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Elucidation of Disintegration Mechanism of Microcapsules including a Gas Bubble and Nano-particles for Drug Delivery in Blood Flows Using Underwater Shock Waves

Research Project

Project/Area Number 16360092
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Fluid engineering
Research InstitutionKyushu Institute of Technology

Principal Investigator

TAMAGAWA Masaaki  Kyushu Institute of Technology, Graduate school of Life Science and Systems Engineering, Associate Professor (80227264)

Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥13,400,000 (Direct Cost: ¥13,400,000)
Fiscal Year 2006: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2005: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2004: ¥7,000,000 (Direct Cost: ¥7,000,000)
KeywordsShock wave / DDS / Micro jet / Micro capsule / Nano particle / マイクロカプセル / ナノ薬物粒子 / レーザ / ドラッグデリバリシステム
Research Abstract

In this study, our aim is to investigate this mechanism and apply the shock wave technology to disintegrate cell in the bioprocess industry and medical field such as Drug Delivery Systems (DDS). In this project, especially, the following important things for applying to DDS were investigated
(A-1) Stimulus of the capsule and the cell near the arterial wall and thrombus in the shock wave DDS.
(A-2) Establishment of disintegration of microcapsule and stimulus of the cell by shock wave
The results about these topics are obtained as follows;
(A-1) The stimulus of shock waves on the cell increases the growth rate of the cell number in case of endothelial cells. Although this result shows possibility of decreasing the effects of anti-cancer, it is possible to optimize two parameters such as disintegration and cell-growth because the growth rate is dependent on the rise frequency and amplitude of pressure wave (shock wave)
(A-2) To apply theoretical model of the shock wave propagation to the cell, … More the cell model was composed of three structures such as the surrounding fluid, cell membrane and internal fluid. Using these models, the stress and pressure wave on the membrane and in the cell were analyzed in case of working underwater shock wave on the cell. As a result, the higher the rising frequency becomes high, the larger the stress wave on the cell increases. Then it was found that the effect of frequency on the stimulus is high.
For the development of generating shock wave method, the following two things are investigated as the actual application;
(B-1) Generation of shock wave using Laser
(B-2) Development of small scale microcapsule including a gas bubble and measurement of their mechanical properties.
The results about these topics are obtained as follows;
(B-1) The generation method of shock wave using Yag Laser was established, but energy loss in the part of optical coupling between optical fiber and lens is high and the stability of shock wave generation was not good. So the method to introduce the shock wave in the test water tank will be changed, then the laser beam will be directly to the water tank system.
(B-2) The special microcapsules composed of gas bubble, liquid, capsule membrane can be obtained, and the diameter size of them is 20-30 μm. This size is 30% of the previous investigation up to 2003, and it is found that these size is applicable to use as bladder DDS in human body. Less

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (56 results)

All 2007 2006 2005 2004

All Journal Article (25 results) (of which Peer Reviewed: 6 results) Presentation (28 results) Book (3 results)

  • [Journal Article] 衝撃波DDSカプセルの開発とその設計法について2006

    • Author(s)
      石松 憲和, 玉川 雅章, 山野 井一郎
    • Journal Title

      生体医工学 43-4

      Pages: 730-737

    • NAID

      110004704989

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Deformation Analysis of Bubblenear Curved Elastic Wall for or Developing Shock Wave DDS2006

    • Author(s)
      Ichhio YAMANOI, Masaaki TAMAGAWA
    • Journal Title

      JSME International Journal, Series B 49-3

      Pages: 755-760

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Development of microcapsule for a shock wave drug delivery system and its design2006

    • Author(s)
      Norikazu, ISHIMATSU, Masaaki, TAMAGAWA, Ichiro, YAMANOI
    • Journal Title

      Transactions of Japanese Society for Medical and Biological Engineering Vol.43, No.4

      Pages: 730-737

    • NAID

      110004704989

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Deformation Analysis of Bubble near Curved Elastic Wall for Developing Shock Wave DDS2006

    • Author(s)
      Ichiro, YAMANOI, Masaaki, TAMAGAWA
    • Journal Title

      JSME International Journal, Series B Vol.49, No.3

      Pages: 755-760

    • NAID

      110004773150

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 衝撃波DDSカプセルの開発とその設計法について2006

    • Author(s)
      石松憲和, 玉川雅章, 山野井一郎
    • Journal Title

      生体医工学 43・4

      Pages: 730-730

    • NAID

      110004704989

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Deformation Analysis of Bubble near Curved Elastic Wall for Developing Shock Wave DDS2006

