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Development of carbon-carbon bond forming reaction under environmentally benign conditions and its application to combinatorial synthesis

Research Project

Project/Area Number 16390010
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionKobe Pharmaceutical University

Principal Investigator

NAITO Takeaki  Kobe Pharmaceutical University, 薬学部, Professor (00068339)

Co-Investigator(Kenkyū-buntansha) MIYATA Okiko  Kobe Pharmaceutical University, 薬学部, Professor (90102110)
UEDA Masafumi  Kobe Pharmaceutical University, 薬学部, Assistant Professor (00340935)
Project Period (FY) 2004 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥15,520,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2005: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2004: ¥10,700,000 (Direct Cost: ¥10,700,000)
Keywordsenvironmentally benign / radical reaction / carbon-carbon bond formation / one-pot / aqueous solvent / rearrangement / domino reaction / 固相反応 / Fischer Indolization
Research Abstract

1. Carbon-carbon bond formation by radical reaction
The use of water as a solvent has generated considerable interest from both economical and environmental points of view. We have developed novel carbon-carbon forming reactions employing radical as a crucial reaction species and aqueous media as solvent. Newly-found radical reactions are proved to be synthetically useful by completing synthesis of several biologically active compounds.
We firstly investigated selective and efficient alkyl radical addition to various types of imine derivatives. Structure of an intermediate generated by alkyl radical addition to oxime ethers was firmly established by carbon, hydrogen, and boron NMR analyses. Total synthesis of an abnormal amino acid, penmacric acid was completed for the first time via our radical addition reaction. Domino type of radical addition-cydization-(trapping) reaction was also developed and used for efficient construction of functionalized cyclic compounds. Novel synthetic route for Martinellic acid, isolated as a first pyrroloquinoline alkaloid was developed.
Newly-found radical addition-aldol type of reaction is expected to be an efficient and environmentally benign reaction.
2. Rearrangement reaction under mild conditions
Rearrangement reaction is one of atom-economy reactions. During our systematic investigation on 1,2-Wittig rearrangement of hydroximates, we completed the total synthesis of (+)-cytoxazone. In our continuing study on [3, 3]-sigmatropic rearrangement of hydrazones under the acylating conditions, we developed a short step and efficient method for the synthesis of benzofurans via acylation of O-aryl oxime ethers under very mild reaction conditions, even in the presence of free hydroxyl group.
As an environmentally benign synthetic method, one-pot synthesis of N-alkyl arylamines from oxime ethers was also developed.

Report

(5 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (56 results)

All 2007 2006 2005 2004 2003 Other

All Journal Article (45 results) (of which Peer Reviewed: 16 results) Presentation (9 results) Remarks (2 results)

  • [Journal Article] Novel one-pot synthesis of N-alkyl arylamines from oxime ethers using organometallic reagents2007

    • Author(s)
      Partha P.Mukhopadhyay
    • Journal Title

      Synlett

      Pages: 1403-1406

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Direct observation of the unstable intermediates in radical addition reaction by using an interfacing microchip combined with an NMR2007

    • Author(s)
      中越 雅道
    • Journal Title

      Magn.Reson.Chem. 45

      Pages: 989-992

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Development of radical addition-cyclization-elimination reaction of oxime ethers and its application to formal synthesis of (±)-martinelline2007

    • Author(s)
      宮田 興子
    • Journal Title

      Tetrahedron 63

      Pages: 10092-10117

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] First Total Synthesis of Penmacric Acid and Its Stereoisomer.2007

    • Author(s)
      Masafumi Ueda, Ayako Ono, Dai Nakao, Okiko Miyata, Takeaki Naito.
    • Journal Title

      Tetrahedron Lett. 48

      Pages: 841-844

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Novel One-pot Synthesis of N-AJkyl Arylamines from Oxime Ethers Using Organometallic Reagents2007

    • Author(s)
      Partha P. Mukhopadhyay, Okiko Miyata, Takeaki Naito.
    • Journal Title

      Synlett

      Pages: 1403-1406

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Direct Observation of the Unstable Intermediates in Radical Addition Reaction by Using an Interfacing Microchip Combined with an NMR.2007

    • Author(s)
      Masamichi Nakakoshi, Masafumi Ueda, Satoshi Sakurai, Katsuo Asakura, Hiroshi Utsumi, Okiko Miyata, Takeaki Naito, Yutaka Takahashi.
    • Journal Title

      Magn. Reson. Chem. 45

      Pages: 989-992

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Development of Radical Addition-Cyclization-Elimination Reaction of Oxime Ether and Its Application Formal Synthesis of(±)-Martinelline.2007

    • Author(s)
      Okiko Miyata, Atsushi Shirai, Shintaro Yoshino, Toshiki Nakabayashi, Yoshifumi Takeda, Toshiko Kiguchi, Daisuke Fukumoto, Masafumi Ueda, Takeaki Naito.
    • Journal Title

