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Development of Medical Micro Needle Made of Biodegradable Material

Research Project

Project/Area Number 16310103
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Microdevices/Nanodevices
Research InstitutionKansai University

Principal Investigator

AOYAGI Seiji  Kansai University, Faculty of Engineering, Professor, 工学部, 教授 (30202493)

Co-Investigator(Kenkyū-buntansha) YAMAGUCHI Tomomi  Kansai University, Faculty of Engineering, Associate Professor, 工学部, 助教授 (10268310)
NAKAHARA Sumio  Kansai University, Faculty of Engineering, Associate Professor, 工学部, 助教授 (90067760)
ARAI Yasuhiko  Kansai University, Faculty of Engineering, Professor, 工学部, 教授 (80131415)
MAKIHIRA Kenji  Kansai University, Faculty of Engineering, Fulltime Lecturer, 工学部, 専任講師 (10253569)
戸倉 精一  関西大学, 工学部, 教授 (40000806)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥16,200,000 (Direct Cost: ¥16,200,000)
Fiscal Year 2005: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2004: ¥14,300,000 (Direct Cost: ¥14,300,000)
KeywordsMicro Needle / Biodegradable Material / Micro Molding / Excimer Laser Machining / Micromachining
Research Abstract

The aim of this research is the development of micro needle, of which outer shape is jagged imitating the mosquito. This needle would be effective for reducing pain and fear when penetrating a needle into skin, realizing a trace blood system, realizing a portable glucose level measurement system for diabetics, etc. As the structural material, biodegradable polymer of PLA (Poly Lactic Acid) is employed. In this year, the following items are tried and successful results are obtained : 1) establishment of fabrication process of solid needle by micro molding method for PLA material, 2) estimation of resistance force during insertion to artificial skin of silicone rubber, 3) development of fabrication method of drilling the high aspect ratio hole to the solid PLA needle by excimer laser, 4) sampling blood by capillary force. As for 1), optimal condition of injection temperature and injection pressure is searched. As the result, it is proved that setting the temperature to just above the melting point of PLA and setting the pressure to the allowable maximal value of the injection machine lead to realizing a surely rigid needle bearing the insertion to human skin. As for 2), a measuring system of resistance force during insertion is newly developed. This system employs a high performance load cell and combines it with a 1DOF linear stage, all function of which are controlled by a personal computer. It is proved that the sharp tip and thin shank is effective for reducing the resistance force. However, the effect of jagged shape is not prominent on reducing the force. As for 3), a hole with high aspect ratio of 20 micro meter diameter and 1mm length is realized. As for 4), it is observed by a zoom microscope that the blood surely runs up inside the hole of the needle.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (18 results)

All 2006 2005 2004

All Journal Article (14 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] Biodegradable Polymer Needle having a Trench for Collecting Blood by Capillary Force2006

    • Author(s)
      S.Aoyagi, H.Izumi, Y.Isono, K.Makihira, M.Fukuda
    • Journal Title

      Technical Digest of the 19th IEEE International Conference on Micro Electro Mechanical Systems(MEMs 2006)

      Pages: 450-453

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] マイクロマシン技術を応用した微小ランセット針ノ作製2006

    • Author(s)
      青柳誠司, 泉隼人
    • Journal Title

      砥粒加工学会誌 50-4(印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Fabrication of a Micro Needle Made of Biodegradable Polymer Material2006

    • Author(s)
      T.Aoki, H.Izumi, S.Aoyagi
    • Journal Title

      Selected Papers of The International Conference on Machine Automation ICMA2004 印刷中

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Biodegradable Polymer Needle having a Trench for Collecting Blood by Capillary Force2006

    • Author(s)
      S.Aoyagi, H.Izumi, Y.Isono, K.Makihira, M.Fukuda
    • Journal Title

      Technical Digest of the 19th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2006)

      Pages: 450-453

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Fabrication of a micro lancet needle using micromachining2006

    • Author(s)
      S.Aoyagi, H.Izumi
    • Journal Title

      Journal of the Japan Society for Abrasive Technology Vol.50, No.4(in print)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Fabrication of a Micro Needle Made of Biodegradable Polymer Material2006

