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Research for radio-sensitizers which specifically attack tumor cells

Research Project

Project/Area Number 16209036
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

RYUICHI Okayasu  National Institute of Radiological Sciences, Heavy-Ion Radiobiology Research Group, Group Leader (50356135)

Co-Investigator(Kenkyū-buntansha) YAMADA Shigeru  National Institute of Radiological Sciences, Charged Particle Therapy Hospital, Chief Doctor (80311380)
安藤 興一  独立行政法人放射線医学総合研究所, 重粒子医科学センター・粒子線生物研究グループ, 特別上席研究員 (00159526)
窪田 宣雄  茨城県立医療大学, 保健医療学部, 教授 (20046139)
Project Period (FY) 2004 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥46,540,000 (Direct Cost: ¥35,800,000、Indirect Cost: ¥10,740,000)
Fiscal Year 2007: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2006: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2005: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2004: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
KeywordsRadio-sensitization / Hsp90 inhibitor / 17AAG / DNA DSB repair / Homologous recombination repair / BRCA2 / siRNA / Rad51 / Homologous recombination repair / 放射線増感材 / DNA DSB修復 / 17-AAG / 放射線抵抗性 / non-homologous end joining / DNA-PKcs / アポトーシス / 癌細胞 / 正常細胞 / 非相同末端結合 / RNA干渉 / DNA ligase IV
Research Abstract

We performed two specific aims on this project. Results for the individual aim are described.
Aim 1) lb investigate Hsp90 inhibitors as effective radio-sensitizers which have much higher affinity for tumor cells than for normal cells. We showed that 17-AAG effectively radio-sensitized human tumor cells in vitro and in vivo, while normal cells were not affected by the drug. The cause of this sensitization was found out to be inhibition of DNA double strand break (DSB) repair by 17AAG. We also discovered that 17AAG affected the homologous recombination repair (HRR) pathway of DSB repair. Furthermore, the proteins influenced by this chemical were found out to be BRCA2 and Rad51. (Noguchi, et. al. 2006)
Aim 2) lb find an efficient strategy to specifically damage tumor cells, the inhibition of HRR repair mechanism was pursued; the HRR mechanism is known to be active only at late-S and G2 phases of the cell cyde. We used RNA interference technology to knockdown the expression of BRCA2 protein, a crucial molecule for HRR pathway. After efficiently knocking down the protein expression by transfecting tumor cells by BRCA2 small interference RNA (siRNA), significant radio-sensitization was observed in HeLa cells. The cause of this sensitization was found out to be DNA DSB repair inhibition and the HRR pathway was again affected by BRCA2 siRNA transfection in tumor cells. The radio-sensitization was also observed in animal zenograft model. (Yu, et. al. 2008)

Report

(5 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (78 results)

All 2008 2007 2006 2005 2004 Other

All Journal Article (50 results) (of which Peer Reviewed: 22 results) Presentation (20 results) Book (6 results) Remarks (2 results)

  • [Journal Article] Comparison of the induction and disappearance of DNA double strand breaks and gamma-H2AX foci after irradiation of chromosome in G1-phase or in condensed metaphase cells2008

    • Author(s)
      Takamitsu Kato, ^*Ryuichi Okayasu, ^*Joel S. Bedford
    • Journal Title

      Mutation Research 639

      Pages: 108-112

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Role of the major, small, acid-soluble spore proteins and spore-specific and universal DNA repair mechanisms in resistance of Bacillus subtilis spores to ionizing radiation from X rays and high energy charged-particle bombardment2008

    • Author(s)
      Ralf Moeller, Peter Setlow, Gerda Horneck, Thomas Berger, Gunther Reitz, Petra Rettberg, Aidan J. Doherty, Ryuichi Okayasu, Wayne L Nicholson
    • Journal Title

      Journal of Bacteriology 190

      Pages: 1134-1140

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] High LET heavy ion radiation induces lower numbers of initial chromosome breaks with minimal repair than low LET radiation in normal human cells2008

    • Author(s)
      Eimiko Sekine, Maki Okada, Naruhiro Matsufuji, Dong Yu, Yoshiya Furusawa, ^*Ryuichi Okayasu
    • Journal Title

