| Project/Area Number |
16390041
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
OHTA Shigeru Hiroshima University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 (60160503)
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| Co-Investigator(Kenkyū-buntansha) |
KITAMURA Shigeyuki Hiroshima University, Graduate School of Biomedical Sciences, Associate Professor, 大学院・医歯薬学総合研究科, 助教授 (40136057)
SUGIHARA Kazumi Hiroshima University, Faculty of Medicine Educational, Associate, 医学部, 教務員 (20271067)
TASHIRO Tomoko Aoyama Gakuin University, College of Science and Engineering, Professor, 理工学部, 教授 (50114541)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥13,100,000 (Direct Cost: ¥13,100,000)
Fiscal Year 2005: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2004: ¥10,200,000 (Direct Cost: ¥10,200,000)
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| Keywords | tetrahydroisoguinoline / Parkinson's disease / P-glycoprotein / drug transporter / expression level / テトラヒドロイソキノリン酸 |
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| Research Abstract |
We are investigating multiple functions of neurotoxic tetrahydroisoquinoline (TIQ) derivatives. In the present study, we examined the effects of TIQ derivatives on transporters such as P-glycoprotein (P-gp). Some of TIQ derivatives were recognized by P-gp and evacuated from the brain. The administration of TIQ derivatives to P-gp -inhibited mice promoted parkinsonism. Treatment of TIQ derivatives also change the expression level of P-gp : P-gp expression transiently went up, and then decreased. Thus, malfunction of P-gp is a candidate of Parkinson's disease-inducing factors.
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