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Immunological approach for the molecular mechanism ofintestinal motility functions

Research Project

Project/Area Number 16208029
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionThe University of Tokyo

Principal Investigator

OZAKI Hiroshi  The University of Tokyo, Graduate school of Agriculture and Life Sciences, Professor (30134505)

Co-Investigator(Kenkyū-buntansha) HORI Masatoshi  The University of Tokyo, Graduate school of Agriculture and Life Sciences, Associate Professor (70211547)
Project Period (FY) 2004 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥49,790,000 (Direct Cost: ¥38,300,000、Indirect Cost: ¥11,490,000)
Fiscal Year 2007: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2006: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2005: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2004: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Keywordsgut / motility / smooth muscle / macrophage / nerve / interstitial cell of Caial / inflammatory bowel disease / cytokines / 消化管運動 / 平滑筋収縮 / 常在型マクロファージ / IBD / 神経機能 / ICC / 肥満細胞
Research Abstract

In this study, we investigated an possible involvement of macrophages and immune cells in intestinal motility disorders by using several IBD models. Detailed findings are as follows;
1) In clinical IBD, many mast cells are identified in muscularis. We analyzed a mechanism of mast cell degranulation especially focusing on microfilaments in the cells. Am J Physiol 286: C256-C263, 2004; J Immunology 174:4584-4589, 2005
2) We first found that PAR-2 was down regulated in DSS-induced colitis model, indicating that relaxing mechanism is also deregulated in IBD. Br J Pharmacol 148 : 200-2007, 2006
3) We found that ICC networks were destroyed in the artificial intestinal obstruction model in rat. Neurogastroenterology Motility 18, 53-61, 2006
4) We also found the ICC disorder in intestinal ischemia-reperfusion model mice. J Surgical Research 135 : 255-261, 2006
5) We identified an importance of TNF-a in the muscularis inflammation in gut using TNF-a deficient mice. This finding was picked up in the … More Editorial Comment. Neurogastroenterology Motility 18, 578-588, 2006
6) In the TNBS colitis mode, the destroyed ICC network was found to be quickly recovered after the cessation of inflammation. Neurogastroenterology Motility 18, 1019-1030, 2006
7) As well as Crohn's disease model, CPI-17 was found to be down regulated in ulcerative colitis model. Neurogastroenterology Motility 19, 504-514, 2007
8) Using histochemical technique, we identified that ICC and also nerve networks were destroyed in the TNBS induced colitis model. Histochem Cell Biol 127 : 41-53, 2007
9) The down regulation of CPI-17 induced by IL-1β was found to be mediated by the secondary production of TNFα using TNFα and IL-1α/β knockout mice. Am J Physiol 292: G1429-G1438, 2007
10) We found that IL-1β acts as an anti-proliferative mediator, which acts indirectly through the production of PGE2 and NO from resident macrophage within Real smooth muscle tissue. Am J Physiol 292 : G1315-G1322, 2007
11) Other studies revealed an involvement of the change in vascular activity in the inflammatory reactions. Am J Resp Crit Care Med 170 : 647-655, 2004; Arteriosclerosis Thrombosis Vascular Biology 25; 1796-1803, 2005; Arteriosclerosis Thrombosis Vascular Biology 25; 1-7, 2005; Eur J Pharmacol 515, 134-141, 2005 etc.
Overall, we provided strong evidence for an importance of muscularis inflammation in IBD. Less

Report

(5 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (87 results)

All 2008 2007 2006 2005 2004

All Journal Article (75 results) (of which Peer Reviewed: 29 results) Presentation (12 results)

  • [Journal Article] MCP-1 targeting inhibits muscularis macrophage recruitment and intestinal smooth muscle dysfunction in colonic inflammation2008

    • Author(s)
      Hori M, Nobe H, Horiguchi K, Ozaki H
    • Journal Title

      Am J Physiol 294

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Attenuation by dietary taurine of dextran sulfate sodium-induced colitis in mice and of THP-1-induced damage to intestinal Caco-2 cell monolayers2008