      Mutation Research 652

      Pages: 95-101

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Down regulation of BRCA2 causes radio-sensitization of human tumor cells2008

    • Author(s)
      Dong Yu, Eimiko Sekine, Akira, Fujimori, Takahiro Ochiya, ^*Ryuichi Okayasu :
    • Journal Title

      Cancer Science 99

      Pages: 810-815

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans2008

    • Author(s)
      Akira Fujimori, Wang Bing, Katsutoshi Suetomi, Eimiko Sekine, Dong Yu, Takamitsu Kato, Sentaro Takahashi, Ryuichi Okayasu, et. al.
    • Journal Title

      Biochemical and Biophysical Research Communications 369

      Pages: 953-957

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] JS Comparison of the induction and disappearance of DNA double strand breaks and gamma-H2AX foci after irradiation of chromosomes in G1-phase or in condensed metaphase cell, Fundamental and Molecular Mechanisms of Mutagenesis.2008

    • Author(s)
      Kato, T., ^*Okayasu, R., Bedford^*Bedford
    • Journal Title

      Mutat. Res. 639

      Pages: 108-112

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Role of the major, small, acid-soluble spore proteins and spore-specific and universal DNA repair mechanisms in resistance of Bacillus subtilis spores to ioninzing radiation from X rays and high energy charged-particle bombardment.2008

    • Author(s)
      Moeller, R., Stelow, P., Horneck, G., Berger, T., Reitz, G., Rettberg, P., Doherty, A. J., Okayasu, R., Nicholson, W. L.
    • Journal Title

      J. Bacteriol. 190

      Pages: 1134-1140

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] High LET heavy ion radiation induces lower numbers of initial chromosome breaks with minimal repair than low LET radiation in normal human cells.2008

    • Author(s)
      Sekine, E., Okada, M., Matsufuji, N., Yu, D., Furusawa, Y. ^*Okayasu, R.
    • Journal Title

      Mutat. Res. 652

      Pages: 95-101

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Down regulation of BRCA2 causes radio-sensitization of human tumor cells in vitro and in vivo.2008

    • Author(s)
      Yu, D., Sekine, E., Fujimori, A., Ochiya, T., ^*Okayasu, R.
    • Journal Title

      Cancer Sci. 99(4)

      Pages: 810-815

    • NAID

      10024005276

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans.2008

    • Author(s)
      Fujimori, A, Bing, W., Suetomi, K., Sekine, E., Yu, D., Kato, T., Takahashi, S., Okayasu, R. et. Al
    • Journal Title

      Biochem. Biophys. Res. Commun. 369

      Pages: 953-957

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Down regulation of BRCA2 causes radio-sensitization of human tumor cells2008

    • Author(s)
      Dong Yu, Eimiko Sekine, Akira, Fujimori, Takahiro Ochiya,* Ryuichi Okayasu:
    • Journal Title

      Cancer Science 99

      Pages: 810-815

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the induction and disappearance of DNA double strand breaks and gamma-H2AX foci after irradiation of chromosome in G1-phase or in condensed metaphase cells2008

    • Author(s)
      Takamitsu Kato, *Ryuichi Okayasu, *Joel S. Bedford
    • Journal Title

      Mutation Research 639

      Pages: 108-112

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High LET heavy ion radiation induces lower numbers of initial chromosome breaks with minimal repair than low LET radiation in normal human cells2008

    • Author(s)
      Eimiko Sekine, Maki Okada, Naruhiro Matsufuji, Dong Yu, Yoshiya Furusawa, *Ryuichi Okayasu
    • Journal Title

      Mutation Research 652

      Pages: 95-101

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of the major, small,acid-soluble spore proteins and spore-specific and universal DNA repair mechanisms in resistance of Bacillus subtilis spores to ionizing radiation from X rays and high energy charged-particle bombardment2008

    • Author(s)
      Ralf Moeller, Peter Setlow, Gerda Homeck, Thomas Berger, Gunther Reitz, Petra Rettberg, Aidan J.Doherty, Rynichi Okayasu, Wayne L Nicholson
    • Journal Title

