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Terahertz biophotonics by use of ultrafast telecommunication devices

Research Project

Project/Area Number 16360037
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied physics, general
Research InstitutionTohoku University

Principal Investigator

SHIKATA Jun-ichi  Tohoku University, Research Institute of Electrical Communication, Associate Professor, 電気通信研究所, 助教授 (50302237)

Co-Investigator(Kenkyū-buntansha) MIYAZAKI Hitoshi  University of Tsukuba, Gene Research Center, Professor, 応用生物化学系, 教授 (40183636)
MIYAMOTO Katsuhiko  Tohoku University, Research Institute of Electrical Communication, Research Associate, 電気通信研究所, 助手 (20375158)
水津 光司  東北大学, 電気通信研究所, 助手 (20342800)
横山 弘之  東北大学, 未来科学技術共同研究センター, 教授 (60344727)
近藤 丘  東北大学, 加齢医学研究所, 教授 (10195901)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥15,200,000 (Direct Cost: ¥15,200,000)
Fiscal Year 2006: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 2005: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 2004: ¥8,400,000 (Direct Cost: ¥8,400,000)
Keywordsbiophotonics / coherent Raman effect / terahertz molecular vibration / semiconductor laser / ultrafast photonics
Research Abstract

The objectives of this research are to realize a novel, compact, high-accuracy coherent Raman spectrometer using ultrafast photonics devices for the in vivo detection of terahertz (THz) molecular vibrations in biological tissues, and demonstrate the advantages in biophotonics applications. Firstly, we developed a confocal THz-frequency CARS spectrometer based on the conventional nanosecond-pulsed CARS system, and then measured and performed polarization analysis of CARS spectra of organic and biomolecules in the wide frequency range of 1.5-54 THz, to obtain a database for THz biophotonics. We then have developed a THz-CARS microscope, and performed near-infrared imaging of a cancer tissue, to study the biological information obtained by conventional THz imaging. From the clear, high-resolution images, the near-infrared imaging was found to be effective for the detection of not only the cancer portions, but also the necrotic portions surrounded by cancer cells. Using THz-phonon resonances in solid samples, THz-CARS imaging was also demonstrated for the first time. Furthermore, we have developed a high-peak power, tunable near-infrared source using picosecond pulsed laser diode, fiber amplifiers, and nonlinear frequency conversions using a photonic crystal fiber and periodically poled lithium niobate. The compact, flexible light source was successfully applied to nonlinear optical (two-photon-fluorescence) bioimaging of mouse neuron cells. Through the above fruitful results, we have contributed to the new basis for THz biophotonics and the advance of THz science and technology.

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (28 results)

All 2007 2006 2005 2004

All Journal Article (27 results) Book (1 results)

  • [Journal Article] Output Power Enhancement of a Palmtop Terahertz-wave Parametric Generator2007

    • Author(s)
      S.Hayashi
    • Journal Title

      Applied Optics 46・1

      Pages: 117-123

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Change of molecular damping during solidification and melting in scattering samples studied by Raman spectroscopy2007

    • Author(s)
      K.M.Abedin
    • Journal Title

      Journal of Luminescence (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Output enhancement of a palmtop terahertz-wave parametric generator2007

    • Author(s)
      S.Hayashi
    • Journal Title

      Appl.Opt. Vol.46, No.1

      Pages: 117-123

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Change of molecular damping during solidification and melting in scattering sample studied by Raman spectroscopy2007

    • Author(s)
      K.M.Abedin
    • Journal Title

      J.Luminescence (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Terahertz biophotonics using coherent anti-Stokes Raman Spectroscopy2007

    • Author(s)
      Jun-ichi Shikata
    • Journal Title

      Proc. of 4th International Symposium on System Construction of Global-Network-Oriented Information Electroniccs 120

      Pages: 120-126

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 半導体レーザ利用のスーパーコンチニュウム光を用いた高ピークパワー920nm超短パルス光源2007

    • Author(s)
      横山弘之
    • Journal Title

      第54回応用物理学関係連合講演会講演予稿集 AP0711108-03

      Pages: 1160-1160

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 光学界の進展2005(4.分光)2006

    • Author(s)
      四方潤一
    • Journal Title

      光学 35・4

      Pages: 182-183

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] テラヘルツ帯分光データベースと振動スペクトルの一考察2006

    • Author(s)
      石川陽一
    • Journal Title

      電子情報通信学会テラヘルツ応用システム 時限研究専門委員会 研究技術報告

      Pages: 36-40

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Terahertz-wave near-field imaging with subwavelength resolution using surface-wave-assisted bow-tie aperture2006

