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Role of inhibition in adaptation of vestibular and saccadic eye movements.

Research Project

Project/Area Number 16300129
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology and muscle physiology
Research InstitutionUniversity of Tsukuba

Principal Investigator

YOSHIDA Kaoru  University of Tsukuba, Graduate School of Comprehensive Human Sciences, Professor, 大学院人間総合科学研究科, 教授 (50111373)

Co-Investigator(Kenkyū-buntansha) IWAMOTO Yoshiki  University of Tsukuba, Graduate School of Comprehensive Human Sciences, Associate Professor, 大学院人間総合科学研究科, 助教授 (50184908)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥11,700,000 (Direct Cost: ¥11,700,000)
Fiscal Year 2006: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2005: ¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 2004: ¥5,700,000 (Direct Cost: ¥5,700,000)
Keywordssaccade / burst neuron / omnipause neuron / glycinergic inhibition / iontophoresis / adaptation / error signal / microstimulation / グレシン抑制 / 運動学習 / 適応 / 眼振急速相 / ボーズニューロン / グリシン抑制 / 学習捉通 / 小脳 / 眼振 / 緩徐相 / 急速相 / GABA / グリシン / 抑制遮断 / 前庭神経核
Research Abstract

The accuracy of vestibular and saccadic eye movements is maintained by motor learning mechanisms. We examined 1) a role of inhibition in the premotor pathways participating in these eye movements, and 2) the pathways mediating error signals for saccadic adaptation.
Using a multibarel microelectrode, we recorded single unit activity from cells in the vestibular nucleus and pontine reticular formation, and iontophoretically applied GABA receptor antagonists or glycine receptor antagonist. Following application of GABA antagonists, horizontal canal-related secondary vestibular neurons showed a marked increase in the gain of their response to head rotation. Analysis of the response phase suggested that these neurons received GABAergic input of non-commissural origin, most likely from the flocculus. On the other hand, glycinergic inhibition played critical roles in generation of saccadic command. Thus, both the inhibitory trigger and latch signals to omnipause neurons were mediated by glycin … More ergic afferents. Inhibition from omnipause neurons to premotor burst neurons was also glycinergic and found to be necessary to suppress visual responses.
We examined effects of repetition of saccadic adaptation during single experiments. Analyses revealed that a memory of previous learning remains during recovery and facilitates subsequent adaptation. This memory does not disappear merely with time but is erased actively by repeated zero-error movements. Results suggest that the saccadic system is equipped with more than one plasticity process.
Error signals are vital to motor learning. However, little is known about pathways that transmit error signals for saccadic adaptation. We found that microstimulation of the midbrain tegmentum following saccades produces gradual and marked changes in saccade gain. The spatial and temporal characteristics of the produced changes were similar to those of adaptation induced by real visual error. We conclude that microstimulation created powerful learning signals that dictate the direction of adaptive shift in saccade endpoints. Less

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (23 results)

All 2007 2006 2005 2004

All Journal Article (23 results)

  • [Journal Article] Microst imulat ion of raidbra in tegmentum creates lerning signals for saccade adaptation.2007

    • Author(s)
      Kojima Y. et al.
    • Journal Title

      Journal of Neuroscience J 27

      Pages: 3759-3767

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Glycinergic inputs cause the pause of pontine omnipause neurons during saccades.2007

    • Author(s)
      Kanda T. et al.
    • Journal Title

      Neuroscience Letters 413

      Pages: 16-27

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Microstimulation of midbrain tegmentum creates learning signals for saccade adaptation.2007

    • Author(s)
      Kojima, Y., Yoshida, K., Iwamoto, Y.
    • Journal Title

      J.Neurosci. 27

      Pages: 3759-3767

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Glycinergic inputs cause the pause of pontine omnipause neurons during saccades.2007

    • Author(s)
      Kanda, T., Iwamoto, Y., Yoshida, K., Shimazu H.
    • Journal Title

      Neurosci.Lett. 413

      Pages: 16-20

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Microstimulation of midbrain tegmentum creates lerning signals for saccade adaptation.2007

    • Author(s)
      Kojima Y. et al.
    • Journal Title

      J. Neuroscience 27

      Pages: 3759-3767

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Glycinergic inputs cause the pause of pontine omnipause neurons during saccades.2007

