A functional analyses of PDGF expressed in CNS

• Project/Area Number: 16390114
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: University of Toyama (2005-2007); Toyama Medical and Pharmaceutical University (2004)
• Principal Investigator: SASAHARA Masakiyo University of Toyama, Graduate School ofMedicine and Pharmaeeutiral Sciences for Reseanh, Professor (20154015)
• Co-Investigator(Kenkyū-buntansha): FUJIMORI Toshihiko University of Kyoto, Graduate School of Medicine and Faculty of Medicine, Assistant Professor (80301274) ; OYA Takeshi University of Toyama, Graduate School of Medicine and Pharmaceutical Sciences for Research, Assistant Professor (00343179) ; ISHII Yoko University of Toyama, Graduate School of Medicine and Pharmaceutical Sciences for Research, Assistant Professor (00361949) ; HORI Etsuro University of Toyama, Graduate School of Medicine and Pharmaceutiral SriPn es for Research, Associated Professor (90313600)
• Project Period (FY): 2004 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥15,310,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2006: ¥2,900,000 (Direct Cost: ¥2,900,000); Fiscal Year 2005: ¥4,100,000 (Direct Cost: ¥4,100,000); Fiscal Year 2004: ¥6,100,000 (Direct Cost: ¥6,100,000)
• Keywords: PDGF / Conditional knockout / Cre / loxP / Brain / Behavior analyses / Neurotrophic factor / Receptor / Neuronal differentiation / Crelox P / 血小板由来増殖因子 / knockout / conditional / 線維芽細胞 / Akt / MAP kinase

Research Abstract

Platelet-derived growth factors (PDGFs) and the receptors (PDGFRs) appear to the internal organs of the whole body, and they are distributed in the brain tissue especially widely, and abundantly. They are potent biological molecules with multiple functions, being involved in diverse biological phenomena of our body, and the application to the medical treatment has been hoped for. The present project aimed to understand the functional relevance of PDGFs expressed in the brain through a set of the expression intervention studies.
To evade the neonatal lethality in null knockout model, we established the mouse lines of PDGFR-β conditional knockout by Cre-loxP method. This, for the first time, allowed us the functional analyses of the gene in postnatal life. The mutant mice survived after birth and grown up normally, so far examined. However, the mice in which PDGFR-β gene was deleted in neuroepithelium-derived cells, showed increased vulnerability of the brain to the excitotoxicity and cryogenic injuries in which oxidative stress is one of the major cause of death. We could show that PDGF system in the CNS is neuroprotective, and that the effects were mediated by PDGFR-β expressed in neurons in adult mouse brain. We further extended in vivo studies to in vitro, in which we could induce the PDGFR-β gene deletion in cultured cells with non-invasive and stable manner. We could show that the two types of PDGFRs convey similar and distinctive effects in different cells. PDGFR-β but not PDGFR-α specifically mediated migratory response of fibroblasts and the neuronal differentiation of neural stem cells, but inhibited the osteogenic differentiation of mesenchymal stromal cells.
Thus, due to the establishment of novel system to appreciate the PDGFR-β gene function, we are starting to reveal the functions that have not been reported. Our project should further give us new vistas to understand the growth factor function in our body.

