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Analysis on the biological roles of STAT3 in cardiac protection, repair and regeneration

Research Project

Project/Area Number 16390065
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General pharmacology
Research InstitutionOsaka University

Principal Investigator

FUJIO Yasushi  Osaka University, Graduate School of Pharmacuetical Sciences, Associate Professor (20359839)

Co-Investigator(Kenkyū-buntansha) AZUMA Junichi  Osaka University, Graduate School of Phannacuetical Sciences, Professor (30144463)
Project Period (FY) 2004 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥13,240,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥540,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2006: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2005: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2004: ¥5,500,000 (Direct Cost: ¥5,500,000)
KeywordsSTAT3 / Interleukin / Signal transduction / Cardiovascular / Cytoprotection / Tissue repai / Regeneration / 組織幹細胞 / 血管内皮細胞 / 分化 / 血管新生 / 血管発生 / IL-11 / cadherin / Wnt / メタロチオネイン / 活性酸素 / 心筋
Research Abstract

Cardiac homeostasis is maintained by various kinds of neurohumoral factors. Among them, IL-6 family cytokines play important roles in cardiac protection. In response to pathological stresses, IL-6 family cytokines, such as leukemia inhibitory factor (LIF) and cardiotrophin-1 (CT1) are secreted from cardiac myocytes These cytokines activates three signaling pathways; PI3 kinase/Akt, ERKs, and STAT1/3. In this study, we focused on STAT3 pathway and investigated on its biological significances in cytoprotection, tissue repair and regeneration.
STAT3-mediated cytoprotection: We generated cardiac specific transgenic mice expressing constitutively-active STAT3 (CASTAT3-TG) and analyzed the effects of the overexpression of CASTAT3 on cardiac protection by exposure to ischemia/reperfusion (I/R) injury. CASTAT3-TG hearts exhibited the resistance to I/R injury with the reduction in reactive oxygen species (ROS) production. We also found that CASTAT3-TG hearts showed the upregulation of metallothi … More onein (MT). By using MT-null mice, we demonstrated that MT-dependent ROS scavenging is a critical event for STAT3-mediated cardioprotection.
Roles of STAT3 in cardiac repair : Wnt family proteins play important roles in tissue organization. In this project, we identified Wnt5a as a downstream target of STAT3. STAT3 activation induced Wnt5a, which promoted the expression of N-cadherin in cardiomyocytes. We also demonstrated that IL-6 family cytokines promoted cell-cell interaction via STAT3/Wnt5a/N-cadherin pathway. Since cell-cell interaction is important in the process of cardiac repair after injury, these findings propose the importance of STAT3-mediated induction of Wnt5a in cardiac repair.
Cardiac regeneration and STAT3: Recently cardiac stem cells have been identified as sources of cardiomyocytes. We examined the biological effects of LIF in cardiac stem cells. The stimulation of cardiac stem cells with LIF resulted in the activation of STAT3 and ERK1/2. LIF induced endothelial differentiation in cardiac stem cells, which was inhibited by the inhibition of STAT3 pathway. These findings suggest that LIF induces vasculogenesis in the tissue resident stem cells through STAT3.
The experimental results, described above, propose that STAT3 is a therapeutic target for the onset of heart failure. In this context, we examined the cardioprotective effects of IL-11, because IL-11, a member of IL-6 family, is clinically available with its safety guaranteed. As a result, we found that IL-11 activates STAT3 in cardiac myocytes and that the intravenous administration, prior to I/R injury, exhibited the reduced myocardial damages. Less

Report

(5 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (75 results)

All 2008 2007 2006 2005 2004 Other

All Journal Article (44 results) (of which Peer Reviewed: 14 results) Presentation (28 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 2 results)

  • [Journal Article] Identification of cardiac myocytes as targets of interleukin-11, acardioprotective cytokine. Cytokine 38, 107-1152007

    • Author(s)
      Kimura, R., et. al.
    • Journal Title

      Cytokine 38

      Pages: 107-115

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Gab family scaffolding adaptor proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/EBrbB signaling.2007

    • Author(s)
      Nakaoka, Y., et. al.
    • Journal Title

      J. Clin. Invest. 117

      Pages: 1771-1781

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Degradation of NFAT5, a transcriptional regulator of osmotic stress-related genes, is a critical event for doxorubicin-induced cytotoxicity in cardiac myocytes.2007

    • Author(s)
      Ito, T., et. al.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 1152-1160

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Identification of cardiac myocytes as targets of interleukin-11, a cardioprotective cytokine2007