    • Author(s)
      Zhao Z, Satsu H, Fujisawa M, Hori M, Ishimoto Y, Totsuka M, Nambu A, Kakuta S, Ozaki H, Shimizu M
    • Journal Title

      Amino Acids (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory effects of phytosteryl ferulates in dextran sulfate sodium (DSS)-induced colitis in mice2008

    • Author(s)
      Islam MS, Murata T, Fujisawa M, Nagasaka R, Ushio H, Bari AM, Hori M, Ozaki H
    • Journal Title

      Br J Pharmacol (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 腸炎疾患における平滑筋機能異常とその治療戦略2008

    • Author(s)
      堀正敏
    • Journal Title

      メディカルバイオ 5(2)

      Pages: 48-52

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Attenuation by dietary taurine of dextran sulfate sodium-induced colitis in mice and of THP-1-induced damage to intestinal Caco-2 cell monolayers2008

    • Author(s)
      Zhao Z, Satsu H, Fujisawa M, Hori M, Ishimoto Y, Totsuka M, Nambu A, Kakuta S, Ozaki H, Shimizu M
    • Journal Title

      Amino Acids (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] MCP-1 targeting inhibits muscularis macrophage recruitment and intestinal smooth muscle dysfunction in colonic inflammation2008

    • Author(s)
      Hori M, Nobe H, Horiguchi K, Ozaki H
    • Journal Title

      Am J Physiol 294

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Anti-inflammatory effects of phytosteryl ferulates in dextran sulfate sodium (DSS)-induced colitis in mice2008

    • Author(s)
      Islam MS, Murata T, Fujisawa M, Nagasaka R, Ushio H, Bari AM, Hori M, Ozaki H
    • Journal Title

      Br J Pharmacol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] MCP-1 targeting hlhibits muscularis macrophage recruitment and in testinal smooth muscle dysfunction in colonic inflammation2008

    • Author(s)
      Hori M, Nobe H, Horiguchi K, Ozaki H
    • Journal Title

      Am J Physiol 294

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Attenuation by dietary taurine of dextran sulfate sodium-induced colitis in mice and of THP-1-induced damage to intestinal Caco-2 cell monolayers2008

    • Author(s)
      Zhao Z, Satsu H, Fujisawa M, Hori M, Ishimoto Y, Totsuka M, Nambu A, Kakuta S, Ozaki H, Shinizu M
    • Journal Title

      Amino Acids (掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory effects of phytosteryl ferulates in dextran sulfate sodium(DSS)-induced colitis in mice2008

    • Author(s)
      Islam MS, Murata T, Fujisawa M, Nagasaka R, Ushio H, Bari AM, Hori M, Ozaki H
    • Journal Title

      Br J Phamacol (掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腸炎疾患における平滑筋機能異常とその治療戦略2008

    • Author(s)
      堀 正敏
    • Journal Title

      メディカルバイオ 5(2)

      Pages: 48-52

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intestinal inflammation down-regulates smooth muscle CPI-17 through induction of TNF-α and causes motility disorders2007

    • Author(s)
      Ohama T, Hori M, Momotani E, Iwakura Y, Guo F, Kishi H, Kobayashi S, Ozaki H
    • Journal Title

      Am J Physiol 292

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] IL-1β inhibits intestinal smooth muscle proliferation in an organ culturesystem: Involvement of COX-2 and iNOS induction in muscularisresident macrophages2007

    • Author(s)
      Ohama T, Hori M, Momotani E, Elorza M, Gerthoffer WT, Ozaki H
    • Journal Title

      Am J Physiol 292

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Possible involvement of muscularis resident macrophages in impairment of interstitial cells of Cajal and myenteric nerve systems in rat models of TNBS-induced colitis.2007

    • Author(s)
      Kinoshita K, Horiguchi K, Fujisawa M, Kobirumaki F, Yamato S, Hori M, Ozaki H
    • Journal Title

