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Development of comprehensive technology for practical use of bone-inducing capacity of synthesized BMP

Research Project

Project/Area Number 16109009
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionOsaka City University

Principal Investigator

TAKAOKA Kunio  Osaka City University, department of Orthopaedic Surgery, Chairman and professor (30112048)

Co-Investigator(Kenkyū-buntansha) KAZUKI Kennichi  Osaka City University, Graduate School of Medicine Orthopaedic Surgery, Associate professor (80254407)
WAKITANI Shigeyuki  Osaka City University, Graduate School of Medicine Orthopaedic Surgery, Associate professor (70243243)
小林 章郎  大阪市立大学, 大学院医学研究科, 客員助教授 (70285287)
大橋 弘嗣  済生会中津病院, 整形外科, 部長 (70254406)
Project Period (FY) 2004 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥98,020,000 (Direct Cost: ¥75,400,000、Indirect Cost: ¥22,620,000)
Fiscal Year 2007: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2006: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2005: ¥44,070,000 (Direct Cost: ¥33,900,000、Indirect Cost: ¥10,170,000)
Fiscal Year 2004: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Keywordsbone / regeneration / BMP / polymer / CAD / biomaterial / 再生医療 / コンピューター支援デザイン / 骨形成 / 骨形成タンパク / 人工関節 / 骨欠損修復 / 薬物伝達系 / ポリマー材料
Research Abstract

Currently, recombinant BMP-2 (rhBMP-2) is approved in USA and Europe and practically utilized in limited clinical cases for the treatment of severe open fracture or to achieve spinal fusion with use of the BMP-retaining implant as bone graft substitute. However, further wide use of the BMP-2 to repair damaged bone is not realized mainly due to 2 reasons; too expensive cost of the BMP due to requirement of high dose (mg order) of BMP in humans and inadequate delivery systems of the BMP (bovine-derived type 1 collagen with drawbacks of weak mechanical strength and potential concern for immunogenic reaction and/or prion disease transmission). This study aimed at the solution of the issues to enable wide use of the BMP with improved safety, efficacy and reasonable cost In order to eliminate the use of bovine collagen as carrier material for BMP, we originally developed synthetic biodegradable polymer carrier. In order to minimize BMP dose (consequently reduce the cost of BMP-retaing implan … More t), we screened drugs with capacity to intensify bone inducing capacity of BMP. We also attempted to establish a bone defect repairing system with use the BMP-retaining implant in combination with computer aided design system (CAD) and computer aided surgery system (CAS). We believe that these experimental results will be helpful to establish an innovative clinical technology to regenerate or reconstruct damaged skeletal tissue. More details of the results obtained from this project are described below.
1) Development of new drug delivery system for recombinant BMP-2. We have succeeded to develop new biodegradable synthetic polymer (polylactic acid- polyethylene glycol block co-polymer, PLA-PEG) that work well as carrier material for BMP. Optimized molecular size of a block co-polymer polymer is approximately 10,000 daotons and molar ratio of PLA to PEG is 2 by 1. The polymers presented highly sticky nature and not convenient to handle in intra-operative situation. In order to eliminate the difficulty, we added equal volume of biodegradable β -tricalcium phosphate (TCP) powder to the polymer to make to composite material with dough nature. With use of the dough implant in combination with the recombinant BMP-2(mixture ratio of TCP / polymer BMP-2 is 10000 / 10000 / 1 in weight)large bone defects in femur of rabbits or pelvis of dogs were successfully repaired in 6〜8 weeks. And with use of the BMP retaining implants, postero-lateral lumbar fusion (PLF) was successfully achieved in sheep without use of autogeneic bone grafting which has routinely been done in current spine surgery. No adverse event was seen in the use of the implant. Consequently, the artificial bioactive implant consisted of recombinant BMP, TCP and PLA-PEG polymer would be a useful material to repair large bone defects that are difficult in current orthopaedic technology. With use of the new synthetic BMP delivery materials, bone repairing surgery would be less invasive due to no need of additional surgery to procure graft bone mass from other part of the body.
2) Screening of drugs to intensity bone-inducing activity of recombinant BMP. Intracellurar signaling after binding of BMP to BMP receptors (BMPR1 and BMPR2) locating at the cell surface is mediated by Smad family molecules, R-Smad (Smad 1,5), C-Smad(Smad 4) that regulate transcriptional activity of the BMP responding genes that are essential for differentiation of the cell to osteogenic cells. We previously found that protein A kinase (PKA) / cAMP responsive element binging protein (CREB) signaling pathway potentiates the BMP signaling. Based on this fact, we added drugs that elevate intracellular cAMP levels to the above described BMP-retaining implant to examine the capacity to enhance the bone-inducing activity of BMP both in vitro and in vivo mice models. The examined drugs included phosphodiesterase (PDE) inhibitors (rolipram-a PDE4 specific inhibitors, pentoxifylline-a non-specific PDE inhibitor), a prostaglandin E2-redceptor Ep4 agonist (ONO 4819), and teriparatide (PTH1-34 fragmenta). Each of the drugs consistentry potentiated the bone-inducing capacity of the BMP-2 because approximatery 2 times larger bone mass was ectopically generated in the muscle of mice in 3 weeks after implantation of the constant volume of BMP/TCP/polymer composite pellet implant added by small dose of the respective drug. These results indicated half reduction of BMP dose would be possible with concomitant use of those drugs to the implants and lead to potential cost reduction of the BMP-retaining implant with bone-inducing capacity.
3) New individualizes bone defect repairing system based on 3-dimensional computed tomography (3-D CT) data. Usually size and shape of bone defect to be regenerated varied from case to case. To repair such bone defect, we used 3D-CT image data to estimate the size and shape of the defect by subtracting the defect by subtracting the damaged bone (with bone defect) image from symmetrical mirror image of the normal contralateral bone. The image data were then used to make a porous biomaterial implant compatible to the bone defect by a computer aided designing machine. Then the BMP-retaining dough was pasted on and in the implant to add bone-inducing capacity and implanted into the bone defect, This individualized bone defect repairing system worked well in model and expected to be useful in clinical practice. Less

Report

(5 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (261 results)

All 2008 2007 2006 2005 2004

All Journal Article (157 results) (of which Peer Reviewed: 73 results) Presentation (101 results) Book (3 results)

  • [Journal Article] Increased hepatic cytochrome P450A activity decreases the risk of developing steroid-induced osteonecrosis in a rabbit model2008

    • Author(s)
      Masada T, Iwakiri K, Oda Y, Kaneshiro Y, Iwaki H, Ohhashi H, Takaoka K.
    • Journal Title

      Journal of Orthopaedic Research 26

      Pages: 91-95

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Increased hepatic cytochrome P450A activity decreases the risk of developing steroid-induced osteonecrosis in a rabbit model.2008

    • Author(s)
      Masada, T., Iwakiri, K., Oda, Y., Kaneshiro, Y., Iwaki, H., Ohhashi, H., Takaoka, K
    • Journal Title

      Journal of Orthopaedic Research 26

      Pages: 91-95

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Comparative roles of Twist-1 and Id1 in transcriptional regulation by BMP signaling2007

    • Author(s)
      Hayashi M, Nimura K, Kashiwagi K, Harada T, Takaoka K, Kato H, Tamai K, Kaneda Y.
    • Journal Title

      J Cell Science 120

      Pages: 1350-1357

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Regenerative repair of long intercalated rib defects using porous cylinders of β-tricalcium phosphate:An experimental study in a canine model2007

    • Author(s)
      Hoshino M, Egi T, Terai H, Namikawa T, Takaoka K.
    • Journal Title

      Plast.Reconstr.Surg 119

      Pages: 1431-1439

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Generation of tendon-to-bone interface "enthesis" with use of recombinant BMP-2 in a rabbit model2007

    • Author(s)
      Hashimoto Y, Yoshida G, Toyoda H, Takaoka K.
    • Journal Title

      J Orthop.Res

      Pages: 1415-1424

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Repair of bone defects in revision hip arthroplasty by implantation of a new bone-inducing material comprised of recombinant human BMP-2,betaTCP and abiodegradable polymer.An experimental study in dogs2007

    • Author(s)
      Hoshino M, Namikawa T, Kato M, Terai H, Taguchi S, Takaoka K.
    • Journal Title

      J Orthop.Res 25

      Pages: 1042-1051

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Reconstruction of bone defects using rhBMP-2-coated devitalized bone2007

    • Author(s)
      Taguchi S, Namikawa T, Ieguchi M, Takaoka K.
    • Journal Title

      Clin.Orthop.Relat.Res 461

      Pages: 162-169

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Prostagrandin E2 EP4 agonist(ONO-4819) accerarates BMP-induced osteoblastic differentiation2007

    • Author(s)
      Nakagawa K, Imai Y, Ohta Y, Takaoka K.
    • Journal Title

      Bone 41

      Pages: 543-548

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Enhancing effects of prostagrandin EP4 receptor agonist onrecombinant human bone morphogenetic protein-2 mediated spine fusion in arabbit model2007

    • Author(s)
      Namikawa T, Twrai H, Hoshino M, Kato M, Toyoda H, Yano K, Nakamura H, Takaoka K.
    • Journal Title

      Spine 32

      Pages: 2294-2299

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Calcaneal appophyseal avulsion fracture2007

    • Author(s)
      Imai Y, Kitano T, Nakagawa K, Takaoka.K.
    • Journal Title

      Arch.Orthop.Trauma.Surg 127

      Pages: 331-333

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Clinical effect of bisphosphonete and vitamin D on osteoporosis:reappraisal of amulticenter double blind clinical compareing etidronate and alphacalcidol2007

    • Author(s)
      Fujita T, Orimo H, Inoue T, Kaneda K, Sakurai M, Morita R, Yamamoto K, Sugioka Y, Inoue A, Takaoka K, Yamamoto I, Hoshino Y, Kawaguchi H.
    • Journal Title

      J Bone Miner.Metab 25

      Pages: 130-137

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Sagitalal ignment of the lower extremity while standing in Japanese male2007

    • Author(s)
      Minoda Y, Kobayashi A, Iwaki H, Sugama R, Iwakiri K, Kadoya Y, Ohashi H, Takaoka K.
    • Journal Title

      Arch.Orthop.Surg 28

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts2007

    • Author(s)
      Nakamura T, Imai Y, Matsumoto T, Sato S, Takeuchi K, Igarashi K, Harada Y, Azuma Y, Krust A, Yamamoto Y, Nishiura H, Takeda S, Takayanagi H, Metzger D, KannoJ, Takaoka K, Martin TJ, Chambon P, Kato S.
    • Journal Title

      Cell 130

      Pages: 811-823

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 【BMPの基礎と臨床】BMPの新しいDDSによる実験的脊椎固定手術2007

    • Author(s)
      並川 崇, 寺井 秀富, 高岡 邦夫
    • Journal Title

      Clinical Calcium 16

      Pages: 793-800

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 骨誘導能を有するrhBMP-2含有ペーストマテリアル2007

    • Author(s)
      加藤 相勲, 中村 博亮, 並川 崇, 星野 雅俊, 寺井 秀富, 高岡 邦夫
    • Journal Title

      整形・災害外科 50

      Pages: 834-535

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] BMPによる骨再生-人工股関節周囲巨大骨欠損への応用2007

    • Author(s)
      星野 雅俊、脇谷 滋之、大田 陽一、岩切 健太郎、高岡 邦夫
    • Journal Title

      人工臓器 36

      Pages: 195-197

    • NAID

      10025704014

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] BMPと新しいDDSを用いた骨再生2007

    • Author(s)
      星野 雅俊、並川 崇、田口 晋、高岡 邦夫
    • Journal Title

      再生医療 6

      Pages: 38-44

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Comparative roles of Twist-1 and Idl in transcriptional regulation by BMP signaling.2007

