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Development of Bone-bonding Bioactive Titanium Using Nanotechnology and its' Application for Orthopedic Implant.

Research Project

Project/Area Number 16200035
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionKyoto University

Principal Investigator

NAKAMURA Takashi  Kyoto University, Graduate School of Medicine, Professor, 医学研究科, 教授 (10201675)

Co-Investigator(Kenkyū-buntansha) NEO Masashi  Kyoto University, Graduate School of Medicine, Lecturer, 医学研究科, 講師 (80311736)
KAWASHITA Masakazu  Kyoto University, Graduate School of Engineering, Lecturer, 工学研究科, 講師 (70314234)
松下 富春  株式会社神戸製鋼所, 役員補佐(研究職)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥49,790,000 (Direct Cost: ¥38,300,000、Indirect Cost: ¥11,490,000)
Fiscal Year 2006: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2005: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2004: ¥33,280,000 (Direct Cost: ¥25,600,000、Indirect Cost: ¥7,680,000)
Keywordstitanium / anodically oxidization / anatase / nano / bone cement / biomaterial / osteoconduction / animal study / ナノ構造 / 生体活性 / 骨伝導 / 骨結合 / 生体材料
Research Abstract

1.We investigated nanoporous structure, in vitro bioactivity, and in vivo bone-bonding ability of anodically oxidized titanium (AO Ti) with a nanoporous anatase crystal layer on its surface. AO Ti plates, anodically oxidized at 150V and 200V in 1 M-H_2SO_4, were implanted into the proximal metaphyses of mature rabbit tibiae for 4, 8, 16, and 24 weeks and investigated by light microscopy, scanning electron microscopy and detaching test. High bone-bonding ability, comparable to our previous study data of the bioactive titanium, was observed during post implantation times.
2.Various types of bioactive polymethylmethacrylate (PMMA)-based bone cement containing nano-sized titania (TiO2) particles were prepared, and their mechanical properties and osteoconductivity are evaluated. Commercially available PMMA cement (PMMAc) was used as a control. The cements were inserted into rat tibiae and allowed to solidify in situ. After 6 and 12 weeks, tibiae were removed for evaluation of osteoconductivi … More ty using scanning electron microscopy (SEM), contact microradiography (CMR), and Giemsa surface staining. The PMMA-baced cement with nanosized rutile or anatase showed superior osteoconduction compared to the commercially available PMMA cement. These results show that PMMA-based bone cement containing nanosized titania particles is a promising material for use as a bone substitute.
3.We investigated the relationship between nanosized bioactive porous surface and micronsized macropore structure, various types of bioactive porous titanium implants with different pore sizes and porosities (6mm in diameter and 15mm long) were analyzed using specific algorithms for 3D analysis of interconnectivity based on a micro focus X-ray computed tomography system. In vivo histomorphometric analysis was performed using the very same implants implanted into the femoral condyles of male rabbits for 6 and 12 weeks. This matching study analysis revealed the importance of wide interconnections (diameter more than 52 μm) for bone ingrowth into porous structure with nanosized titania surface. Less

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (45 results)

All 2007 2006 2005 2004 Other

All Journal Article (45 results)

  • [Journal Article] Surface modification of organic polymers with bioactive titanium oxide without the aid of a silane-coupling agent.2007

    • Author(s)
      Balas F, et al.
    • Journal Title

      J Mater Sci Mater Med 18

      Pages: 1167-1174

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Novel micro-CT based 3-dimentional structural analyses of porous biomaterials.2007

    • Author(s)
      Otsuki B, et al.
    • Journal Title

      Key Engineering Materials 330-332

      Pages: 967-970

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Bone ingrowth into porous bioactive titanium implant for load-bearing use : Experimental study using a novel canine anterior interbody fusion model.2007

    • Author(s)
      Takemoto M, et al.
    • Journal Title

      Key Engineering Materials 330-332

      Pages: 987-990

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Novel micro-Ct based 3-dimentional structural analyses of porous biomaterials.2007

    • Author(s)
      Otsuki B, et al.
    • Journal Title

      Key Engineering Materials 330-332 II

      Pages: 967-970

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Bone ingrowth into porous bioactive titanium implant for load-bearing use : Experimental study using a novel canine anterior interbody fusion model.2007

    • Author(s)
      Takemoto M, et al.
    • Journal Title

      Key Engineering Materials 330-332 II

      Pages: 987-990

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Formation of bone-like apatite on organic polymers treated with a silane-coupling agent and a titania solution.2006