      Histochemistry and Cell Biology 127

      Pages: 41-53

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2006 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of CPI-17 down-regulation in the dysmotility of the colon from dextran sodium sulfate-induced experimental colitis in a mouse model2007

    • Author(s)
      Sato K, Ohkura S, Kitahara Y, Ohama T, Hori M, Sato M, Kobayashi S, Sasaki Y, Hayashi T, Nasu T, Ozaki H
    • Journal Title

      Neurogastroenterology and Motility 19

      Pages: 504-514

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory effects of hydroxycinnamic acid derivatives2007

    • Author(s)
      Nagasaka R, Chotimarkorn C, Shafiqul IM, Hori M, Ozaki H, Ushio H
    • Journal Title

      Biochem Biophys Res Commun 358

      Pages: 615-619

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Phagocytotic Activation of Muscularis Resident Macrophages Inhibits Smooth Muscle Contraction in Rat Ileum.:2007

    • Author(s)
      Sato K, Torihashi S, Hori M, Nasu T, Ozaki H
    • Journal Title

      J Vet Med Sci 69

      Pages: 1053-1060

    • NAID

      130000447588

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] IBD・IBSにおける消化管運動機能障害:平滑筋層の炎症応答を中心に2007

    • Author(s)
      尾崎博
    • Journal Title

      Pharma Medica 25

      Pages: 148-150

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Possible involvement of muscularis resident macrophages in impairment of interstitial cells of Cajal and myenteric nerve systems in rat models of TNBS-induced colitis2007

    • Author(s)
      Kinoshita K, Horiguchi K, Fujisawa M, Kobinimaki F, Yamato S, Hori M, Ozaki H
    • Journal Title

      Histochemistry and Cell Biology 127

      Pages: 41-53

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] H IL-1β inhibits intestinal smooth muscle proliferation in an organ culture system : Involvement of COX-2 and iNOS induction in muscularis resident macrophages2007

    • Author(s)
      Ohama T, Hori M, Momotani E, Elorza M, Gerthoffer WT, Ozaki H
    • Journal Title

      Am J Physiol 292

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Intestinal inflammation down-regulates smooth muscle CPI-17 throughinduction of TNF-α and causes motility disorders2007

    • Author(s)
      Ohama T, Hori M, Momotani E, Iwakura Y, Guo F, Kishi H, Kobayashi S, Ozaki H
    • Journal Title

      Am J Physiol 292

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Anti-inflammatory effects of hydroxycinnamic acid derivatives2007

    • Author(s)
      Nagasaka R, Chotimarkom C, Shafiqul IM, Hori M, Ozaki H, Ushio H
    • Journal Title

      Biochem Biophys Res Commun 358

      Pages: 615-619

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Phagocytotic Activation of Muscularis Resident Macrophages Inhibits Smooth Muscle Contraction in Rat Ileum2007

    • Author(s)
      Sato K, Torihashi S, Hori M, Nasu T, Ozaki H
    • Journal Title

      J Vet Med Sci 69

      Pages: 1053-1060

    • NAID

      130000447588

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] Intestinal inflammation down-regulates smooth muscle CPI-17 through induction of TNF-α and causes motility disorders2007

    • Author(s)
      Ohama T, Hori M, Momotani E, Iwakura Y, Guo F, Kishi H, Kobavashi S, Ozaki H
    • Journal Title

      Am J Physiol 292

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-1β inhibits intestinal smooth muscle proliferation in an organ culture system:Involvement of COX-2 and iNOS induction in muscularis resident macrohages2007

    • Author(s)
      Ohama T, Hori M, Momotani E, Elorza M, Gerthoffer WT, Ozaki H
    • Journal Title

      Am J Physiol 292

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of muscularis resident macrophages in impairment of interstitial cells of Cajal and myenteric nerve systems in rat models of TNBS-induced colitis2007

    • Author(s)
      Kinoshita K, Horiguchi K, Fujisawa M, Kobirumaki F, Yamato S, Hori M, Ozaki H
    • Journal Title