    • Author(s)
      Hayashi, M., Nimura, K., Kashiwagi, K., Harada, K., Takaoka, T., Kato, H., Tamai, K., Kaneda, Y
    • Journal Title

      J Cell Science 120

      Pages: 1350-1357

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Regenerative repair of long intercalated rib defects using porous cylinders of 5-tricalcium phosphate: An experimental study in a canine model.2007

    • Author(s)
      Hoshino, M., Egi, T., Terai, H., Namikawa, T., Takaoka, K
    • Journal Title

      Plast. Reconstr. Surg 119

      Pages: 1431-1439

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Generation of tendon-to-bone interface"enthesis"with use of recombinant BMP-2 in a rabbit model.2007

    • Author(s)
      Hashimoto, Y., Yoshida, G., Toyoda, H., Takaoka, K
    • Journal Title

      J Orthop. Res.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Repair of bone defects in revision hip arthroplasty by implantation of a new bone-inducing material comprised of recombinant human BMP-2, betaTCP and a biodegradable polymer. An experimental study in dogs.2007

    • Author(s)
      Hoshino, M., Namikawa, T., Kato, H., Taguchi, S., Takaoka, K
    • Journal Title

      J Orthop. Res. 25

      Pages: 1042-1051

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Reconstruction of bone defects using rhBMP-2-coated devitalized bone.2007

    • Author(s)
      Taguchi, S., Namikawa, T., Ieguchi, M., Takaoka, K
    • Journal Title

      CIin.Orthop.Relat. Res. 461

      Pages: 162-169

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Prostagrandin E2 EP4 agonist (ONO-4819) accerarates BMP-induced osteoblastic differentiation.2007

    • Author(s)
      Nakagawa, K., Imai, Y., Ohta, Y., Takaoka, K
    • Journal Title

      Bone 41

      Pages: 543-548

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Enhancing effects of prostagrandin EP4 receptor agonist on recombinant human bone morphogenetic protein-L meaiatea spine fusion in a rabbit model.2007

    • Author(s)
      Namikawa, T., Twrai, H., Hoshino, M., Kato, M., Toyoda, H., Yano, K., Nakamura, H., Takaoka, K
    • Journal Title

      Spine 32

      Pages: 2294-2299

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Calcaneal appophyseal avulsion fracture.2007

    • Author(s)
      Imai, Y., Kitano, T., Nakagawa, K., Takaoka, K
    • Journal Title

      Arch. Orthop.Trauma. Surg 127

      Pages: 331-3

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Clinical effect of bisphosphonete and vitamin D on osteoporosis: reappraisal of a multicenter double blind clinical compareing etidronate and alphacalcidol.2007

    • Author(s)
      Fujita, T., Orimo, H., Inoue, T., Kaneda, K., Sakurai, M., Morita, R., Yamamoto, K., Sugioka, Y., Inoue, A., Takaoka, K., Yamamoto, I., Hoshino, Y., Kawaguchi, H
    • Journal Title

      J Bone Miner.Metab 25

      Pages: 130-137

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Sagital alignment of the lower extremity while standing in Japanese male.2007

    • Author(s)
      Minoda, Y., Kobayashi, A., Iwaki, H., Sugama, R., Iwakiri, K., Kadoya, Y., Ohashi, H., Takaoka, K
    • Journal Title

      Arch. Orthop. Surg 28

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts.2007

    • Author(s)
      Nakamura, T., Imai, Y., Matsumoto, T., Sato, S., Takeuchi, K., Igarashi, K., Harada, Y., Azuma, Y., Krust, A., Yamamoto, Y., Nishiura, H., Takeda, S., Takayanagi, H., Metzger, D., Kanno, J., Takaoka, K., Martin, TJ., Chambon, P., Kato, S
    • Journal Title

      Cell 130

      Pages: 811-823

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Comparative roles of Twist-1 and Id1 in transcriptional regulation by BMP signaling.2007

    • Author(s)
      Hayashi M, Nimura K, Kashiwagi K Harada T, Takaoka K, Kato H, Tamai K, Kaneda Y.
    • Journal Title

      Journal of Cell Science 120

      Pages: 1350-1357

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regenerative repair of long intercalated rib defects using porous cylinders of β-tricalcium phosphate: An experimental study in a canine model.2007

    • Author(s)
      Hoshino M, Egi T, Terai H. Namikawa T, Takaoka K.
    • Journal Title

      Plastics and Reconstructive Surgery 119

      Pages: 1431-1439

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of tendon-to-bone interface"enthesis"with use of recombinant BMP-2 in a rabbit model.2007

    • Author(s)
      Hashimoto Y, Yoshida G, Toyoda H, Takaoka K.
    • Journal Title

      Journal of Orthopaedic Research 25

      Pages: 1415-1425

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Repair of bone defects in revision hip arthroplasty by implantation ofa new bone-inducing material comprised of recombinant human BMP-2, betaTCP and a biodegradable polymer. An experimental study in dogs.2007

    • Author(s)
      Hoshino M, Namikawa T, Kato H, Taguchi S, Takaoka K.
    • Journal Title

      Journal of Orthopaedic Research 25

      Pages: 1042-1051

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reconstruction of bone defects using rhBMP-2-coated devitalized bone.2007

    • Author(s)
      Taguchi S, Namikawa T, Ieguchi M, Takaoka K.
    • Journal Title

      Clinical Orthopaedics and Related Research 461

      Pages: 162-169

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostagrandin E2 EP4 agonist (ONO-4819) accerarates BMP-induced osteoblastic differentiation.2007

    • Author(s)
      Nakagawa K, Imai Y, Ohta Y, Takaoka K.
    • Journal Title

      Bone 41

      Pages: 543-548

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancing effects of prostagrandin EP4 receptor agonist on recombinant human bone morphogenetic protein-2 mediated spine fusion in a rabbit model.2007

    • Author(s)
      Namikawa T, Terai H, Hoshino M, Kato, M, Toyoda H, Yano K. Nakamura H, Takaoka K.
    • Journal Title

      Spine 32

      Pages: 2294-2299

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calcaneal apophyseal avulsion fracture.2007

    • Author(s)
      Imai Y, Kitano T, Nakagawa K, Takaoka T
    • Journal Title

      Archives of Orthopaedic and Trauma Surgery 27

      Pages: 331-333

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical effect of bisphosphonate and vitamin D on osteoporosis: reappraisal of a multicenter double-blind clinicaltrial comparing etidronate and alfacalcidol.2007

    • Author(s)
      Fujita T, Orimo H, Inoue T, Kaneda K, Sakurai M, Morita R, Yamamoto K, Sugioka Y, Inoue A, Takaoka K, Yamamoto I, Hoshino Y, Kawaguchi H.
    • Journal Title

      Journal of Bone and Mineral Metabolism. 25

      Pages: 130-137

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sagittal alignment of the lower extremity while standing in Japanese male.2007

    • Author(s)
      Minoda Y, Kobayashi A, Iwaki H, Sugama R, Iwakiri K, Kadoya Y, Ohashi H, Takaoka K.
    • Journal Title

      Archives of Orthopaedic and Trauma Surgery (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen prevents bone loss via estrogen receptor alpha and induction of Fasligand in osteociasts.2007

    • Author(s)
      Nakamura T, Imai Y, Matsumoto T, Sato S, Takeuchi K, Igarashi K, Harada Y, Azuma Y, Krust A, Yamamoto Y, Nishina H, Takeda S, Takayanagi H, Metzger D, Kanno J, Takaoka K, Martin TJ, Chambon P, Kato S.
    • Journal Title

      Cell. 130

      Pages: 811-823

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone morphogenetic protein activities are enhanced by 3',5'-cyclic adenosine monophosphate through suppression of smad6 expression in osteoprogenitor cells2006

    • Author(s)
      Sugama R, Koike T, Imai Y, Nomura-Furuwatari C, Takaoka K.
    • Journal Title

      Bone 38

      Pages: 206-214

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Optimized use of a biodegradable polymer as a carrier material for the local delivery of recombinant human bone morphogenetic protein-2(rhBMP-2)2006

    • Author(s)
      Kato M, Toyoda H, Namikawa T, Hoshino M, Terai H, Miyamoto S, Takaoka, K.
    • Journal Title

      Biomaterial 27

      Pages: 2035-2041

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A biodegradable delivery system for antibiotics and recombinant human bone morphogenetic protein-2:A potential treatment for infected bone defect2006

    • Author(s)
      Suzuki A., Terai H, Toyoda H, Namikawa T, Yokota Y, Tsunoda T, Takaoka K.
    • Journal Title

      J.orthop.Res 24

      Pages: 327-332

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Heparin potentiates the in vivo ectopic bone formation induced by bone morphogenetic protein-22006

    • Author(s)
      Zhao B, Katagiri, Toyoda H, Takada T, Yanai T, Fukuda T, Chung U, Koike T, Takaoka K, Kamijo R.
    • Journal Title

      J Biol.Chem

      Pages: 327-332

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Repair of long intercalated defect using porous beta-tricalcium phosphate cylinders contaning recombinant human bone morphogeneticprotein-2 in dogs2006

    • Author(s)
      Hoshino M, Egi T, Terai H, Namikawa T, Takaoka, K.
    • Journal Title

      Biomaterials 27

      Pages: 4934-4940

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Ectopic bone formation in mice associated with alactic acid/dioxanone/ethyleneglycole copolymer-tricalcium phosphate composite with added recombinant human bone morphogenetic protein-22006

    • Author(s)
      Kato M, Namikawa T, TeraiH, Hoshino M, Miyamoto S, Takaoka K.
    • Journal Title

      Biomaterials 27

      Pages: 3927-3933

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Osteoblasts provide a suitable microenvironment for the action of receptor activator of nuclear factor-kB ligand2006

    • Author(s)
      Yamamoto Y, Udagawa N, Matsumoto S, Nakamichi Y, Horiuchi H, Hosoya A, Nakamura M, Ozawa H, Takaoka K, Penninger JM, Noguchi T, Takahashi N.
    • Journal Title

      Endocrinology 147

      Pages: 375-379

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Use of glycyrrhizin in prevention of tissue damage caused by ischemia-reperfusion in rabbit hind limbs2006

    • Author(s)
      Nakata N, Takaoka K.
    • Journal Title

      Clin.Pharmacol.ther 80

      Pages: 396-402

    • NAID

      10018227204

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Low hepatic cytochrome P450 3A activity is a risk factor for corticosteroid-induced osteonecrosis2006

    • Author(s)
      Kaneshiro Y, Oda Y, Iwakiri K, Masada T, Iwaki K, Hirota Y, Kondo K, Takaoka K.
    • Journal Title

      Clin.Pharmacol.ther 80

      Pages: 396-402

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Volar dislocation of the extensor carpi ulnalis tendon on magnetic resonance imaging is associated with extensor digitomm communis tendon rupture in rheumatoid wrists2006

    • Author(s)
      Egi T, Inui K, Koike T, Takaoka K, Kazuki K.
    • Journal Title

      J Hnad Surgery 31A

      Pages: 1454-1460

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Efficacy and tolerability of once-weekly administration of 17.5mg risedronate in Japanese patients with involutional osteoporosis:a comparison with2.5-mg once-daily dosage regimen2006

    • Author(s)
      Kishimoto H, Fukunaga M, Kushida K, Shiraki M, Itabashi A, Nawata H, Nakamura T, Ohta H, Takaoka K, OhhashiH.
    • Journal Title

      J Bone Miner.Metab 24

      Pages: 405-413

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Accelerated repair of a bone defect with a synthetic biodegradable bone-inducing implant2006

    • Author(s)
      Matsushita N, Terai H.Okada T.Nozaki K.Inoue H.Miyamoto S and Takaoka K.
    • Journal Title