      Tetrahedron 63

      Pages: 10092-10117

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Novel one-pot synthesis of Nalkyl arylamines from oxime ethers using organometallic reagents2007

    • Author(s)
      Partha P. Mukhopadhyay
    • Journal Title

      Synlett

      Pages: 1403-1406

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of radical addition-cyclization-elimination reaction of oximeethers and its application to formal synthesis of(±)-martinelline2007

    • Author(s)
      宮田 興子
    • Journal Title

      Tetrahedron 63

      Pages: 10092-10117

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient synthesis of indoles using[3,3]-sigmatropic rearrangement of N-trifluoroacetyl enehydrazines2006

    • Author(s)
      宮田 興子
    • Journal Title

      Tetrahedron 62

      Pages: 3629-3647

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Structure elucidation of the intermediate in triethylborane-triethylborane-mediated radical addition of oxime ethers with 2D-and 3D-DOSY NMR2006

    • Author(s)
      中越 雅道
    • Journal Title

      Magnetic Resonance in Chemistry 44

      Pages: 807-812

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Improved Synthesis of (-)-Martinellic Acid via Radical Addition-Cyclization-Elimination Reaction of Chiral Oxime Ether2006

    • Author(s)
      宮田 興子
    • Journal Title

      Synlett

      Pages: 893-896

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Reagent-Controlled Regioselective [3,3]-Sigmatropic Rearrangement of N-Trifluoroacetyl Enehydroxyamine and Its Synthetic Application2006

    • Author(s)
      宮田 興子
    • Journal Title

      Synlett

      Pages: 3415-3418

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] First total synthesis of penmacric acid and its stereoisomer2006

    • Author(s)
      上田 昌史
    • Journal Title

      Tetrahedron Lett. 48

      Pages: 841-844

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Efficient Synthesis of Indoles using[3, 3]-sigmatropic Rearrangement of N-Trifluoroacetyl Enehydrazines.2006

    • Author(s)
      Okiko Miyata, Norihiki Takeda, Yasuo Kimura, Yoshiji Takemoto, Norimitsu Tohnai, Mikiji Miyata, Takeaki Naito.
    • Journal Title

      Tetrahedron 62

      Pages: 3629-3647

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Structure Elucidation of the Intermediate in Triethylborane-mediated Radical Addition of Oxime Ethers with 2D-and 3D-DOSY NMR.2006

    • Author(s)
      Masamichi Nakakoshi, Masafumi Ueda, Satoshi Sakurai, Okiko Miyata, Makiko Sugiura, Takeaki Naito.
    • Journal Title

      Magn. Reson. Chem. 44

      Pages: 807-812

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] An Improved Synthesis of(-)-Martinellic Acid via Radical Addition-Cyclization-Elimination Reaction of Chiral Oxime Ether.2006

    • Author(s)
      Okiko Miyata, Atsushi Shirai, Shintaro Yoshino, Yoshifumi Takeda, Makiko Sugiura, Takeaki Naito.
    • Journal Title

      Synlett

      Pages: 893-896

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Reagent-Controlled Regioselective[3, 3]-Sigmatropic Rearrangement of N-Trifluoroacetyl Enehydroxylamine and Its Synthetic Application.2006

    • Author(s)
      Norihiko Takeda, Okiko Miyata, Maria Kitamura, Shunsuke Kagehira, Takeaki Naito.
    • Journal Title

      Synlett

      Pages: 3415-3418

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Efficient synthesis of indoles using [3,3]-sigmatropic rearrangement of N-trifluoroacetyl enehydrazines2006

    • Author(s)
      宮田興子
    • Journal Title

      Tetrahedron 62

      Pages: 3629-3647

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Structure elucidation of the intermediate in triethylborane-mediated radical addition of oxime ethers with 2D- and 3D-DOSY NMR2006

    • Author(s)
      中越雅道
    • Journal Title

      Magnetic Resonance in Chemistry 44

      Pages: 807-812

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Improved Synthesis of (-)-Martinellic Acid via Radical Addition-Cyclization-Elimination Reaction of Chiral Oxime Ether.2006

    • Author(s)
      宮田興子
    • Journal Title

      Synlett

      Pages: 893-896

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Reagent-Controlled Regioselective [3,3]-Sigmatropic Rearrangemet of N-Trifluoroacetyl Enehydroxyamine and Its Synthetic Applicatoin.2006

    • Author(s)
      宮田興子
    • Journal Title

      Synlett

      Pages: 3415-3418

    • Related Report
      2006 Annual Research Report
  • [Journal Article] First total synthesis of penmacric acid and its stereoisomer2006

    • Author(s)
      上田昌史
    • Journal Title

      Tetrahedron Lett. 48

      Pages: 841-844

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Diastereoselective intermolecular radical addition to nitrones2005

