| Project/Area Number |
16300146
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biomedical engineering/Biological material science
|
|---|
| Research Institution | HOKKAIDO UNIVERSITY |
|---|
Principal Investigator |
KAKUCHI Toyoji Hokkaido Univ., Graduate School of Engineering, Prof., 大学院・工学研究科, 教授 (80113538)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SATOH Toshifumi Hokkaido Univ., Graduate School of Engineering, Instructor, 大学院・工学研究科, 助手 (80291235)
KAGA Harumi National Institute of Advanced Industrial Science and Technology (AIST), Chief scientist, 産業技術総合研究所・ゲノムファクトリー研究部門, 主任研究員 (20356752)
YANO Shigenobu Nara women Univ., Graduate School of Humanities and Sciences, Prof., 大学院・人間文化研究科, 教授 (60011186)
金子 憲明 コスモテック株式会社, 技術開発部, 部長
|
|---|
| Project Period (FY) |
2004 – 2005
|
| Project Status |
Completed (Fiscal Year 2005)
|
| Budget Amount *help |
¥15,100,000 (Direct Cost: ¥15,100,000)
Fiscal Year 2005: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 2004: ¥10,100,000 (Direct Cost: ¥10,100,000)
|
|---|
| Keywords | Cellulose / Hyperbranched Carbohydrate Polymer / Gel / Hemostat / Sealant / Polycarbohydrate Derivative |
|---|
| Research Abstract |
Gel-materials, such as gelatin, collagen, and fibrinogen, derived from animals and humans, have been used widely in medical applications, although the materials include the possibilities of the contagions of a virus and an allergic material. We recently discovered that a novel carbohydrate polymer having a specific structure formed a new class of gel-material. Depending on the formulation and preparation method, materials ranging from viscous liquids, soft gels, and tough films can be obtained with widely varying gel formation kinetics. Since the starting materials are classified as biocompatible and biodegradable, this new class of gels has many potential medical applications, such as hemostatic, adhesive, and coating agents. Carbohydrate polymers having a specific structure can be synthesized from naturally occurring sugars or compounds microwave-decomposed from polysaccharide. The novel carbohydrate polymers have characteristics as follows ; 1)basic materials for medical applications at a reasonable cost, 2)easy control of the chemical and physical properties, 3)biocompatible and biodegradable materials. The reaction of the carbohydrate polymer with a gelling agent immediately forms the gel-materials, which offers several advantages over conventional gel preparations, including the use of non-contagion materials and short preparation times. The gel-materials are a versatile new class of biomaterials that hold promise for a wide variety of medical applications.
|