      Journal of Bacteriology 190

      Pages: 1134-1140

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of chromosomal aberrations in tumor cells with a non-labeled Cu-PTSM and irradiation with Cu K-shell monochromatic X rays.2007

    • Author(s)
      Takakura K, Yaguchi S, Kanansugi Y, Kobayashi K, Okayasu R, Fujibayashi Y.
    • Journal Title

      Radiation Protection Dosimetry 122

      Pages: 188-194

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Single extreme low dose/low dose rate irradiation causes alteration in lifespan and genome instability in primary human cells.2007

    • Author(s)
      Okada M, Okabe A, Uchihori Y, Kitamura H, Sekine E, Ebisawa S, Suzuki M, Okayasu R.
    • Journal Title

      British Journal of Cancer 96

      Pages: 1707-1710

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] DNA topoisomerase inhibitor, etoposide, enhances GC-box-dependent promoter activity via Sp1 phosphorylation.2007

    • Author(s)
      Niina I, Uchiumi T, Izumi H, Torigoe T, Wakasugi T, Igarashi T, Miyamoto N, Onitsuka T, Shiota M, Okayasu R, Chijiiwa K, Kohno K.
    • Journal Title

      Cancer Science 98

      Pages: 858-863

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cytotoxicity of cigarette smoke condensate is not due to DNA double strand breaks : Comparative studies using radiosensitive mutant and wild-type CHO cells2007

    • Author(s)
      Takamitsu Kato, Hatsumi Nagasawa, Christy Warner, ^*Ryuichi Okayasu, Joel S. Bedford
    • Journal Title

      International Journal of Radiation Biology 83

      Pages: 583-591

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] CELLULAR SIGNAL TRANSDUCTION EVENTS AS A FUNCTION OF LINEAR ENERGY TRANSFER(LET)2007

    • Author(s)
      Furweger Christoph, Michael Hajek, Norbert Vana, R Kodym, Ryuichi Okayasu
    • Journal Title

      Radiation Protection Dosimetry 126

      Pages: 418-422

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] ENHANCEMENT OF CHROMOSOMAL ABERRATIONS INTUMOR CELLS WITH A NON-LABELED CU-PTSM ANDIRRADIATION WITH CU-K SHELL MONOCHROMATIC X RAYS.2007

    • Author(s)
      Takakura, K., Yaguchi, S., Kanasugi, Y., Kobayashi, K., Okayasu, R., Fujibayashi, Y.
    • Journal Title

      Radiat. Protec. Dosimetry 122

      Pages: 188-194

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Single extreme low dose/low dose rate irradiation causes alteration in life span and genome instability in primary human cells.2007

    • Author(s)
      Okada, M., Okabe, A., Uchihori, Y., Kitamura, H., Sekine, E., Ebisawa, S., Suzuki, M., ^*Okayasu R.
    • Journal Title

      Br. J. Cancer 96

      Pages: 1707-1710

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] DNA topoisomerase inhibitor, etoposide, enhances GC-box-dependent promoter activity via Spl phosphorylation.2007

    • Author(s)
      Niina I, Uchiumi T, Izumi H, torigoe T, Wakasugi T, Igarashi T, Miyamoto N, Onitsuka T, Shiota M, Okayasu R, Chijiiwa K, Kohno K.
    • Journal Title

      Cancer Sci. 98

      Pages: 858-863

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] JS Cytotoxicity of cigarette smoke condensate is not due to DNA double strand breaks : Comparative studies using radiosensitive mutant and wild-type CHO cells2007

    • Author(s)
      Kato, T., Nagasawa, H., Warner, C., ^*Okayasu R., Bedford^*
    • Journal Title

      Int. J. Radiat. Biol. 83

      Pages: 583-591

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] CELLULAR SIGNAL TRANSDUCTION EVENTS AS A FUNCTION OF LINEAR ENERGY TRANSFER(LET).2007

    • Author(s)
      Furweger C., Hajek, M., Vana, N., Kodym, R., Okayasu, R.
    • Journal Title