    • Author(s)
      Ichiro YAMANOI, Masaaki TAMAGAWA
    • Journal Title

      JSME International Journal, Series B 49・3

      Pages: 755-755

    • NAID

      110004773150

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Prototype of microcapsule for shock wave drug delivery systems and analysis of deformation process of a bubble in a capsule model2006

    • Author(s)
      M.Tamagawa, I.Yamanoi, N.Ishimatsu, S.Suetsugu
    • Journal Title

      Proc. of the World Congress on Medical Physics and Biomedical Engineering 2006

      Pages: 3110-3110

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of plane shock wave on the endothelial cells in vitro using shock tube2006

    • Author(s)
      Masaaki Tamagawa, Seiya Iwakura, Sirou Suetsugu, Ichiro Yamanoi
    • Journal Title

      Proc. of the 5th World Congress of Biomechanics

      Pages: 6759-6759

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of gradient of cytokine concentration on chemotaxis of suspended neutrophile in liquid2006

    • Author(s)
      Masaaki Tamagawa, Satoshi Harada, Kusuhiro Mukai, Yoshinori Furukawa
    • Journal Title

      Proc. of the 5th World Congress of Biomechanics

      Pages: 5463-5463

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 衝撃波DDSのための曲率弾性壁近傍での気泡変形挙動解析(第2報,気泡内気体と曲率弾性壁の影響)2005

    • Author(s)
      山野 井一郎, 玉川 雅章
    • Journal Title

      日本機械学会論文集 71-701

      Pages: 1762-1767

    • NAID

      110005051596

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 衝撃波DDS開発のためのマイクロカプセルあ試作と力学的特性2005

    • Author(s)
      山野 井一郎, 玉川 雅章, 川島 真一
    • Journal Title

      日本機械学会論文集, A編 71-707

      Pages: 1088-1093

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Bubble Deformation Analysis Near Curved Elastic Wall for Developing Shock Wave DDS(2nd Report, Effect of Gas of Bubble and Curved Elastic Wall)2005

    • Author(s)
      Ichiro, YAMANOI, Masaaki, TAMAGAWA
    • Journal Title

      Transaction of JSME, Series B Vol.71, No.701

      Pages: 1762-1767

    • NAID

      110005051596

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Prototype of Microcapsules and Their Mechanical Properties for Developing Shock Wave Drug Delivery Systems2005

    • Author(s)
      Ichiro, YAMANOI, Masaaki, TAMAGAWA, Shinichi, KAWASHIMA
    • Journal Title

      Transaction of JSME, Series A Vol.71, No.707

      Pages: 1088-1093

    • NAID

      110004999052

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 衝撃波DDS開発のためのマイクロカプセルの試作と力学特性2005

    • Author(s)
      山野井一郎, 玉川雅章, 川島真一
    • Journal Title

      日本機械学会論文集 A編71-707

      Pages: 1088-1093

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 衝撃波DDS開発のための曲率弾性壁近傍での気泡変形挙動解析2005

    • Author(s)
      山野井一郎, 玉川雅章
    • Journal Title

      日本機械学会論文集 B編71-701

      Pages: 1762-1767

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 衝撃波DDS開発のためのマイクロカプセルの試作と力学的特性*2005

    • Author(s)
      山野井一郎, 玉川雅章, 川島真一
    • Journal Title

      日本機械学会論文集 (印刷中)

    • NAID

      110004999052

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Prototype of microcapsule including a gas bubble for developing shock wave drug delivery systems2005

    • Author(s)
      Masaaki TAMAGAWA, Ichiro YAMANOI
    • Journal Title

      2005 ASME International Mechanical Engineering Congress & Exposition (To be presented)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 衝撃波DDSのための曲率弾性壁近傍での気泡変形挙動解析2004

    • Author(s)
      山野 井一郎, 玉川 雅章
    • Journal Title

      日本機械学会論文集, A編 70-697

      Pages: 1269-1275

    • NAID

      110004998828

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Prediction of Thrombus Formation Using Lattice Boltzmann Method(Modeling of Adhesion Force for or Particle to Wall)2004

    • Author(s)
      Masaaki TAMAGAWA, Sumiaki MATSUO
    • Journal Title

      JSME International Journal, Series C 47-4

      Pages: 1027-1034

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Bubble Deformation Analysis near Curved Elastic Wall for Developing Shock Wave DDS2004

