Assessment of Central Dopamine Release by Exercise in Hunian in vivo.

• Project/Area Number: 16300199
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sports science
• Research Institution: Tohoku University
• Principal Investigator: ITOH Masatoshi Tohoku University, Cyclotron Radioisotope Center, Professor, サイクロトロン・ラジオアイソトープセンター, 教授 (00125501)
• Co-Investigator(Kenkyū-buntansha): TASHIRO Manabu Tohoku University, Cyclotron Radioisotope Center, Lecturer, サイクロトロン・ラジオアイソトープセンター, 講師 (00333477) ; FUJIMOTO Toshihiko Tohoku University, Center for the Advancement of Higher Education, Lecturer, 高等教育開発推進センター, 講師 (00229048) ; 井戸 達雄 東北大学, サイクロトロン・ラジオアイソトーフセンター, 教授 (80134063)
• Project Period (FY): 2004 – 2006
• Project Status: Completed (Fiscal Year 2006)
• Budget Amount: ¥9,600,000 (Direct Cost: ¥9,600,000); Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000); Fiscal Year 2005: ¥3,200,000 (Direct Cost: ¥3,200,000); Fiscal Year 2004: ¥4,700,000 (Direct Cost: ¥4,700,000)
• Keywords: Dopamine / Brain / PET / Raclopride / Exercise / ポジトロン / ドーパミン / 運動 / 脳活動 / 脳マッピング / Brain Imaging / Microdialysis / Positron tomography / D2 receptors

Research Abstract

Assessment of central dopamine (DA) release in vivo in human using D_2 PET mapping is a novel technique for neuroscience. We applied this technique to assess DA release by enduring ergometer exercise. We hypothesized that failure of the previous studies to reveal DA release by exercise may be from technical problems. They measured D_2 receptor distribution after completion of exercise. By using a modified ergometer that allows bicycling while lying on PET couch, we carried out raclopride PET simultaneously during exercise. To minimize head movements due to bicycling, we used a plastic face mask for each subject developed for conformal radiotherapy. In addition head movements were mathematically corrected using an image alignment algorithm equipped in SPM5 (Functional Imaging Laboratory, London). Eight healthy male volunteers aged 21.4±2.0 (s.d.) years collaborated the study. They made an ergometer exercise of moderate intensity (VO2Max 35〜60%) for 50 minutes. [^<11>C]Raclopride was injected intravenously at 20 minutes after start of the exercise and then a sequential PET images were collected using 3D positron camera (Shimadzu 2400W) with scatter correction. ROIs were placed at the caudate, putamen, and cerebellum of each side. Choosing cerebellum as a reference tissue we calculated raclopride binding potential (BP) to D_2 receptors using the simplified reference tissue model (Lammersma and Gunn), Logan noninvasive model, and Ichise model. The BP in the striatum were significantly reduced at exercise (-12.9〜17.0%, P<0.01) when compared to a control condition (lying on PET couch only). The reductions were almost similar between the caudate and the putemen and between hemispheres. The results strongly support DA release at this ergometer exercise condition. Dopamine release in our brain may explain refreshing feeling after exercise and its habituations.