      Radiat. Protec. Dosimetry

      Pages: 1-5

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cytotoxicity of cigarette smoke condensate is not due to DNA double strand breaks: Comparative studies using radiosensitive mutant and wild-type CHO cells2007

    • Author(s)
      Takamitsu Kato, Hatsumi Nagasawa, Christy Wamer,* Ryuichi Okayasu,*Joel S.Bedfbrd
    • Journal Title

      Intemational Journal of Radiation Biology 83

      Pages: 583-591

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of chromosomal aberrations in tumor cells with a non-labeled Cu-PTSM and irradiation with Cu K-shell monochromatic X rays.2007

    • Author(s)
      Takakura K, Yaguchi S, Kanansugi Y, Kobayashi K, Okayasu R, Fujibayashi Y.
    • Journal Title

      Radiat Prot Dosimetry. (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] DNA topoisomerase inhibitor, etoposide, enhances GC-box-dependent promoter activity via Sp1 phosphorylation.2007

    • Author(s)
      Niina I, Uchiumi T, Izumi H, Torigoe T, Wakasugi T, Igarashi T, Miyamoto N, Onitsuka T, Shiota M, Okayasu R, Chijiiwa K, Kohno K.
    • Journal Title

      Cancer Sci. (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Single extreme low dose/low dose rate irradiation causes alteration in lifespan and genome instability in primary human cells.2007

    • Author(s)
      Okada M, Okabe A, Uchihori Y, Kitamura H, Sekine E, Ebisawa S, Suzuki M, Okayasu R.
    • Journal Title

      Br J Cancer (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Repair of DNA damage induced by accelerated heavy ions in mammalian cells proficient and deficient in the Non-homologous End-joining pathway2006

    • Author(s)
      Ryuichi Okayasu, Maki Okada, Atsushi Okabe, Miho Noguchi, Kaoru Takakura, Sentaro Takahashi
    • Journal Title

      Radiation Research 165

      Pages: 59-67

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2005 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The PCC assay can be used to predict radiosensitivity in biopsy cultures irradiated with different types of radiation.2006

    • Author(s)
      Suzuki M, Tsuruoka C, Nakano T, Ohno T, Furusawa Y, Okayasu R.
    • Journal Title

      Oncology Report 18

      Pages: 1293-1299

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin.2006

    • Author(s)
      Noguchi M, Yu D, Hirayama R, Ninomiya Y, Sekine E, Kubota N, Ando K, Okayasu R.
    • Journal Title

      Biochemistry Biophysics Research Communications 351

      Pages: 658-663

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Heavy ion radiation induces complex DNA damage that cannot be efficiently repaired by non-homologous end joining.2006

    • Author(s)
      Okayasu, R., Okada, M, Okabe, A., Noguchi, M., Takakara, K., takahashi, S.
    • Journal Title

      Radiat. Res. 165

      Pages: 59-67

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The PCC assay can be used to predict radiosensitivity in biopsy cultures irradiated with different types of radiation.2006

    • Author(s)
      Suzuki, M., Tsuruoka, C., Nakano, T., Ohno, Y., Furusawa, Okayasu, R.
    • Journal Title

      Oncol. Rep. 16

      Pages: 1293-1299

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Inhibition of Homologous Recombination Repair in Irradiated Tumor Cells Pretreated with Hsp90 Inhibitor 17-Allylamino-17-demethoxygeldanamycin.2006

    • Author(s)
      Noguchi, M, Yu, D., Hirayama, R., Ninomiya, Y., Sekine, E., Kubota, N., Ando, K. Okayasu, R.
    • Journal Title

      Biochem. Biophys. Res. Commun. 351

      Pages: 658-663

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin.2006

    • Author(s)
      Noguchi M, Yu D, Hirayama R, Ninomiya Y, Sekine E, Kubota N, Ando K, Okayasu R.
    • Journal Title

      Biochem Biophys Res Commun 351

      Pages: 658-663

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The PCC assay can be used to predict radiosensitivity in biopsy cultures irradiated with different types of radiation.2006

    • Author(s)
      Suzuki M, Tsuruoka C, Nakano T, Ohno T, Furusawa Y, Okayasu R.
    • Journal Title

