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Cell-biological analyses on the mechanism of infertility induced in gene knockout mice and sperm preparation leading to oocyte activation.

Research Project

Project/Area Number 16390046
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General anatomy (including Histology/Embryology)
Research InstitutionChiba University

Principal Investigator

TOSHIMORI Kiyotaka  Chiba University, Graduate School of Medicine, PROFESSOR, 大学院・医学研究院, 教授 (20094097)

Co-Investigator(Kenkyū-buntansha) TOYOTA Fumie  Chiba University, Graduate School of Medicine, ASSOCIATE PROFESSOR, 大学院・医学研究院, 助教授 (60009751)
TOYAMA Yoshiro  Chiba University, Graduate School of Medicine, ASSISTANT PROFESSOR, 大学院・医学研究院, 講師 (70009637)
MAEKAWA Mamiko  Chiba University, Graduate School of Medicine, RESEARCH ASSOCIATE, 大学院・医学研究院, 助手 (20181571)
ITO Chizuru  Chiba University, Graduate School of Medicine, RESEARCH ASSOCIATE, 大学院・医学研究院, 助手 (80347054)
KUWAJIMA Masamiti  The University of Tokushima, Department of Clinical Biology and Medicine, ASSOCIATE PROFESSOR (00205262)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥13,500,000 (Direct Cost: ¥13,500,000)
Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2004: ¥10,000,000 (Direct Cost: ¥10,000,000)
Keywordstestis / sperm antigen / infertility / gene defect / sperm maturation / fertilization / carnitine / 静止抗原 / 不妊 / GOPC / GCl / Cnot 7
Research Abstract

The major results obtained were as follows.
1.The mechanisms of the infertility found in gene knockout mice. 1) Inability of GOPC -/- sperm (acrosome-less head) paralleled to the degree of MN13 storage but not to the disruption degree of DNA chromatin. This strongly suggests the importance of MN13 molecule storage in ther sperm head. 2) The infertility of Gc/ -/- sperm (teratozoospermia) did not reflect the degree of MN13 storage. 3) The infertility of Caf-1 -/- sperm (oligo-astheno-teratozoospermia) was essentially due to the failure between Sertoli cell-germ cell interaction. This failure was mediated by the dysfunction of retinoid X receptor beta in Sertoli cells, causing spermiogenesis arrest at early elongating spermatic stage. 3) The infertility of BREK -/- was essentially due to apoptosis in premature germ cells and ill formation of ectoplasmic specialization at early elongating spermatids. 2.Sperm preparation, priming, leading to oocyte activation. 1) Immunoglobulin superfamily proteins, besieging and MC31 /CE9, were posttestically modified, reducing the molecular weight after the acrosome reaction. This was due to deglycosylation. 2) Analyses to detect the intracrosomla transport route to developing acrosomal membranes and the behavior of MN9/equatorin indicated that MN9/equatorin locates to the inner acrosomal membrane and becomes a stable marker to evaluate the acrosome status during acrosome reaction because of the staining ability of the equatorial segment. 3) Perinuclear theca protein MN13 was also a stable marker to evaluate the sperm status at the level of sperm-egg fusion because of the staining ability of the postacrosomal region. 3.Sperm maturation-related camitine. Carnitine-dependent sperm maturation in the epididymis was found to depend on the expression of carnitine transporter OCTN2 in the dital caput epididymis.

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (68 results)

All 2007 2006 2005 2004

All Journal Article (63 results) Book (5 results)

  • [Journal Article] Factors maintaining normal sperm tail structure during epididymal maturation studied in GOPC^<-/->mice.2007

    • Author(s)
      Suzuki-Toyota F., et al.
    • Journal Title

      Biol. Reprod. (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Factors maintaining normal sperm tail structure during epididymal maturation studied GOPC^<-/-> mice.2007

    • Author(s)
      Suzuki-Toyota F., et al.
    • Journal Title

      Biol.Reprod. (In press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Factors maintaing normal sperm tail structure during epididymal maturation studied GOPC mice.2007

    • Author(s)
      Suzuki-Toyota F., et al.
    • Journal Title

      Biol. Reprod. (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression and distribution of OCTN2 in mouse epididymis and its association with obstructive azoospermia in juvenile visceral steatosis mice.2006

    • Author(s)
      Yakushiji K., et al.
    • Journal Title

      Int. J. Urol. 13(4)

      Pages: 420-426

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Azoospermia in mice with targeted disruption of the BREK/Lmtk2 (brain-enriched kinase/lemur tyrosine kinase 2) gene.2006