    • Author(s)
      Kimura, R., Maeda, M., Arita, A., et. al.
    • Journal Title

      Cytokine 38

      Pages: 107-115

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Gab family scaffolding adaptor proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling2007

    • Author(s)
      Nakaoka, Y., Nishida, K., Narimatsu, M., et. al.
    • Journal Title

      J. Clin. Invest 117

      Pages: 1771-1781

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Degradation of NFAT5, a transcriptional regulator of osmotic stress-related genes, is a critical event for doxorubicin-induced cytotoxicity in cardiac myocytes2007

    • Author(s)
      Ito, T., Fujio, Y., Takahashi, K., et. al.
    • Journal Title

      J. Biol. Chem 282

      Pages: 1152-1160

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Identification of cardiac myocytes as targets of interleukin-11, a cardioprotectivecytokine2007

    • Author(s)
      Kimura, R., Maeda, M.
    • Journal Title

      Cytokine 38

      Pages: 107-115

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gab family scaffolding adaptor proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling.2007

    • Author(s)
      Nakaoka, Y., Nishida, K.
    • Journal Title

      J. Clin. Invest. 117

      Pages: 1771-1781

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carbacyclin induces carnitine palmitoyltransferase-1 in cardiomyocytes via peroxisome proliferator-activated receptor (PPAR) d independent of the IP receptor signaling pathway2007

    • Author(s)
      Kuroda, T., Masaki, M.
    • Journal Title

      J. Mol. Cell. Cardiol. 43

      Pages: 54-62

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Racl activity is required for cardiac myocyte alignment in response to mechanical stress2007

    • Author(s)
      Yamane, M.
    • Journal Title

      Biochem. Biophys. Res. Commun. 353

      Pages: 1023-1027

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Degradation of NFAT5, a transcriptional regulator of osmotic stress-related genes, is a critical event for doxorubicin-induced cytotoxicity in cardiac myocytes2007

    • Author(s)
      Ito, T.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 1152-1160

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Leukemia inhibitory factor induces endothelial differentiation in cardiacstem cells.2006

    • Author(s)
      Mohri, T., et. al.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 6442-6447

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] N-cadherin signals through Racl determined the localization of connexi 43 in cardiac myocytes. J. Mol. Cell. Cardiol. 40 495-5022006

    • Author(s)
      Matsuda, T., et. al.
    • Journal Title

      J. Mol. Cell. Cardiol. 40

      Pages: 495-502

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Leukemia inhibitory factor induces endothelial differentiation in cardiac stem cells2006

    • Author(s)
      Mohri, T., Fujio, Y, Maeda, M., et. al.
    • Journal Title

      J. Biol. Chem 281

      Pages: 6442-6447

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] N-cadherin signals through Racl determined the localization of connexin 43 in cardiac myocytes2006

    • Author(s)
      Matsuda, T., Fujio, Y, Nariai, T., et. al.
    • Journal Title

      J. Mol. Cell. Cardiol 40

      Pages: 495-502

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Antisense to cyclin Dl inhibits vascular endothelial growth factor-stimulated growth of vascular endothelial cells: Implication of tumor vascularization2006

    • Author(s)
      Yasui, M.
    • Journal Title

      Clin. Cancer Res. 12

      Pages: 4720-4729

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Leukemia inhibitory factor induces endothelial differentiation in cardiac stem cells2006

    • Author(s)
      Mohri, T.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 6442-6447

    • Related Report
      2006 Annual Research Report
  • [Journal Article] N-cadherin signals through Racl determined the localization of connexin 43 in cardiac myocytes2006

    • Author(s)
      Matsuda, T.
    • Journal Title

      J. Mol. Cell. Cardiol. 40

      Pages: 495-502

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Myogenic differentiation induces taurine transporter in association with taurine-mediated cytoprotection in skeletal muscles2006

    • Author(s)
      Uozumi, Y.
    • Journal Title

      Biochemical J. 394

      Pages: 699-706

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Myogenic differentiation induces taurine transporter in association with taurine-mediated cytoprotection in skeletal muscles2006

    • Author(s)
      Uozumi, Y.
    • Journal Title

      Biochem.J. 394

      Pages: 699-706

    • Related Report
      2005 Annual Research Report
  • [Journal Article] STAT3 mediates cardioprotection against ischemia/reperfusion injury through metallothionein induction in the heart.2005

    • Author(s)
      Oshima, Y., et. al.
    • Journal Title

      Cardiovasc. Res. 65

      Pages: 428-435

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: Inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells.2005

