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Functional regulation and clinical application of the organic anion transporter LST family.

Research Project

Project/Area Number 16390038
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

ABE Takaaki  Tohoku University, Hospital, Lecturer, 病院, 講師 (80292209)

Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥14,900,000 (Direct Cost: ¥14,900,000)
Fiscal Year 2005: ¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 2004: ¥10,100,000 (Direct Cost: ¥10,100,000)
Keywordsgastrointestinal cancers / LST / organic anion transporter / MTX / adenovirus / 蛍光標識
Research Abstract

In the last decade, many transporters have been isolated, characterized their distribution and substrates. Among them, the organic anion transporter OATP family, transport bile acids, hormones as well as eicosanoids and various compounds (BSP, HMG-CoA reductase inhibitor, angiotensin converting enzyme inhibitor, etc.). So far, applicant isolated more than 15 clones of the oatp family firstly in the world and reported. We have isolated the organic anion transporter OATP/LST family which exclusively expressed in various gastrointestinal cancers.
Thenm we established LST-2 recombinant adenoviruses, termed AdLST-2. In vivo effects of the combination of MTX with the adenoviruses were estimated in a subcutaneous tumor model using SCID mice. Tumors treated with AdLST-2/MTX grew more slowly than those treated with Adβ-gal/MTX. Whole-body autoradiograph confirmed that incorporation of [^3H]-MTX in tumors of mice treated with AdLST-1/MTX and AdLST2/MTX.
Our observations strongly support the possibility that overexpression of influx pumps is a new avenue in the enhancement of cancer chemotherapy. We also raised a ligand-screening method using adenovirus and fluorescent lignd of LST-2. This system unable us to screening various compounds preferable to transported by LST-2.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (16 results)

All 2005 2004

All Journal Article (16 results)

  • [Journal Article] Renal artery dissection after angiographic evaluation of lower extremities.2005

    • Author(s)
      Tanemoto M, Abe M, Satoh F, Abe T, Ito S
    • Journal Title

      Hypertens Res. 28(10)

      Pages: 853-5

    • NAID

      10018367321

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Predictors of undiagnosed renal artery stenosis among Japanese patients with risk factors of atherosclerosis.2005

    • Author(s)
      Tanemoto M, Saitoh H, Satoh F, Satoh H, Abe T, Ito S
    • Journal Title

      Hypertens Res. 28(3)

      Pages: 237-242

    • NAID

      10016431173

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] PDZ-binding and di-hydrophobic motifs regulate distribution of Kir4.1 channels in renal cells.2005

    • Author(s)
      Tanemoto M, Abe T, Ito S
    • Journal Title

      J Am Soc Nephrol. 16(9)

      Pages: 2608-14

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cutting balloon angioplasty of resistant renal artery stenosis caused by fibromuscular dysplasia.2005

    • Author(s)
      Tanemoto M, Abe T, Chaki T, Satoh F, Ishibashi T, Ito S
    • Journal Title

      J Vasc Surg. 41(5)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Bilateral calcified renal artery aneurysms in a patient with von Recklinghausen's disease.2005

    • Author(s)
      Tanemoto M, Abe T, Satoh F, Ito S
    • Journal Title

      Nephrol Dial Transplant. 20(5)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Plasma renin activity revealed renal artery stenosis concealed by aneurysms.2005

    • Author(s)
      Tanemoto M, Abe T, Satoh F, Ito S
    • Journal Title

      Urology. 65(3)

      Pages: 592-592

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Renal artery dissection after angiographic evaluation of lower extremities.2005

    • Author(s)
      Tanemoto M, Abe M, Satoh F, Abe T, Ito S.
    • Journal Title

      Hypertens Res. 28(10)

      Pages: 853-855

    • NAID

      10018367321

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Predictors of undiagnosed renal artery stenosis among Japanese patients with risk factors of atherosclerosis.2005

    • Author(s)
      Tanemoto M, Saitoh H, Satoh F, Satoh H, Abe T, Ito S.
    • Journal Title

      Hypertens Res. 28(3)

      Pages: 237-242

    • NAID

      10016431173

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] PDZ-binding and di-hydrophobic motifs regulate distribution of Kir4.1 channels in renal cells.2005

    • Author(s)
      Tanemoto M, Abe T, Ito S.
    • Journal Title

      J Am Soc Nephrol. 16(9)

      Pages: 2608-2614

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Cutting balloon angioplasty of resistant renal artery stenosis caused by fibromuscular dysplasia.2005

    • Author(s)
      Tanemoto M, Abe T, Chaki T, Satoh F, Ishibashi T, Ito S.
    • Journal Title

      J Vasc Surg. 41(5)

      Pages: 898-901

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Bilateral calcified renal artery aneurysms in a patient with von Recklinghausen's disease.2005

    • Author(s)
      Tanemoto M, Abe T, Satoh F, Ito S.
    • Journal Title

      Nephrol Dial Transplant. 20(5)

      Pages: 1007-1008

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Plasma renin activity revealed renal artery stenosis concealed by aneurysms.2005

    • Author(s)
      Tanemoto M, Abe T, Satoh F, Ito S.
    • Journal Title

      Urology. 65(3)

      Pages: 592-592

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] The organic anion transporter(OATP)family.2004

    • Author(s)
      Mikkaichi T et al.
    • Journal Title

      Drug Metab Pharmacokinet 19

      Pages: 171-179

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Involvement of multiple transporters in the efflux of HMG-CoA reductase inhibitors he blood-brain barrier.2004

    • Author(s)
      Kikuchi R et al.
    • Journal Title

      J Pharmacol Exp Ther 311

      Pages: 1147-1153

    • Related Report
      2004 Annual Research Report
  • [Journal Article] PDZ binding motif dependent localization of K^+ channel on basolateral-side in distal tubules.2004

    • Author(s)
      Tanemoto M et al.
    • Journal Title

      Am J Physiol 287

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney.2004

    • Author(s)
      Mikkaichi T et al.
    • Journal Title

      Proc Natl Acad Sci USA 101

      Pages: 3569-3574

    • Related Report
      2004 Annual Research Report

URL: 

Published: 2004-04-01   Modified: 2016-04-21  

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