    • Author(s)
      Kawa S., et al.
    • Journal Title

      PNAS 103(51)

      Pages: 19344-19349

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Oligo-astheno-teratozoospermia in mice lacking RA175/TSLC1/SynCAM/IGSF4A, a cell adhesion molecule in the immunoglobulin superfamily.2006

    • Author(s)
      Fujita E., et al.
    • Journal Title

      Mol. Cell. Biol. 26(2)

      Pages: 718-726

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Deletion of macrophage migration inhibitory factor gene induces down regulation of sex hormones and ultrastructural abnormalities in mouse testes.2006

    • Author(s)
      Anahara R., et al.
    • Journal Title

      Reprod. Toxicol. 21(2)

      Pages: 167-170

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Flutamide depresses expression of cortactin in the ectoplasmic specialization between the Sertoli cells and spermatids in the mouse testis.2006

    • Author(s)
      Anahara R., et al.
    • Journal Title

      Food Chem. Toxicol. 44

      Pages: 1050-1056

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Anti-estrogen ICI 182.780 and anti-androgen fultamide induce tyrosin phosphorylation of cortactin in the ectoplasmic specialization between the Sertoli cell and spermatids in the mouse testis.2006

    • Author(s)
      Anahara R., et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 346

      Pages: 276-280

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Estrogen agonists, 17β -estradiol, bisphenol A, and diethylstilbestrol, decrease cortactin expression in the mouse testis.2006

    • Author(s)
      Anahara R., et al.
    • Journal Title

      Arch. Histol. Cytol. 69(2)

      Pages: 101-107

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The involvement of immunoglobulin superfamily proteins in spermatogenesis and sperm-egg interaction.2006

    • Author(s)
      Toshimori K., et al.
    • Journal Title

      Repro. Med. Biol.(総説) 5

      Pages: 87-93

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Expression and distribution of OCTN2 in mouse epididymis and its association with obstructive azoospermia in juvenile visceral steatosis mice.2006

    • Author(s)
      Yakushiji K., et al.
    • Journal Title

      Int.J.Urol. 13(4)

      Pages: 420-426

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Azoospermia in mice with targeted disruption of the BREK/Lmtk2 (brain-enriched kinase/lemur tyrosine kinase 2) gene.2006

    • Author(s)
      Kawa S., et al.
    • Journal Title

      PNAS. 103(51)

      Pages: 19344-19349

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Oligo-astheno-teratozoospermia in mice lacking RA175/TSLC1/SynCAM/IGSF4A, a cell adhesion molecule in the immunoglobulin superfamily.2006

    • Author(s)
      Fujita E., et al.
    • Journal Title

      Mol.Cell.Biol. 26(2)

      Pages: 718-726

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Deletion of macrophage migration inhibitory factor gene induces down regulation of sex hormones and ultrastructural abnormalities in mouse testes.2006

    • Author(s)
      Anahara R., et al.
    • Journal Title

      Reprod.Toxicol. 21(2)

      Pages: 167-170

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Flutamide depresses expression of cortactin in the ectoplasmic specialization between the Sertoli cells and spermatids in the mouse testis.2006

    • Author(s)
      Anahara R., et al.
    • Journal Title

      Food Chem.Toxicol. 44

      Pages: 1050-1056

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Anti-estrogen ICI 182.780 and anti-androgen fultamide induce tyrosin phosphorylation of cortactin in the ectoplasmic specialization between the Sertoli cell and spermatids in the mouse testis.2006

    • Author(s)
      Anahara R., et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 346

      Pages: 276-280

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Estrogen agonists, 17β-estradiol, bisphenol A, and diethylstilbestrol, decrease cortactin expression in the mouse testis.2006

    • Author(s)
      Anahara R., et al.
    • Journal Title

      Arch.Histol.Cytol. 69(2)

      Pages: 101-107

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The involvement of immunoglobulin superfamily proteins in spermatogenesis and sperm-egg interaction.2006

    • Author(s)
      Toshimori K., et al.
    • Journal Title

      Repro.Med.Biol. 5

      Pages: 87-93

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Azoospermia in mice with targeted disruption of the BREK/Lmtk2 (brain-enriched kinase/lemur tyrosine Kinase 2) gene.2006

    • Author(s)
      Kawa S., et al.
    • Journal Title

      PNAS 103(51)

      Pages: 19344-19349

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Oligo-astheno-teratozoospermia in mice lacking RA175/TSLCl/SynCAM/IGSF4A, a cell adhesion molecule in the immunoglobulin superfamily.2006