      J Orthop Sci 11

      Pages: 505-511

    • NAID

      10020299223

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 骨の再生医療2006

    • Author(s)
      今井 祐記、高岡 邦夫
    • Journal Title

      ティッシュエンジニアリング

      Pages: 112-119

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 【BMPの基礎と臨床】BMPの骨再生医学への応用2006

    • Author(s)
      寺井 秀富, 高岡 邦夫
    • Journal Title

      Clinical Calcium 16

      Pages: 745-751

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Bone morphogenetic protein activities are enhanced by 3',5'-cyclic adenosine monophosphate through suppression of smad6 expression in osteoprogenitor cells.2006

    • Author(s)
      Sugama, R., Koike, T., Imai, Y., Nomura-Furuwatari, C., Takaoka, K
    • Journal Title

      Bone 38

      Pages: 206-214

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Optimized use of a biodegradable polymer as a carrier material for the local delivery of recombinant human bone morphogenetic protein-2(rhBMP-2)2006

    • Author(s)
      Kato, M., Toyoda, H., Namikawa, T., Hoshino, M., Terai, H., Miyamoto, S., Takaoka, K
    • Journal Title

      Biomaterial 27

      Pages: 2035-2041

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A biodegradable delivery system for antibiotics and recombinant human bone morphogenetic protein-2: A potential treatment for infected bone defect.2006

    • Author(s)
      Suzuki, A.,Terai, H., Toyoda, H.,Namikawa, T., Yokota, Y., Tsunoda, T., Takaoka, K
    • Journal Title

      J. orthop. Res 24

      Pages: 327-332

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Heparin potentiates the in vivo ectopic bone formation induced by bone morphogenetic protein-2.2006

    • Author(s)
      Zhao, B., Katagiri, Toyoda, H., Takada, T., Yanai, T., Fukuda, T., Chung, U., Koike, T., Takaoka, K., Kamijo, R
    • Journal Title

      J Biol. Chem.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Repair of long intercalated defect using porous beta-tricalcium phosphate cylinders contaning recombinant human bone morphogeneticprotein-2 in dogs.2006

    • Author(s)
      Hoshino, M., Egi, T., Terai, H., Namikawa, T., Takaoka, K
    • Journal Title

      Biomaterials 27

      Pages: 4934-4940

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Ectopic bone formation in mice associated with a lactic acid/dioxanone/ethylene glycole copolymer-tricalcium phosphate composite with added recombinant human bone morphogenetic protein-2.2006

    • Author(s)
      Kato, M., Namikawa, T., Terai, H., Hoshino, M., Miyamoto, S., Takaoka, K
    • Journal Title

      Biomaterials 27

      Pages: 3927-3933

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Osteoblasts provide a suitable microenvironment for the action of receptor activator of nuclear factor-kB ligand.2006

    • Author(s)
      Yamamoto, Y., Udagawa, N., Matsumoto, S., Nakamichi, Y., Horiuchi, H., Hosoya, A., Nakamura, M., Ozawa, H., Takaoka, K., Penninger, JM., Noguchi, T., Takahashi, N
    • Journal Title

      Endocrinology 147

      Pages: 3366-3374

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Use of glycyrrhizin in prevention of tissue damage caused by ischemia-reperfusion in rabbit hind limbs.2006

    • Author(s)
      Nakata, N., Takaoka, K
    • Journal Title

      Journal of Orthopaedic Science 11

      Pages: 375-379

    • NAID

      10018227204

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Low hepatic cytochrome P450 3A activity is a risk factor for corticosteroid-induced osteonecrosis.2006

    • Author(s)
      Kaneshiro, Y., Oda, Y., Iwakiri, K., Masada, T., Iwaki, K., Hirota, Y., Kondo, K., Takaoka, K
    • Journal Title

      Clin.Pharmacol. ther 80

      Pages: 396-402

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Volar dislocation of the extensor carpi ulnalis tendon on magnetic resonance imaging is associated with extensor digitorum communis tendon rupture in rheumatoid wrists.2006

    • Author(s)
      Egi, T., Inui, K., Koike, T., Takaoka, K., Kazuki, K
    • Journal Title

      J Hnad Surgery31A

      Pages: 1454-1460

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Efficacy and tolerability of once-weekly administration of 17.5mg risedronate in Japanese patients with involutional osteoporosis: a comparison with 2.5-mg once-daily dosage regimen.2006

    • Author(s)
      Kishimoto, H., Fukunaga, M., Kushida, K., Shiraki, M., Itabashi, A., Nawata, H., Nakamura, T., Ohta, H., Takaoka, K., Ohhashi, H
    • Journal Title

      J Bone Miner.Metab. 24

      Pages: 405-413

    • NAID

      10018193553

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Accelerated repair of a bone defect with a synthetic biodegradable bone-inducing implant.2006

    • Author(s)
      Matsushita, N., Terai, H., Okada, T., Nozaki, K., Inoue, H., Miyamotod, S., Takaoka, K
    • Journal Title

      J Orthop Sci. 11

      Pages: 505-511

    • NAID

      10020299223

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Encoscopic vertebroplasty for the treatment of chronic vertebral compression fracture. Technical note.2006

    • Author(s)
      Hoshino M, Nakamura H, Konishi S, Nagayama R, Terai H, Tsujio T, Namikawa T, Kato M, Takaloka K
    • Journal Title

      Journal of Neurosurgery. Spine 5・5

      Pages: 461-467

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Repair of long intercalated rib defects using porous beta-tricalcium phosphate cylinders containing recombinant human bone morphogenetic protein-2 in dogs.2006

    • Author(s)
      Hoshino M, Egi T, Terai H, Namikawa T, Takaoka K
    • Journal Title

      Biomaterials 27・28

      Pages: 4934-4940

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Accelerated repair of a bone defect with a synthetic biodegradable bone-inducing implant.2006

    • Author(s)
      Matsushita N, Terai H, Okada T, Nozaki K, Inoue H, Miyamoto S, Takaoka K
    • Journal Title

      Journal of Orthopaedic Science 11・5

      Pages: 505-511

    • NAID

      10020299223

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Heparin potentiates the in vivo ectopic bone formatin induced by bone morpjogenetic protein-2.2006

    • Author(s)
      Zhao B, Katagiri T, Toyoda H, Takada T, Yanai T, Fukuda T, Chung UI, Koike T, Takaoka K, Kamijo R
    • Journal Title

      Journal of Biological Chemistry 281・32

      Pages: 23246-23253

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Ectopic bone formation in mice associated with a lactic acid/dioxanone/ethylene glycol copolymer-tricalcium pjosphate composite with added recombinant human bone morphogenetic protein-2.2006

    • Author(s)
      Kato M, Namikawa T, Terai H, Hoshino M, Miiyamoto S, Takaoka K
    • Journal Title

      Biomaterials 27・21

      Pages: 3927-3933

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Osteoblasts provide a suitable microenvironment for the action of receptor activator of nuclear factor-kappaB ligand.2006

    • Author(s)
      Yamamoto Y, Udagawa N, Matsuura S, Nakamichi Y, Horiuchi H, Hosoya A, Nakamura M, Ozawa H, Takaoka K, Penninger JM, Noguchi T, Takahashi N.
    • Journal Title

      Endocrinology 147・7

      Pages: 3366-74

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Objective assessment of reduced invasiveness in MED. compared with conventional one-level laminotomy.2006

    • Author(s)
      Sasaoka R, Nakamura H, Konishi S, Nagayama R, Suzuki E, Terai H, Takaoka K
    • Journal Title

      European Spine Journal 15・5

      Pages: 577-582

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Optimized use of a biodegradable polymer as a carrier material for the local delivery of recombinant human bone morphogenetic protein-2 (rhBMP-2).2006

    • Author(s)
      Kato M, Toyoda H, Namikawa T, Hoshino M, Terai H, Miyamoto S, Takaoka K
    • Journal Title

      Biomaterials. 27・9

      Pages: 2035-2041

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A biodegradable delivery system for antibiotics and recombinant human bone morphogenetic protein-2 : A potential treatment for infected bone defects.2006

    • Author(s)
      Suzuki A, Terai H, Toyoda H, Namikawa T, Yokota Y, Tsunoda T, Takaoka K
    • Journal Title

      Journal of Orghopaedic Research 24・3

      Pages: 327-332

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Bone morphogenetic protein activities are enhanced by 3', 5'-cyclic adenosine monophosphate through suppression of Smad6 expression in osteoprogenitor cells.2006

    • Author(s)
      Sugama R, Koike T, Imai Y, Nomura-Furuwatari C, Takaoka K
    • Journal Title

      Bone. 38・2

      Pages: 206-214

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 【BMPの基礎と臨床】 BMPの新しいDDSによる実験的脊髄固定手術2006

    • Author(s)
      並川崇, 寺井秀富, 富岡邦夫
    • Journal Title

      Clinical Calcium 16・5

      Pages: 793-800

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 【BMPの基礎と臨床】 BMPの骨再生医学への応用2006

    • Author(s)
      寺井秀富, 富岡邦夫
    • Journal Title

      Clinical Calcium 16・5

      Pages: 745-751

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Use of bone morphogenetic protein 2 and diffusion chambers to engineer cartilage tissue for the repair of defects in articular cartilage2005

    • Author(s)
      Nawata M, Wakitani S, Nakayta A, Tanigami A, Seki T, Nakamura Y, Saito N, Sano K, Hidaka E, Takaoka K.
    • Journal Title

      Arthritis & Rheumatism 52

      Pages: 155-163

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Use of local electroporation enhances methothrexate effects with minimum dose in adjuvant-induced arthritis2005

    • Author(s)
      Tada M, Inui K, Koike T, Takaoka K.
    • Journal Title

      Arthritis & Rheumatism 52

      Pages: 637-641

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Potentiation of the activity of bone morphogenetic protein-2 by a PLA/PEG/hydroxyapatite composite2005

    • Author(s)
      Kaito T, Myoui A, Takaoka K, Saito N, Nishikawa M, Tamai N, Ohgushi H, Yoshikawa H.
    • Journal Title

      Biomaterials 26

      Pages: 73-79

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Synthetic biodegradable polymers as drug delivery systems for bone morphogenetic proteins2005

    • Author(s)
      Saito N, Murakami N, Takahashi J, Horiuchi H, Ota H, Okada T, Nozaki K, Takaoka K
    • Journal Title

      Advanced Drug Delivery Review 57

      Pages: 1037-1048

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Repair of intercalated long bone defect with a synthetic biodegradable bone-inducing implant2005

    • Author(s)
      Yoneda M, Terai H, Imai Y, Okada T, Nozaki K, Inoue H, Miyamoto S, Takaoka K.
    • Journal Title

      Biomaterials 26

      Pages: 5145-5152

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The effect of heat on biological activity of recombinant BMP-22005

    • Author(s)
      Ohta H, Wakitani S, Tenshou K, Horiuchi H, Wakabayashi S, Saito N, Nakamura Y, Nozaki K, Imai Y, Takaoka K.
    • Journal Title

      J, Bone & Miner.Metab 23

      Pages: 420-425

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Expression profiles of BMP-related molecules induced by BMP or BMP-4 inmuscle-derived primary culture cells2005

    • Author(s)
      Nakamura Y, Wakitani S, Saito N, Takaoka K.
    • Journal Title

      J, Bone & Miner.Metab 23

      Pages: 426-434

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A new biotechnology for articular cartilage repair:Subchondral implantation of a composite of interconnected porous hydroxyapatite,synthetic polymer (PLA-PEG) and bone morphogenetic protein-2(rhBMP-2)2005

    • Author(s)
      Tamai N, Myoui A, Hirao M, Kaito T, Ochi T, Tanaka J, Takaoka K, Yoshikawa, H.
    • Journal Title

      Osteoarthritis and Cartilage 13

      Pages: 405-417

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Microbubble-enhanced ultrasound exposure promotes uptake of methotrexate into synovial cells and enhanced anti-inflammatory effects in the knees of rabbits with antigen-induced arthritis2005