      Histochemistry and Cell Biology 127

      Pages: 41-53

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory effects of hydroxycinnamic acid dedvatives2007

    • Author(s)
      Nagasaka R, Chotimarkorn C, Shafiqul IM, Hori M, Ozaki H. Ushio H
    • Journal Title

      Biochem Biophys Res Commun 358

      Pages: 615-619

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IBD・IBSにおける消化管運動機能障害:平滑筋層の炎症応答を中心に2007

    • Author(s)
      尾崎 博
    • Journal Title

      Phamma Medica 25

      Pages: 148-150

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intestinal inflammation down-regulates smooth muscle CPI-17 through induction of TNF-a and causes motility disorders2007

    • Author(s)
      Ohama T, Hori M, Momotani E, Iwakura Y, Guo F, Kishi H, Kobayashi S, Ozaki H
    • Journal Title

      Am J Physiol(a) (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] IL-1βinhibits intestinal smooth muscle proliferation in an organ culture system : Involvement of COX-2 and iNOS induction in muscularis resident macrophages2007

    • Author(s)
      Ohama T, Hori M, Momotani E, Elorza M, Gertitioffer WT, Ozaki H
    • Journal Title

      Am J Physiol (b) (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Involvement of CPI-17 down-regulation in the dysmotility of the colon from dextran sodium sulfate-induced experimental colitis in a mouse model2007

    • Author(s)
      Sato K, Ohkura S, Kitahara Y, Ohama T, Hori M, Sato M, Kobayashi S, Sasaki Y, Hayashi T, Ozaki H, Nasu T
    • Journal Title

      Neurogastroenterology and Mofility(b) (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] IBD・IBSにおける消化管運動機能障害 : 平滑筋眉の炎症応答を中心に2007

    • Author(s)
      尾崎博
    • Journal Title

      Pharma Medica 25

      Pages: 148-150

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Motility disorder in experimentally obstructed intestine: Relationship between muscularis inflammation and disruption of the ICC network2006

    • Author(s)
      Won KJ, Suzuki T, Hori M, Ozaki H
    • Journal Title

      Neurogastroenterology and Motility 18

      Pages: 53-61

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Impairment of PAR-2-mediated relaxation system in colonic smooth muscle after intestinal inflammation2006

    • Author(s)
      Sato K, Ninomiya H, Ohkura S, Ozaki H, Nasu T
    • Journal Title

      Br J Pharmacol 148

      Pages: 200-207

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2006 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two phase expressions of NOD1 and NOD2 in murine macrophages: implication of TLR4 and TNF-α in LPS-induced up-regulation2006

    • Author(s)
      Takahashi Y, Isuzugawa K, Murase M, Imai M, Yamamoto S, Iizuka, M, Akira S, Bahr GM, Momotani E, Hori M, Ozaki H, Imakawa K
    • Journal Title

      J Vet Med Sci 68

      Pages: 471-478

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Interstitial cells of Cajal in dysmotility in intestinal ischemia and reperfusion injury in rats2006

    • Author(s)
      Shimojima N, Takaki, T, Morikawa Y, Hoshino K, Ozaki H, Hori M, Kitajima M
    • Journal Title

      J Surgical Research 135

      Pages: 255-261

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Identification of Card15/Nod2mRNA in intestinal tissue of experimentally induced colitis in rats2006

    • Author(s)
      Fujisawa M, Kiyosue M, Hori M, Ozaki H
    • Journal Title

      J Vet Med Sci 68

      Pages: 701-708

    • NAID

      110004763179

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The role of TNF-α in muscularis inflammation and motility disorder in a TNBS-induced colitis model: Clues from TNF-α deficien2006

    • Author(s)
      Kinoshita K, Hori M, Fujisawa M, Sato K, Momotani E, Ozaki H
    • Journal Title

      Neurogastroenterology and Motility 18

      Pages: 578-588

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Different susceptibilities of spontaneous rhythmicity and myogenic contractility to intestinal muscularis inflammation in the hapten-induced colitis2006

