| Project/Area Number |
16300203
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
NISHIYASU Takeshi University of Tsukuba, Graduate School of Comprehensive Human Sciences, Associate Professor, 大学院人間総合科学研究科, 助教授 (90237751)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAMATSU Kaoru University of Tsukuba, Graduate School of Comprehensive Human Sciences, Professor, 大学院人間総合科学研究科, 教授 (90015727)
SOYA Hideaki University of Tsukuba, Graduate School of Comprehensive Human Sciences, Associate Professor, 大学院人間総合科学研究科, 助教授 (50221346)
OGATA Mitsugi University of Tsukuba, Graduate School of Comprehensive Human Sciences, Associate Professor, 大学院人間総合科学研究科, 助教授 (90177121)
TAKAGI Hideki University of Tsukuba, Graduate School of Comprehensive Human Sciences, Associate Professor, 大学院人間総合科学研究科, 助教授 (80226753)
SAITO Mitsuru Toyota Technological Institute, Applied Physiology Laboratory, Professor, 工学部, 教授 (80126862)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥15,200,000 (Direct Cost: ¥15,200,000)
Fiscal Year 2006: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2004: ¥10,900,000 (Direct Cost: ¥10,900,000)
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| Keywords | muscle metaboreflex / carotid baroreflex / sympathetic nervous activity / 動脈圧反射 / ハンドグリップ / 筋代謝受容器反射 / 筋代謝受容器 / 筋機械受容器 / 筋交感神経活動 / エコードップラーカルジオグラフ / 運動 |
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| Research Abstract |
We aimed to investigate the interactions between arterial baroreflex (ABR) and muscle metabo-reflex, and between arterial baroreflex and cardiopulmonary baroreflex, each with respect to the regulation of muscle sympathetic nervous activity (MSNA) and blood pressure, and by examining the time course of the carotid-baroreflex-induced alterations in muscle sympathetic nerve activity (MSNA), mean arterial blood pressure (MAP) and heart rate (HR) in humans.
1) It was suggested that the modulation of ABR function is one of the mechanisms underlying the progressive increase in blood pressure and MSNA during the course of isometric exercise.
2) During activation of the muscle metaboreflex, it was suggested that, in humans, modulation of the dynamic relationship between MAP and femoral arterial vascular resistance reflects complex interactions between intrinsic vascular regulatory mechanisms and sympathetic vascular regulation.
3) During orthostatic condition, it was suggested that ABR control over MSNA is progressively modulated as orthostatic stress increases, so that its sensitivity is substantially reduced during the period immediately preceding the severe hypotension associated with orthostatic syncope.
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