    • Author(s)
      Lin, Q., et. al.
    • Journal Title

      Am J. Pathol. 167

      Pages: 969-980

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] STAT3 mediates cardioprotection against ischemia/reperfusion injury through metallothionein induction in the heart2005

    • Author(s)
      Oshima, Y, Fujio, Y., Nakanishi, T., et. al.
    • Journal Title

      Cardiovasc. Res 65

      Pages: 428435-428435

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines : Inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells2005

    • Author(s)
      Lin, Q., Lai, R., Chirieac, L., R., et. al.
    • Journal Title

      Am J., Pathol 167

      Pages: 969-980

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] No positive association between adrenergic receptor variants of alpha2c Del 322-325, beta1Ser49, beta1Arg389 and the risk for heart failure in Japanese population.2005

    • Author(s)
      Nonen, S.
    • Journal Title

      Br.J.Clin.Pharmacol 60

      Pages: 414-417

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Platelet activating factor induces cytoskeletal reorganization through Rho family pathway in THP-1 macrophages2005

    • Author(s)
      Sumita, C.
    • Journal Title

      FEBS letters 579

      Pages: 4038-4042

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines : Inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells2005

    • Author(s)
      Lin, Q.
    • Journal Title

      Am J.Pathol. 167

      Pages: 969-980

    • Related Report
      2005 Annual Research Report
  • [Journal Article] STAT3 mediates cardioprotection against ischemia/reperfusion injury through metallothionein induction in the heart.2005

    • Author(s)
      Oshima, Y., et al.
    • Journal Title

      Cardiovasc.Res. 65

      Pages: 428-435

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes2004

    • Author(s)
      Fujio, Y., et. al.
    • Journal Title

      FEBS letters 573

      Pages: 202-206

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Circulating interleukin-6 family cytokines and their receptors in patients with congestive heart failure.2004

    • Author(s)
      Hirota, H., et. al.
    • Journal Title

      Heart Vessels 19

      Pages: 237-241

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Signal transducer and activator of transcription-3 activation contributes to high tissue inhibitor of metalloproteinase-1 expression in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma.2004

    • Author(s)
      Lai, R., et. al.
    • Journal Title

      Am. J. Pathol 164

      Pages: 2251-2258

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Leptin stimulates ischemia-induced retinal neovasculization: possiblerole of vascular endothelial growth factor expressed in retinalendothelial cells.2004

    • Author(s)
      Suganami, E., et. al.
    • Journal Title

      Diabetes 53

      Pages: 2443-2448

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes2004

    • Author(s)
      Fujio, Y., Matsuda, T., Oshima, Y., et. al.
    • Journal Title

      FEBS letters 573

      Pages: 202-206

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Circulating interleukin-6 family cytokines and their receptors in patients with congestive heart failure2004

    • Author(s)
      Hirota, H., Izumi, M., Hamaguchi, T., et. al.
    • Journal Title

      Heart Vessels 19

      Pages: 237-241

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Signal transducer and activator of transcription-3 activation contributes to high tissue inhibitor of metalloproteinase-1 expression in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma2004

    • Author(s)
      Lai, R., Rassidakis, G., Z., Medeiros, L., J., et. al.
    • Journal Title

      Am. J. Pathol 164

      Pages: 2251-2258

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Leptin stimulates ischemia-induced retinal neovasculization : possible role of vascular endothelial growth factor expressed in retinal endothelial cells2004

    • Author(s)
      Suganami, E., Takagi, H., Ohashi, H., et. al.
    • Journal Title

      Diabetes 53

      Pages: 2443-2448

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes2004

    • Author(s)
      Fujio, Y., et al.
    • Journal Title

      FEBS letters 573

      Pages: 202-206

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Circulating interleukin-6 family cytokines and their receptors in patients with congestive heart failure.2004

    • Author(s)
      Hirota, H., et al.
    • Journal Title

      Heart Vessels 19

      Pages: 237-241

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Leptin stimulates ischemia-induced retinal neovasculation : possible role of vascular endothelial growth factor expressed in retinal endothelial cells2004

    • Author(s)
      Suganami, E., et al.
    • Journal Title

      Diabetes 53

      Pages: 2443-2448

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The expression of taurine transporter is regulated through TonE/TonEBP pathway and contributes to cytoprotection in HepG2 cells2004

    • Author(s)
      Ito, T., et al.
    • Journal Title

      Biochem.J. 382

      Pages: 177-182

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Selective inhibition of STAT3 induces apoptosis and G1 cell cycle arrest in ALK-positive anaplastic large cell lymphoma2004

    • Author(s)
      Amin, H.
    • Journal Title

      Oncogene 23

      Pages: 5426-5434

    • Related Report
      2004 Annual Research Report
  • [Journal Article] CYP2A6 polymorphisms are associated with nicotine dependence and influence withdrawal symptoms in smoking cessation

    • Author(s)
      Kubota, T.
    • Journal Title

      Pharmacogenomics J. (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] N-cadherin signals through Rac1 determined the localization of connexin 43 in cardiac myocytes.