    • Author(s)
      Nakaya, H.Shimizu, T., Isobe K., Tenshou, K., Okabe, T.Nakamura, Y., Nawata, M., Yoshikawa, H.Takaoka, K.and Wakitani, S.
    • Journal Title

      Arthritis & Rheumatism 52

      Pages: 2559-2566

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Experimental spinal fusion with recombinant human bone morphogenetic protein-2 delivered by a synthetic polymer and β-tricalcium phosphate in a rabbit model2005

    • Author(s)
      Namikawa T, Terai H, Suzuki E, Hoshino M, Toyoda H, Nakamura H, Miyamoto S, Takahashi N, Ninomiya T, Takaoka K.
    • Journal Title

      Spine 30

      Pages: 1717-1722

    • NAID

      10020581460

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Indivisuality and reproducibility in high speed motion of volleyball spike jumps by phase-matching and averaging2005

    • Author(s)
      Tokuyama M, Ohhashi H, Iwamoto H, Takaoka K, Okubo, M.
    • Journal Title

      Journal of Biomechanics 38

      Pages: 2050-2057

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Augmentation of bone morphogenetic protein-induced bone mass by local delivery of a prostagrandin E EP-4 receptor agonist2005

    • Author(s)
      Toyoda H, Terai H, Sasaoka R, Oda K, Takaoka K.
    • Journal Title

      Bone 37

      Pages: 555-562

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Hepatocyte growth factor contributes to fracture repair by upregulating the expression of BMP receptors2005

    • Author(s)
      Imai Y, Terai H, Nomura-Furuwatari C, Mizuno S, Matsumoto K, Nakamura T, TakaokaK.
    • Journal Title

      Journal of Bone and Mineral Research 20

      Pages: 1723-1730

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Magnetic resonance and computed tomography-based scoring system for the defferential diagnosis of vertebral fractures caused by osteoporosis and malignant tumors2005

    • Author(s)
      Yuzawa Y, Ebara S, Kamimura M, Tateiwa Y, Kinoshita T, Itoh H, Takahashi J, Karakida O, Sheena Y, Takaoka K.
    • Journal Title

      Journal of Orthopaedic Science 10

      Pages: 345-352

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Evaluation of rotator cufftears with magnetic resonance arthrography2005

    • Author(s)
      Toyoda H, Ito Y, Tomo H, Nakao Y, Koike T, Takaoka K.
    • Journal Title

      Clinical Orthopaedics and Related Research 439

      Pages: 109-115

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] rhBMP-2/PLA-DX-PEG/β-TCP compositeを使用した家兎腰椎後側方固定術での脊椎固定率に関する研究2005

    • Author(s)
      並川 崇、寺井 秀富、鈴木 英介、星野 雅俊、中村 博亮、高岡 邦夫
    • Journal Title

      Orthopaedic Ceramic Implants 23-24

      Pages: 105-109

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 【再生医療の進歩2005年の総括(臨床到達分野)】骨組織再生2005

    • Author(s)
      今井 祐記、高岡 邦夫
    • Journal Title

      再生医療 4

      Pages: 524-530

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Use of bone morphogenetic protein 2 and diffusion chambers to engineer cartilage tissue for the repair of defects in articular cartilage2005

    • Author(s)
      Nawata, M., Wakitani, S., Nakayta, A., Tanigami, A., Seki, T., Nakamura, Y., Saito, N., Sano, K., Hidaka, E., Takaoka, K
    • Journal Title

      Arthritis & Rheumatism 52

      Pages: 155-163

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Use of local electroporation enhances methothrexate effects with minimum dose in adjuvant-induced arthritis.2005

    • Author(s)
      Tada, M., Inui, K., Koike, T., Takaoka, K
    • Journal Title

      Arthritis & Rheumatism 52

      Pages: 637-641

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Potentiation of the activity of bone morphogenetic protein-2 by a PLA-PEG / hydroxyapatite composite.2005

    • Author(s)
      Kaito, T., Myoui, A., Takaoka, K., Saito, N., Nishikawa, M., Tamai, N., Ohgushi, H., Yoshikawa, H
    • Journal Title

      Biomaterials 26

      Pages: 73-79

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Synthetic biodegradable polymers as drug delivery systems for bone morphogenetic proteins.2005

    • Author(s)
      Saito, N., Murakami, N., Takahashi, J., Horiuchi, H., Ota, H., Okada, T., Nozaki, K., Takaoka, K
    • Journal Title

      Advanced Drug Delivery Review 57

      Pages: 1037-1048

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Repair of intercalated long bone defect with a synthetic biodegradable bone- inducing implant.2005

    • Author(s)
      Yoneda, M., Terai, H., Imai, Y., Okada, T., Nozaki, K., Inoue, H., Miyamoto, S., Takaoka, K
    • Journal Title

      Biomaterials 26

      Pages: 5145-5152

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The effect of heat on biological activity of recombinant BMP-2.2005

    • Author(s)
      Ohta, H., Wakitani, S., Tenshou, K., Horiuchi, H., Wakabayashi, S., Saito, N., Nakamura, Y., Nozaki, K., Imai, Y., Takaoka, K
    • Journal Title

      J, Bone & Miner. Metab 23

      Pages: 420-425

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Expression profiles of BMP-related molecules induced by BMP or BMP-4 in muscle-derived primary culture cells.2005

    • Author(s)
      Nakamura, Y., Wakitani, S., Saito, N., Takaoka, K
    • Journal Title

      J, Bone & Miner. Metab 23

      Pages: 426-434

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A new biotechnology for articular cartilage repair: Subchondral implantation of a composite of interconnected porous hydroxyapatite,synthetic polymer(PLA-PEG)and bone morphogenetic protein-2(rhBMP-2)2005

    • Author(s)
      Tamai, N., Myoui, A., Hirao, M., Kaito, T., Ochi, T., Tanaka, J., Takaoka, K., Yoshikawa, H
    • Journal Title

      Osteoarthritis and Cartilage 13

      Pages: 405-417

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Microbubble-enhanced ultrasound exposure promotes uptake of methotrexate into synovial cells and enhanced anti-inflammatory effects in the knees of rabbits with antigen-induced arthritis.2005

    • Author(s)
      Nakaya, H., Shimizu, T., sobe, IK., Tenshou, K., Okabe, T., Nakamura, Y., Nawata, M., Yoshikawa, H., Takaoka, K., Wakitani, S
    • Journal Title

      Arthritis & Rheumatism 52

      Pages: 2559-2566

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Experimental spinal fusion with recombinant human bone morphogenetic protein-2 delivered by a synthetic polymer and 6-tricalcium phosphate in a rabbit model.2005

    • Author(s)
      Namikawa, T., Terai, H., Suzuki, E., Hoshino, M., Toyoda, H., Nakamura, H., Miyamoto, S., Takahashi, N., Ninomiya, T., Takaoka, K
    • Journal Title

      Spine 30

      Pages: 1717-1722

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Indivisuality and reproducibility in high speed motion of volleyball spike jumps by phase-matching and averaging.2005

    • Author(s)
      Tokuyama, M., Ohhashi, H., Iwamoto, H., Takaoka, K., Okubo, M
    • Journal Title

      Journal of Biomechanics 38

      Pages: 2050-2057

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Augmentation of bone morphogenetic protein-induced bone mass by local delivery of a prostagrandin E EP-4 receptor agonist.2005

    • Author(s)
      Toyoda, H., Terai, H., Sasaoka, R., Oda, K., Takaoka, K
    • Journal Title

      Bone 37

      Pages: 555-562

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Hepatocyte growth factor contributes to fracture repair by upregulating the expression of BMP receptors.2005

    • Author(s)
      Imai, Y., Terai, H., Nomura-Furuwatari, C., Mizuno, S., Matsumoto, K., Nakamura, T., Takaoka, K
    • Journal Title

      Journal of Bone and Mineral Research 20

      Pages: 1723-1730

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Magnetic resonance and computed tomography-based scoring system for the defferential diagnosis of vertebral fractures caused by osteoporosis and malignant tumors.2005

    • Author(s)
      Yuzawa, Y., Ebara, S., Kamimura, M., Tateiwa, Y., Kinoshita, T., Itoh, H., Takahashi, J., Karakida, O., Sheena, Y., Takaoka, K
    • Journal Title

      Journal of Orthopaedic Science 10

      Pages: 345-352

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Evaluation of rotator cuff tears with magnetic resonance arthrography.2005

    • Author(s)
      Toyoda, Y., Ito, H., Tomo, H., Nakao, Y., Koike, T., Takaoka, K
    • Journal Title

      Clinical Orthopaedics and Related Research 439

      Pages: 109-115

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Potentiation of the activity of bone morphogenetic protein-2 in bone regeneration by a PLA-PEG/hydroxyapatite composite.2005

    • Author(s)
      Kaito, T.
    • Journal Title

      Biomaterials 26・1

      Pages: 73-79

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Synthetic biodegradable polymers as drug delivery systems for bone morphogenetic proteins.2005

    • Author(s)
      Saito, N.
    • Journal Title

      Advanced Drug Delivery Review 57・7

      Pages: 1037-1048

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Repair of an intercalated long bone defect with a synthetic biodegradable bone-inducing implant.2005

    • Author(s)
      Yoneda, M.
    • Journal Title

      Biomaterials 26・25

      Pages: 5145-5152

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Bone morphogenetic protein activities are enhanced by 3',5'-cyclic adenosine monophosphate through suppression of Smad6 expression in osteoprogenitor cells.2005

    • Author(s)
      Sugama, R.
    • Journal Title

      Bone 38・2

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Experimental spinal fusion with recombinant human bone morphogenetic protein-2 delivered by a synthetic polymer and beta-tricalcium phosphate in a rabbit model.2005

    • Author(s)
      Namikawa T
    • Journal Title

      Spine 30・15

      Pages: 1717-1722

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Augmentation of bone morphogenetic protein-induced bone mass by local delivery of a prostaglandin E EP4 receptor agonist.2005

    • Author(s)
      Toyoda H
    • Journal Title

      Bone 37・4

      Pages: 555-562

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Use of bone morphogenetic protein 2 and diffusion chambers to engineer cartilage tissue for the repair of defects in articular cartilage.2005

    • Author(s)
      Nawata, M.
    • Journal Title

      Arthritis & Rheumatism 52・1

      Pages: 155-163

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Use of local electroporation enhances methotrexate effects with minimum dose in adjuvant-induced arthritis.2005

    • Author(s)
      Tada, M.
    • Journal Title

      Arthritis & Rheumatism 52・2

      Pages: 637-641

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Expression profiles of BMP-related molecules induced by BMP-2 or -4 in muscle-derived primary culture cells2005

    • Author(s)
      Nakamura, Y.
    • Journal Title

      J.Bone & Miner.Metab. 23・6

      Pages: 426-434

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A new biotechnology for articular cartilage repair : subchondral implantation of a composite of interconnected porous hydroxyapatite, synthetic polymer (PLA-PEG), and bone morphogenetic protein-2(rhBMP-2).2005

    • Author(s)
      Tamai, N.
    • Journal Title

      Osteoarthritis and Cartilage 13・5

      Pages: 405-417

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Microbubble-enhanced ultrasound exposure promotes uptake of methotrexate into synovial cells and enhanced antiinflammatory effects in the knees of rabbits with antigen-induced arthritis.2005

    • Author(s)
      Nakaya, H.
    • Journal Title

      Arthritis & Rheumatism 52・8

      Pages: 2559-2566

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Indivisuality and reproducibility in high speed motion of volleyball spike jumps by phase-matching and averaging.2005

    • Author(s)
      Tokuyama, M.
    • Journal Title

      Journal of Biomechanics 38・10

      Pages: 2050-2057

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The effects of heat on the biological activity of recombinant human bone morphogenetic protein-2.2005