    • Author(s)
      Ichiro, YAMANOI, Masaaki, TAMAGAWA
    • Journal Title

      Transaction of JSME, Series A Vol.70, No.697

      Pages: 1269-1275

    • NAID

      110004998828

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Prediction of Thrombus Formation Using Lattice Boltzmann Method(Modeling of Adhesion Force for Particle to Wall)2004

    • Author(s)
      Masaaki, TAMAGAWA, Sumiaki, MATSUO
    • Journal Title

      JSME International Journal, Series C Vol.47, No.4

      Pages: 1027-1034

    • NAID

      110004820832

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 衝撃波DDSのための曲率弾性壁近傍での気泡変形挙動解析2004

    • Author(s)
      山野井一郎, 玉川雅章
    • Journal Title

      日本機械学会論文集,A編 70巻697号

      Pages: 1269-1275

    • NAID

      110004998828

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Deformation Process of a Gas Bubble near Curved Elastic Wall by Shock Waves for Design of Drug Delivery Systems2004

    • Author(s)
      Masaaki TAMAGAWA, Ichiro YAMANOI
    • Journal Title

      Proceedings of the 1^<st> Asian Pacific Conference on Biomchanicse No.04-203

      Pages: 17-18

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Development of Drug Delivery Systems using Shock Wave and Bubble Collapsing2004

    • Author(s)
      Ichiro YAMANOI, Masaaki TAMAGAWA
    • Journal Title

      Proceedings of the 4^<th> International Symposium on Advanced Fluid Information and the 1^<st> International Symposium on Transdiciplinary Fluid Integration Vol.1

      Pages: 32-33

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Prediction of Thrombus Formation Using Lattice Boltzmann Method (Modeling of Adhesion Force for Particle to Wall)2004

    • Author(s)
      Masaaki TAMAGAWA, Sumiaki MATSUO
    • Journal Title

      JSME International Journal, Series C Vol.47 No.4

      Pages: 1027-1034

    • NAID

      110004820832

    • Related Report
      2004 Annual Research Report
  • [Presentation] The effects of plane shock wave on the endothelial cells in vitro and the numerical analysis of pressure wave in the cell2006

    • Author(s)
      Masaaki Tamagawa, Seiya Iwakura, Shiro Suetsugu, Jun Fujii
    • Organizer
      4th Joint Meeting of ASA and JSA(The Journal of the Acoustical Society of America), Vol.120, No.5, pp.3066
    • Place of Presentation
      USA,Hawai
    • Year and Date
      2006-12-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] The effects of plane shock wave on the endothelial cells in vitro and the numerical analysis of pressure wave in the cell2006

    • Author(s)
      Masaaki, Tamagawa, Seiya, Iwakura, Shiro, Suetsugu, Jun, Fujii
    • Organizer
      4th Joint Meeting of ASA and JSA(The Journal of the Acoustical Society of America)
    • Place of Presentation
      USA, Hawai
    • Year and Date
      2006-12-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] The effects of cytokine concentration on the flow around a suspended chemotactic neutrophile in liquid2006

    • Author(s)
      Masaaki Tamagawa, Satoshi Harada, Kusuhiro Mukai, Yoshinori Furukawa
    • Organizer
      Proc.of Fifth East Asian Biophysics Symposium&Forty-Fourth Annual Meeting of the Biophysical Society of Japan, pp.86
    • Place of Presentation
      Japan,Okinawa
    • Year and Date
      2006-10-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] The effects of cytokine concentration on the flow around a suspended chemotactic neutrophile in liquid2006

    • Author(s)
      Masaaki, Tamagawa, Satoshi, Harada, Kusuhiro, Mukai, Yoshinori, Furukawa
    • Organizer
      Proc. of Fifth East Asian Biophysics Symposium & Forty-Fourth Annual Meeting of the Biophysical Society of Japan
    • Place of Presentation
      Japan, Okinawa
    • Year and Date
      2006-10-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Effects of plane shock wave ont the endothelial cells in vitro using shock tube2006

    • Author(s)
      Masaaki Tamagawa, Seiya Iwakura, Sirou Suetsugu, Ichiro Yamanoi
    • Organizer
      Proc.of the 5th Wbrld Congress of Biomechanics, pp.6759
    • Place of Presentation
      Germany,Munich
    • Year and Date
      2006-08-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Effects of gradient of cytokine concentration on chemotaxis of suspended neutrophile in liquid2006

    • Author(s)
      Masaaki Tamagawa, Satoshi Harada, Kusuhiro Mukai, Yoshinori Furukawa
    • Organizer
      Proc.of the 5th Wbrld Congress of Biomechanics, pp.5463
    • Place of Presentation
      Germany,Munich
    • Year and Date
      2006-08-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Effects of plane shock wave on the endothelial cells in vitro using shock tube2006

