediatrics Cordiology and Cardiac Surgery
  • Place of Presentation: Korea
• [Presentation] Retrospective Analysis of Prenatally Detected Congenital Heart Defects : Six-year Experience of 4 Institutions in Japan (2008)
  • Author(s): Yashikane Y, Yoshizato T, Meno Y, Nishibatake M, Kan N, Fusazaki N, Hirose S.
  • Organizer: 15^<th> Congress of the FAOPS
  • Place of Presentation: Nagoya, JAPAN
• [Presentation] Study of Septicemia Due to Enterbacter Cloacae in a Tertiary Neonatal Intensive Care Unit during 1997-2007 (2008)
  • Author(s): Ohta E, Setoue T, Tsutsumi M, Inoue S, Kinoshita R, Nakamura M, Mori T, Ogawa A, Hirose S.
  • Organizer: 15^<th> Congress of the FAOPS
  • Place of Presentation: Nagoya, JAPAN
• [Presentation] Prognoses of the Neonates of Multiple Births Admitted in NICU in recent Years (2008)
  • Author(s): Inoue T, Tsutsumi M, Kiposhita R, Ohta E, Nakamura M, Mori T, Hirose S.
  • Organizer: 15^<th> Congress of the FAOPS
  • Place of Presentation: Nagoya, JAPAN
• [Presentation] A new mode of prespore gene regulation : DdMybF functions as a reoressor for nresnore differentiation (2008)
  • Author(s): Tomita K, Fukuzawa M.
  • Organizer: Dictyostelium international conference
  • Place of Presentation: Tsukuba, Japan
• [Presentation] A novel differentiation inducing factor with low molecular weight in Dictyostelium discoideum : its purifi cation and characte rization (2008)
  • Author(s): Takaya Y, Fukuzawa M, Hotta R, Nakagawa M, Oohata AA.
  • Organizer: Dictyostelium international conference
  • Place of Presentation: Tsukuba, Japan
• [Presentation] Dictyostelium PKB/AKT related kinase may function as an activator for a putative switch of stalk formation (2008)
  • Author(s): Ochiai H, Koki, Nagayama K, Takeda K, Fukuzawa M, Takiya S, Ohmachi T.
  • Organizer: Dictyostelium international conference
  • Place of Presentation: Tsukube, Japan
• [Presentation] 統合失調症薬物治療における薬物相互作用・副作用に関する文献的考察(高プロラクチン血症を中心に). (2007)
  • Author(s): 古郡規雄, 斉藤まなぶ, 中神卓, 兼子直.
  • Organizer: 平成19年度精神・神経疾患研究委託費(18指-7)研究報告会
  • Place of Presentation: 東京
  • Year and Date: 2007-12-16
• [Presentation] てんかんの個別化治療の開発に関する研究. (2007)
  • Author(s): 兼子直, 岩佐博人, 古郡規雄, 岡田元宏, 土嶺章子, 佐々木智美, 藤井学, 吉田秀一, 廣瀬伸一, 石津棟暎, 小国弘量, 大澤真木子, 前澤真理子, 小島俊男, 金井数明, 和田一丸.
  • Organizer: 平成19年度精神・神経疾患研究委託費(19指-6)研究報告会
  • Place of Presentation: 東京
  • Year and Date: 2007-12-16
• [Presentation] シンポジウムI:強迫の臨床,思春期発症の摂食障害女性・A子の長期治療経過-摂食障害における強迫性をめぐって-. (2007)
  • Author(s): 栗林理人, 兼子直.
  • Organizer: 第61回東北精神神経学会
  • Place of Presentation: 仙台
  • Year and Date: 2007-10-07
• [Presentation] てんかんの薬物治療-現状と展望-. (2007)
  • Author(s): 兼子直.
  • Organizer: 第43回(社)日本脳神経外科学会東北支部会
  • Place of Presentation: 弘前
  • Year and Date: 2007-09-08
• [Presentation] てんかん・熱性けいれん遺伝子解析グループ.マイクロサテライトマーカーを用いたFS・GEFS+・SMEIにおける新規責任遺伝子の網羅的検索(第1報). (2007)
  • Author(s): 吉田秀一, 桑野良三, 宮下哲典, 小島俊男, 佐々木智美, 朱剛, 金井数明, 伊藤正利, 藤田浩史, 廣瀬伸一, 兼子直, ,
  • Organizer: 第1回日本てんかん学会東北地方会
  • Place of Presentation: 仙台
  • Year and Date: 2007-07-14
• [Presentation] 機能性精神疾患の皮質錐体細胞回路障害のtwo hit model仮説の構築. (2007)
  • Author(s): 兼子直.