    • Author(s)
      K.Ishihara
    • Journal Title

      Applied Physics Letters 89・20

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Progress 2005 in Optical Society of Japan2006

    • Author(s)
      J.Shikata
    • Journal Title

      Kougaku Vol.35, No.4

      Pages: 182-183

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Terahertz-region spectroscopic database and some studies on vibrational THz spectra2006

    • Author(s)
      Y.Ishikawa
    • Journal Title

      IEICE Tech.Report on the 6th Domestic Conference on Applied Terahertz System

      Pages: 36-40

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Terahertz-wave near-field imaging with subwavelength resolution using surface-wave-assisted bow-tie aperture2006

    • Author(s)
      K.Ishihara
    • Journal Title

      Appl.Phys.Lett. Vol.89, No.20

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 共焦点型CARS分光計による生体分子の広帯域THz帯振動スペクトル測定2006

    • Author(s)
      鈴木要
    • Journal Title

      第53回応用物理学関係連合講演会講演予稿集 AP061110-03

      Pages: 1184-1184

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Widely-tunable, confocal coherent anti-Stokes Raman spectrometer for THz-frequency modes in biomolecules2006

    • Author(s)
      Jun-ichi Shikata
    • Journal Title

      Tech. Digest of Conference on Lasers and Electro-Optics 2006 (CD-ROM)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Study of solidification process by tunable mid-infrared laser spectroscopy and Raman spectroscopy2006

    • Author(s)
      Kazi Monowar Abedin
    • Journal Title

      Tech. Digest of ATP Congress Brisbane 2006

      Pages: 132-132

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Confocal coherent anti-Stokes Raman spectrometer for THz-frequency modes in biomolecules2006

    • Author(s)
      Jun-ichi Shikata
    • Journal Title

      Tech.Digest of 9th International Symposium on Contemporary Photonic Technology

      Pages: 60-61

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Widely-tunable, confocal coherent anti-Stokes Raman spectrometer for THz-frequency modes in biomolecules2006

    • Author(s)
      Jun-ichi Shikata
    • Journal Title

      Tech.Digest of Conference on Lasers and Electra-optics 2006 (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 光波を用いた生体分子のテラヘルツ・センシング2005

    • Author(s)
      四方潤一
    • Journal Title

      光技術コンタクト 43・4

      Pages: 34-42

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] THz near-field imaging using enhanced transmission through a single sub-wavelength aperture2005

    • Author(s)
      K.Ishihara
    • Journal Title

      Japanese Journal of Applied Physics 44・29

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Terahertz biosensing using optical waves2005

    • Author(s)
      J.Shikata
    • Journal Title

      Opt.Electro-Optic Eng.Contact Vol.43, No.4

      Pages: 34-42

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] THz near-field imaging using enhanced transmission through a single sub-wavelength aperture,2005

    • Author(s)
      K.Ishihara
    • Journal Title

      Jpn.J.Appl.Phys. Vol.44, No.29

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 生体関連物質のコヒーレントラマン分光2005

    • Author(s)
      四方潤一
    • Journal Title

      第52回応用物理学関係連合講演会講演予稿集 APO51110-00

      Pages: 5-5

    • Related Report
      2005 Annual Research Report
  • [Journal Article] THz帯CARS分光法によるタンパク質分子の動態研究2005

    • Author(s)
      四方潤一
    • Journal Title

      第66回応用物理学会学術講演会講演世予稿集 APO51133-00

      Pages: 79-79

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Rapidly tunable coherent anti-Stokes Raman spectrometer for terahertz-frequency modes in biomelcules and symmetric analysis2005

    • Author(s)
      Jun-ichi Shikata
    • Journal Title

      Tech.Digest of International Conference on Quantum Electronics 2005 and the Pacific Rim Conference on Lasers and Electra-optics 2005 (CD-ROM)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 生体関連物質のコヒーレントラマン分光2005

    • Author(s)
      四方 潤一
    • Journal Title

      第52回応用物理学関係連合講演会講演予稿集 (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 光波を用いた生体分子のテラヘルツ・センシング2005

    • Author(s)
      四方 潤一
    • Journal Title

      光技術コンタクト 43・4(印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 偏光依存型CARSによる液体試料測定の高感度化2004

    • Author(s)
      鈴木 要
    • Journal Title

      第65回応用物理学会学術講演会講演予稿集 AP041136-03

      Pages: 984-984

    • Related Report
      2004 Annual Research Report
  • [Book] テラヘルツ技術(第9章 バイオメディカル応用)2006

    • Author(s)
      四方潤一
    • Total Pages
      18
    • Publisher
      オーム社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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