    • Author(s)
      Matsuda, T.
    • Journal Title

      J.Mol.Cell.Cardiol. (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Leukemia inhibitory factor induces endothelial differentiation in cardiac stem cells

    • Author(s)
      Mohri, T.
    • Journal Title

      J.Biol.Chem. (In press)

    • Related Report
      2005 Annual Research Report
  • [Presentation] Gp130シグナル経路の活性化は心筋組織幹細胞の内皮細胞への分化を誘導する.2008

    • Author(s)
      毛利友美, ら
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 骨格筋組織幹細胞の血管内皮細胞への分化はLeukemia inhibitory factor(LIF)により誘導される.2008

    • Author(s)
      岩倉智彦, ら
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Interleukin(IL)-11は血管新生作用、抗炎症効果を有し、心筋梗塞後心筋リモデリングを抑制する.2008

    • Author(s)
      尾花理徳, ら
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Interleukin-11 Prevents Cardiac Remodeling after Myocardial Infarction with Neovascularization in Murine Model2007

    • Author(s)
      Obana, M., Maeda, M.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2007-11-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] Signals Through Glycoprotein 130 Promote the Endothelial Differentiation of Cardiac Sca-1+Cells2007

    • Author(s)
      Mohri, T., Fujio, Y.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2007-11-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] 血小板減少症治療薬インターロイキン(IL)-11を用いた心不全に対するサイトカイン療法I -急性モデルを用いた検討-2007

    • Author(s)
      前田真貴子, ら
    • Organizer
      第28回日本臨床薬理学会年会
    • Place of Presentation
      宇都宮
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 血小板減少症治療薬インターロイキン(IL)-11を用いた心不全に対するサイトカイン療法II -慢性モデルを用いた検討-2007

    • Author(s)
      藤尾 慈, ら
    • Organizer
      第28回日本臨床薬理学会年会
    • Place of Presentation
      宇都宮
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Signals Through Glycoprotein 130 Promote the Endothelial Differentiation of Cardiac Sca-1+Cells.2007

    • Author(s)
      Tomomi Mohri, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, Florida, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Interleukin-11 Prevents Cardiac Remodeling after Myocardial Infarction with Neovascularization in Murine Model.2007

    • Author(s)
      Masanori Obana, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, Florida, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 【シンポジウム】"新しい心不全評価法:心臓超音波検査・核医学検査・バイオマーカーを中心として"Cytokine Signaling and its Clinical Implications in Heart Failure.2007

    • Author(s)
      藤尾慈, 東純一
    • Organizer
      第11回日本心不全学会学術集会
    • Place of Presentation
      千葉県浦安
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 血小板減少症治療薬インターロイキン11の心不全発症予防薬としての可能性と研究意義.2007

    • Author(s)
      前田真貴子, ら
    • Organizer
      医療薬学フォーラム2007/第15回クリニカルファーマシーシンポジウム
    • Place of Presentation
      山形
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Signals Through Glycoprotein 130 Promote the Endothelial Differentiation of Cardiac Sca-1+ Cells2007

    • Author(s)
      Tomomi, Mohri, Yasushi, Fujio, Tomohiko, Iwakura, et. al.
    • Organizer
      The American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, Florida, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Interleukin-11 Prevents Cardiac Remodeling after Myocardial Infarction with Neovascularization in Murine Model2007

    • Author(s)
      Masanori, Obana, Makiko, Maeda, Yasuhiro, Yamamoto, et. al.
    • Organizer
      The American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, Florida, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Atrogin-1 Ubiquitin Ligase is Upregulated by Doxorubicin, Leading to Muscle Atrophy in Cardiac Myocytes.2006

    • Author(s)
      Yasushi Fujio, et. al.
    • Organizer
      The American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, Illinois, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Interleukin(IL)-11 Prevents Ischemia/Reperfusion Injury in Hearts as a Novel Cardioprotective Cytokine.2006