      Oncol Rep. 16

      Pages: 1293-1299

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 高LET放射線と非相同末端結合修復2006

    • Author(s)
      岡安 隆一
    • Journal Title

      放射線生物研究 41

      Pages: 424-432

    • NAID

      40015265468

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Radio-sensitivity of the cells from amyotrophic lateral sclerosis model mice transfected with human mutant SOD1.2005

    • Author(s)
      Iimuro, R, Takahashi, S, Ito, H, Kubota, Y, Suetomi, K, Sato, H, Okayasu, R.
    • Journal Title

      Journal of Radiation Research 46

      Pages: 67-73

    • NAID

      110004041097

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Caffeine sensitizes non-dividing human fibroblasts to X-rays by inducing high frequency of misrepair.2005

    • Author(s)
      Kawata, T., Ito, H., Saito, M., Uno, T., Okayasu, R, et. al.
    • Journal Title

      Radiation Research 164

      Pages: 509-513

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Extremely Low-Dose Ionizing Radiation Upregulates CXC Chemokines in Normal Human Fibroblasts2005

    • Author(s)
      Akira Fujimori, Ryuichi Okayasu, Hiroshi Ishihara, Satoshi Yoshida, Kiyomi Eguchi-Kasai, Kumie Nojima, Satoru Ebisawa, Sentaro Takahashi
    • Journal Title

      Cancer Research 65

      Pages: 10159-10163

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2005 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radio-sensitivity of the cells from amyotrophic lateral sclerosis model mice transfected with human mutant SOD12005

    • Author(s)
      Iimuro, R, Takahashi, S, Ito, H, Kubota, Y, Suetomi, K, Sato, H, Okayasu, R.
    • Journal Title

      J. Radiat. Res. 46

      Pages: 67-73

    • NAID

      110004041097

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Caffeine sensitizes non-dividing human fibroblasts to X-rays by inducing high frequency of misrepair.2005

    • Author(s)
      Kawata, T., Ito, H., Saito, M., Uno, T., Okayasu, R., Liu, C., Kan'o, M., George, K., Cucinotta, F. A.
    • Journal Title

      Radiat. Res. 164

      Pages: 509-513

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Extremely low-dose ionizing radiation upregulates CXC chemokines in normal human fibroblasts.2005

    • Author(s)
      Fujjimori, A., Okayasu, R., Ishihara, H., Yoshida, S., Eguchi-Kasai, K., Nojima, K., Ebisawa, S., takahashi, S.
    • Journal Title

      Cancer Res. 65

      Pages: 10159-10163

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Caffeine sensitizes non-dividing human fibroblasts to X-rays by inducing high frequency of misrepair2005

    • Author(s)
      Tetsuya Kawata, Hisao Ito, Masayoshi Saito, Taskashi Uno, Ryuichi Okayasu, et al.
    • Journal Title

      Radiation Research 164

      Pages: 509-513

    • Related Report
      2005 Annual Research Report
  • [Journal Article] RNAi技法によるDNA二重鎖切断修復抑制:放射線治療への応用は可能か2005

    • Author(s)
      岡安 隆一, 末冨 勝敏, 高橋 千太郎
    • Journal Title

      放射線生物研究 40

      Pages: 260-269

    • NAID

      40006931641

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Radio-sensitivity of the cells from amyotrophic lateral sclerosis model mice transfected with human mutant SOD12005

    • Author(s)
      Wate et al.
    • Journal Title

      Joumal of Radiation Research 46

      Pages: 67-73

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Caffeine sensitizes non-dividing human fibroblasts to X-rays by inducing high frequency of misrepair2005

    • Author(s)
      Kawata et al.
    • Journal Title

      Radiation Research 発表予定

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Facilitated detection of chromosome break and repair at low levels of ionizing radiation by addition of wortmannin to G1-type PCC.2004

    • Author(s)
      Okada, M., S. Saito, Okayasu, R.
    • Journal Title

      Mutation Research 562

      Pages: 11-17

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Facilitated detection of chromosome break and repair at low levels of ionizing radiation by addition of wortmannin to G1-type PCC fusion incubation.2004