    • Author(s)
      Ohta, H.
    • Journal Title

      J.Bone & Miner.Metab. 23・6

      Pages: 426-434

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Use of bone morphogenetic protein 2 and diffusion chambers to engineer cartilage tissue for the repair of defects in articular cartilage2005

    • Author(s)
      Nawata, M
    • Journal Title

      Arthritis & Rheumatism 52

      Pages: 155-163

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Repair of an Intercalated Long Bone Defect with a Synthetic Biodegradable Bone-inducing Implant2005

    • Author(s)
      Masahiro Yoneda
    • Journal Title

      Biomaterials 26(In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Experimental Spinal Fusion with Recombinant Human Bone Morphogenetic Protein-2 Delivered by a Synthetic Polymer and Beta-Tricalcium Phosphate in a Rabbit Model2005

    • Author(s)
      Takashi Namikawa
    • Journal Title

      Spine 30(In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Osteonecrosis of the femoral head in Japanese adults after liver transplantation:a preliminary report2004

    • Author(s)
      Horiuchi H, Hashikura Y, Hisa K, Saito N, Ikegami T, Nakazawa Y, Karakida O, Kobayashi S, Nawata S, Kawasaki S, Takaoka, K
    • Journal Title

      J Orthop.Sci 9

      Pages: 119-121

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A prostanoid receptor ER4 agonist enhances ectopic bone formation induced by recombinant human bone morphogenetic protein-22004

    • Author(s)
      Sasaoka R, Terai H, Toyoda H, Imai Y, Sugama R, Takaoka, K
    • Journal Title

      Biochemical and Biophysical Research Communication 318

      Pages: 704-709

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Capillary vessel network integration by inserting a vascular pedicle enhances bone formation in tissue-engineered bone using interconnected porous hydroxylapatite ceramics2004

    • Author(s)
      Akita S, Tamai N, Myoui A, Nishikawa M, Kaito T, Takaoka K, Yoshikawa, H
    • Journal Title

      Tissue Engineering 10

      Pages: 789-795

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Continuous local cooling for pain relief following total hip replacement2004

    • Author(s)
      Saito N, Horiuchi H, Kobayashi S, Nawata M, Takaoka K
    • Journal Title

      Journal of Arthroplasty 19

      Pages: 334-337

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A new bone-inducing biodegradable porous beta-tricalcium phosphate2004

    • Author(s)
      Matsusita N, Terai H, Okada T, Nozaki K, Inoue H, Miyamoto S, Takaoka K
    • Journal Title

      J Biomed.Mater.Res 70(A)

      Pages: 450-458

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Enhancement of recombinant human bone morphogenetic protein-2(rhBMP)-induced new bone formation by concurrent treatment with parathyroid hormone and phosphodiesterase inhibitor,pentoxifylline2004

    • Author(s)
      Horiuchi H, Saito N, Kinoshita T, Wakabayashi S, Tsutsumimoto T, Otsuru S, Takaoka K
    • Journal Title

      J BoneMiner.Metab 22

      Pages: 450-458

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Atrophy of the deltoid muscle following rotator cuff Surgery2004

    • Author(s)
      Hata Y, Saitoh S, Murakami N, Kobayashi K, Takaoka K
    • Journal Title

      J Bone Joint Surgery 86

      Pages: 1414-1419

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Does chronic cervical myelopathy affect respiratory function?2004

    • Author(s)
      Toyoda H, Nakamura H, Konishi S, Terai S, Takaoka K.
    • Journal Title

      J Neurosurg.Spine 2

      Pages: 175-178

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Low-voltage electrochemotherapy with Low-dose methotrexate enhances survival in mice with osteosarcoma2004

    • Author(s)
      Isobe K, Shimizu T, Nikaido T, Takaoka K.
    • Journal Title

      Clin.Orthop 426

      Pages: 226-231

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Intradural extramedullary hemangioblastoma diffentiated by MR images in the cervical spine2004

    • Author(s)
      Toyoda H, Seki M, Nakamura H, Inoue Y, Yamano Y, Takaoka K.
    • Journal Title

      J Spinal Dis ord.Tech 4

      Pages: 343-347

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Blood management for patients with hemoglobin level lower than 130g/l in total knee arthroplasty2004

    • Author(s)
      Minoda Y, Sakawa A, Fukuoka S, Tada K, Takaoka K.
    • Journal Title

      Arch Orthop.Trauma Surg 124

      Pages: 317-319

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Carcinogenic Potential of 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) in Severe Combined Immunodeficient (SCID )Mice2004

    • Author(s)
      Hoshi M, Wanibuchi H, Salim E.L., Morimura K, Murai T, Nomura T, Takaoka K, Fukushima S
    • Journal Title

      Journal of Toxicologic Pathology 17

      Pages: 17-23

    • NAID

      10025851434

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] New Synthetic Biodegradable Polymers for Bone Morphogenetic Protein Delivery Systems2004

    • Author(s)
      Saito N, Horiuchi H, Murakami N, Takahashi J, Okada T, Nozaki K, Takaoka K.
    • Journal Title

      Tissue Engineering and Novel Delivery Systems

      Pages: 475-482

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Differential regulation of regulatory subunit for phosphatidylinositol 3-kinase in response to motor nerve injury2004

    • Author(s)
      Okamoto T, Namikawa K, Asano T, Takaoka K, Kiyama, H.
    • Journal Title

      Molecular Brain Research

      Pages: 119-125

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 【骨形成の分子医学】BMPによる骨形成の制御2004

    • Author(s)
      寺井 秀富、高岡 邦夫
    • Journal Title

      Medical Science Digest 30

      Pages: 91-94

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Osteonecrosis of the femoral head in Japanese adults after liver transplantation: a preliminary report.2004

    • Author(s)
      Horiuchi, H., Hashikura, Y., Hisa, K., Saito, N., Ikegami, T., Nakazawa, Y., Karakida, O., Kobayashi, S., Nawata, S., Kawasaki, S., Takaoka, K
    • Journal Title

      J Orthop.Sci 9

      Pages: 119-121

    • NAID

      10012842344

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A prostanoid receptor ER4 agonist enhances ectopic bone formation induced by recombinant human bone morphogenetic protein-22004

    • Author(s)
      Sasaoka, R., Terai, H., Toyoda, H, Imai, Y., Sugama, R., Takaoka, K
    • Journal Title

      Biochemical and Biophysical Research communication 318

      Pages: 704-709

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Capillary vessel net work integration by inserting a vascular pedicle enhances bone formation in tissue-engineered bone using interconnected porous hydroxylapatite ceramics.2004

    • Author(s)
      Akita, S., Tamai, N., Myoui, A., Nishikawa, M., Kaito, T., Takaoka, K., Yoshikawa, H
    • Journal Title

      Tissue Engineering 10

      Pages: 789-795

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Continuous local cooling for pain relief following total hip replacement2004

    • Author(s)
      Saito, N., Horiuchi, H., Kobayashi, S., Nawata, M., Takaoka, K
    • Journal Title

      Journal of Arthroplasty 19

      Pages: 334-337

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A new bone-inducing biodegradable porous beta-tricalcium phosphate2004

    • Author(s)
      Matsusita, N., Terai, H., Okada, T., Nozaki, K., Inoue, H., xMiyamoto, S., Takaoka, K
    • Journal Title

      J Biomed. Mater. Res 70(A)

      Pages: 450-458

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Enhancement of recombinant human bone morphogenetic protein-2 (rhBMP)-induced new bone formation by concurrent treatment with parathyroid hormone and phosphodiesterase inhibitor, pentoxifylline2004

    • Author(s)
      Horiuchi, H., Saito, N., Kinoshita, T., Wakabayashi, S., Tsutsumimoto, T., Otsuru, S., Takaoka, K
    • Journal Title

      J Bone Miner. Metab 22

      Pages: 329-334

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Atrophy of the deltoid muscle following rotator cuff Surgery2004

    • Author(s)
      Hata, Y., Saitoh, S., Murakami, N., Kobayashi, K., Takaoka, K
    • Journal Title

      J Bone Joint Surgery 86-A

      Pages: 1414-1419

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Does chronic cervical myelopathy affect respiratory function?2004

    • Author(s)
      Toyoda, H., Nakamura, H., Konishi, S., Terai, S, Takaoka, K
    • Journal Title

      J Neurosurg. Spine 2

      Pages: 175-178

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Low-voltage electrochemotherapy with Low-dose methotrexate enhances survival in mice with osteosarcoma.2004

    • Author(s)
      Isobe, K., Shimizu, T., Nikaido, T., Takaoka, K
    • Journal Title

      Clin. Orthop 426

      Pages: 226-231

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Blood management for patients with hemoglobin level lower than 130g/lin total knee arthroplasty2004

    • Author(s)
      Minoda, Y., Sakawa, A., Fukuoka, S., Tada, K., Takaoka, K
    • Journal Title

      Arch Orthop. Trauma Surg 124

      Pages: 317-319

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Intradural extramedullary hemangioblastoma diffentiated by MR images in the cervical spine2004

    • Author(s)
      Toyoda, H., Seki, M., Nakamura, H., Inoue, Y., Yamano, Y., Takaoka, K
    • Journal Title

      J Spinal Dis ord.Tech 4

      Pages: 343-347

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Carcinogenic Potential of 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) in Severe Combined Immunodeficient (SCID) Mice.2004

    • Author(s)
      Hoshi, M., Wanibuchi, H., Salim, E. I., Morimura, K., Murai, T., Nomura, T., Takaoka, K., Fukushima, S
    • Journal Title

      Journal of Toxicologic Pathology 17

      Pages: 17-23

    • NAID

      10025851434

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] New Synthetic Biodegradable Polymers for Bone Morphogenetic Protein Delivery Systems.2004

    • Author(s)
      Saito, N., Horiuchi, H., Murakami, N., Takahashi, J., Okada, T., Nozaki, K., Takaoka, K
    • Journal Title

      Tissue Engineering and Novel Delivery Systems

      Pages: 475-482

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Differential regulation of regulatory subunit for phosphatidylinositol 3-kinase in resnonse to motor nerve ininry2004

    • Author(s)
      Okamoto, T., Namikawa, K., Asano, T., Takaoka, K., Kiyama, H
    • Journal Title

      Molecular Brain Research

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A prostanoid receptor ER4 agonist enhances ectopic bone formation induced by recombinant human bone morphogenetic protein-22004

    • Author(s)
      Sasaoka, R
    • Journal Title

      Biochemical and Biophysical Research Communication 318

      Pages: 704-709

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A new bone-inducing biodegradable porous beta-tricalcium phosphate2004

    • Author(s)
      Matsusita, N
    • Journal Title

      Journal of Biomedical Materials Research 70(A)

      Pages: 450-458

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Enhancement of recombinant human bone morphogenetic protein-2 (rhBMP-2)-induced new bone formation by concurrent treatment with parathyroid hormone and a phosphodiesterase inhibitor, pentoxifylline2004

    • Author(s)
      Horiuchi, H
    • Journal Title

      Journal of Bone and Mineral Metabolism 22

      Pages: 329-334

    • Related Report
      2004 Annual Research Report
  • [Presentation] 骨形成性人工骨ペースト(BMPIPolymer/β-TCP複合体)による骨欠損修復-イヌ人工股関節周囲骨欠損モデル2008

    • Author(s)
      星野 雅俊、並川 崇、加藤 相勲、寺井 秀富、田口 晋、高岡 邦夫
    • Organizer
      第27回整形外科セラミック・インプラント研究会
    • Place of Presentation
      大阪
    • Year and Date
      2008-12-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 骨形成性人工骨ペースト(BMPIPolymer/β-TCP複合体)による骨欠損修復-イヌ人工股関節周囲骨欠損モデル2008

