| Project/Area Number |
16300131
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SHINODA Yoshikazu Tokyo Med & Dent Univ., Graduate Sch.of Med, Professor, 大学院・医歯学総合研究科, 教授 (60010104)
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| Co-Investigator(Kenkyū-buntansha) |
IZAWA Yoshiko Tokyo Med & Dent Univ., Graduate Sch.of Med., PostDoc., 大学院・医歯学総合研究科, COE拠点形成特別研究員 (40372453)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥10,800,000 (Direct Cost: ¥10,800,000)
Fiscal Year 2005: ¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 2004: ¥6,200,000 (Direct Cost: ¥6,200,000)
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| Keywords | frontal eye field / saccade / fixation / smooth pursuit eye movement |
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| Research Abstract |
To understand the neural mechanism of fixation, we investigated effects of electrical stimulation of the frontal eye field (FEF) and its vicinity on visually guided (Vsacs) and memory-guided saccades (Msacs) in trained monkeys and found that there were two types of suppression induced by the electrical stimulation : suppression of ipsilateral saccades and suppression of bilateral saccades. In this report, we characterized the properties of the suppression of bilateral Vsacs and Msacs. Stimulation of the bilateral 'suppression sites suppressed the initiation of both Vsacs and Msacs in all directions during and 〜50ms after stimulation but did not affect the vector of these saccades. The suppression was stronger for ipsiversive larger saccades and contraversive smaller saccades, and saccades with initial eye positions shifted more in the saccadic direction. The most effective stimulation timing for the suppression of ipsilateral and contralateral Vsacs was 〜40-50ms before saccade onset, indicating that the suppression occurred most likely in the superior colliculus and/or the paramedian pontine reticular formation. Suppression sites of bilateral saccades were located in the prearcuate gyrus facing the inferior arcuate sulcus where stimulation induced suppression at 【less than or equal】40μA but usually did not evoke any saccades at 80μA and were different from those of ipsilateral saccades where stimulation evoked saccades at 【less than or equal】50μA The smooth pursuit area of the FEF was different from the bilateral suppression area. The bilateral suppression sites contained fixation neurons. The results suggest that fixation neurons in the bilateral suppression area of the FEF may play roles in maintaining fixation by suppressing saccades in all directions.
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