  • Organizer: 平成19年度特定領域研究「統合脳」夏のワークショップ合同班会議・統合シンポジウム・サテライトシンポジウム
  • Place of Presentation: 札幌
• [Presentation] ミスマッチ陰性電位における時間窓統合機能内部の逸脱検出感度と刺激呈示確率との関係について. (2007)
  • Author(s): 松岡貴志, 朝井廉, 原悦子, 矢部博興, 兼子直.,
  • Organizer: 第24回日本脳電磁図トポグラフィ研究会
  • Place of Presentation: 岡崎
• [Presentation] パロキセチンの薬物動態に対するイトラコナゾールの影響-消化管の役割-. (2007)
  • Author(s): 古郡規雄, 斉藤まなぶ, 新岡武典, 井上義政, 佐藤靖, 兼子直.
  • Organizer: 第17回日本臨床精神神経薬理学会
  • Place of Presentation: 大阪
• [Presentation] 統合失調症におけるリスペリドンによる治療効果と血漿薬物濃度の関係について. (2007)
  • Author(s): 古郡規雄, 斉藤まなぶ, 中神卓, 古郡華子, 鈴木昭仁, 三原一雄, 近藤毅, 兼子直.
  • Organizer: 第17回日本臨床精神神経薬理学会
  • Place of Presentation: 大阪
• [Presentation] 急性期におけるrisperidoneと選択的dopamine遮断薬の治療反応性の比較. (2007)
  • Author(s): 斉藤まなぶ, 古郡規雄, 中神卓, 古郡華子, 石田正之, 田中治, 三原一雄, 鈴木昭仁, 大谷浩一, 近藤毅, 兼子直.
  • Organizer: 第17回日本臨床精神神経薬理学会
  • Place of Presentation: 大阪
• [Presentation] オランザピンおよびリスペリドネ内服中の統合失調症患者のクッキーテストによる代謝性因子の比較検討. (2007)
  • Author(s): 佐藤靖, 古郡規雄, 斉藤まなぶ, 中神卓, 古郡華子, 兼子直.
  • Organizer: 第17回日本臨床精神神経薬理学会
  • Place of Presentation: 大阪
• [Presentation] リスペリドンの薬物反応性における主要MDR1遺伝子型C3435Tの役割について. (2007)
  • Author(s): 中神卓, 古郡規雄, 土嶺章子, 斉藤まなぶ, 古郡華子, 高橋一志, 樋口久, 近藤毅, 兼子直.
  • Organizer: 第17回日本臨床精神神経薬理学会
  • Place of Presentation: 大阪
• [Presentation] 早期治療反応性を用いたリスペリドンの初期治療におけるプロラクチン反応. (2007)
  • Author(s): 楠木将人, 古郡規雄, 斉藤まなぶ, 中神卓, 古郡華子, 鈴木昭仁, 近藤毅, 兼子直.
  • Organizer: 第17回日本臨床精神神経薬理学会
  • Place of Presentation: 大阪
• [Presentation] 抗てんかん薬慢性投与による細胞内カルシウム放出(CICR)機構に対する発現変化の検討. (2007)
  • Author(s): 吉田淑子, 岡田元宏, 朱剛, 兼子直.
  • Organizer: 第41回日本てんかん学会
  • Place of Presentation: 福岡
• [Presentation] 乳児重症ミオクロニー患者におけるSCN1A遺伝子を含んだ染色体微小欠失. (2007)
  • Author(s): 倉橋宏和, 王紀文, 大府正治, 井上貴仁, 小川厚, 安元佐和, 小島俊男, 兼子直, 廣瀬伸一.
  • Organizer: 第41回日本てんかん学会
  • Place of Presentation: 福岡
• [Presentation] てんかん治療における新規抗てんかん薬の使い方-トピラマートを中心に-. (2007)
  • Author(s): 兼子直.
  • Organizer: 第41回日本てんかん学会
  • Place of Presentation: 福岡
• [Presentation] 逸脱音検出時に誘発される事象関連反応に対する注意の影響. (2007)
  • Author(s): 朝井廉, 矢部博興, 原悦子, 晝間臣治, 松岡貴志, 朝井春子, 兼子直.
  • Organizer: 第37回日本臨床神経生理学会学術大会
  • Place of Presentation: 宇都宮
• [Presentation] 時間統合窓(TWI)内部における逸脱呈示確率の効果について:第二報. (2007)
  • Author(s): 松岡貴志, 矢部博興, 朝井廉, 原悦子, 晝間臣治, 兼子直.
