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Elucidation of C-reactive proteins in atherosclerosis

Research Project

Project/Area Number 16390089
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionUniversity of Yamanashi (2006)
University of Tsukuba (2004-2005)

Principal Investigator

FAN Jianglin  University of Yamanashi, Interdisciplinary Graduate School of Medicine and Engineering, Professor, 医学工学総合研究部, 教授 (60272192)

Co-Investigator(Kenkyū-buntansha) SUGIYAMA Fumihiro  University of Tsukuba, Graduate School of Comprehensive Human Sciences, Associate Professor, 大学院人間総合科学研究所, 助教授 (90226481)
YAMADA Nobuhiro  University of Tsukuba, Graduate School of Comprehensive Human Sciences, Professor, 大学院人間総合科学研究所, 教授 (40200729)
WATANABE Teruo  Saga University, Honorary Professor, 名誉教授 (40037396)
MORIMOTO Masatoshi  Saga University, Analytic Research Center of Experimental Sciences, Associate Professor, 総合分析実験センター・生物資源開発部門, 助教授 (90136482)
孫 慧君  筑波大学, 大学院・人間総合科学研究科, 助手 (00361329)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥14,400,000 (Direct Cost: ¥14,400,000)
Fiscal Year 2006: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2005: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 2004: ¥6,400,000 (Direct Cost: ¥6,400,000)
KeywordsTransgenic rabbits / CRP / Atherosclerosis / Hypercholesterolemia / Macrophages / Plaque / Animal model / Inflammation / C-反応蛋白 / 遺伝子改変 / 動物モデル / 脂質代謝 / 遺伝子導入 / CRP
Research Abstract

In this project, we have performed two studies in order to elucidate the functional roles of CRP in atherosclerosis. In the initial study, we used both human and rabbit specimens in attempt to clarify (1) whether CRP is present in the lesions, (2) if so, where CRP is deposited, (3) whether vascular cells especially macrophages can synthesize CRP. Our study showed that CRP is ubiquitously present in the lesions regardless of the lesion stage. CRP is closely associated with apoB but not macrophages. Using both Northern blotting and real-time RT-PCR, we demonstrated that CRP mRNA is basically expressed in the liver but rarely, if any, by macrophages. We also demonstrated that in hypercholesterolemic rabbits, the aortic lesion size is positively correlated with the levels of plasma CRP. In order to demonstrate whether CRP is directly involved in the lesion formation, we also generate transgenic rabbits expressing human CRP in the liver. For this study, we used a liver-specific expression construct along with insulators and established three independent lines of CRP transgenic rabbits. Now, we are using these CRP transgenic rabbits to perform atherosclerosis study. We also obtained CRP inhibitors from ISIS company and hope to investigate whether inhibition of CRP can prevent atherosclerosis.

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (48 results)

All 2007 2006 2005 2004

All Journal Article (47 results) Book (1 results)

  • [Journal Article] Increased expression of VEGF in kidney leads to progressive impairment of gomerular functions in transgenic rabbits.2007

    • Author(s)
      Liu, E., Morimoto, M., Kitajima, S., Yu, Y., Koike, T., Shiiki, H., Nagata, M., Watanabe, T., Fan, J.
    • Journal Title

      J Am Soc Nephrol (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Lp(a) enhances coronary atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits.2007

    • Author(s)
      Kitajima, S., Jin, Y., Koike, T., Yu, Y., Liu, E., Shiomi, M., Marcovina, SM., Morimoto, M., Watanabe, T., Fan, J.
    • Journal Title

      Atherosclerosis (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Increased expression of VEGF in kidney leads to progressive impairment of glomerular functions2007

    • Author(s)
      Liu E, Morimoto M, Kitajima S, Yu Y, Koike T, Shiiki H, Nagata M, Watanabe T, Fan J
    • Journal Title

      J Am Soc Nephrol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Lp(a) enhances coronary atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits2007