    • Author(s)
      Fujita E., et al.
    • Journal Title

      Mol. Cell. Biol. 26(2)

      Pages: 718-726

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Flutamide depresses expression of cortactin in the ectoplasmic specialization between the Sertoli cells and spermatids inthe mouse testis.2006

    • Author(s)
      Anahara R., et al.
    • Journal Title

      Food Chem. Toxicol. 44

      Pages: 1050-1056

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Estrogen agonists. 17 β-estradiol, bisphenol A, and diethylstilbestrol, decrease cortactin expression in the mouse testis.2006

    • Author(s)
      Anahara R., et al.
    • Journal Title

      Arch. Histol. Cytol. 69(2)

      Pages: 101-107

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression and distribution of OCTN2 in mouse epididymis and its association with obstructive azoospermia in juvenile visceral steatosis mice.2006

    • Author(s)
      Yakushiji K., Kai S., Yamauchi M., Ito C., Kuwajima M., Osada Y., Toshimori K.
    • Journal Title

      International J Urology (In press)

    • NAID

      10017474986

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The involvement of immunoglobulin superfamily proteins in spermatogenesis and sperm-egg interaction.2006

    • Author(s)
      Toshimori K., Maekawa M., Ito C., Toyama Y., Suzuki-Toyota F., Saxena D.K
    • Journal Title

      Reproductive Medicine and Biology (In press)

    • NAID

      10018141925

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Oligo-astheno-teratozoospermia in mice lacking RA175/TSLC1/SynCAM, cell adhesion molecule in the immunoglobulin superfamily.2006

    • Author(s)
      Fujita E, Kouroku Y., Tanabe Y., Toyama, Y., Maekawa M., Kojima N., Senoo H., Toshimori K., Momoi T.
    • Journal Title

      Mol Cell Biol 26(2)

      Pages: 718-726

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Expression of novel organic cation/carnitine transporter (OCTN2) in the mouse pancreas.2005

    • Author(s)
      Kai S., et al.
    • Journal Title

      Tissue. Cell. 37(4)

      Pages: 309-315

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Molecular cloning of rat spetex-2 family gene mapped on chromosome 15p16 encoding a23-kilodalton protein associated with the plasma membranes of haploid spermatids.2005

    • Author(s)
      Iwamoto Y., et al.
    • Journal Title

      Biol. Reprod. 72(2)

      Pages: 284-292

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Functional characterization of a conditionally immortalized mouse epididymis caput epithelial cell line MEPC5 using temperature-sensitive simian virus 40 large T-antigen.2005

    • Author(s)
      Tabuchi Y., et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 329(3)

      Pages: 812-823

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Mouse Polycomb M33 is required for splenic vascular and adrenal gland formation through regulating Ad4BP/SF1 expression.2005

    • Author(s)
      Katoh-Fukui Y., et al.
    • Journal Title

      Blood 106(5)

      Pages: 1612-1620

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] HANP1/H1T2, a novel histone H1-like protein involved in nuclear formation and sperm fertility.2005

    • Author(s)
      Tanaka H., et al.
    • Journal Title

      Mol. Cell. Biol. 25(16)

      Pages: 7107-7119

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Molecular cloning of rat spetex-2 family gene mapped on chromosome 15p16 encoding a 23-kilodalton protein associated with the plasma membranes of haploid spermatids.2005

    • Author(s)
      Iwamoto Y., et al.
    • Journal Title

      Biol.Reprod. 72(2)

      Pages: 284-292

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Functional characterization of a conditionally immortalized mouse epididymis caput epithelial cell line MEPC5 using temperature-sensitive simian virus 40 large T-antigen.2005

    • Author(s)
      Tabuchi Y., et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 329(3)

      Pages: 812-823

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Mouse Polycomb M33 is required for splenic vascular and adrenal gland formation through regulating Ad4BP/SF1 expression.2005

    • Author(s)
      Katoh-Fukui Y., et al.
    • Journal Title

      Blood. 106(5)

      Pages: 1612-1620

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] HANP1/H1T2, a novel histoneMol. H1-like protein involved in nuclear formation and sperm fertility.2005

    • Author(s)
      Tanaka H., et al.
    • Journal Title

      Cell.Bio. 25(16)

      Pages: 7107-7119

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Expression of novel organic cation/carnitine transporter (OCTN2) in the mouse pancreas.2005