    • Author(s)
      Makiko Maeda, et. al.
    • Organizer
      The American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, Illinois, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cardiac Sca-1+Cells were Differentiated into Endothelial Cells by Leukemia Inhibitory Factor, a Paracrine Cytokine.2006

    • Author(s)
      Tomomi Mohri, et. al.
    • Organizer
      The American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, Illinois, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Degradation of transcription factor NFAT5 is induced by doxorubicin exposure in cultured cardiomyocytes.2006

    • Author(s)
      Takashi Ito, et. al.
    • Organizer
      The 15th World Congress of Pharmacology IUPHAR 2006
    • Place of Presentation
      Beijing, China
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Leukemia inhibitory factor induces endothelial differentiation in cardiac Sca-1+stem cells.2006

    • Author(s)
      Mohri T., et. al.
    • Organizer
      The 15th World Congress of Pharmacology IUPHAR 2006
    • Place of Presentation
      Beijing, China
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DoxorubicinによるNFAT5の分解が心筋細胞における細胞毒性に関与する.2006

    • Author(s)
      伊藤崇志, ら
    • Organizer
      第79回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 高ホモシステイン血症は糖尿病ラット網膜において炎症性サイトカインの発現を増強する.2006

    • Author(s)
      前田真貴子, ら
    • Organizer
      第79回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DoxorubicinはFOXOを介してユビキチンライゲースであるatrogin-1の発現を誘導する.2006

    • Author(s)
      星野有紀, ら
    • Organizer
      第79回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Leukemia inhibitory factor(LIF)は心筋組織幹細胞の血管内皮細胞分化を誘導する.2006

    • Author(s)
      毛利友美, ら
    • Organizer
      第79回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Atrogin-1 Ubiquitin Ligase is Upregulated by Doxorubicin, Leading to Muscle Atrophy in Cardiac Myocytes2006

    • Author(s)
      Yasushi, Fujio, Yuki, Hoshino-Nariai, Yasuhiro, Yamamoto, et. al.
    • Organizer
      The American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, Illinois, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Interleukin(IL)-11 Prevents Ischemia/Reperfusion Injury in Hearts as a Novel Cardioprotective Cytokine2006

    • Author(s)
      Makiko, Maeda, Yasushi, Fujio, Ryusuke, Kimura, et. al.
    • Organizer
      The American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, Illinois, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cardiac Sca-1+ Cells were Differentiated into Endothelial Cells by Leukemia Inhibitory Factor, a Paracrine Cytokine2006

    • Author(s)
      Tomomi, Mohri, Yasushi, Fujio, Makiko, Maeda, et. al.
    • Organizer
      The American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, Illinois, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Degradation of transcription factor NFAT5 is induced by doxombicin exposure in cultured cardiomyocytes2006

    • Author(s)
      Takashi, Ito, Yoriko, Uozumi, Makiko, Maeda, et. al.
    • Organizer
      The 15th World Congress of Pharmacology IUPHAR 2006
    • Place of Presentation
      Beijing, China
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Leukemia inhibitory factor induces endothelial differentiation in cardiac Sca-1+ stem cells2006

    • Author(s)
      Mohri, T, Fujio, Y, Maeda, M, et. al.
    • Organizer
      The 15th World Congress of Pharmacology IUPHAR 2006
    • Place of Presentation
      Beijing, China
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Transcription factor NFAT5 is necessary for regulation of taurine transporter and cell survival in cardiomyocytes.2005

    • Author(s)
      Takashi Ito, et. al.
    • Organizer
      第9回日本心不全学会学術集会
    • Place of Presentation
      下関
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Remarks]

    • URL

      http://www.phs.osaka-u.ac.jp/homepage/b014/

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] インターロイキン11の心疾患治療薬としての利用2007

    • Inventor(s)
      東 純一、藤尾 慈、木村 竜介、前田真貴子、有田惇之、尾花理徳、伊藤崇志、福田剛史
    • Industrial Property Rights Holder
      新産業創造研究機構、大阪大学
    • Filing Date
      2007-10-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Overseas
  • [Patent(Industrial Property Rights)] インターロイキン11の心疾患治療薬としての利用2007

    • Inventor(s)
      東純一、藤尾慈, 他6名
    • Industrial Property Rights Holder
      大阪大学
    • Filing Date
      2007-10-24
    • Related Report
      2007 Annual Research Report
    • Overseas

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Published: 2004-04-01   Modified: 2016-04-21  

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