    • Author(s)
      Kanda T. et al.
    • Journal Title

      Neurosci. Lett. 413

      Pages: 16-27

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Saccade-related inhibitory burst neurons (IBNs) alter their activity in relation to amplitude-decreasing adaptation in the monkey.2006

    • Author(s)
      Kojima Y., et al.
    • Journal Title

      The Japanese Journal of Physiology 56(in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effect of saccadic amplitude adaptation on subsequent adaptation of saccades in different direction.2005

    • Author(s)
      Kojima Y. et al.
    • Journal Title

      Neuroscience Research 53

      Pages: 404-412

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of saccadic amplitude adaptation on subsequent adaptation of saccades in different directionsin.2005

    • Author(s)
      Kojima, Y., Iwamoto, Y., Yoshida, K.
    • Journal Title

      Neuroscience Res. 53

      Pages: 404-412

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of saccadic amplitude adaptation on subsequent adaptation of saccades in different direction.2005

    • Author(s)
      Kojima Y., et al.
    • Journal Title

      Neuroscience Research 53

      Pages: 404-412

    • Related Report
      2005 Annual Research Report
  • [Journal Article] alterations in saccade metrics related to the erasure of the memory of preceding adaptation.2005

    • Author(s)
      Kojima Y., et al.
    • Journal Title

      The Japanese Journal of Physiology 55

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Control of head position during driving : Neck muscle activity and vehicle dynamics.2005

    • Author(s)
      Iwamoto Y., et al.
    • Journal Title

      Neuroscience Research 52

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Activity of reticular inhibitory burst neurons (IBNs) during saccadic amplitude adaptation in the monkey.2005

    • Author(s)
      Kojima Y., et al.
    • Journal Title

      Soc.Neurosci.Abstr. 31

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Vertical eye movements-related type II neurons with down-ward on-directions in the vestibular nucleus in alert cats2004

    • Author(s)
      Niwa M.et al.
    • Journal Title

      Experimental Brain Research 155

      Pages: 401-412

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Memory of learning facilitates saccadic adaptation in the monkey.2004

    • Author(s)
      Kojima Y. et al.
    • Journal Title

      Journal of Neuroscience 24

      Pages: 7531-7539

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Memory of learning facilitates saccadic adaptation in the monkey.2004

    • Author(s)
      Kojima, Y., Iwamoto, Y., Yoshida, K.
    • Journal Title

      J.Neurosci. 24

      Pages: 7531-7539

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Vertical eye movements-related type II neurons with downward on-directions in the vestibular nucleus in alert cats.2004

    • Author(s)
      Niwa, M., Chimoto, S., Iwamoto, Y., Yoshida, K.
    • Journal Title

      Exp.Brain Res. 155

      Pages: 401-412

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Vertical eye movements-related type II neurons with downward on-directions in the vestibular nucleus in alert cats2004

    • Author(s)
      Niwa, M.et al.
    • Journal Title

      Experimental Brain Research 155

      Pages: 401-412

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Memery of learning facilitates saccadic adaptation in the monkey.2004

    • Author(s)
      Kojima Y.et al.
    • Journal Title

      Jounal of Neurosciencs 24

      Pages: 7531-7539

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Changes in firing behavior of saccadic burst neurons induced by iontophoretic application of strychnine in alert cats.2004

    • Author(s)
      Yoshida K.et al.
    • Journal Title

      Journal of Vestibular Research 14

      Pages: 149-150

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of glycine receptor antagonist upon pontine omnipause neurons during saccadic eye movements.2004

    • Author(s)
      Kate R.et al.
    • Journal Title

      Journal of Vestibular Research 14

      Pages: 275-276

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Adaptation of oblique saccades following adaptation of horizontal and vertical saccades.2004

    • Author(s)
      Iwamoto Y.et al.
    • Journal Title

      Soc.Neurosci.Abstr. 30

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Changes in saccade metrics associated with adaptation and recovery in monkey.2004

    • Author(s)
      Kojima Y.et al.
    • Journal Title

      Soc.Neurosci.Abstr. 30

    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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