    • Author(s)
      Balas F, et al.
    • Journal Title

      Biomaterials 27

      Pages: 1704-1710

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Bioactive bone cements containing micron-sized titania particles.2006

    • Author(s)
      Goto K, et al.
    • Journal Title

      Key Engineering Materials 309-311

      Pages: 793-796

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Bioactive PMMA-based cement incorporated with nano-sized rutile particles.2006

    • Author(s)
      Hashimoto M, et al.
    • Journal Title

      Key Engineering Materials 309-311

      Pages: 797-800

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] TiO2-HDPE composite : Bone bonding ability and biocompatibility.2006

    • Author(s)
      Nasu T, et al.
    • Journal Title

      Key Engineering Materials 309-311

      Pages: 415-418

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Pore throat size and connectivity determine bone and tissue ingrowth into porous implants : three-dimensional micro-CT based structural analyses of porous bioactive titanium implants.2006

    • Author(s)
      Otsuki B, et al.
    • Journal Title

      Biomaterials 27

      Pages: 5892-5900

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Enhanced osteoinductivity of porous titanium implant by sodium removal.2006

    • Author(s)
      Takemoto M, et al.
    • Journal Title

      Key Engineering Materials 309-311

      Pages: 1315-1318

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Bone-bonding ability of a hydroxyapatite coated zirconia-alumina nanocomposite with a microporous surface.2006

    • Author(s)
      Takemoto M, et al.
    • Journal Title

      Journal of biomedical materials research 78

      Pages: 693-701

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Osteoinductive porous titanium implants : effect of sodium removal by dilute HCl treatment.2006

    • Author(s)
      Takemoto M, et al.
    • Journal Title

      Biomaterials 27

      Pages: 2682-2691

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 3-D analysis of pore structure of porous biomaterials using micro focus X-ray computed tomography.2006

    • Author(s)
      Takemoto M, et al.
    • Journal Title

      Key Engineering Materials 309-311

      Pages: 1095-1098

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Bioactive bone cements containing micron-sized titania particles.2006

    • Author(s)
      Goto K, et al.
    • Journal Title

      Key Engineering Materials 309-311 II

      Pages: 793-796

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Bioactive PMMA-based cement incorporated with nano-sized rutile particles.2006

    • Author(s)
      Hashimoto M, et al.
    • Journal Title

      Key Engineering Materials 309-311 II

      Pages: 797-800

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] TiO2-HDPE composite : Bone bonding ability and biocompatibility.2006

    • Author(s)
      Nasu T, et al.
    • Journal Title

      Key Engineering Materials 309-311 II

      Pages: 415-418

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Enhanced osteoinductivity of porous titanium implant by sodium removal.2006

    • Author(s)
      Takemoto M, et al.
    • Journal Title

      Key Engineering Materials 309-311 II

      Pages: 1315-1318

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Osteoinductive porous titanium implants : effect of sodium removal by dilute HC1 treatment.2006

    • Author(s)
      Takemoto M, et al.
    • Journal Title

      Biomaterials 27

      Pages: 2682-2691

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 3-D analysis of pore structure of porous biomaterials using micro focus X-ray computed tomography.2006

    • Author(s)
      Takemoto M, et al.
    • Journal Title

      Key Engineering Materials 309-311 II

      Pages: 1095-1098

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 3-d analysis of pore structure of porous biomaterials using micro focus X-ray computed tomography2006

    • Author(s)
      Takemoto M., et al.
    • Journal Title

      Key Engineering Materials 309-311

      Pages: 1095-1098

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Osteoinductive porous titanium implants : Effect of sodium removal by dilute HCl treatment2006

    • Author(s)
      Takemoto M., et al.
    • Journal Title

      Biomaterials 27

      Pages: 2682-2691

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Enhanced osteoinductivity of porous titanium implant by sodium removal2006

    • Author(s)
      Takemoto M., et al.
    • Journal Title

      Key Engineering Materials 309-311

      Pages: 1315-1318

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Pore throat size and connectivity determine bone and tissue ingrowth into porous implants : Three-dimensional micro-CT based structural analyses of porous bioactive titanium implants2006

    • Author(s)
      Otsuki B., et al.
    • Journal Title

      Biomaterials 27

      Pages: 5892-5900

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Ti02-HDPE composite : Bone bonding ability and biocompatibility2006

    • Author(s)
      Nasu T., et al.
    • Journal Title

      Key Engineering Materials 309-311

      Pages: 415-418

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Bioactive PMMA-based cement incorporated with nano-sized rutile particles2006

