| Project/Area Number |
16300170
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
WAKAMATSU Hidetoshi Tokyo Medical and Dental University, Graduate school of Health Science, Professor, 大学院保健衛生学研究科, 教授 (40014237)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAZATO Itsuro Tokyo Medical and Dental University, Graduate school of Health Science, Associate Professor, 大学院保健衛生学研究科, 助教授 (10014375)
HONMA Satoru Tokyo Medical and Dental University, Graduate school of Health Science, Instructor, 大学院保健衛生学研究科, 助手 (60361721)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 2006: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2004: ¥3,100,000 (Direct Cost: ¥3,100,000)
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| Keywords | Brain hypothermia / Automatic administration / Adaptive control / Fuzzy control / Administration of brain temperature / Respiration / Surface water-cooling / Surface air-cooling / ファジィ制御 / 水冷式表明冷却 / 集中治療・管理 / 脳圧制御 / 生理状態測定 / 冷却媒体 / 冷却装置 / 脳温制御 |
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| Research Abstract |
Automatic control systems of brain tissue temperature were experimentally studied for the brain hypothermia treatment. The water-cooling and warming system was designed and constructed according to the heat exchange dynamic characteristics. In order to realize human friendly control mechanism, an automatic temperature regulation systems were constructed by adaptive and fuzzy algorithm for possible environmental and characteristic change of patients. The brain temperature was successfully realized to follow up automatically the desired temperature course prescribed by physicians. Thus, the model reference control of the brain temperature based on water-cooling blankets was verified for the clinical application to brain hypothermia treatment through the various kinds of experiments using a human thermal model. For the effectiveness and convenience of emergency or in ambulance, air-cooling system was developed based on the its simulation in consequence to water-cooling system, including the study of optimal cranial pressure control on the injury or ischemic damage of brain and of the automatic respiratory control by adaptive pole placement method.
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