    • Author(s)
      Kai S., Yakushiji K., Yamauchi M., Ito, C., Kuwajima M., Osada Y., Toshimori K.
    • Journal Title

      Tissue Cell 37

      Pages: 309-315

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Establishment and functional characterization of a conditionally immortalized mouse epididymis caput epithelial cell line MEPC5 with some epididymis cell-specific functions using temperature-sensitive simian virus 40 large T-antigen gene2005

    • Author(s)
      Tabuchi, Y., Toyama, Y., Toshimori, K., Komiyama, M., Mori C., Kondo T.
    • Journal Title

      BBRC 329

      Pages: 812-823

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Molecular cloning of rat spetex2 family genes mapped on chromosome 15p16, encoding a 23-kilodalton protein associated with the plasma membranes of haploid spermatids.2005

    • Author(s)
      Iwamoto Y, Kaneko T, Ichinose J, Mori T, Shibata Y, Toshimori K, Iida H.
    • Journal Title

      Biol Reprod 72(2)

      Pages: 284-292

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Molecular modifications of MC31/CE9, a sperm surface molecule, during sperm capacitation and the acrosome reaction in the rat.2004

    • Author(s)
      Saxena DK., et al.
    • Journal Title

      Biol. Reprod. 70

      Pages: 993-1000

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of flanking gene on the phenotypes of mice deficient in basigin/CD147.2004

    • Author(s)
      Chen S., et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 324

      Pages: 147-153

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Oligo-astheno-teratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta.2004

    • Author(s)
      Nakamura T., et al.
    • Journal Title

      Nature Genet. 36(5)

      Pages: 528-533

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Abnormal sperm morphology caused by defects in Sertoli cells of Cnot7 knockout mice.2004

    • Author(s)
      Ogawa T., et al.
    • Journal Title

      Arch. Histol. Cytol. 67(4)

      Pages: 307-314

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Stage-specific expression of mouse germ cells-less-1(mGCL-1), and multiple deformations during mgcl-1 deficient spermatogenesis leading to reduced fertility.2004

    • Author(s)
      Maekawa M., et al.
    • Journal Title

      Arch. Histol. Cytol. 67(4)

      Pages: 335-347

    • NAID

      10014259520

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Failure to assemble the peri-nuclear structure in GOPC deficient spermatids as found in round-headed spermatozoa.2004

    • Author(s)
      Ito C., et al.
    • Journal Title

      Arch. Histol. Cytol. 67(4)

      Pages: 349-360

    • NAID

      10014259556

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The coiled tail of the round-headed spermatozoa appears during epididymal passage in GOPC-deficient mice.2004

    • Author(s)
      Suzuki-Toyota F., et al.
    • Journal Title

      Arch. Histol. Cytol. 67(4)

      Pages: 361-371

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Adverse effects of bisphenol A to adult mice and rats.2004

    • Author(s)
      Toyama Y., et al.
    • Journal Title

      Arch. Histol. Cytol. 67(4)

      Pages: 373-381

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Hybrid breakdown caused by substitution of the X chromosome between two mouse subspecies.2004

    • Author(s)
      Oka A., et al.
    • Journal Title

      Genetics 166

      Pages: 913-924

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Impairment of spermatogenesis leading to infertility.2004

    • Author(s)
      Toshimori K., et al.
    • Journal Title

      Anat. Sci. Int.(総説) 79

      Pages: 101-111

    • NAID

      10014025318

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Molecular modifications of MC31/CE9, a sperm surface molecule, during sperm capacitation and the acrosome reaction in the rat.2004

    • Author(s)
      Saxena DK., et al.
    • Journal Title

      Biol.Reprod. 70

      Pages: 993-1000

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of flanking gene on the phenotypes of mice deficient in basigin/CD147.2004

    • Author(s)
      Chen S., et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 324

      Pages: 147-153

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Abnormal sperm morphology caused by defects in Sertoli cells of Cnot7 knockout mice.2004

    • Author(s)
      Ogawa T., et al.
    • Journal Title

      Arch.Histol.Cytol. 67(4)

      Pages: 307-314

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Stage-specific expression of mouse germ cells-less-1(mGCL-1), and multiple deformations during mgcl-1 deficient spermatogenesis leading to reduced fertility.2004

    • Author(s)
      Maekawa M., et al.
    • Journal Title

      Arch.Histol.Cytol. 67(4)

      Pages: 335-347

    • NAID

      10014259520

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Failure to assemble the peri-nuclear structure in GOPC deficient spermatids as found in round-headed spermatozoa.2004