    • Author(s)
      Kitajima S, Jin Y, Koike T, Yu Y, Liu E, Morimoto M, Shiomi M, Marcovina S, Watanabe N, Fan J
    • Journal Title

      Atherosclerosis (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Increased expression of VEGF in kidney leads to progressive impairment of glomerular functions in transgenic rabbits.2007

    • Author(s)
      Liu, E., Morimoto, M., Kitajima, S., Yu, Y., Koike, T., Shiiki, H., Nagata, M., Watanabe, T., Fan, J.
    • Journal Title

      J Am Soc Nephrol In press

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Lp(a) enhances coronary atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits.2007

    • Author(s)
      Kitajima, S., Jin, Y., Koiki, T., Yu, Y., Liu, E., Shiomi, M., Marcovina, SM., Morimoto, M., Watanabe, T., Fan, J.
    • Journal Title

      Atherosclerosis In press

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Source(s) of CRP in atherosclerotic lesions.2006

    • Author(s)
      Fan, J., Chen, YE.
    • Journal Title

      Am J Pathol. 168

      Pages: 1054-1056

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Macrophage Metalloelastase accelerates the progression of atherosclerosis in transgenic rabbits.2006

    • Author(s)
      Liang, J., Liu, E., Yu, Y., Kitajima, S., Koike, T., Jin, Y., Morimoto, M., Hatakeyama, K., Asada, Y., Watanabe, T., Sasaguri, Y., Watanabe, S., Fan, J.
    • Journal Title

      Circulation 113

      Pages: 1993-2001

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Source(s) of CRP in atherosclerotic lesions2006

    • Author(s)
      Fan J, Chen YE
    • Journal Title

      Am J Pathol 168

      Pages: 1054-1056

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Macrophage elastase (MMP-12) accelerates the progression of atherosclerosis in transgenic rabbits2006

    • Author(s)
      Liang J, Liu E, Koike T, Yu Y, Kitajima Yingji J, Morimoto M, Watanabe T, Sasaguri Y, Watanabe S, Fan J 5, Yingji J, Morimoto M, Watanabe T, Sasaguri Y, Watanabe S, Fan J
    • Journal Title

      Circulation 113

      Pages: 1993-2001

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Macrophage Metalloelastase accelerates the progression of atherosclerosis in transgenic rabbits.2006

    • Author(s)
      Liang, J., Liu, E., Yu, Y., Kitajima, S., Koike, T., Jin, Y., Morimoto, M., Hatakeyama, K., Asada, Y., Watanabe, T., Sasaguri, Y., Watanabe, S., Fan, J.
    • Journal Title

      Circulation. 113

      Pages: 1993-2001

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Source(s) of CRP in atherosclerotic lesions.2006

    • Author(s)
      Fan, J, Chen, YE.
    • Journal Title

      Am J Pathol. 168

      Pages: 1054-1056

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Macrophage elastase (MMP-12) accelerates the progression of atherosclerosis in transgenic rabbits.2006

    • Author(s)
      Liang J, Liu E, Koike T, Yu Y, Kitajima S, Yingji J, Morimoto M, Watanabe T, Sasaguri Y, Watanabe S, Fan J.
    • Journal Title

      Circulation. (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] C-Reactive Procein in Atherosclerotic Lesions its Origin and Pathophysiologieal Significance.2005

    • Author(s)
      Sun, H., Koike, T., Ichikawa, T., Hatakeyama, K., Shiomi, M., Zhang, B., Kitajima, S., Morimoto, M., Watanabe, T., Asada, Y., Chen, YE., Fan, J.
    • Journal Title

      Am J Pathol 167

      Pages: 1139-1148

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Enhanced aortic atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits expressing lipoprotein lipase.2005

    • Author(s)
      Koike, T., Liang, J., Wang, X., Ichikawa, T., Shiomi, M., Sun, H., Watanabe, T., Liu, G., Fan, J.
    • Journal Title

      Cardiovascular Research 65

      Pages: 524-534

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Macrophage-derived lipoprotein lipase increases aortic atherosclerosis in cholesterol-fed Tg rabbits.2005