    • Author(s)
      Okada M, Saito S, ^*Okayasu R
    • Journal Title

      Mutat Res. 562

      Pages: 11-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Facilitated detection of chromosome break and repair at low levels of ionizing radiation by addition of wortmannin to G1-type PCC2004

    • Author(s)
      Okada, M., S.Saito, Okayasu, R.
    • Journal Title

      Mutation Research 562

      Pages: 11-17

    • Related Report
      2004 Annual Research Report
  • [Presentation] Radiobiology for Heavy-Ion Radiotherapy2008

    • Author(s)
      Okayasu, R.
    • Organizer
      NIRS-MD Anderson Symposium on Clinical Issues for Particle Therapy
    • Place of Presentation
      Houston,USA
    • Year and Date
      2008-03-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] BRCA2 siRNAを用いたin vitro,in vivoでの放射線増感2008

    • Author(s)
      岡安 隆一
    • Organizer
      第10回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良市
    • Year and Date
      2008-02-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] BRCA2 siRNAを用いたin vitro, in vivoでの放射線増感2008

    • Author(s)
      岡安 隆一、干 冬、関根 絵美子、落谷 孝広、藤森 亮
    • Organizer
      第10回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Radiobiology for Heavy-Ion Radiotherapy,2008

    • Author(s)
      Okayasu, R., Kato, T., Noguchi, M., Okada, M., Fujimori, A., Sekine, E.
    • Organizer
      NIRS-MD Anderson Symposium on Clinical Issues for Particle Therapy
    • Place of Presentation
      Houston,
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Radiobiology for Heavy-Ion Radiotherapy2008

    • Author(s)
      Okayasu, R., Kato, T., Noguchi, M., Okada, M., Fujimori, A., Sekine, E.
    • Organizer
      NIRS-MD Anderson Symposium on Clinical Issues for Particle Therapy
    • Place of Presentation
      Houston, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Down regulation of BRCA2 enhances tumor radio-sensitivity throughinhibition of homologous recombination repair2007

    • Author(s)
      Okayasu, R.
    • Organizer
      アメリカ癌学会
    • Place of Presentation
      Los Angels,USA
    • Year and Date
      2007-04-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] 極低線量・低線量率重粒子線1回照射による細胞老化およびゲノム不安定性2007

    • Author(s)
      岡安 隆一、岡田 真希、岡部 篤史、関根 絵美子、内堀 幸夫、北村 尚、鈴木 雅雄
    • Organizer
      日本放射線影響学会第50回大会
    • Place of Presentation
      千葉市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Application of HiCEP, a novel method which can deteck known and unknown gene expression changes after exposure to low dse X-rays,2006

    • Author(s)
      Okayasu, R., Fujimori, A., Takahashi, S.
    • Organizer
      The sixth Japan-France workshop on radiobiology and isotopic imaging,
    • Place of Presentation
      Paris, France
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ATM protein plays a critical role in repairing the complex DNA double strand breaks induces by high LET radiation,2006

    • Author(s)
      Okayasu, R., Okabe, A., Takakura, K.
    • Organizer
      Radiation Research Society 53rd Annual Meeting,
    • Place of Presentation
      Philadelphia, PA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Comparison of phosphorylation kinetics in DNA repair proteins after exposure to high and low LET radiations,2006

    • Author(s)
      Okayasu, R., Okabe, A., Takakura, K
    • Organizer
      The 36th COSPAR Scientific Assembly,
    • Place of Presentation
      北京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Application of HiCEP, a novel method which can detect known and unknown gene expression changes after exposure to low dose X-rays.2006

    • Author(s)
      Okayasu, R., Fujimori, A., Takahashi, S.
    • Organizer
      The sixth Japan-France workshop on radiobiology and isotopic imaging
    • Place of Presentation
      Paris, France
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Comparison of phosphorylation kinetics in DNA repair proteins after exposure to high and low LET radiations.2006

    • Author(s)
      Okayasu, R., Okabe, A., Takakura, K
    • Organizer
      The 36th COSPAR Scientific Assembly
    • Place of Presentation
      Beijing, China
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ATM protein plays a critical role in repairing the complex DNA double strand breaks induced by high LET radiation.2006