  • Organizer: 第37回日本臨床神経生理学会学術大会
  • Place of Presentation: 宇都宮
• [Presentation] 日本人のTCIによる人格特性とMAO-AおよびCOMT遺伝子多型との関係について. (2007)
  • Author(s): 土嶺章子, 古郡規雄, 金田絢子, 斉藤まなぶ, 中神卓, 兼子直.
  • Organizer: 第29回日本生物学的精神医学会, 第37回日本神経精神薬理学会合同年会
  • Place of Presentation: 札幌
• [Presentation] ドパミン受容体遺伝子多型と日本人における人格特性との関係について (2007)
  • Author(s): 古郡規雄, 土嶺章子, 金田絢子, 斉藤まなぶ, 中神卓, 兼子直.
  • Organizer: 第29回日本生物学的精神医学会, 第37回日本神経精神薬理学会合同年会
  • Place of Presentation: 札幌
• [Presentation] ポア形成領域以外に生じたSCN1Aミスセンス変異のアミノ酸置換が表現型に与える影響. (2007)
  • Author(s): 金井数明, 廣瀬伸一, 小国弘量, 福間五龍, 桑原聡, 吉田秀一, 澤井摂, 岩佐博人, 清水俊夫, 伊藤正利, 服部孝道, 兼子直.
  • Organizer: 第41回日本てんかん学会
  • Place of Presentation: 福岡
• [Presentation] DRIP-1遺伝子欠損マウスの自発性けいれん発現機序の解明. (2007)
  • Author(s): 朱剛, 岡田元宏, 吉田淑子, 吉田秀一, 森秋文, 上野伸哉, 兼松隆, 若林孝一, 兼子直.
  • Organizer: 第41回日本てんかん学会
  • Place of Presentation: 福岡
• [Presentation] 機能性精神疾患の皮質錐体細胞回路障害のtwo hit model仮説の構築. (2007)
  • Author(s): 兼子直.
  • Organizer: 平成19年度特定領域研究「統合脳」冬のシンンポジウム
  • Place of Presentation: 東京
• [Book] てんかんの生物学的背景-病態解明から個別化治療の開発へ-. てんかん-臨床的側面-. 松下正昭, 加藤敏, 神庭重信編. 精神医学対話. (2008)
  • Author(s): 兼子直
  • Total Pages: 1064
  • Publisher: (株)弘文堂・東京発行
• [Book] Progress in genetics of severe myoclonic epilepsy in fancy. In : Fukuyama Y, Takahashi T, editors. Progress in Epileptic Disorders Biology of Seizere Susceptibility in Developing Brain. 1-3 (2008)
  • Author(s): Kurahashi K, Wang J, Ishii A, Fukuma G, Hamachi A, Yonetani M, Ogawa A, Ohfu M, Inoue T, Yasumoto S, Hirose S.; 2008
  • Total Pages: 734
  • Publisher: Paris : Editions John Libbey Eurotext Montrouge
• [Book] Roadmap抗精神病薬の精神薬理を生かした重度精神疾患個別化治療(ed. by Peter JW et.al. Translating the psychopharmacology of antipsychotics to individualized treatment for severe mental illness : a roadmap). 兼子直監訳 (2008)
  • Author(s): 兼子直
  • Total Pages: 77
  • Publisher: アルタ出版(株)・東京
• [Book] てんかんの生物学的背景-病態解明から個別化治療の開発ヘ-. てんかん-臨床的側面-. 松下正昭, 加藤敏, 神庭重信編. 精神医学対話. 1002-14 (2008)
  • Author(s): 兼子直
  • Total Pages: 1064
  • Publisher: (株)弘文堂・東京
• [Book] てんかん.コア・ローテイション精神科(改訂2版) (2007)
  • Author(s): 和田一丸, 兼子直.
  • Total Pages: 426
  • Publisher: 金芳堂
• [Book] チャネロパチー.KEY WORD精神(第4版) (2007)
  • Author(s): 兼子直.
  • Total Pages: 240
  • Publisher: (株)先端医学社
• [Book] 佐藤光源, 丹羽真一, 井上新平編:統合失調症の治寮-臨床と基礎-. (2007)
  • Author(s): 森園修一郎, 菊池淳宏, 近藤毅, 兼子直.