    • Author(s)
      Ichikawa, T., Liang, J., Kitajima, S., Koike, T., Wang, X., Sun, H., Morimoto, M., Shikama, H., Watanabe, T., Yamada, N., Fan, J.
    • Journal Title

      Atherosclerosis 179

      Pages: 87-95

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] High lipoprotein lipase activity increases insulin sensitivity in transgenic rabbits.2005

    • Author(s)
      Liu, E., Kitajima, S., Higaki, Y., Morimoto, M., Sun, H., Watanabe, T., Yamada, N., Fan, J.
    • Journal Title

      Metabolism Clinical and Experimental 54

      Pages: 132-138

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Transgenic rabbits with increased VEGF expression develop hemangiomas in the liver : a new model for Kasabach-Merritt syndrome.2005

    • Author(s)
      Kitajima, Shuji., Liu, E., Morimoto, M., Koike, T., Yu, Y., Watanabe, T., Imagawa, S., Fan, J.
    • Journal Title

      Laboratory Investigation 85

      Pages: 1517-1527

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Establishment of a SPF Colony of Human Apo(a) Transgenic Rabbits by Frozen-Thawed Embryo Transfer2005

    • Author(s)
      Watanabe, N., Nakagawa, H., Kitajima, S., Liu, E., Morimoto, M., Watanabe, T., Fan, J.
    • Journal Title

      Exp. Anim. 54・4

      Pages: 353-357

    • NAID

      10016627654

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] C-reactive protein in atherosclerotic lesions : its origin and pathophysiological significance2005

    • Author(s)
      Sun H, Koike T, Ichikawa T, Hatakeyama K, Shiomi M, Zhang B, Kitajima S, Morimoto M, Watanabe T, Asada Y, Chen YE, Fan J
    • Journal Title

      Am J Pathol 167

      Pages: 1139-1148

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Transgenic rabbits with increased VEGF expression develop hemangiomas in the liver : a new model for Kasabach-Merritt syndrome2005

    • Author(s)
      Kitajima S, Liu E, Morimoto M, Koike T, Yu Y, Watanabe T, Imagawa S, Fan J
    • Journal Title

      Lab Invest 85

      Pages: 1517-1527

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Establishment of a SPF colony of human apo(a) transgenic rabbits by frozen-thawed embryo transfer2005

    • Author(s)
      Watanabe N, Nakagawa H, Kitajima S, Liu E, Morimoto M, Watanabe T, Fan J
    • Journal Title

      Exp Anim 54

      Pages: 353-357

    • NAID

      10016627654

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Macrophage-derived lipoprotein lipase increases aortic atherosclerosis in cholesterol-fed transgenic rabbits2005

    • Author(s)
      Ichikawa T, Liang J, Kitajima S, Koike T, Wang X, Sun H, Morimoto M, Shikama H, Watanabe T, Yamada N, Fan J
    • Journal Title

      Atherosclerosis 179

      Pages: 87-95

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] High lipoprotein lipase increases insulin sensitivity in transgenic rabbits2005

    • Author(s)
      Liu E, Kitajima S, Morimoto M, Sun H, Watanabe T, Yamada N, Fan J
    • Journal Title

      Metabolism 54

      Pages: 132-138

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Enhanced atherosclerosis in WHHL transgenic rabbits expressing lipoprotein lipase2005

    • Author(s)
      Koike T, Liang J, Shiomi M, Ichikawa T, Wang X, Sun H, Shikama H, Watanabe T, Liu G, Fan J
    • Journal Title

      Cardiovasc Res 65

      Pages: 524-534

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] C-reactive protein in atherosclerotic lesions : its origin and pathophysiological significance.2005

    • Author(s)
      Sun H, Koike T, Ichikawa T, Hatakeyama K, Shiomi M, Zhang B, Kitajima S, Morimoto M, Whtanabe T, Asada Y, Chen YE, Fan J.
    • Journal Title