    • Author(s)
      上田 昌史
    • Journal Title

      J.Org.Chem. 70

      Pages: 6653-6660

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Radical cyclization in heterocycle synthesis 15.Relationship between a radical species and radical acceptors of three different types of double bond in radical addition-cyclization2005

    • Author(s)
      宮田 興子
    • Journal Title

      Chem.Pharm.Bull. 53

      Pages: 995-1002

    • NAID

      10016655997

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Zinc-mediated carbon radical addition to glyoxylic imines in aqueous media for the synthesis of α-amino acids2005

    • Author(s)
      上田 昌史
    • Journal Title

      Org.Biomol.Chem. 3

      Pages: 1124-1128

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Preparation of optically active α-hydroxy oxime ether by diastereoselective imino1,2-Witting rearrangement of hydoximates and its application to synthesis of (+)-cytoxazone2005

    • Author(s)
      宮田 興子
    • Journal Title

      Tetrahedron Lett. 46

      Pages: 4015-4018

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Diastereoselective Intermolecular Radical Addition to Nitrones.2005

    • Author(s)
      Masafumi Ueda, Hideto Miyabe, Masako Teramachi, Okiko Miyata, Takeaki Naito.
    • Journal Title

      J. Org. Chem. 70

      Pages: 6653-6660

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Radical Cyclization in Heterocycle Synthesis 15. Relationship between a Radical Species and Radical Acceptors of Three Different Types of Double Bond in Radical Addition-Cyclization.2005

    • Author(s)
      Okiko Miyata, Seiko Kajisa, Masafumi Ueda, Masashige Yamauchi, Takeaki Naito.
    • Journal Title

      Chem. Pharm. Bull. 53

      Pages: 995-1002

    • NAID

      10016655997

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Zinc-mediated carbon radical addition to glyoxylic imines in aqueous media for the synthesis of α-amino acids.2005

    • Author(s)
      Masafumi Ueda, Hideto Miyabe, Hisako Sugino, Takeaki Naito.
    • Journal Title

      Org. Biomol. Chem. 3

      Pages: 1124-1128

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Preparation of Optically Active α-Hydroxy Oxime Ether by Diastereoselective Imino 1 , 2-Wittig Rearrangement of Hydroximates and its Application to Synthesis of(+)-Cytoxazone.2005

    • Author(s)
      Okiko Miyata, Jun Hashimoto, Ryuuichi Iba, Takeaki Naito.
    • Journal Title

      Tetrahedron Lett. 46

      Pages: 4015-4018

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Diastereoselective intermolecular radical addition to nitrones2005

    • Author(s)
      上田昌史
    • Journal Title

      J.Org.Chem. 70・17

      Pages: 6653-6660

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Radical cyclization in heterocycle synthesis 15. Relationship between a radical species and radical acceptors of three different types of double bond in radical addition-cyclization2005

    • Author(s)
      宮田興子
    • Journal Title

      Chem.Pharm.Bull. 53・8

      Pages: 995-1002

    • NAID

      10016655997

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Zinc-mediated carbon radical addition to glyoxylic imines in aqueous media for the synthesis of α-amino acids2005

    • Author(s)
      上田昌史
    • Journal Title

      Org.Biomol.Chem. 3

      Pages: 1124-1128

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Preparation of optically active α-hydroxy oxime ether by diastereoselective imino 1,2-Wittig rearrangement of hydoximates and its application to synthesis of (+)-cytoxazone2005

    • Author(s)
      宮田興子
    • Journal Title

      Tetrahedron Lett. 46

      Pages: 4015-4018

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Tandem Carbon-Carbon Bond-Forming Radical Addition-Cyclization Reaction of Oxime Ether and Hydrazone2004

    • Author(s)
      宮田 興子
    • Journal Title

      Tetrahedron 60

      Pages: 3893-3914

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Zinc-mediated radical reaction of glyoxylic oxime ether and hydrazone in aqueous media:asymmetric synthesis of α-amino acids2004

    • Author(s)
      宮田 興子
    • Journal Title

      Org.Lett. 6

      Pages: 1761-1763

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Imino 1, 2-Wittig Rearrangement of Hydroximates and its Application to Synthesis of Cytoxazone.2004

    • Author(s)
      Okiko Miyata, Tomoko Koizumi, Hiroshi Asai, Ryuichi Iba, Takeaki Naito
    • Journal Title

      Tetrahedron 60

      Pages: 3893-3914

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Highly Effective Synthetic Methods for Substituted 2-Arylbenzofurans Using[3, 3]-Sigmatropic Rearrangement : Short Syntheses of Stemofuran A and Eupomatenoid 6.2004

    • Author(s)
      Okiko Miyata, Norihiko Takeda, Takeaki Naito.
    • Journal Title