    • Author(s)
      Masaaki, Tamagawa, Seiya, Iwakura, Sirou Suetsugu, Ichiro, Yamanoi
    • Organizer
      Proc. of the 5th World Congress of Biomechanics
    • Place of Presentation
      Germany, Munich
    • Year and Date
      2006-08-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Effects of gradient of cytokine concentration on chemotaxis of suspended neutrophile in liquid2006

    • Author(s)
      Masaaki, Tamagawa, Satoshi, Harada, Kusuhiro, Mukai, Yoshinori, Furukawa
    • Organizer
      Proc. of the 5th World Congress of Biomechanics
    • Place of Presentation
      Germany, Munich
    • Year and Date
      2006-08-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Analysis of Deformation Process of a Bubble in a Cell Model by Shock Wave for Developing Drug Delivery Systems2006

    • Author(s)
      M. Tamagawa, I. Yamanoi, N.
    • Organizer
      Proc.of the World Congress on Medical Physics and Biomedical Engineering 2006, pp.3110
    • Place of Presentation
      Korea,Soeul
    • Year and Date
      2006-08-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Prediction of thrombus formation in blood flow by CFD and its modeling2006

    • Author(s)
      M. Tamagawa, K. Fukushima, M. Hiramoto
    • Organizer
      Proc.of the World Congress on Medical Physics and Biomedical Engineering 2006, pp.3034
    • Place of Presentation
      Korea,Soeul
    • Year and Date
      2006-08-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] N., Analysis of Deformation Process of a Bubble in a Cell Model by Shock Wave for Developing Drug Delivery Systems2006

    • Author(s)
      M., Tamagawa, I., Yamanoi
    • Organizer
      Proc. of the World Congress on Medical Physics and Biomedical Engineering 2006
    • Place of Presentation
      Korea, Soeul
    • Year and Date
      2006-08-10
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Prediction of thrombus formation in blood flow by CFD and its modeling2006

    • Author(s)
      M., Tamagawa, K., Fukushima, M., Hiramoto
    • Organizer
      Proc. of the World Congress on Medical Physics and Biomedical Engineering 2006
    • Place of Presentation
      Korea, Soeul
    • Year and Date
      2006-08-10
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Development of microcapsules for shock wave DDS and angiogenesis using shock waves2005

    • Author(s)
      M. Tamagawa, I. Yamanoi, S. Iwakura
    • Organizer
      Proc of International Symposium on Therapeutic Ultrasound
    • Place of Presentation
      Boston,USA
    • Year and Date
      2005-12-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Development of microcapsules for shock wave DDS and angiogenesis using shock waves2005

    • Author(s)
      M., Tamagawa, I., Yamanoi, S., Iwakura
    • Organizer
      Proc of International Symposium on Therapeutic Ultrasound
    • Place of Presentation
      Boston, USA
    • Year and Date
      2005-12-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Prototype of Microcapsule including a Gas Bubble for Developing Shock Wave Drug Dehvery Systems2005

    • Author(s)
      Masaaki TAMAGAWA, Ichhio YAMANOI
    • Organizer
      Proc.of 2005 ASME International Mechanical Engineering Congress and EXposition, pp.80697
    • Place of Presentation
      USA,Orland
    • Year and Date
      2005-11-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Prototype of Microcapsule including a Gas Bubble for Developing Shock Wave Drug Delivery Systems2005

    • Author(s)
      Masaaki, TAMAGAWA, Ichiro, YAMANOI
    • Organizer
      Proc. of 2005 ASME International Mechanical Engineering Congress and EXposition
    • Place of Presentation
      USA, Orland
    • Year and Date
      2005-11-10
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Effects of gradient of cytekine concentration on chemotaxis of neutrophlie(white blood cells)2005

    • Author(s)
      Masaaki TAMAGAWA, Satoshi HARADA
    • Organizer
      Particulate Process in the Pharmaceutical Industry, pp.10
    • Place of Presentation
      Canada,Montreal
    • Year and Date
      2005-06-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Effects of gradient of cytekine concentration on chemotaxis of neutrophlie(white blood cells)2005

    • Author(s)
      Masaaki, TAMAGAWA, Satoshi, HARADA
    • Organizer
      Particulate Process in the Pharmaceutical Industry
    • Place of Presentation
      Canada, Montreal
    • Year and Date
      2005-06-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Effects of Plane Shock Waves on Endthelial Cells in Vitro2005