      Am J Pathol. 167

      Pages: 1139-1148

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Transgenic rabbits with increased VEGF expression develop hemangiomas in the liver : a new model for Kasabach-Merritt syndrome.2005

    • Author(s)
      Kitajima S, Liu E, Morimoto M, Koike T, Yu Y, Watanabe T, Imagawa S, Fan J.
    • Journal Title

      Lab Invest 85

      Pages: 1517-1527

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Macrophage-derived lipoprotein lipase increases aortic atherosclerosis in cholesterol-fed transgenic rabbits.2005

    • Author(s)
      Ichikawa T, Liang J, Kitajima S, Koike T, Wang X, Sun H, Morimoto M, Shikama H, Watanabe T, Yamada N, Fan J.
    • Journal Title

      Atherosclerosis. 179

      Pages: 87-95

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Enhanced atherosclerosis in WHHL transgenic rabbits expressing lipoprotein lipase.2005

    • Author(s)
      Koike T, Liang J, Shiomi M, Ichikawa T, Wang X, Sun H, Shikama H, Watanabe T, Liu G, Fan J.
    • Journal Title

      Cardiovasc Res. 65

      Pages: 524-534

    • Related Report
      2005 Annual Research Report
  • [Journal Article] C-reactive protein in atherosclerotic lesions : its origin and pathophysiological significance.2005

    • Author(s)
      Sun H, et al. (Last)
    • Journal Title

      Am J Pathol (In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Macrophage-derived lipoprotein lipase increases aortic atherosclerosis in cholesterol-fed transgenic rabbits.2005

    • Author(s)
      Ichikawa T, et al. (Last)
    • Journal Title

      Atherosclerosis 179

      Pages: 87-95

    • Related Report
      2004 Annual Research Report
  • [Journal Article] High lipoprotein lipase increases insulin sensitivity in transgenic rabbits.2005

    • Author(s)
      Liu E, et al. (Last)
    • Journal Title

      Metabolism 54

      Pages: 132-138

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Enhanced atherosclerosis in WHHL transgenic rabbits expressing lipoprotein lipase.2005

    • Author(s)
      Koike T, et al. (Last)
    • Journal Title

      Cardiovascular Res 65

      Pages: 524-534

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Association of Increased Expression of Macrophage Elastase (Matrix Metalloproteinase 12) With Rheumatoid Arthritis.2004

    • Author(s)
      Liu, M., Sun, H., Wang, X., Koike, T., Mishima, H., Ikeda, K., Watanabe, T., Ochiai, N., Fan, J.
    • Journal Title

      Arthritis & Rheumatism 50・10

      Pages: 3112-3117

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Overexpression of Human Matrix Metalloproteinase-12 Enhances the Development of Inflammatory Arthritis in Transgenic Rabbits.2004

    • Author(s)
      Wang, X., Liang, J., Koike, T., Sun, H., Ichikawa, T., Kitajima, S., Morimoto, M., Shikama, H., Watanabe, T., Sasaguri, Y., Fan, J.
    • Journal Title

      Am J Pathol 165

      Pages: 1375-1383

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Overexpression of lipoprotein lipase in transgenic rabbits leads to increased small dense LDL in plasma and promotes atherosclerosis.2004

    • Author(s)
      Ichikawa, T., Kitajima, S., Liang, J., Koike, T., Wang, X., Sun, H., Okazaki, M., Morimoto, M., Shikama, H., Watanabe, T., Yamada, N., Fan, J.
    • Journal Title

      Laboratory Investigation 84

      Pages: 715-726

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Overexpression of lipoprotein lipase improves insulin resistance induced by a high-fat diet in transgenic rabbits.2004

    • Author(s)
      Kitajima, S., Morimoto, M., Liu, E., Koike, T., Higaki, Y., Taura, Y., Mamba, K., Itamoto, K., Watanabe, T., Tsutsumi, K., Yamada, N., Fan, J.
    • Journal Title

      Diabetologia 47

      Pages: 1202-1209

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Overexpression of Lipoprotein Lipase in Transgenic Watanabe Heritable Hyperlipidemic Rabbits Improves Hyperlipidemia and Obesity.2004