      Org. Lett. 6

      Pages: 1761-1763

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Imino 1,2-Wittig rearrangement of hydroximates and its application to synthesis of cytoxazone2004

    • Author(s)
      宮田 興子
    • Journal Title

      Tetrahedron 60

      Pages: 3893-3914

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Highly effective synthetic methods for substituted 2-arylbenzofurans using [3,3]-sigmatropic rearrangement : short syntheses of Stemfuran A and Eupomateid 62004

    • Author(s)
      宮田 興子
    • Journal Title

      Org.Lett. 6・11

      Pages: 1761-1763

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Diastereoselective Solid-Phase Radical Addition to Oxime Ether Anchored to Polymer Support.2003

    • Author(s)
      Hideto Miyabe, Chihiro Konishi, Takeaki Naito.
    • Journal Title

      Chem. Pharm. Bull. 51

      Pages: 540-544

    • NAID

      110003615345

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Zinc-mediated radical reaction of glyoxylic oxime ether and hydrazone in aqueous media : asymmetric synthesis of α-amino acids.2003

    • Author(s)
      Masafumi Ueda, Hideto Miyabe, Azusa Nishimura, Hisako Sugino, Takeaki Naito.
    • Journal Title

      Tetrahedron : Asymmetry 14

      Pages: 2857-2859

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Diastereoselective solid-phase radical addition to oxime ether anchored to polymer support2003

    • Author(s)
      宮部 豪人
    • Journal Title

      Chem.Pharm.Bull. 51・5

      Pages: 540-544

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Zinc-mediated radical reaction of glyoxylic oxime ether and hydrazone in aqueous media : asymmetric synthesis of α-amino acids2003

    • Author(s)
      上田 昌史
    • Journal Title

      Tetrahedron: Asymmetry 14

      Pages: 2857-2859

    • Related Report
      2004 Annual Research Report
  • [Presentation] 位置選択的転位反応を利用した4級炭素を有するジヒドロベンゾフラン類の合2007

    • Author(s)
      武田 紀彦
    • Organizer
      第37回複素環化学討論会
    • Place of Presentation
      長野
    • Year and Date
      2007-10-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 「位置選択的転位反応を利用した4級炭素を有するジヒドロベンゾフラン類の合成」2007

    • Author(s)
      武田 紀彦、影平 俊介、宮田 興子、内藤 猛章
    • Organizer
      第37回複素環化学討論会
    • Place of Presentation
      長野
    • Year and Date
      2007-10-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 位置運択的転位反応を利用した4級炭素を有するジヒドロベンゾフラン類の合成2007

    • Author(s)
      武田 紀彦
    • Organizer
      第37回複素環化学討論会
    • Place of Presentation
      長野
    • Year and Date
      2007-10-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] 共役オキシムエーテル類の新規ドミノ型ラジカル反応の開発2006

    • Author(s)
      上田 昌史
    • Organizer
      第32回反応と合成の進歩シンポジウム
    • Place of Presentation
      広島
    • Year and Date
      2006-12-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 「共役オキシムエーテル類の新規ドミノ型ラジカル反応の開発」2006

    • Author(s)
      上田 昌史、杉野 久子、吉田 勤一、宮田 興子、内藤 猛章、宮部 豪人
    • Organizer
      第32回反応と合成の進歩シンポジウム
    • Place of Presentation
      広島
    • Year and Date
      2006-12-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラジカル付加閉環脱離反応を鍵反応とするMartinelline類の合成研究2005

    • Author(s)
      白井 淳
    • Organizer
      第47回天然有機化合物討論会
    • Place of Presentation
      徳島
    • Year and Date
      2005-10-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 「ラジカル付加閉環脱離反応を鍵反応とするMartinelline類の合成研究」2005

    • Author(s)
      宮田 興子、白井 淳、吉野 新太郎、中林 俊樹、武田 良文、内藤 猛章
    • Organizer
      第47回天然有機化合物討論会
    • Place of Presentation
      徳島
    • Year and Date
      2005-10-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Water-Assisted Radical Reaction Using Indium as a Radical Initiator2004

    • Author(s)
      上田 昌史
    • Organizer
      15th International Conference on Organic Synthesis
    • Place of Presentation
      名古屋
    • Year and Date
      2004-08-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Water-Assisted Radical Reaction Using Indium as a Radical Initiator2004

    • Author(s)
      上田 昌史、宮部 豪人、内藤 猛章
    • Organizer
      Fifteenth International Conference on Organic Svnthesis
    • Place of Presentation
      名古屋
    • Year and Date
      2004-08-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.kobepharma-u.ac.jp/~medchem/Research/research.html

    • Related Report
      2007 Final Research Report Summary
  • [Remarks]

    • URL

      http://www.kobepharma-u.ac.jp/~medchem/Research/research.html

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2004-04-01   Modified: 2016-04-21  

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