| Project/Area Number |
16380087
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kyoto University |
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Principal Investigator |
KAWADA Teruo Kyoto University, Graduate School of Agriculture, Professor, 農学研究科, 教授 (10177701)
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| Co-Investigator(Kenkyū-buntansha) |
井上 和生 京都大学, 農学研究科, 助手 (80213148)
都築 巧 京都大学, 農学研究科, 助手 (50283651)
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| Project Period (FY) |
2004 – 2006
|
| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥15,700,000 (Direct Cost: ¥15,700,000)
Fiscal Year 2006: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2005: ¥5,200,000 (Direct Cost: ¥5,200,000)
Fiscal Year 2004: ¥7,200,000 (Direct Cost: ¥7,200,000)
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| Keywords | lifestyle related disease / high fat diet / cytokine / chemokine / macrophage / adipocyte / obesity |
|---|
| Research Abstract |
Obesity increases the risk for many pathological processes including type II diabetes, cardiovascular diseases, and several types of cancers. Chemokines, chemotactic cytokines, play a critical role in various inflammatory pathophysiological processes including the obesity-related pathologies. It appears that adipose tissue, which is a source of chemokines and their receptors, can be a target of the proinflammatory chemokine signals, and thus they play a role in the inflammatory responses in adipose tissue through autocrine and/or paracrine signaling pathway. The levels of chemokines expression and secretion in adipose tissue increase with increasing adiposity, and the circulating levels increase in obese individuals and/ or the patients with obesity-related pathologies such as atherosclerosis or diabetes. In this study, it has been shown that modulation of chemokine and their receptors improve or ameliorate various inflammatory diseases, which suggest that chemokines and their receptors may be a valid target to develop new strategies for obesity-related inflammatory pathologies Obesity chemokine network in terms of the role of chemokines, especially monocyte chemoattractant protein-1 (MCP-1), in controlling inflammatory responses in adipose tissue such as macrophage infiltration and activation, and the link between chemokines and the obesity-related inflammatory pathologies be highlighted.
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