Research Products

• [Journal Article] Reactivation of medial temporal lobe and occipital lobe during the retrieval of color information : A positron emission tomography study (2007)
  • Author(s): Ueno, Aya., Abe, N., Suzuki, M., Hirayama, K., Mori, E., Tashiro, M., Itoh, M., Fujii,T.
  • Journal Title: Neuroimage. 34・3 Pages: 1292-1298
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Autonomic nervous function and localization of cerebral activity during lavender aromatic immersion. (2007)
  • Author(s): X.Duan, M.Tashiro, D.Wu, T.Yambe, Q, Wang, T, Sasaki, K, Kumagai, M, Itoh.et al.
  • Journal Title: Technology and Health Care 15・2 Pages: 69-78
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Deceiving others : distinct neural responses of the prefrontal cortex and amygdala in simple fabrication and deception with social interactions. (2007)
  • Author(s): Abe N, Suzuki M, Mori E, Itoh M, Fujii T.
  • Journal Title: J Cogn Neurosci 19・2 Pages: 287-295
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Reactivation of medial temporal lobe and occipital lobe during the retrieval of color information : A positron emission tomography study (2007)
  • Author(s): Ueno, Aya., Abe, N., Suzuki, M., Hirayama, K., Mori, E., Tashiro, M., Itoh, M., Fujii, T.
  • Journal Title: Neuroimage. 34・3 Pages: 1292-1298
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Autonomic nervous function and localization of cerebral activity during lavender aromatic immersion. (2007)
  • Author(s): X.Duan, M.Tashiro, D.Wu, T.Yambe, Q, Wang, T, Sasaki, K, Kumagai, M, Itoh, et al.
  • Journal Title: Technology and Health Care 15・2 Pages: 69-78
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Deceiving others : distinct neural responses of the prefrontal cortex and amygdala in simple fabrication and deception with social interactions.. (2007)
  • Author(s): Abe N, Suzuki M, Mori E, Itoh M, Fujii T.
  • Journal Title: J Cogn Neurosci 19・2 Pages: 287-95
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Reactivation of medial temporal lobe and occipital lobe during the retrieval of color information : A positron emission tomography study (2007)
  • Author(s): Ueno, Aya., Abe, N., Suzuki, M., Hirayama, K., Mori, E., Tashiro, M., Itoh, M., Fujii, T.
  • Journal Title: J. Neurosurg 34・3 Pages: 1292-1298
• [Journal Article] Deceiving others : distinct neural responses of the prefrontal cortex and amygdala in simple fabrication and deception with social interactions. (2007)
  • Author(s): Abe N, Suzuki M, Mori E, Itoh M, Fujii T
  • Journal Title: J Cogn Neurosci 19・2 Pages: 287-295
• [Journal Article] Medial frontal cortex perfusion abnormalities as evaluated by positron emission tomography in women with climacteric symptoms. (2006)
  • Author(s): Abe T, Bereczki D, Takahashi Y, Tashiro M, Iwata R, Itoh M.
  • Journal Title: Menopause. 13・6 Pages: 891-901
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Functional brain mapping of actual car-driving using [18F]FDG-PET. (2006)
  • Author(s): Joeng M, Tashiro M, Singh LN, Yamaguchi K, Horikawa E, M, Itoh M. et al.
  • Journal Title: Ann Nucl Med 20・9 Pages: 623-628
  • NAID: 10031135823
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Medial frontal cortex perfusion abnormalities as evaluated by positron emission tomography in women with climacteric symptoms. (2006)
  • Author(s): Abe T, Bereczki D, Takahashi Y, Tashiro M, Iwata R, Itoh M
  • Journal Title: Menopause. 13・6 Pages: 891-901
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Attenuation of fluctuating striatal synaptic dopamine levels in patients with Parkinson disease in response to subthalamic nucleus stimulation : a positron emission tomography study (2006)
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  • Journal Title: J.Neurosurg. 100・4 Pages: 968-973
• [Journal Article] Histamine HI receptors in schizophrenic patients measured with positron emission tomography. (2006)
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  • Journal Title: Eru.Neuropsychopharmacol 15・2 Pages: 185-191
• [Journal Article] Recruitment of fusiform face area associated with listening to degraded speech sounds in auditory-visual speech perception : PET study. (2006)
  • Author(s): Abe, N., Suzuki, M., Tsukiura, T., Mori, E., Yamaguchi, K., Itoh, M., Fujii, T.
  • Journal Title: Cereb Cortex 15・2 Pages: 192-199
• [Journal Article] Classical conditioned response of rectosigmoid motility and regional cerebral activity in humans (2006)
  • Author(s): Kanazawa, M., Endo, M., Yamaguchi, K., Hamaguchi, T., Whitehead, WE., Itoh, M., Fukudo, S.
  • Journal Title: Neurogastroenterol 382・3 Pages: 705-713
• [Journal Article] Dissociable roles of prefrontal and anterior cingulate cortices in deception. (2006)
  • Author(s): Kawase, T., Yamaguchi, K., Ogawa, T., Suzuki, K., Suzuki, M., Itoh, M., Kobayashi, T., Fujii, T.
  • Journal Title: Neurosci Lett 58・2
• [Journal Article] Decreased histamine H1 receptor binding in the brain of depressed patients. (2004)
  • Author(s): Kano, M., Fukudo, S., Tashiro, A., Utsumi, A., Itoh, M et al.
  • Journal Title: European Journal of Neuroscience 16,3 Pages: 803-810
• [Journal Article] Central effects of fexofenadine and cetirizine : measurement of psychomotor performance, subjective sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography. (2004)
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  • Journal Title: Journal of Clinical Pharmacology 100,4 Pages: 606-610
• [Journal Article] Risperidone is effective for wandering and disturbed sleep/wake patterns in Alzheimer's disease. (2004)
  • Author(s): Meguro, K., Meguro, M., Tanaka, Y., Akanuma, K., Yamaguchi, K., Itoh, M.
  • Journal Title: Geriatr Psychiatry Neurol 17,2 Pages: 61-67
• [Book] クリニカルPETの最前線 (2004)
  • Author(s): 伊藤正敏, 遠藤啓吾, 畑沢順, 福田寛, 米倉義春, 石渡喜一
  • Total Pages: 338
  • Publisher: 先端医療社