| Project/Area Number |
16350027
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
HAN Li-Biao National Institute of Advanced Industrial Science and Technolog, search Institute for Innovation in Sustainable Chemistry, Senior Research Scientist, 環境化学技術研究部門, 主任研究員 (30356860)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥15,300,000 (Direct Cost: ¥15,300,000)
Fiscal Year 2006: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 2005: ¥5,100,000 (Direct Cost: ¥5,100,000)
Fiscal Year 2004: ¥5,700,000 (Direct Cost: ¥5,700,000)
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| Keywords | Organophosphorus compounds / Preparation / Catalyst / Optically active compounds / Selectivity / 立体特異的 / P-キラリティー / 不斉付加 / 不斉 / 求核置換反応 / ラジカル付加 / ニッケル触媒 / ヒドロホスホリル化 / ニッケルヒドリド錯体 / リン置換ブタジエン / プロパルギルアルコール |
|---|
| Research Abstract |
Diphenylphosphine oxide and related P(0)-H compounds react with propargyl alcohols at room temperature in the presence of a catalytic amount of Ni(0) complex and Ph2P(0)OH to produce high yields of phosphinoyl 1,3-dienes though an efficient in situ dehydration process. On the other hand, by using Josiphos ligands, palladium-catalyzed hydrophosphorylation of norbornenes with hydrogen phosphonates proceeded efficiently to give the corresponding phosphonates in high enantioselectivities. More over, a variety of functionalized optically pure (RP)-alkylphenylphosphinates are readily prepared by stereospecific radical or base-catalyzed additions of the easily available (RP)-menthyl phenylphosphinate to alkenes.
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