    • Author(s)
      Kiyosue M, Fujisawa M, Kinoshita K, Hori M, Ozaki H
    • Journal Title

      Neurogastroenterology and Motility 18

      Pages: 1019-1030

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 消化管運動と炎症性サイトカイン2006

    • Author(s)
      尾崎博、堀正敏
    • Journal Title

      G.I. Research 14

      Pages: 25-36

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 腸炎疾患における消化管筋層部炎症応答と運動機能障害2006

    • Author(s)
      堀正敏、藤澤雅彦、尾崎博
    • Journal Title

      日本薬理学雑誌 128

      Pages: 72-77

    • NAID

      10018333109

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 腸管マクロファージは消化管運動にどのようにかかわっているか?2006

    • Author(s)
      尾崎博、堀正俊
    • Journal Title

      分子消化器病学 3

      Pages: 300-305

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Motility disorder in experimentally obstructed intestine : Relationship between muscularis inflammation and disruption of the ICC network2006

    • Author(s)
      Won KJ, Suzuki T, Hori M, Ozaki H
    • Journal Title

      Neurogastroenterology and Motility 18

      Pages: 53-61

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Nasu Tlmpairment of PAR-2-mediated relaxation system in colonic smooth muscle after intestinal inflammation2006

    • Author(s)
      Sato K, Ninomiya H, Ohkura S, Ozaki H
    • Journal Title

      Br J Pharmacol 148

      Pages: 200-207

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Two phase expressions of NOD1 and NOD2 in murine macrophages : implication of TLR4 and TNF-α in LPS-induced up-regulation2006

    • Author(s)
      Takahashi Y, Isuzugawa K, Murase M, Imai M, Yamamoto S, Iizuka, M, Akira S, Bahr GM, Momotani E, Hori M, Ozaki H, Iinakawa K
    • Journal Title

      J Vet Med Sci 668

      Pages: 471-478

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Interstitial cells of Cajal in dysmotility in intestinal ischemia and reperfusion injury in rats2006

    • Author(s)
      Shimojima N, Takaki, T, Morikawa Y, Hoshino K, Ozaki H, Hori M, Kitajima, M
    • Journal Title

      J Surgical Research 135

      Pages: 255-261

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary 2006 Annual Research Report
  • [Journal Article] Identification of Cardl5/Nod2 mRNA in intestinal tissue of experimentally induced colitis in rats2006

    • Author(s)
      Fujisawa M, Kiyosue M, Hori M, Ozaki H
    • Journal Title

      J Vet Med Sci 68

      Pages: 701-708

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The role of TNF-α in muscularis inflammation and motility disorder in a TNBS-induced colitis model : Clues from TNF-α deficient mice2006

    • Author(s)
      Kinoshita K, Hori M, Fujisawa M, Sato K, Momotani E, Ozaki H
    • Journal Title

      Neurogastroenterology and Motility 18

      Pages: 578-588

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The role of TNF-a in muscularis inflammation and motility disorder in a TNBS-induced colitis model : Clues from TNF-a deficient mice2006

    • Author(s)
      Kinoshita K, Hori M, Fujisawa M, Sato K, Momotani E, Ozaki H
    • Journal Title

      Neurogastroenterology and Motility (a) 18

      Pages: 578-588

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification of Cardl5/Nod2 mRNA in intestinal tissue of experimentally induced colitis in rats2006

    • Author(s)
      Fujisawa M, Kiyosue M, Hori M, Ozaki H
    • Journal Title

      J Vet Med Sci (a) 68

      Pages: 701-708

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Different susceptibilities of spontaneous rhythmicity and myogenic contractility to intestinal muscularis inflammation in the hapten-induced colitis2006

    • Author(s)
      Kiyosue M, Fujisawa M, Kinoshita K, Hori M, Ozaki H
    • Journal Title

      Neurogastroenterology and Motility (c) 18

      Pages: 1019-1030

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Two phase expressions of NODI and N0D2 in murine macrophages : implication of TLR4 and TNF-α in LPS-induced up-regulation2006

