| Project/Area Number |
16380075
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
KUWAHARA Shigefumi Tohoku University, Graduate School of Agricultural Science, Division of Life Science, Professor, 大学院農学研究科, 教授 (30170145)
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| Co-Investigator(Kenkyū-buntansha) |
KIYOTA Hiromasa Tohoku University, Graduate School of Agricultural Science, Division of Life Science, Associate Professor, 大学院農学研究科, 助教授 (30234397)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥10,300,000 (Direct Cost: ¥10,300,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2005: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2004: ¥6,000,000 (Direct Cost: ¥6,000,000)
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| Keywords | enokipodin / pteridic acid / tabtoxinine / litseaverticillol / Drosophila / communiol / pyricuol / epoxyquinol / petridic acid / azadirachtin / gizzeroshine / plant growth promoter / antifeedant / antibacterial / pheromone / gizzerosine / synthesis / chemicalecology / azadiracthtin / clavigerin / ascaulitoxin / pteroenone |
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| Research Abstract |
The total synthesis of the following biologically active natural products have been accomplished : (1)enokipodins A,B,C, and D (highly oxygenated a-cuparenone-type sesquiterpenoids exhibiting antimicrobial activity produced by the edible mushroom, Flammulina velutipes) ; (2)pteridic acids A and B (potent plant-growth promoters possessing unique spirocyclic polyketidic structures isolated form the phytoepiphytic actinomycete, Streptomyces hygroscopicus TP-A0451) ; (3)tabtoxinine-β-lactom (a phytotoxin produced by the pathogen Pseudomonas syringae pv. tabaci) ; (4)pteroenone (a defensive metabolite of the pteropod, Clione antarctica) ; (5)the major sex pheromone components of the fruit flies, Drosophila ananassae and D.pallidosa ; (6)communiols A,B,C,D,E,F,and H (antimicrobial metabolites produced by the coprophilous fungus, Podospora communis) ; (7)pyricuol (a phytotoxin produced by the rice blast fungus, Magnaporthe grisea) ; (8)gizzerosine (a potent inducer of gizzard erosion in chicks contained in heat-treated fish meal) ; (9)apoptosis-inducing polyunsaturated conjugated fatty acids ; (10)litseaverticillols A and B (anti-HIV sesquterpenoids bearing a novel carbon sketeton produced by the perennial shrub, Litsea verticillata). Partial syntheses of pamamycin-635A (an arerial mycelium-inducing metabolite produced by Streptomyces alboniger) and elaiophylin (an antibiotic as well as a plant-growth inhibitor) were conducted. Studies directed toward the total synthesis of azadirachtin (a potent antifeedant contained in the neem tree, Azadirachta indica) was also made.
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