    • Author(s)
      T.Aoki, H.Izumi, S.Aoyagi
    • Journal Title

      Selected Papers of The International Conference on Machine Automation ICMA2004 (in print)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Biodegradable Polymer Needle having a Trench for Collecting Blood by Capillary Force2006

    • Author(s)
      S. Aoyagi, H. Izumi, Y. Isono, K. Makihira, M. Fukuda
    • Journal Title

      Technical Digest of the 19th IEEE International Gonference, on Micro Electro Mechanical Systems(MEMS 2006)

      Pages: 450-453

    • Related Report
      2005 Annual Research Report
  • [Journal Article] マイクロマシン技術を応用した微小ランセット針の作製2006

    • Author(s)
      青柳誠司, 泉隼人
    • Journal Title

      砥粒加工学会誌 vol.50,No.4(印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Fabrication of a Micro Needle Made of Bidodegradable Polymer Material2006

    • Author(s)
      T. Aoki, H. Izumi, S. Aoyagi
    • Journal Title

      Selected Papers of The International Conference on Machine Automation ICMA2004 (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Development of a Micro Lancet Needle made of Biodegradable Polymer for Low-Invasive Medical Treatment2005

    • Author(s)
      S.Aoyagi, H.Izumi, T.Aoki, M.Fukuda
    • Journal Title

      Digest of Technical Papers of The 13th International conference on Solid-state Sensors and Actuators(Transducers'05)

      Pages: 1195-1198

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Development of a Micro Lancet Needle made of Biodegradable Polymer for Low-Invasive Medical Treatment2005

    • Author(s)
      S.Aoyagi, H.Izumi, T.Aoki, M.Fukuda
    • Journal Title

      Digest of Technical Papers of The 13th International Conference on Solid-State Sensors and Actuators (Transducers'05)

      Pages: 1195-1198

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Development of a Micro Lancet Needle made of Biodegradable Polymer for Low-Invasive Medical Treatment2005

    • Author(s)
      S. Aoyagi, H. Izumi, T. Aoki, M. Fukuda
    • Journal Title

      Digest of Technical Papers of The 13th International Conference on Solid-State Sesors and Actuators (Transducers'05)

      Pages: 1195-1198

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 生分解性材料を用いた医療用マイクロ注射針の開発2004

    • Author(s)
      青木俊朗, 牧平憲治, 青柳誠司他
    • Journal Title

      精密工学会2004年度関西地方定期学術講演会講演論文集

      Pages: 35-36

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Fabrication of a Micro Needle made of Biodegradable Polymer Material2004

    • Author(s)
      T.Aoki, K.Makihira, S.Aoyagi, et al.
    • Journal Title

      Proceedings of International Conference on Machine Automation (ICMA2004)

      Pages: 211-214

    • Related Report
      2004 Annual Research Report
  • [Patent(Industrial Property Rights)] 微細針ノ射出成形方法2005

    • Inventor(s)
      青柳誠司, 福田光男
    • Industrial Property Rights Holder
      関西大学, (株)ライトニックス
    • Industrial Property Number
      2005-164334
    • Filing Date
      2005-06-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 微細針の成形鋳型の製造方法2005

    • Inventor(s)
      青柳誠司, 福田光男
    • Industrial Property Rights Holder
      関西大学, (株)ライトニックス
    • Industrial Property Number
      2005-164353
    • Filing Date
      2005-06-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 穿刺デバイスおよびその製造方法2005

    • Inventor(s)
      青柳誠司, 福田光男
    • Industrial Property Rights Holder
      関西大学, (株)ライトニックス
    • Industrial Property Number
      2005-294472
    • Filing Date
      2005-10-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 微細針の射出成形方法2005

    • Inventor(s)
      青柳誠司, 福田光男
    • Industrial Property Rights Holder
      関西大学(株)イトニックス
    • Industrial Property Number
      2005-164334
    • Filing Date
      2005-06-03
    • Related Report
      2005 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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