Development of On-chip Cellomoics Analysis System for Studies on "Community Effect of Cells"
Project/Area Number |
16370068
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Biophysics
|
Research Institution | Tokyo Medical and Dental University (2006-2007) The University of Tokyo (2004-2005) |
Principal Investigator |
YASUDA Kenji Tokyo Medical and Dental University, Institute of Boimaterials and Biosystems, Professor (20313158)
|
Project Period (FY) |
2004 – 2007
|
Project Status |
Completed (Fiscal Year 2007)
|
Budget Amount *help |
¥16,540,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2007: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2006: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2005: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2004: ¥4,000,000 (Direct Cost: ¥4,000,000)
|
Keywords | on-chip cellomics / agarose microchamber / single cell inheritance / cardiomyocyte network / cell-based drug toxicology / tetanuic stimulation / DNA aptamer / macrophage memory / マクロファージ / 圧力効果 / QT延長 / テタヌス刺激 / 金ナノ粒子 / DNAアダプター / オンチップ細胞計測 / マイクロチャンバ / 1細胞培養 / 大腸菌 / 酵母プリオン / 神経細胞ネットワーク |
Research Abstract |
We began a series of studies aimed at developing methods and systems of analyzing epigenetic information in cells, as well as that of genetic information, to expand our understanding of how living systems are determined. Because cells are minimum units reflecting epigenetic information, which is considered to map the history of a parallel-processing recurrent network of biochemical reactions, their behaviors cannot be explained by considering only conventional DNA information-processing events. The role of epigenetic information on cells, which complements their genetic information, was inferred by comparing predictions from genetic information with cell behavior observed under conditions chosen to reveal adaptation processes and community effects. A system of analyzing epigenetic information was developed starting from the twin complementary viewpoints of cell regulation as an 'algebraic' system (emphasis on temporal aspects) and as a 'geometric' system (emphasis on spatial aspects). The knowlege acquired from this study may lead to the use of cells that fully control practical applications like cell-based drug screening and the regeneration of organs.
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Report
(5 results)
Research Products
(529 results)
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[Presentation] 1細胞から生命システムを創る2006
Author(s)
安田賢二
Organizer
「東京大学の生命科学」シンポジウム
Place of Presentation
東京
Year and Date
2006-04-15
Description
「研究成果報告書概要(和文)」より
Related Report
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[Presentation] On-chip single cell-based in situ expression analysis2005
Author(s)
Kim H, Kira A, Kohno H, Matsumura K, Orita K, Oikawa K, Kaneko T, Okano K, Yasuda K.
Organizer
Kyoto Workshop "Frontiers in Environmental Science"
Place of Presentation
Shiran Kaikan Annex, Kyoto, Japan
Year and Date
2005-10-07
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] Analysis of yeast prion aggregation dynamics in a single cell.2005
Author(s)
Ayano S, Noma S, Yoshida M, Taguchi H, Yasuda K.
Organizer
The 21st Century COE Program "Research Station for Integrated Sciences" The Second International Symposium "Life as a Complex System : Constructive and Dynamic Approach to Cell and Developmental Biology"
Place of Presentation
Mathematical Sciences Bldg., The University of Tokyo, Komaba Japan
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] Relation between two cell cycle control mechanisms in Chlamydomonas.2005
Author(s)
Matsumura K, Yagi T, Yasuda K.
Organizer
The 21st Century COE Program "Research Station for Integrated Sciences" The Second International Symposium "Life as a Complex System : Constructive and Dynamic Approach to Cell and Developmental Biology"
Place of Presentation
Mathematical Sciences Bldg., The University of Tokyo, Komaba Japan
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Patent(Industrial Property Rights)] 細胞応答計測装置及び方法2007
Inventor(s)
安田賢二, 金子智行, 鈴木郁郎, 寺薗英之, 服部明弘, 福島守
Industrial Property Rights Holder
安田賢二, 金子智行, 鈴木郁郎, 寺薗英之, 服部明弘, 福島守
Industrial Property Number
2007-111322
Filing Date
2007-04-20
Description
「研究成果報告書概要(和文)」より
Related Report
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[Patent(Industrial Property Rights)] 心臓リエントリーモデルチップおよび心臓ジエントリーモデルチップによる薬剤の評価装置および方法2007
Inventor(s)
安田賢二, 杉山篤, 安東賢太郎, 野村典正, 寺薗英之, 金子智行, 福島守
Industrial Property Rights Holder
安田賢二, 杉山篤, 安東賢太郎, 野村典正, 寺薗英之, 金子智行, 福島守
Industrial Property Number
2007-152692
Filing Date
2007-06-08
Description
「研究成果報告書概要(和文)」より
Related Report
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[Patent(Industrial Property Rights)] モデル細胞による薬効評価装置2007
Inventor(s)
安田賢二, 杉山篤, 安東賢太郎, 野村典正, 寺薗英之, 金子智行, 福島守
Industrial Property Rights Holder
安田賢二, 杉山篤, 安東賢太郎, 野村典正, 寺薗英之, 金子智行, 福島守
Industrial Property Number
2007-152696
Filing Date
2007-06-08
Description
「研究成果報告書概要(和文)」より
Related Report
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[Patent(Industrial Property Rights)] 心筋毒性検査装置、心筋毒性検査チップおよび心筋毒性検査方法2007
Inventor(s)
安田賢二, 杉山篤, 安東賢太郎, 野村典正, 寺薗英之, 金子智行, 福島守
Industrial Property Rights Holder
安田賢二, 杉山篤, 安東賢太郎, 野村典正, 寺薗英之, 金子智行, 福島守
Industrial Property Number
2007-152711
Filing Date
2007-06-08
Description
「研究成果報告書概要(和文)」より
Related Report
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