    • Author(s)
      Ito C., et al.
    • Journal Title

      Arch.Histol.Cytol. 67(4)

      Pages: 349-360

    • NAID

      10014259556

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The coiled tail of the round-headed spermatozoa appears during epididymal passage in GOPC-deficient mice.2004

    • Author(s)
      Suzuki-Toyota F., et al.
    • Journal Title

      Arch.Histol.Cytol. 67(4)

      Pages: 361-371

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Adverse effects of bisphenol A to adult mice and rats.2004

    • Author(s)
      Toyama Y., et al.
    • Journal Title

      Arch.Histol.Cytol. 67(4)

      Pages: 373-381

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Expression of novel organic cation/carnitine transporter (OCTN2) in the mouse pancreas.2004

    • Author(s)
      Kai S., et al.
    • Journal Title

      Tissue.Cell. 37(4)

      Pages: 309-315

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Impairment of spermatogenesis leading to infertility.2004

    • Author(s)
      Toshimori K., et al.
    • Journal Title

      Anat.Sci.Int. 79

      Pages: 101-111

    • NAID

      10014025318

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Molecular modifications of MC31/CE9,a sperm surface molecule, during sperm capacitation and the acrosome reaction in the rat : Is MC31/CE9 required for fertilization?2004

    • Author(s)
      Saxena DK., Toshimori K.
    • Journal Title

      Biol.Reprod. 70

      Pages: 993-1000

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Hybrid breakdown caused by substitution of the x chromosome between two mouse subspecies.2004

    • Author(s)
      Toshimori K, Ito C, Maekawa M, Toyama Y, Suzuki-Toyota F, Saxena D.K.
    • Journal Title

      Anat Sci Int. 166

      Pages: 913-924

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Oligo-astheno-teratozoospermia in mice lacking Cnot7,a regulator of retinoid X receptor beta2004

    • Author(s)
      Nakamura T, Yao R, Ogawa T, Suzuki T, Ito C, Tsunekawa N, Inoue K, Ajima R, Miyasaka T, Yoshida Y, Ogura A, Toshimori K, Noce T, Yamamoto T, Noda T.
    • Journal Title

      Nature Genetics 36

      Pages: 528-533

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Stage-specific expression of mouse germ cell-less-1 (mGCL-1) and multiple deformation during mgcl-1 deficient spermatogenesis leading to reduced fertility.2004

    • Author(s)
      Maekawa M, Ito C, Toyama Y, Suzuki-Toyota F, Kimura T, Nakano T, Toshimori K
    • Journal Title

      Arch Histol Cytol 67

      Pages: 335-347

    • NAID

      10014259520

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Failure to assemble the peri-nuclear structures in GOPC deficient spermatids as found in round-headed spermatozoa2004

    • Author(s)
      Ito C., Suzuki-Toyota F., Maekawa M., Toyama Y., Yao R., Noda T., Toshimori K.
    • Journal Title

      Arch Histol Cytol 67

      Pages: 349-360

    • NAID

      10014259556

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Coiled tail of the round-headed spermatozoa appears during epididymal passage in the GOPC-deficient mice.2004

    • Author(s)
      Suzuki-Toyota F, Ito C, Toyama Y, Maekawa N, Yao R, Noda T, Toshimori K.
    • Journal Title

      Arch Histol Cytol 67

      Pages: 361-371

    • NAID

      10014259591

    • Related Report
      2004 Annual Research Report
  • [Book] 受精と精子成熟 産婦人科の世界2005

    • Author(s)
      年森 清隆
    • Publisher
      医学の世界社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 生命の誕生に向けて 生殖補助医療(ART)胚培養の理論と実際 第5章 受精の形態学2005

    • Author(s)
      年森 清隆
    • Publisher
      近代出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] Fertilization and sperm maturation. The world of obstetrics & gynecology.2005

    • Author(s)
      Toshimori K.
    • Publisher
      Igakunosekaisha
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] For birth of life. Assisted reproductive technology(ART). Theory and practice of embryo culture. Chapter 5 Morphology of fertilization.2005

    • Author(s)
      Toshimori K.
    • Publisher
      Kindai Shuppan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 生命の誕生に向けて-生殖補助医療(ART)胚培養の理論と実際2005

    • Author(s)
      年森 清隆
    • Total Pages
      273
    • Publisher
      近代出版
    • Related Report
      2005 Annual Research Report

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Published: 2004-04-01   Modified: 2021-09-27  

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