    • Author(s)
      星野 雅俊、並川 崇、加藤 相勲、寺井 秀富、田口 晋、大田 陽一、岩切健 太郎、高岡 邦夫
    • Organizer
      第26回日本運動器移植・再生医学研究会
    • Place of Presentation
      浜松
    • Year and Date
      2008-10-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 腰椎椎間板ヘルニアによる筋力低下発生に関わる危険因子解析2008

    • Author(s)
      鈴木 亨暢, 松村 昭, 寺井 秀富, 辻尾 唯雄, 並川 崇, 星野 雅俊, 高山 和士, 中村 博亮, 高岡 邦夫
    • Organizer
      第36回日本脊椎脊髄病学会
    • Place of Presentation
      金沢
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 多変量解析による頸椎椎弓形成術の術後軸性疹痛に影響を与える因子の検討C2,C7棘突起付着筋温存の影響に着目して2008

    • Author(s)
      加藤 相勲, 中村 博亮, 小西 定彦, 堂園 将, 福島 若葉, 近藤 亨子, 高岡 邦夫, 松田 英樹
    • Organizer
      第36回日本脊椎脊髄病学会
    • Place of Presentation
      金沢
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 術前に三次元切削加工した連通多孔体人工骨を用いた橈骨遠位端変形治癒骨折に対する矯正骨切り術2008

    • Author(s)
      米田 昌弘, 香月 憲一, 佐々木 康介, 岡田 充弘, 高岡 邦夫
    • Organizer
      第50回日本手の外科学会
    • Place of Presentation
      山形
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 選択的に除圧した椎弓形成術における臨床成績についての前向き観察研究C2,C7棘突起付筋温存の影響に着目して2008

    • Author(s)
      加藤 相勲, 松田 英樹, 中村 博亮, 小西 定彦, 堂園 将, 高岡 邦夫
    • Organizer
      第80回日本整形外科学会
    • Place of Presentation
      神戸
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 骨折治癒におけるBMPの役割2008

    • Author(s)
      今井 祐記, 寺井 秀富, 高岡 邦夫
    • Organizer
      第22回日本整形外科学会基礎学術集会
    • Place of Presentation
      浜松
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 橈骨遠位端変形治癒骨折に対する術前三次元切削加工人工骨を用いたコンピュータ支援矯正骨切り術の治療成績2008

    • Author(s)
      米田 昌弘, 香月 憲一, 佐々木 康介, 矢野 公一, 上村 卓也, 高岡 邦夫
    • Organizer
      第109回中部日本整形外科災害外科学会
    • Place of Presentation
      奈良
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] cAMPIPKA系からのBMP転写活性促進作用2007

    • Author(s)
      大田 陽一、中川 敬介、今井 祐記、片桐 岳信、小池 達也、高岡 邦夫
    • Organizer
      第57回関西カルシウム懇話会
    • Place of Presentation
      大阪
    • Year and Date
      2007-11-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 骨折治癒におけるBMPの役割2007

    • Author(s)
      今井 祐記, 寺井 秀富, 高岡 邦夫
    • Organizer
      第22回日本整形外科学会基礎学術集会
    • Place of Presentation
      浜松市
    • Year and Date
      2007-10-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] 橈骨遠位端変形治癒骨折に対する術前三次元切削加工人工骨を用いたコンピュータ支援矯正骨切り術の治療成績2007

    • Author(s)
      米田 昌弘, 香月 憲一, 佐々木 康介, 矢野 公一, 上村 卓也, 高岡 邦夫
    • Organizer
      第109回中部日本整形外科災害外科学会
    • Place of Presentation
      奈良市
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Endogenous Cyclic adenosine3',5'-,monophosphate response Element-Binding Protein(CREB)signaling enhances smad-mediated Bone Morphogenetic Protein(BMP)signaling.2007

    • Author(s)
      Ohta Y, Nakagawa K, Imai Y, Katagiri T, Koike T, Takaoka K
    • Organizer
      29^<th> Annual Meeting of the American Society for Bone and Mineral Research(ASBMR)
    • Place of Presentation
      Hawaii
    • Year and Date
      2007-09-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] Risk factor analysis of motor deficits associated with lumber disc herniation2007

    • Author(s)
      Suzuki A, Matsumura A, Tsujio T, Terai H, Namikawa T, Hoshino M, Takayama K, Nakamura H, Takaoka K
    • Organizer
      34^<th> Annual Meeting of the International Society for the Study of the Lumber Spine
    • Place of Presentation
      Hong Kong
    • Year and Date
      2007-06-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] 選択的に除圧した椎弓形成術における臨床成績についての前向き観察研究C2,C7棘突起付筋温存の影響に着目して2007

    • Author(s)
      加藤 相勲, 松田 英樹, 中村 博亮, 小西 定彦, 堂園 将, 高岡 邦夫
    • Organizer
      第80回日本整形外科学会
    • Place of Presentation
      神戸市
    • Year and Date
      2007-05-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] 多変量解析による頸椎椎弓形成術の術後軸性痩痛に影響を与える因子の検討C2,C7棘突起付着筋温存の影響に着目して2007

    • Author(s)
      加藤 相勲, 中村 博亮, 小西 定彦, 堂園 将, 福島 若葉, 近藤 亨子, 高岡 邦夫, 松田 英樹
    • Organizer
      第36回日本脊椎脊髄病学会
    • Place of Presentation
      金沢市
    • Year and Date
      2007-04-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] 腰椎椎間板ヘルニアによる筋力低下発生に関わる危険因子解析2007

    • Author(s)
      鈴木 亨暢, 松村 昭, 寺井 秀富, 辻尾 唯雄, 並川 崇, 星野 雅俊, 高山 和士, 中村 博亮, 高岡 邦夫
    • Organizer
      第36回日本脊椎脊髄病学会
    • Place of Presentation
      金沢市
    • Year and Date
      2007-04-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 新生体材料の開発と臨床応用への関門BMPIPolymer/β-TCP複合体による骨欠損修復イヌ人工股関節周囲骨欠損モデル2007

    • Author(s)
      星野 雅俊、寺井 秀富、並川 崇、加藤 相勲、高岡 邦夫
    • Organizer
      第21回日本整形外科学会基礎学術集会
    • Place of Presentation
      長崎
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cyclic AMPは転写レベルでBMPシグナル伝達を促進する2007

    • Author(s)
      大田 陽一、中川 敬介、今井 祐記、片桐 岳信、小池 達也、高岡 邦夫
    • Organizer
      第21回日本整形外科学会基礎学術集会
    • Place of Presentation
      長崎
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Prostaglandin E2 EP4 Agonist(ONO-4819)によるBMP骨形成作用促進効果の作用機構解明2007

    • Author(s)
      中川 敬介、大田 陽一、豊田 宏光、今井 祐記、野村 千澄、高岡 邦夫
    • Organizer
      第21回日本整形外科学会基礎学術集会
    • Place of Presentation
      長崎
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 基礎と臨床の融合骨欠損の修復手術ナビゲーションシステム、CAD,CAMの使用による解剖学的健常な骨修復BMPによる骨再生の新たな手法2007

    • Author(s)
      並川 崇、星野 雅俊、寺井 秀富、高岡 邦夫
    • Organizer
      第21回日本整形外科学会基礎学術集会
    • Place of Presentation
      長崎
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] BMPを用いた骨腱靱帯移行部の再生2007

    • Author(s)
      橋本 祐介、吉田 玄、豊田 宏光、高岡 邦夫
    • Organizer
      第21回日本整形外科学会基礎学術集会
    • Place of Presentation
      長崎
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Endogenous Cyclic adenosine3',5'-,monophosphate response Element-Binding Protein (CREB) signaling enhances smad-mediated Bone Morphogenetic Protein(BMP) signaling2007

    • Author(s)
      Ohta Y, Nakagawa K, Imai Y, Katagiri T, Koike T, Takaoka K
    • Organizer
      29th Annual Meeting of the American Society for Bone and Mineral Research(ASBMR)発表年月目
    • Place of Presentation
      Hawaii
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Risk factor analysis of motor deficits associated with lumber disc herniation2007

    • Author(s)
      Suzuki A, Matsumura A, Tsujio T, Terai H, Namikawa T, Hoshino M, Takayama K, Nakamura H, Takaoka K
    • Organizer
      34th Annual Meeting of the International Society for the Study of the Lumber Spine
    • Place of Presentation
      Hong Kong
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Endogenous Cyclic adenosine 3', 5'-,monophosphate response Element-Binding Protein(CREB) signaling enhances smad-mediated Bone Morphogenetic Protein (BMP) signaling.2007

    • Author(s)
      Ohta, Y., Nakagawa, K., Imai, Y., Katagiri, T., Koike, T., Takaoka, K
    • Organizer
      29th Annual Meeting of the American Society for Bone and Mineral Research(ASBMR)
    • Place of Presentation
      Hawaii
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 術前に三次元切削加工した連通多孔体人工骨を用いた橈骨遠位端変形治癒骨折に対する矯正骨切り術2007

    • Author(s)
      米田 昌弘, 香月 憲一, 佐々木 康介, 岡田 充弘, 高岡 邦夫
    • Organizer
      第50回日本手の外科学会
    • Place of Presentation
      山形市
    • Related Report
      2007 Annual Research Report
  • [Presentation] BMPIPolymer/β-TCP複合体による骨欠損修復-イヌ人工股関節周囲骨欠損モデル2006

    • Author(s)
      星野 雅俊、寺井 秀富、並川 崇、加藤 相勲、田口 晋、高岡 邦夫
    • Organizer
      第12回人工関節基礎研究会
    • Place of Presentation
      東京
    • Year and Date
      2006-09-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Protein KinaseA系を介したBMP転写活性促進作用2006

    • Author(s)
      大田 陽一、中川 敬介、今井 祐記、野村 千澄、片桐 岳信、高岡 邦夫
    • Organizer
      第13回BMP研究会
    • Place of Presentation
      東京
    • Year and Date
      2006-07-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 骨誘導能を有する新しいrhBMP-2含有ペーストマテリアル2006

    • Author(s)
      加藤 相勲、並川 崇、寺井 秀富、星野 雅俊、高岡 邦夫
    • Organizer
      第13回BMP研究会
    • Place of Presentation
      東京
    • Year and Date
      2006-07-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] イヌ人工股関節周囲骨欠損モデルでのBMPIPolymer/β-TCP複合体による骨欠損修復2006

    • Author(s)
      星野 雅俊、寺井 秀富、並川 崇、加藤 相勲、高岡 邦夫
    • Organizer
      第13回BMP研究会
    • Place of Presentation
      東京
    • Year and Date
      2006-07-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 犬巨大肋骨欠損モデルに対するBMP/β-TCPを用いた骨再生2006

    • Author(s)
      星野 雅俊、恵木 丈、寺井 秀富、並川 崇、高岡 邦夫
    • Organizer
      第2回連通多孔体セラミックス研究会
    • Place of Presentation
      横浜
    • Year and Date
      2006-05-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] rhBMP-2と新しいドラッグデリバリーシステムを使用した家兎腰椎後側方固定術2006

    • Author(s)
      並川 崇、寺井 秀富、鈴木 英介、星野 雅俊、豊田 宏光、中村 博亮、高岡 邦夫
    • Organizer
      第56回関西カルシウム懇話会
    • Place of Presentation
      大阪
    • Year and Date
      2006-04-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Enhancement of BMP signaling by cyclic AMP:Its role and mechanism2006

    • Author(s)
      Ohta Y, Nakagawa K, Imai Y, Nomura C, Katagiri T, Koike T, Takaoka K
    • Organizer
      Frontiers of Skeletal Biology
    • Place of Presentation
      Davos
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cyclic AMP accelerates BMP signaling by enhancing the transcriptional activity of BMP responsive element through cyclic AMP responsive element2006

    • Author(s)
      Ohta Y, Nakagawa K, Imai Y, Nomura C, Katagiri T, Koike T, Takaoka K
    • Organizer
      The 28th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Philadelphia
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Repair of acetabular and proximal femoral bone defects in dogs by implantation of a new bone-inducing material comprised of beta-TCP powder, a biodegradable polymer, and recombinant human BMP-22006