    • Author(s)
      Okayasu, R., Okabe, A., Takakura, K.
    • Organizer
      Radiation Research Society 53rd Annual Meeting
    • Place of Presentation
      Philadelphia, PA USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] High LET radiation affects non-homologous end joining repair in human cells.2005

    • Author(s)
      Okayasu, R., Okada, M., Okabe, A., Takahashi, S.
    • Organizer
      96th Annual Meeting.
    • Place of Presentation
      Anaheim, CA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Extreme low dose rate irradiation with heavy ions induces accelerated senescence in primary human cells.2005

    • Author(s)
      Okayasu, R., Okada, M., Okabe, A., Uchihori, Y., Suzuki, M., Takahashi, S.
    • Organizer
      The 52nd Radiation Research Society Annual Meeting,
    • Place of Presentation
      Denver,
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] High LET radiation uncovers a new aspect of DNA double strand break repair.2005

    • Author(s)
      Okayasu, R., Okada, M., Okabe, A., Noguchi, M., Takahashi, S.
    • Organizer
      Japan Radiation Research Society Annual Meeting and The 1st Asian Radiation Research Conference
    • Place of Presentation
      Hiroshima, Japan,
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] High LET radiation affects non-homologous end joining repair in human cells.2005

    • Author(s)
      Okayasu, R., Okada, M, Okabe, A., Takahashi, S.
    • Organizer
      96th Annual Meeting, Anaheim
    • Place of Presentation
      CA, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Extreme low dose rate irradiation with heavy ions induces accelerated senescence in primary human cells.2005

    • Author(s)
      Okayasu, R., Okada, M., Okabe, A., Uchihori, Y., Suzuki, M., Takahashi, S.
    • Organizer
      The 52nd Radiation Research Society Annual Meeting
    • Place of Presentation
      Denve, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] High Let radiation uncovers a new aspect of DNA double strand break repair.2005

    • Author(s)
      Okayasu, R., Okada, M., Okabe, A., Noguchi, M., Takahashi, S.
    • Organizer
      Japan Radiation Research Society Annual Meeting and The 1st Asian Radiation Research Conference
    • Place of Presentation
      Hiroshima, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Characteristic studies of non homologous end joining in human cells irradiated with high LET radiation.2004

    • Author(s)
      Okayasu, R., Okada, M., Okabe, A. and Takakura, K
    • Organizer
      35th COSPAR Scientific Assembly
    • Place of Presentation
      Paris, France
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 癌の臨床(6月号の1章執筆)2007

    • Author(s)
      岡安 隆一、岡田 真希、岡部 篤史、野口 実穂
    • Publisher
      篠原出版新社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 癌の臨床(6月号の一部を執筆)2007

    • Author(s)
      岡安 隆一、岡田 真希、岡部 篤史、野口 実穂
    • Total Pages
      60
    • Publisher
      篠原出版新社
    • Related Report
      2007 Annual Research Report
  • [Book] 放射線生物研究 41巻 (1章執筆)2006

    • Author(s)
      岡安 隆一
    • Publisher
      放射線生物研究会
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 日経サイエンス(1監訳+1自己原稿)2006

    • Author(s)
      岡安 隆一
    • Publisher
      日経サイエンス(印刷中)(不明)
    • Related Report
      2005 Annual Research Report
  • [Book] 放射線生物研究 40巻 (1章執筆)2005

    • Author(s)
      岡安 隆一、末冨 勝敏、高橋 千太郎
    • Publisher
      放射線生物研究会
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] The fifth Japan-France Workshop on Radiobiology and Medical Imaging2004

    • Author(s)
      Ogiu, T., Shirota A.et al.
    • Total Pages
      206
    • Publisher
      NIRS, Japan and CEA, France
    • Related Report
      2004 Annual Research Report
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.nirs.go.jp

    • Related Report
      2007 Final Research Report Summary
  • [Remarks]

    • URL

      http://www.nirs.go.jp

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2004-04-01   Modified: 2016-04-21  

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