    • Author(s)
      Koike, T., Liang, J., Wang, X., Ichikawa, T., Shiomi, M., Liu, G., Sun, H., Kitajima, S., Morimoto, M., Watanabe, T., Yamada, N., Fan, J.
    • Journal Title

      J Biol Chem 279・9

      Pages: 7521-7529

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Macrophage-specific overexpression of human matrix metalloproteinase-12 in transgenic rabbits.2004

    • Author(s)
      Fan, J., Wang, X., Wu, L., Matsumoto, S., Liang, J., Koike, T., Ichikawa, T., Sun, H., Shikama, H., Sasaguri, Y., Watanabe, T.
    • Journal Title

      Transgenic Research 13

      Pages: 261-269

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Overexpression of lipoprotein lipase improves insulin resistance induced by a high-fat diet in transgenic rabbits2004

    • Author(s)
      Kitajima S, Morimoto M, Liu E, Koike T, Higaki Y, Taura Y, Mamba K, Itamoto K Watanabe T, Tsutsumi K, Yamada N, Fan J
    • Journal Title

      Diabetologia 47

      Pages: 1202-1209

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Overexpression of lipoprotein lipase in transgenic Watanabe heritable hyperlipidemic rabbits improves hyperlipidemia and obesity2004

    • Author(s)
      Koike T, Liang J, Wang X, Ichikawa T, Shiomi M, Liu G, Sun H, Kitajima S, Morimoto M, Watanabe T, Yamada N, Fan J
    • Journal Title

      J Biol Chem 279

      Pages: 7521-7529

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Overexpression of lipoprotein lipase in transgenic rabbits leads to increased small dense LDL in plasma and promotes atherosclerosis2004

    • Author(s)
      Ichikawa T, Kitajima S, Liang J, Koike T, Wang X, Sun H, Okazaki M, Morimoto M, Shikama H, Watanabe T, Yamada N, Fan J
    • Journal Title

      Lab Invest 84

      Pages: 715-726

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Macrophage-specific overexpression of human matrix metalloproteinase-12 in transgenic rabbits2004

    • Author(s)
      Fan J, Wang X, Wu L, Matsumoto S, Liang J, Koike T, Ichikawa T, Sun H, Shikama H, Sasaguri Y, Watanabe T
    • Journal Title

      Transgenic Res 13

      Pages: 261-269

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Overexpression of human matrix metalloproteinase-12 enhances the development of inflammatory arthritis in transgenic rabbits2004

    • Author(s)
      Wang X, Liang J, Koike T, Sun H, Ichikawa T, Kitajima S, Morimoto M, Shikama H, Watanabe T, Sasaguri Y, Fan J
    • Journal Title

      Am J Pathol 165

      Pages: 1375-1383

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Association of increased expression of macrophage elastase (MMP-12) with rheumatoid arthritis2004

    • Author(s)
      Liu M, Sun H, Wang X, Koike T, Mishima H, Ikeda K, Watanabe T, Ochiai N, Fan J
    • Journal Title

      Arth Rheum 50

      Pages: 3112-3117

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Overexpression of lipoprotein lipase in transgenic Watanabe heritable hyperlipidemic rabbits improves hyperlipidemia and obesity.2004

    • Author(s)
      Koike T, et al. (Last)
    • Journal Title

      J Biol Chem 279

      Pages: 7521-7529

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Overexpression of human matrix metalloproteinase-12 enhances the development of inflammatory arthritis in transgenic rabbits.2004

    • Author(s)
      Wang X, et al. (Last)
    • Journal Title

      Am J.Pathol 165

      Pages: 1375-1383

    • Related Report
      2004 Annual Research Report
  • [Book] Lipoprotein(a) and atherosclerosis : a study from transgenic rabbis.2004

    • Author(s)
      Matsuzawa Y, Kita T, Nagai R, Teramoto T.
    • Publisher
      Amsterdam, Elsevier B.V
    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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