    • Author(s)
      Hoshino M, Terai H, Namikawa T, Kato M, Takaoka K
    • Organizer
      The 6th International Conference on Bone Morphogenetic Proteins
    • Place of Presentation
      Cavtat
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Prostaglandin E2 receptor EP4 agonist(ONO-4819) accelerates BMP-dependent osteoblastic differentiation2006

    • Author(s)
      Nakagawa K, Ohta Y, Imai Y, Nomura C, Takaoka K
    • Organizer
      The 6th International Conference on Bone Morphogenetic Proteins
    • Place of Presentation
      Cavtat
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Concurrent local delivery of prostaglandin E EP-4 receptor agonist and rhBMP-2 to enhance spinal fusion in a rabbit model2006

    • Author(s)
      Namikawa T, Terai H, Hoshino M, Kato M, Toyoda H, Suzuki E, Nakamura H, Takaoka K
    • Organizer
      The 6th International Conference on Bone Morphogenetic ProteinsOctober 11-15, 2006
    • Place of Presentation
      Cavtat
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cyclic AMP accelerates BMP transcriptinal activity through cyclic AMP responsive element2006

    • Author(s)
      Ohta Y, Nakagawa K, Imai Y, Nom ura C, Katagiri T, Koike T, Takaoka K
    • Organizer
      The 6th International Conference on Bone Morphogenetic Proteins
    • Place of Presentation
      Cavtat
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] イヌモデルでのBMP/人工合成担体による股関節部骨欠損修復2006

    • Author(s)
      高岡 邦夫
    • Organizer
      第36回日本人工関節学会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] RhBMP-2使用家兎脊椎固定術へのProstaglandin E EP-4 ReceptorAgonist局所徐放併用によるBMP所要量の低減化に関する研究2006

    • Author(s)
      並川 崇、寺井 秀富、鈴木 英介、加藤 相勲、星野 雅俊、中村 博亮、小田 和健、高岡 邦夫
    • Organizer
      第35回日本脊椎脊髄病学会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 「次の百年へ」骨折治療の新世紀新しいBMPのDDSによる骨修復2006

    • Author(s)
      高岡 邦夫
    • Organizer
      第79回本整形外科学会学術集会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cyclic AMPはBMP転写活性を促進する2006

    • Author(s)
      大田 陽一、中川 敬介、今井 祐記、野村 千澄、片桐 岳信、小池 達也、高岡 邦夫
    • Organizer
      第24回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 骨誘導能を有する新しいrhBMP-2含有ペーストマテリアル2006

    • Author(s)
      加藤 相勲、並川 崇、寺井 秀富、星野 雅俊、高岡 邦夫
    • Organizer
      第21回日本整形外科学会基礎学術集会
    • Place of Presentation
      長崎
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Enhancement of BMP signaling by cyclic AMP : Its role and mechanism2006

    • Author(s)
      Ohta, Y., Nakagawa, K., Imai, Y., Nomura, C., Katagiri, T., Koike, T., Takaoka, K
    • Organizer
      Frontiers of Skeletal Biology
    • Place of Presentation
      Davos
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Prostaglandin E2 receptor EP4 agonist(ONO-4819) accelerates BMP-dependent osteoblastic differentiation2006

    • Author(s)
      Nakagawa, K., Ohta, Y., Imai, Y., Nomura, C., Takaoka, K
    • Organizer
      Frontiers of Skeletal Biology
    • Place of Presentation
      Davos
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cyclic AMP accelerates BMP signaling by enhancing the transcriptional activity of BMP responsive element through cyclic AMP responsive element2006

    • Author(s)
      Ohta, Y., Nakagawa, K., Imai, Y., Nomura, C., Katagiri, T., Koike, T., Takaoka, K
    • Organizer
      The 28th American Society for Bone and Mineral Research
    • Place of Presentation
      Philadelphia
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Prostaglandin E2 receptor EP4 agonist(ONO-4819) accelerates BMP-dependent osteoblastic differentiation2006

    • Author(s)
      Nakagawa, K., Ohta, Y., Imai, Y., Nomura, C., Takaoka, K
    • Organizer
      The 6th International Conference on Bone Morphogenetic Proteins
    • Place of Presentation
      C,avtat.
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Concurrent local delivery of prostaglandin E EP-4 receptor agonist and rhBMP-2 to enhance spinal fusion in a rabbit model2006

    • Author(s)
      Namikawa, T., Terai, H., Hoshino, M., Kato, M., Toyoda, H., Suzuki, E., Nakamura, H., Takaoka, K
    • Organizer
      The 6th International Conference on Bone Morphogenetic Proteins
    • Place of Presentation
      Cavtat
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Posterolateral lumbar spinal fuion using a novelPLA-DX-PEG/β-TCP compositeas a delivery system for rhBMP-2 in a rabbit model2005

    • Author(s)
      Namikawa T, Terai H, Suzuki E, Hoshino M, Toyoda H, Nakamura H, Takaoka K
    • Organizer
      The 32nd International Society for the Study of the Lumbar Spine
    • Place of Presentation
      New York
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Prostaglandin E2 EP4 agonist (ONO-4819) accelerates BMP-inducedoste oblastic differentiation via PKA signaling2005

    • Author(s)
      Nakagawa K, Ohta Y, Imai Y, Nomura-Furuwatari C, Takaoka K
    • Organizer
      The 27th American Society for Bone and Mineral Research
    • Place of Presentation
      Nashville
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Adenosine3',5'-cyclic monophosphate(cAMP)enhances bone morphogenetic protein(BNIP)activities through the suppression of Smad6 expression in osteoprogenitor cells2005

    • Author(s)
      Sugama R, Koike T, Imai Y, Nomura C, Takaoka K
    • Organizer
      The 27th American Society for Bone and Mineral
    • Place of Presentation
      Nashville
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 犬巨大肋骨欠損モデルに対するBMPIPLA-PEG/β-TCPを用いた骨再生2005

    • Author(s)
      星野 雅俊、恵木 丈、寺井 秀富、並川 崇、高岡 邦夫
    • Organizer
      第4回日本再生医療学会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] rhBMP-2の新しいデリバリーシステムとしてのPLA-DX-PEG/β-TCPを用いた家兎腰椎後側方固定術2005

    • Author(s)
      並川 崇、寺井 秀富、鈴木 英介、星野 雅俊、豊田 宏光、中村 博亮、高岡 邦夫
    • Organizer
      第34回日本脊髄脊椎病学会
    • Place of Presentation
      仙台
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] サイクリックAMPによるBMP-4活性増強の機序negativef6edbackへの介入2005

    • Author(s)
      洲鎌 亮、小池 達也、今井 祐記、野村 千澄、高岡 邦夫
    • Organizer
      第23回日本骨代謝学会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] BMPによるphosphodiesterase 4 の誘導2005

    • Author(s)
      野村 千澄、大田 陽一、今井 祐記、中川 敬介、高岡 邦夫
    • Organizer
      第23回日本骨代謝学会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 人工骨による骨再生BMP+ポリマー+β-TCPによる骨再生2005

    • Author(s)
      寺井 秀富
    • Organizer
      第23回日本骨代謝学会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 人工骨による骨再生 連通多孔体HAを用いた骨再生2005

    • Author(s)
      名井 陽、玉井 宣行、西川 昌孝、秋田 鐘弼、海渡 貴司、藤本 哲穂、木澤 卓嗣、中村 憲正、金倉 譲、大串 始、高岡 邦夫、吉川 秀樹
    • Organizer
      第23回日本骨代謝学会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 生体吸収性ポリマーを用いたBMPと抗生剤の徐放2005

    • Author(s)
      鈴木 亨暢、寺井 秀富、豊田 宏光、並川 崇、高岡 邦夫
    • Organizer
      第12回BMP研究会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] rhBMP-2の新しいデリバリーシステム、PLA-DX-PEG/β-TCPを使用した家兎腰椎後側方固定術2005

    • Author(s)
      並川 崇、寺井 秀富、鈴木 英介、星野 雅俊、中村 博亮、高岡 邦夫
    • Organizer
      第12回BMP研究会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] サイクリックAMPはSmad6抑制によりBMP-4活性を増強する2005

    • Author(s)
      洲鎌 亮、小池 達也、今井 祐記、野村 千澄、高岡 邦夫
    • Organizer
      第20回日本整形外科学会基礎学術集会
    • Place of Presentation
      伊勢
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] BMP担体としてのβ-TCPIPLA-DX-PEGPolymer混合体の有用性2005

    • Author(s)
      星野 雅俊、寺井 秀富、並川 崇、加藤 相勲、豊田 宏光、高岡 邦夫
    • Organizer
      第20回日本整形外科学会基礎学術集会
    • Place of Presentation
      伊勢
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] BMP SignalingへのcAMPの増幅効果のメカニズム2005

    • Author(s)
      大田 陽一、中川 敬介、今井 祐記、野村 千澄、片桐 岳信、高岡 邦夫
    • Organizer
      第20回日本整形外科学会基礎学術集会
    • Place of Presentation
      伊勢
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Prostaglandin E2 EP4 Agonist(ONO-4819)によるBMP骨形成作用促進効果の作用機構解明2005

    • Author(s)
      中川 敬介、大田 陽一、豊田 宏光、今井 祐記、野村 千澄、高岡 邦夫
    • Organizer
      第20回日本整形外科学会基礎学術集会
    • Place of Presentation
      伊勢
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] RhBMP-2使用家兎脊椎固定術モデルにおけるProstaglandin E EP-4 ReceptorAgonist局所徐放の骨形成促進効果2005

    • Author(s)
      並川 崇、寺井 秀富、鈴木 英介、中村 博亮、小田 和健、高岡 邦夫
    • Organizer
      第20回日本整形外科学会基礎学術集会
    • Place of Presentation
      伊勢
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] BMP4によるPhosphodiesterase 4の発現誘導2005

    • Author(s)
      野村 千澄、大田 陽一、今井 祐記、中川 敬介、高岡 邦夫
    • Organizer
      第20回日本整形外科学会基礎学術集会
    • Place of Presentation
      伊勢
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 生体吸収性ポリマーを用いたBMPと抗生剤の徐放 感染性骨欠損に対する新治療法の開発2005

    • Author(s)
      鈴木 亨暢、並川 崇、豊田 宏光、寺井 秀富、高岡 邦夫
    • Organizer
      第20回日本整形外科学会基礎学術集会
    • Place of Presentation
      伊勢
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Prostaglandin E2 receptor EP4 agonist(ONOlerates BMP-dependent osteoblastic differentiation2005

    • Author(s)
      Nakagawa K, Ohta Y, Imai Y, Nomura C, Takaoka K
    • Organizer
      Frontiers of Skeletal Biology
    • Place of Presentation
      Davos
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Posterolateral lumbar spinal fusion using a novel PLA-DX-PEG/B-TCP composite as a delivery system for rhBMP-2 in a rabbit model2005

    • Author(s)
      Namikawa, T., Terai, H., Suzuki, E., Hoshino, M., Toyoda, H., Nakamura, H., Takaoka, K
    • Organizer
      The 32nd International Society for the Study of the Lumbar Spine
    • Place of Presentation
      New York
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Prostaglandin E2 EP4 agonist(ONO-4819) accelerates BMP-induced osteoblastic differentiation via PKA signaling2005

    • Author(s)
      Nakagawa, K., Ohta, Y., Imai, Y., Nomura-Furuwatari, C., Takaoka, K
    • Organizer
      The 27th American Society for Bone and Mineral Research
    • Place of Presentation
      Nashville
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Adenosine 3', 5'-cyclic monophosphate (cAMP) enhances bone morphogenetic protein (BMP) activities through the suppression of Smad6 expression in osteoprogenitor cells2005