    • Author(s)
      Hashimoto M., et al.
    • Journal Title

      Key Engineering Materials 309-311

      Pages: 797-800

    • Related Report
      2006 Annual Research Report
  • [Journal Article] New Bioactive Bone Cement Containing Nano-sized Titania Particles2005

    • Author(s)
      Goto K, et al.
    • Journal Title

      Key Engineering Materials 284-286

      Pages: 97-100

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Bioactive bone cements containing nano-sized titania particles for use as bone substitutes.2005

    • Author(s)
      Goto K, et al.
    • Journal Title

      Biomaterials 26

      Pages: 6496-6505

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Mechanical Properties and Osteoconductivity of Porous Bioactive Titanium Metal.2005

    • Author(s)
      Takemoto M, et al.
    • Journal Title

      Key Engineering Materials 284-286

      Pages: 263-266

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Mechanical properties and osteoconductivity of porous bioactive titanium.2005

    • Author(s)
      Takemoto M, et al.
    • Journal Title

      Biomaterials 26

      Pages: 6014-6023

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] チタニア微粒子含有生体活性骨セメントの開発2005

    • Author(s)
      後藤公志, 他
    • Journal Title

      Orthopaedic Ceramic Implants 23-24

      Pages: 95-99

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] New Bioactive Bone Cement Containing Nano-sized Titania Particles.2005

    • Author(s)
      Goto K, et al.
    • Journal Title

      Key Engineering Materials 284-286

      Pages: 97-100

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] チタニア微粒子含有生体活性骨セメントの開発2005

    • Author(s)
      後藤公志, 藤林俊介, 川那辺圭一, 中村孝志, 橋本雅美, 小久保正
    • Journal Title

      Orthopaedic ceramic Implants 23-24巻

      Pages: 95-99

    • Related Report
      2005 Annual Research Report
  • [Journal Article] New Bioactive Bone Cement Containing Nano-Sized Titania Particles2005

    • Author(s)
      Goto K, Hashimoto M, Fujibayashi S, Kokubo T, Nakamura T.
    • Journal Title

      Key Engineering Materials 284-286

      Pages: 97-100

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Bioactive bone cements containing nano-sized titania particles for use as bone substitutes2005

    • Author(s)
      Goto K, Tamura J, Shinzato S, Fujibayashi S, Hashimoto M, Kawashita M, Kokubo T, Nakamura T.
    • Journal Title

      Biomaterials 26(33)

      Pages: 6496-6505

    • Related Report
      2005 Annual Research Report
  • [Journal Article] New Bioactive Bone Cement Containing Nano-Sized Titania Particles.2005

    • Author(s)
      K.Goto.et al.
    • Journal Title

      Key Engineering Materials 284-286

      Pages: 97-100

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Bonelike Apatite Formation on Synthetic Organic Polymers Coated with TiO22004

    • Author(s)
      Balas F, et al.
    • Journal Title

      Key Engineering Materials 254-256

      Pages: 467-470

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Osteoinduction of porous bioactive titanium metal2004

    • Author(s)
      Fujibayashi S
    • Journal Title

      Biomaterials 25

      Pages: 443-450

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Osteoinduction of Bioactive Titanium Metal2004

    • Author(s)
      Fujibayashi S
    • Journal Title

      Key Engineering Materials 254-256

      Pages: 953-956

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Bioactive metals : preparation and properties.2004

    • Author(s)
      Kokubo T, et al.
    • Journal Title

      J Mater Sci Mater Med 15

      Pages: 99-107

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Bonelike Apatite Formation on Synthetic Organic Polymers Coated with TiO2.2004

    • Author(s)
      Balas F, et al.
    • Journal Title

      Key Engineering Materials 254-256

      Pages: 467-470

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Osteoinduction of porous bioactive titanium metal.2004

    • Author(s)
      Fujibayashi S, et al.
    • Journal Title

      Biomaterials 25

      Pages: 443-450

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Osteoinduction of Bioactive Titanium Metal.2004

    • Author(s)
      Fujibayashi S, et al.
    • Journal Title

      Key Engineering Materials 254-256

      Pages: 953-956

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] In vivo aging test for a bioactive bone cement consisting of glass bead filler and PMMA matrix.2004

    • Author(s)
      Shinzato S., et al.
    • Journal Title

      J. Biomed Mater Res B Appl Biomater. 68(2)

      Pages: 132-139

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Mechanical Properties and Osteoconductivity of Biomaterials

    • Author(s)
      M.Takemoto.et al.
    • Journal Title

      J. Biomed. Mater. Res. (in press)

    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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