| Project/Area Number |
16300169
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Medical systems
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
SHIINA Tsuyoshi University of Tsukuba, Graduate School of Systems and Information Engineering, Professor, 大学院システム情報工学研究科, 教授 (40192603)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YAMAKAWA Makoto University of Tsukuba, Graduate School of Systems and Information Engineering, Assistant Professor, 大学院システム情報工学研究科, 講師 (60344876)
MIYANAGA Naoto University of Tsukuba, Graduate School of comprehensive Hamah Science, Assistant Professor, 大学院人間総合科学研究科, 講師 (00241828)
三竹 毅 (株)日立メディコ, 技術研究所第一部, 部長
|
|---|
| Project Period (FY) |
2004 – 2006
|
| Project Status |
Completed (Fiscal Year 2006)
|
| Budget Amount *help |
¥11,400,000 (Direct Cost: ¥11,400,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2005: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2004: ¥5,900,000 (Direct Cost: ¥5,900,000)
|
|---|
| Keywords | ultrasound measurement / tissue elasticity imaging / cancer diagnosis / non-invasive biological measurement / endoscopic method / medical image diagnosis / image-guided therapy / improvement of quality of life |
|---|
| Research Abstract |
Ultrasonic tissue elasticity imaging can provide us novel diagnostic information based on tissue hardness and consequently it is expected to detect tumor with high contrast and also discriminate benign and malignant disease. We recently developed commercial-based equipment for real-time tissue elasticity imaging based on the combined autocorrelation method which we have previously proposed to attain the high precision of diagnosis with simple operation as well as ordinary ultrasonic examination. On the other hand, there remains a problem that conventional elasticity image is not quantitative since it depends on the compression level. In addition, endoscopic measurement is expected to be useful for improving precision of diagnosis based on tissue characterization as well as percutaneous approaches.
From this point of view, we aim to develop the endoscopic ultrasound systems for tissue elasticity imaging by quantification of conventional strain images and expansion of fields for clinical
… More
application.
(1) Active compression type of tissue elasticity imaging
By compression of tissues, strain is induced within tissue as well as palpation. As this type, the system for prostate examination by using transrectal probe was investigated. The balloon which was inflated by water was developed for uniform distribution of stress and independence of operators' skill
2) Passive compression type of tissue elasticity imaging
Deformation of tissues is induced by cardiac motion or blood pressure in this type. The system for evaluation of aortic plaque by transesophageal type of probe was developed. Ultrasonic endoscope was used for reconstruct strain images of pancreas disease.
3) Quantitative measurement of tissue elasticity
To elucidate the relation of tissue elasticity and pathological meaning, phantom and tissue specimen are measured by mechanical compression-tester.
By way of these investigations, it was attained to develop the basic technology for the endoscopic ultrasound systems for tissue elasticity imaging and give direction to development of practical system Less
|