    • Author(s)
      Sugama, R., Koike, T., Imai, Y., Nomura, C., Takaoka, K
    • Organizer
      The 27th American Society for Bone and Mineral Research
    • Place of Presentation
      Nashville
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 犬巨大肋骨欠損モデルに対するBMPIPLA-PEG/β-TCPを用いた骨再生2004

    • Author(s)
      星野 雅俊, 恵木 丈, 寺井 秀富, 並川 崇, 高岡 邦夫
    • Organizer
      第24回整形外科セラミック・インプラント研究会
    • Place of Presentation
      東京
    • Year and Date
      2004-12-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] rhBMP-2/PLA-DX-PEG/β-TCPcompositeを使用した家兎腰椎後側方固定術での脊椎固定率に関する研究2004

    • Author(s)
      並川 崇、寺井 秀富、鈴木 英介、星野 雅俊、中村 博亮、高岡 邦夫
    • Organizer
      第24回整形外科セラミック・インプラント研究会
    • Place of Presentation
      東京
    • Year and Date
      2004-12-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 肝細胞増殖因子による骨形成因子受容体遺伝子発現促進2004

    • Author(s)
      今井 祐記、寺井 秀富、野村 千澄、松本 邦夫、中村 敏一、高岡 邦夫
    • Organizer
      第19回日本整形外科学会基礎学術集会
    • Place of Presentation
      東京
    • Year and Date
      2004-10-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] β-TCPIPLA-DX-PEG/rhBMP-2を使用した長管骨欠損修復2004

    • Author(s)
      米田 昌弘、寺井 秀富、恵木 丈、香月 憲一、高岡 邦夫
    • Organizer
      第23回日本運動器移植・再生医学研究会
    • Place of Presentation
      岡山
    • Year and Date
      2004-09-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] PLA-DX・PEG/β-TCPcompositeをrhBMP-2の担体として用いた家兎腰椎後側方固定術での脊椎固定率に関する研究2004

    • Author(s)
      並川 崇、寺井 秀富、鈴木 英介、星野 雅俊、中村 博亮、高岡 邦夫
    • Organizer
      第23回日本運動器移植・再生医学研究会
    • Place of Presentation
      岡山
    • Year and Date
      2004-09-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 犬巨大胸壁欠損モデルに対するBMPIPLA-PEG/β-TCPを用いた肋骨再生2004

    • Author(s)
      星野 雅俊、恵木 丈、寺井 秀富、並川 崇、高岡 邦夫
    • Organizer
      第23回日本運動器移植・再生医学研究会
    • Place of Presentation
      岡山
    • Year and Date
      2004-09-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 犬巨大肋骨欠損モデルに対するBMPIPLA-PEG/β-TCPを用いた骨再生2004

    • Author(s)
      星野 雅俊, 恵木 丈, 寺井 秀富, 並川 崇, 高岡 邦夫
    • Organizer
      第ll回BMP研究会
    • Place of Presentation
      東京
    • Year and Date
      2004-07-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] rhBMP-2/PLA-DX-PEG/β-TCPcompositeを使用した家兎腰椎後側方固定術での脊椎固定率に関する研究2004

    • Author(s)
      並川 崇、寺井 秀富、鈴木 英介、星野 雅俊、豊田 宏光、中村 博亮、高岡 邦夫
    • Organizer
      第3回大阪バイオセラミックス研究会
    • Place of Presentation
      大阪
    • Year and Date
      2004-02-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Lumbar spinal fusion in arabbit model using a novel PLA-DX-PEG/β-TCP composite as a delivery system for rhBMP-22004

    • Author(s)
      Namikawa T, Terai H, Suzuki E, Hoshino M, Toyoda H, Nakamura H, Miyamoto S, Takaoka K
    • Organizer
      The 5th International Conference on Bone Morhogenetic Proteins
    • Place of Presentation
      Nagoya
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Repair of intercalated bone defects with biodegradable β-tricalcium phosphate combined with a novel delivery system for reconbinant bone morphogenetic protein-22004

    • Author(s)
      Yoneda M, Terai H, Egi T, Kazuki K, Takaoka K
    • Organizer
      The 5th International Conference on Bone Morhogenetic Proteins
    • Place of Presentation
      Nagoya
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Prostaglandin EP4 agonist enhances BMP-induced bone formation2004

    • Author(s)
      Terai H, Sasaoka R, Toyoda H, Imai Y, Sugama R, Takaoka K.
    • Organizer
      The 5th International Conference on Bone Morhogenetic Proteins
    • Place of Presentation
      Nagoya
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Repair of intercalated long bone defect with biodegradable β-tricalcium phosphate added by a new delivery system for reconbinant human bone morphogenetic protein-22004

    • Author(s)
      Yoneda M, Terai H, Miyamaoto S, Takaoka K
    • Organizer
      The 26th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Seattle
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Evaluation of new drug delivery system for rhBMP-2 in a rabbit lumbar spine fusion model2004

    • Author(s)
      Namikawa T, Terai H, Suzuki E, Hoshino M, Toyoda H, Nakamura H, Miyamoto S, Takaoka K
    • Organizer
      The 26th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Seattle
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Local release of a prostanoid receptor EP4 agonist with rhBMP-2 enhances bone morphoeenetic protein-Induced bone formation2004

    • Author(s)
      Toyoda H, Terai H, Sasaoka R, OdaK, Takaoka K
    • Organizer
      The 26th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Seattle
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Up-regulation of Bone Morphogenetic Protein Receptors Induced by Hepatocyte Growth Factor in the Early Phase of Fracture Repair2004

    • Author(s)
      Imai Y, Terai H, Nomura-Furuwatari C, Takaoka K
    • Organizer
      The 26th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Seattle
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Prostaglandin E EP4 Agonistの局所徐放はRhBMP-2誘導骨形成作用増強をさせる2004

    • Author(s)
      豊田 宏光、寺井 秀富、笹岡 隆一、小田 和健、高岡 邦夫
    • Organizer
      第22回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 新しいrhBMP-2のデリバリーシステムを使用した長管骨欠損修復2004

    • Author(s)
      米田 昌弘、寺井 秀富、恵木 丈、香月 憲一、高岡 邦夫
    • Organizer
      第22回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヘパリンは核内のリン酸化Smadレベルを高く保つことでBMP活性を促進する2004

    • Author(s)
      趙 宝紅、片桐 岳信、高田 貴虎、豊田 宏光、高岡 邦夫、小池 達也、上條 竜太郎
    • Organizer
      第22回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 骨芽細胞におけるPDE4splicingvariantの発現と骨分化に与える影響について2004

    • Author(s)
      野村 千澄、洲鎌 亮、小池 達也、高岡 邦夫
    • Organizer
      第22回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 新しいrhBMP-2デリバリーシステムを使用した家兎腰椎後側方固定術での脊椎固定率に関する研究2004

    • Author(s)
      並川 崇、寺井 秀富、鈴木 英介、星野 雅俊、中村 博亮、高岡 邦夫
    • Organizer
      第22回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 新しいrhBMP-2デリバリーシステムを使用した骨皮質欠損の修復家兎大腿骨皮質骨欠損モデルでの評価2004

    • Author(s)
      松下 直史、寺井 秀富、高岡 邦夫
    • Organizer
      第19回日本整形外科学会基礎学術集会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 新しいrhBMP-2デリバリーシステムを使用した家兎腰椎後側方固定術での脊椎固定率に関する研究2004

    • Author(s)
      並川 崇、寺井 秀富、鈴木 英介、星野 雅俊、中村 博亮、高岡 邦夫
    • Organizer
      第19回日本整形外科学会基礎学術集会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 新しいrhBMP-2デリバリーシステムを使用した長管骨欠損修復家兎大腿骨欠損モデルでの評価2004

    • Author(s)
      米田 昌弘、寺井 秀富、恵木 丈、香月 憲一、高岡 邦夫
    • Organizer
      第19回日本整形外科学会基礎学術集会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Prostaglandin E EP 4 Agonistの局所徐放によるRhBMP-2誘導骨形成作用増強効果2004

    • Author(s)
      豊田 宏光、寺井 秀富、笹岡 隆一、高岡 邦夫
    • Organizer
      第19回日本整形外科学会基礎学術集会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 骨形成に関与するPDE 4 Splicing Variantの同定2004

    • Author(s)
      野村 千澄、洲鎌 亮、寺井 秀富、小池 達也、高岡 邦夫
    • Organizer
      第19回日本整形外科学会基礎学術集会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Lumbar spinal fusion in a rabbit model using a novel PLA-DX-PEG/B-TCP composite as a delivery system for rhBMP-2.2004

    • Author(s)
      Namikawa, T., Terai, H., Suzuki, E., Hoshino, M., Toyoda, H., Nakamura, H., Miyamoto, S., Takaoka, K
    • Organizer
      The 5th International Conference on Bone Morphogenetic Proteins
    • Place of Presentation
      Nagoya.
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Repair of intercalated bone defects with biodegradable 0-tricalcium phosphate combined with a novel delivery system for reconbinant bone morphogenetic protein-2.2004

    • Author(s)
      Yoneda, M., Terai, H., Egi, T., Kazuki, K., Takaoka, K
    • Organizer
      The 5th International Conference on Bone Morphogenetic Proteins
    • Place of Presentation
      Nagoya
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Prostaglandin EP4 agonist enhances BMP-induced bone formation.2004

    • Author(s)
      Terai, H., Sasaoka, R., Toyoda, H., Imai, Y., Sugama, R., Takaoka, K
    • Organizer
      The 5th International Conference on Bone Morphogenetic Proteins
    • Place of Presentation
      Nagoya.
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Repair of intercalated long bone defect with biodegradable 6-tricalcium phosphate added by a new delivery system for reconbinant human bone morphogenetic protein-2.2004

    • Author(s)
      Yoneda, M., Terai, H., Miyamaoto, S., Takaoka, K
    • Organizer
      The 26th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Seattle
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Evaluation of new drug delivery system for rhBMP-2 in a rabbit lumbar spine fusion model.2004

    • Author(s)
      Namikawa, T., Terai, H., Suzuki, E., Hoshino, M., Toyoda, H., Nakamura, H., Miyamoto, S., Takaoka, K
    • Organizer
      The 26th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Seattle
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Local release of a prostanoid receptor EP4 agonist with rhBMP-2 enhances bone morphogenetic protein- Induced bone formation.2004

    • Author(s)
      Toyoda, H., Terai, H., Sasaoka, R., Oda, K., Takaoka, K
    • Organizer
      The 26th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Seattle
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Up-regulation of Bone Morphogenetic Protein Receptors Induced by Hepatocyte Growth Factor in the Early Phase of Fracture Repair.2004

    • Author(s)
      Imai, Y., Terai, H., Nomura-Furuwatari, C., Takaoka, K
    • Organizer
      The 26th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Seattle
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 別冊整形外科47【骨・軟骨移植最近の知見】骨移植基礎研究骨形成蛋白(BMP)新しい骨形成蛋白(BMP)デリバリーシステムを利用した長管骨骨欠損の修復の試み2005

    • Author(s)
      米田 昌弘、寺井 秀富、高岡 邦夫
    • Publisher
      南江堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 別冊整形外科47【骨・軟骨移植最近の知見】骨移植基礎研究骨形成蛋白(BMP)連通多孔体ハイドロキシアパタイト/ポリ乳酸ポリエチレングリコール共重合体(PLA-PEG)/ヒト遺伝子組換え骨形成蛋白(rhBMP-2)複合体による骨再生2005

    • Author(s)
      海渡 貴司、名井 陽、高岡 邦夫、西川 昌孝、吉川 秀樹
    • Publisher
      南江堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Tissue Engineering And Novel Delivery Systems2004

    • Author(s)
      Saito N
    • Total Pages
      620
    • Publisher
      Marcel Dekker Inc.
    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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