  • Total Pages: 576
  • Publisher: 朝倉書店
• [Book] バルプロ酸の臨床薬理(改訂版) (2006)
  • Author(s): 兼子直, Heinz Nau
  • Publisher: ライフ・サイエンス
• [Book] Chaptor 6 : mechanisms of calcium-associated exocytosis of striatal dopamine and DOPA release, studied by in vivo microdialysis. (Eds by Misu Yoshimi & Goshima Yoshio), pp.89-99 (2005)
  • Author(s): Okada Motohiro, Zhu Gang, Yoshida Shukuko, Hirose Shinichi, Kaneko Sunao
  • Total Pages: 350
  • Publisher: Taylor & Francis ; New York
• [Book] 「脳の世紀」推進会議(伊藤正男, 晝馬輝夫, 河西春郎, 山口陽子, 兼子直, 酒井邦嘉)編,脳を知る・創る・守る・育む,pp.100-129 (2005)
  • Author(s): 兼子 直
  • Total Pages: 155
  • Publisher: (株)クバプロ,東京
• [Book] Exchangeable gene trapping. In Genetically Engineered Mice (eds Sundberg.J.P. & IchikiT.) pp.131-143. (2005)
  • Author(s): Araki, K.
  • Total Pages: 300
  • Publisher: CRC Press, Boca Raton, USA
• [Book] イオンチャネル仮説 (2004)
  • Author(s): 金井数明
  • Total Pages: 391
  • Publisher: 石郷岡純編「精神疾患100の仮説(改訂版)」,星和書店,東京
• [Book] てんかん (2004)
  • Author(s): 和田一丸, 他
  • Total Pages: 386
  • Publisher: 武田雅俊,鹿島春雄編集「コア・ローテイション精神科」,金芳堂,東京
• [Book] てんかんの仮説 (2004)
  • Author(s): 兼子直, 他
  • Total Pages: 391
  • Publisher: 石郷岡純編「精神疾患100の仮説(改訂版)」,星和書店,東京
• [Book] ニコチン性アセチルコリン受容体のアセチルコリン開口分泌機構に与える効果 (2004)
  • Author(s): 岡田元宏
  • Total Pages: 85
  • Publisher: 佐藤公道編集「セロトニン:最近の話題(第7回神経伝達物質研究会記録集),Excerpta Medica, Elesevier Japan, K.K.
• [Book] 妊娠とてんかん (2004)
  • Author(s): 兼子直, 他
  • Total Pages: 23
  • Publisher: 武谷雄二監修「Recent Advances in Reproductive Medicine」,Excerpta Medica, Elesevier Japan, K.K., Tokyo
• [Remarks]
  • URL: http://www.enieene.ora/mutation/
• [Patent(Industrial Property Rights)] てんかんモデル非ヒトモデル哺乳動物 (2009)
  • Inventor(s): 兼子直, 廣瀬伸一
  • Industrial Property Rights Holder: 兼子直, 廣瀬伸一
  • Industrial Property Number: 2008-031002
  • Filing Date: 2009-02-10
  • Overseas
• [Patent(Industrial Property Rights)] てんかんモデル非ヒト哺乳動物 (2009)
  • Inventor(s): 兼子直, 廣瀬伸一
  • Industrial Property Rights Holder: 兼子直, 廣瀬伸一
  • Filing Date: 2009-02-10
  • Overseas
• [Patent(Industrial Property Rights)] てんかんモデル非ヒト哺乳動物 (2008)
  • Inventor(s): 廣瀬伸一, 兼子直
  • Industrial Property Rights Holder: 廣瀬伸一, 兼子直
  • Industrial Property Number: 2008-031002
  • Filing Date: 2008-02-12
• [Patent(Industrial Property Rights)] けいれん性疾患に関連する遺伝子変異とけいれん性疾患診断方法 (2006)
  • Inventor(s): 小島俊男, 廣瀬伸一, 岡田元宏, 兼子直
  • Industrial Property Rights Holder: 小島俊男, 廣瀬伸一, 岡田元宏, 兼子直
  • Industrial Property Number: 2005-155133
  • Acquisition Date: 2006-12-07
• [Patent(Industrial Property Rights)] てんかんモデル動物(CHRNA4:S284L) (2005)
  • Inventor(s): 廣瀬伸一, 兼子直, 岡田元宏, 斉藤亮
  • Industrial Property Rights Holder: 廣瀬伸一, 兼子直, 岡田元宏, 斉藤亮
  • Industrial Property Number: 2004-062907
  • Acquisition Date: 2005-09-15
  • Overseas
• [Patent(Industrial Property Rights)] てんかんモデル動物(CHRNA4:S284L) (2004)
  • Inventor(s): 廣瀬伸一, 兼子 直, 岡田元宏, 斉藤 亮
  • Industrial Property Rights Holder: 廣瀬伸一, 兼子 直, 岡田元宏, 斉藤 亮
  • Industrial Property Number: 2004-062907
  • Filing Date: 2004-03-05