    • Author(s)
      Takahashi Y, Isuzugawa K, Murase M, Imai M, Yamamoto S, Iizuka, M, Akira S, Bahr GM, Momotani E, Hori M, Ozaki H, Imakawa K
    • Journal Title

      J Vet Med Sci(b) 68

      Pages: 471-478

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 腸管マクロファージは消化管運動にどのようにかかわっているか?2006

    • Author(s)
      尾崎博, 堀正敏
    • Journal Title

      分子消化器病学 3

      Pages: 300-305

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 腸炎疾患における消化管筋局部炎症応答と運動機能障害2006

    • Author(s)
      堀正敏, 藤澤雅彦, 尾崎博
    • Journal Title

      日本薬理学雑誌 128

      Pages: 72-77

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 消化管運動と炎症性サイトカイン2006

    • Author(s)
      尾崎博, 堀正敏
    • Journal Title

      Gl. Research 14

      Pages: 25-36

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Up-regulation of NOD1 and NOD2 through TLR4 and TNF-α in LPS-treated murine macrophages2006

    • Author(s)
      Takahashi Y, Ozaki H, Imakawa Kら(9名)
    • Journal Title

      J Vet Med Sci (印刷中)

    • NAID

      110004775650

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Identification of Card15/Nod2 mRNA in intestinal tissue of experimentally induced colitis in rats.2006

    • Author(s)
      Fujisawa M, Kiyosue M, Hori M, Ozaki H
    • Journal Title

      J Vet Med Sci (印刷中)

    • NAID

      110004763179

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The role of TNF-alpha in muscularis inflammation and motility disorder in a TNBS-induced colitis model : Clues from TNF-alpha deficient mice2006

    • Author(s)
      Kinoshita K, Hori M, Fujisawa M, Sato K, Momotani E, Ozaki H
    • Journal Title

      Neurogastroenterology and Motility (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Microtubule disruption suppresses allergic response through the inhibition of calcium influx in the mast cell degranulation pathway2005

    • Author(s)
      Oka T, Hori M, Ozaki H
    • Journal Title

      J Immunology 174

      Pages: 4584-4589

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Intestinal gene expression in TNBS treated mice using genechip and subtractive cDNA analysis: Implications for Crohn's disease2005

    • Author(s)
      Yamamoto S, Isuzugawa K, Takahashi Y, Murase Y, Iwata M, Arisawa T, Nakano H, Nishimura N, Yamato S, Ohta M, Ina K, Murata T, Hori M, Ozaki H, Imakawa K
    • Journal Title

      Biological & Pharmaceutical Bulletin 28

      Pages: 2046-2053

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 消化管運動機能障害における腸内フローラ/筋層免疫系の役割:ヒルシュスプルング病モデルラットを例に2005

    • Author(s)
      尾崎博、堀正敏、堀口和秀、鈴木敏彦、平山和宏、伊藤喜久治
    • Journal Title

      腸内細菌学会誌 19

      Pages: 9-16

    • NAID

      10019042794

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 消化管運動と筋層常在型マクロファージ:IBD、IBS、FDにおける筋層の炎症と運動機能障害との関係2005

    • Author(s)
      尾崎博
    • Journal Title

      消化管運動 7

      Pages: 10-15

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 見えてきたIBS知覚過敏の病態メカニズム2005

    • Author(s)
      尾崎博
    • Journal Title

      医学のあゆみ 214

      Pages: 1206-1207

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Microtubule disruption suppresses allergic response through the inhibition of calcium influx in the mast cell degranulation pathway2005

    • Author(s)
      Oka T, Hori M, Ozaki H
    • Journal Title

      J Immunology 174

      Pages: 4584-4589

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Intestinal gene expression in TNBS treated mice using genechip and subtractive cDNA analysis : Implications for Crohn's disease2005

    • Author(s)
      Yamamoto S, Isuzugawa K, Takahashi Y, Murase Y, Iwata M, Arisawa T, Nakano H, Nishimura N, Yamato S, Ohta M, Ina K, Murata T, Hori M, Ozaki H, Imakawa K
    • Journal Title