    • Author(s)
      Masaaki TAMAGAWA, Masanobu KITAYAMA, Seiya IWAKURA
    • Organizer
      2005 ASME Summer Bioengineering Conference
    • Place of Presentation
      USA,Vail Spa
    • Year and Date
      2005-06-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Effects of Plane Shock Waves on Endthelial Cells in Vitro2005

    • Author(s)
      Masaaki, TAMAGAWA, Masanobu, KITAYAMA, Seiya, IWAKURA
    • Organizer
      2005 ASME Summer Bioengineering Conference
    • Place of Presentation
      USA, Vail Spa
    • Year and Date
      2005-06-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Effects of shock waves on growth of endotjelial cels in vitro2005

    • Author(s)
      Tamagawa, M., Kitayama, S., Iwakura S
    • Organizer
      149th Meeting Acoustical Society of America, Vol.117, No.4, pp.2384, 2
    • Place of Presentation
      Canada,Vancubor
    • Year and Date
      2005-05-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Effects of shock waves on growth of endotjelial cells in vitro2005

    • Author(s)
      M., Tamagawa, S., Kitayama, S.,Iwakura
    • Organizer
      149th Meeting Acoustical Society of America
    • Place of Presentation
      Canada, Vancubor
    • Year and Date
      2005-05-10
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Development of Drug Dehvery Systems using Shock Wave and Bubble Collapsing2005

    • Author(s)
      Ichiro YAMANOI, Masaaki TAMAGAWA
    • Organizer
      Proceedings of the 4th International Symposium on Advanced Fluid Information and the 1st International Symposium on Transdicipltnary Fluid Integration, pp.32-33
    • Place of Presentation
      Japan,Sendai
    • Year and Date
      2005-03-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Development of Drug Delivery Systems using Shock Wave and Bubble Colla psing2005

    • Author(s)
      Ichiro, YAMANOI, Masaaki, TAMAGAWA
    • Organizer
      Proceedings of the 4th International Symposium on Advanced Fluid Information and the 1st International Symposium on Transdiciplinary Fluid Integration
    • Place of Presentation
      Japan, Sendai
    • Year and Date
      2005-03-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Analysis of Deformation Process of a Bubble in a Cell Model by Shock Wave for Developing Drug Delivery Systems2004

    • Author(s)
      Masaaki TAMAGAWA, Ichiro YAMANOI
    • Organizer
      2004 ASME International Mechanical Engineering Congress&Exposition
    • Place of Presentation
      USA,Anaheim
    • Year and Date
      2004-11-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Analysis of Deformation Process of a Bubble in a Cell Model by Shock Wave for Developing Drug Delivery Systems2004

    • Author(s)
      Masaaki, TAMAGAWA, Ichiro, YAMANOI
    • Organizer
      2004 ASME International Mechanical Engineering Congress & Exposition
    • Place of Presentation
      USA, Anaheim
    • Year and Date
      2004-11-20
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Deformation process of microcapsules and cells using shock waves and gas bubbles for design of drug delivery systems2004

    • Author(s)
      M. Tamagawa, I. Yamanoi
    • Organizer
      Proc.of the 8th International Conference on Mechanicsin Medicine and Biology, pp.141
    • Place of Presentation
      China,Taiwan
    • Year and Date
      2004-11-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Presentation] Deformation process of microcapsules and cells using shock waves and gas bubbles for design of drug delivery systems2004

    • Author(s)
      M., Tamagawa, I., Yamanoi
    • Organizer
      Proc. of the 8th International Conference on Mechanics in Medicine and Biology
    • Place of Presentation
      China, Taiwan
    • Year and Date
      2004-11-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 衝撃波で薬を打ち込む〜衝撃波によるドラッグデリバリー〜, 九工大世界トップ技術2007

    • Author(s)
      玉川 雅章
    • Total Pages
      59
    • Publisher
      西日本新聞社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 衝撃波を用いたドラッグデリバリーシステムの開発2006

    • Author(s)
      玉川 雅章
    • Total Pages
      997
    • Publisher
      日本機械学会誌,Vol.109,No.1057
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] Mechanical behavior and structural changes of cells subjected to mechanical stimuli:Deformation, freezing, and shock waves, Biomechanics at Micro-and Nanoscale Levels(Wada, H.ed.)2005

    • Author(s)
      H. Yamada, H. Ishiguro, M. Tamagawa
    • Total Pages
      154
    • Publisher
      World Scientific
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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