      Biological & Pharmaceutical Bulletin 28

      Pages: 2046-2053

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Intestinal gene expression in TNBS treated mice using genechip and subtractive cDNA analysis : Implications for Crohn's disease2005

    • Author(s)
      Yamamoto S, Hori M, Ozaki H, Imakawa Kら(15名)
    • Journal Title

      Biological & Pharmaceutical Bulletin 28

      Pages: 2046-2053

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Motility disorder in experimentally obstructed intestine : relationship between muscularis inflammation and disruption of the ICC network.2005

    • Author(s)
      Won KJ, Suzuki T, Hori M, Ozaki H
    • Journal Title

      Neurogastroenterology and Motility 18

      Pages: 53-61

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Microtubule disruption suppresses allergic response through the inhibition of calcium influx in the mast cell degranulation pathway2005

    • Author(s)
      Tatsuya Oka, Masatoshi Hori, Hiroshi Ozaki
    • Journal Title

      J.Immunology (In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 消化管運動機能障害における腸内フローラ/筋層免疫系の役割:ヒルシュスプルング病モデルラットを例に2005

    • Author(s)
      尾崎博, 堀正敏, 堀口和秀, 鈴木敏彦, 平山和宏, 伊藤喜久治
    • Journal Title

      腸内細菌学会誌 19

      Pages: 9-16

    • NAID

      10019042794

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Isolation and characterization of resident macrophages from the smooth muscle layers of murine small intestine2004

    • Author(s)
      Ozaki H, Kawai T, Won KJ, Suzuki T, Sato K, Horiguchi H, Hori M, Karaki H, Torihashi S, Ward S, Sanders KM
    • Journal Title

      Neurogastroenterology and Motility 16

      Pages: 39-51

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Musculars inflammation and the loss of interstitial cells of Cajal in the endothelin ETB receptor null rat2004

    • Author(s)
      Suzuki T, Won K-J, Horiguchi K, Kinoshita K, Hori M, Torihashi S, Momotani E, Itoh K, Hirayama K, Ward SM, Sanders KM, Ozaki H
    • Journal Title

      Am J Physiol 287

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 腸内細菌と消化管運動:腸炎症時における消化管運動機能障害と筋層免疫系2004

    • Author(s)
      尾崎博
    • Journal Title

      GI Research 12

      Pages: 311-319

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Muscularis inflammation and the loss of interstitial cells of Cajal in the endothelin ETB receptor null rat2004

    • Author(s)
      Suzuki T, Won K-J, Horiguchi K, Kinoshita K, Hori M, Torihashi S, Momotani E, Itoh K, Hirayama K, Ward SM, Sanders KM, Ozaki H
    • Journal Title

      Am J Physiol 287

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Muscularis inflammation and the loss of interstitial cells of Cajal in the endothelin ETB receptor null rat2004

    • Author(s)
      Toshihiko Suzuki, Kyung-Jong Won, Kazuhide Horiguchi, Kazuya Kinoshita, Masatoshi Hori, Shigeko Torihashi, Eiichi Mo motani, Kikuji Itoh, Kazuhiro Hirayama, Sean M.Ward, Kenton M Sanders, Hiroshi Ozaki
    • Journal Title

      Am J Physiol Gastrointestinal and Liver Physiology 287

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Isolation and characterization of resident macrophages from the smooth muscle layers of murine small intestine2004

    • Author(s)
      Hiroshi Ozaki, Tomoyuki Kawai, Kyung-Jong Won, Toshihiko Suzuki, Koichi Sato, Hidekazu Horiguchi, Masatoshi Hori, Hideaki Karaki, Shigeko Torihashi, Sean Ward, Kenton M.Sanders
    • Journal Title

      Neurogastroenterology and Motility 16

      Pages: 39-51

    • Related Report
      2004 Annual Research Report
  • [Presentation] Phathophysioligical roles of muscularis resident macrophges during intestinal inflammation2008

    • Author(s)
      M Hori, K Horiguchi, M Fujisawa, K Kinoshita, H Nobe, S Torihashi, T Suzuki, M Kiyosue, T Murata, H Ozaki
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Rice bran Y-oryzanol induced ameliorative effects on intestinal inflammation through NFkB inhibition2008

    • Author(s)
      M Hori, MS Islam, T Murata, M Fujisawa, R Nagasaka, H Ushio, H Ozaki
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Phathophysioligical roles of muscularis resident macrophges during intestinal inflammation2008

    • Author(s)
      Masatoshi Hori, Kazuhide Horiguchi, Masahiko, Fujisawa, Kazuya Kinoshita, Hiromi Nobe, Shigeko Torihashi, Toshihiko Suzuki, Masaharu Kiyosue, Takahisa Murata, Hiroshi Ozaki
    • Organizer
      8lth Annual Meeting of Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Rice bran γ-oryzanol induced ameliorative effects on intestinal inflammation through NFkB inhibition2008

    • Author(s)
      M Hori, MS Islam, T Murata, M Fujisawa, R Nagasaka, H Ushio, H Ozaki
    • Organizer
      81th Annual Meeting of Japanese Pharmacological Society
    • Place of Presentation
      Yokohma
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Phathgphysioligical roles of museularis resident macrophges during intestinal inflammation2008

    • Author(s)
      M Hori, K Horiguchi, M Fujisawa, K Kinoshita, H Nobe, S Torihashi, T Suzuki, M Kiyosue, T Murata, H Ozaki
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Rice bran Y-oryzanol indueed ameliorative effects on intestinal inflammation through NFkB inhibition2008

    • Author(s)
      M Hori, MS Islam, T Murata, M Fujisawa, R Nagasaka, H Ushio, H Ozaki
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Impairment of peristalsis of the inflamed terminal ileum in SAMP1/Yit, a spontaneous ileitis model of Crohn disease2007

    • Author(s)
      M Hori, M Fujisawa, Y Yamamoto, K Horiguchi, S Iino, S Matsumoto, Y Umesaki, H Ozaki
    • Organizer
      4th Pfizer Scientific Symposium
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 自然発症クローン病モデルマウスSAMP1/Yitにおける小腸全図運動機能障害2007

    • Author(s)
      堀正敏、藤澤正彦、山本康代、飯野敏、堀口和秀、松本敏、梅崎良則、尾崎博
    • Organizer
      第6回日本神経消化器病学会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] MCP-1 targeting inhibits muscularis macrophage recruitment and intestinal smooth muscle dysfunction in colonic inflammation2007

    • Author(s)
      M Hori, H Nobe, K Horiguchi, H Ozaki
    • Organizer
      5th Congress of the International Symposium for Autonomic Neurosciences
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Impairment of peristalsis of the inflamed terminal ileum in SAMP1/Yit, a spontaneous ileitis model of Crohn disease2007

    • Author(s)
      Hori M, Fujisawa M, Yamamoto Y, Horiguchi K, Iino S, Matsumoto S, Umesaki Y, Ozaki H
    • Organizer
      4th Pfizer Scientific Symposium
    • Place of Presentation
      Nagoya
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] MCP-1 targeting inhibits muscularis macrophage recruitment and intestinal smooth muscle dysfunction in colonic inflammation2007

    • Author(s)
      Masatoshi Hori, Hiromi Nobe, Kazuhide Horiguchi, Hiroshi Ozaki
    • Organizer
      5th Congress of the International Symposi for Autonomic Neurosciences (ISAN)
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] MCP-1 targeting inhibits muscularis macrophage recruitment and intestinal smooth muscle dysfunction in colonic inflammation2007

    • Author(s)
      M Hori, H Nobe, K Horiguchi, H Ozaki
    • Organizer
      5th Congress of theInternational Symposium for Autonomic Neurosciences
    • Place of Presentation
      京都
    • Related Report
      2007 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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