Research Products

• [Journal Article] Characterization of neuroprogenitor cells expressing the PDGF β-receptor within the subventricular zone of postnatal mice. (2008)
  • Author(s): Ishii Y.
  • Journal Title: Mol. Cell. Neurosci. 37 Pages: 507-518
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] PDGF Receptor β is a Potent Regulator of Mesenchymal Stromal Cell Function. (2008)
  • Author(s): Tokunaga A.
  • Journal Title: J. Bone Miner. Res. (in press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Characterization of neuroprogenitor cells expressing the PDGF β -receptor within the subventricular zone of postnatal mice (2008)
  • Author(s): Ishii, Y., Matsumoto, Y., Watanabe, R., Elmi, M., Fujimori, T., Nissen, J., Cao, Y., Nabeshima, Y., Sasahara, M., Funa, K
  • Journal Title: Mol. Cell. Neurosci 37 Pages: 507-518
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] PDGF Receptor β is a Potent Regulator of Mesenchymal Stromal Cell Function (2008)
  • Author(s): Tokunaga, A. Oya T., Ishii Y., Motomura H., Nakamura C., Ishizawa S., Fujimori T., Nabeshima, Y., Umezawa, A. Kanamori, M., Kimura, T., Sasahara, M
  • Journal Title: J. Bone Miner. Res (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Characterization of neuroprogenitor cells expressing the PDGF beta-receptor within the subventricular zone of postnatal mice (2008)
  • Author(s): Ishii Y
  • Journal Title: Mol Cell Neurosci 37(3) Pages: 507-518
• [Journal Article] PDGF Receptor beta is a Potent Regulator of Mesenchymal Stromal Cell Function (2008)
  • Author(s): Tokunaga A
  • Journal Title: J Bone Miner Res
• [Journal Article] Impact of transgenic overexpression of SH2-containing inositol 5'-phosphatase 2 on glucose metabolism and insulin signaling in mice (2008)
  • Author(s): Kagawa S
  • Journal Title: Endocrinology 149(2) Pages: 642-650
• [Journal Article] Platelet-derived growth factor may be associated with fibrosis in aDown syndrome patient with transient myeloproliferative disorder (2008)
  • Author(s): Ogawa J
  • Journal Title: Eur J Haematol
• [Journal Article] Platelet-derived growth factor(PDGF)-BB inhibits AMPA receptor-mediated synaptic transmission via PDGF receptor-beta in murine nucleus tractus solitarius. (2007)
  • Author(s): Ohi Y.
  • Journal Title: Brain Res. 1159 Pages: 77-85
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] In vitro metabolism of isoline, a pyrrolizidine alkaloid from Ligularia duciformis, by rodent liver microsomal esterase and enhanced hepatotoxicity by esterase inhibitors. (2007)
  • Author(s): Tang J.
  • Journal Title: Drug. Metab. Dispos. 35 Pages: 1832-2839
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A functional polymorphism in COL11A1, encoding the alphal chain of type XI collagen, is associated with susceptibility to lumbar discherniation. (2007)
  • Author(s): Mio F.
  • Journal Title: Am. J. Hum. Genet. 81 Pages: 1271-1277
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Neuroprotective role of transgenic PAF-acetyl hydrolase II in mouse models of focal cerebral ischemia. (2007)
  • Author(s): Umemura K.
  • Journal Title: Stroke 38 Pages: 1063-1068
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Effects of vestibular never section on sound-evoked myogenic potentials in the sternocleidomastoid muscle of monkeys. (2007)
  • Author(s): Tsubota M.
  • Journal Title: Clin. Neurophysiol. 118 Pages: 1488-1493
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Specific acupuncture sensation correlates with EEGs and autonomic changes in human subjects. (2007)
  • Author(s): Sakai S.
  • Journal Title: Auton. Neurosci. 133 Pages: 158-169
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Effects of maternal exposure to 2,3,8-Tetrachlorodibenzo-p-dioxin on fetal brain growth and motor and behavioral development in offspring rats. (2007)
  • Author(s): Nishijo M.
  • Journal Title: Toxicl. Lett. 173 Pages: 41-47
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Blastocyst axis is specified independently of early cell lineage but aligns with the ZP shape. (2007)
  • Author(s): Kurotaki Y.
  • Journal Title: Science 316 Pages: 719-723
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Alfa-Klotho as a regulator of calcium homeostasis. (2007)
  • Author(s): Imura A.
  • Journal Title: Science 316 Pages: 1615-1618
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Platelet-derived growth factor(PDGF)-BB inhibits AMPA receptor-mediated synaptic transmission via PDGF receptor-beta in murine nucleus tractus solitarius (2007)
  • Author(s): Ohi, Y., Ishii, Y, Haji, A. Noguchi, S., Sasaoka, T., Fujimori, T., Nabeshima, Sasahara, M., Hattori, Y
  • Journal Title: Brain Res 1159 Pages: 77-85
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] In vitro metabolism of isoline, a pyrrolizidine alkaloid from Ligularia duciformis, by rodent liver microsomal esterase and enhanced hepatotoxicity by esterase inhibitors (2007)
  • Author(s): Tang, J., Akao, T., Nakamura, N., Wang, Z.T., Takagawa, K., Sasahara, M., Hattori, M
  • Journal Title: Drug. Metab. Dispos 35 Pages: 1832-1839
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A functional polymorphism in COL11A1, encoding the alphal chain of type XI collagen, is associated with susceptibility to lumbar disc herniation (2007)
  • Author(s): Mio, F., Chiba, K, Hirose, Y., Kawaguchi, Y., Mikami, Y., Oya, T., Mori, M., Kamata, M., Matsumoto, M., Ozaki, K, Tanaka, T., Takahashi, A. Kubo, T., Kimura, T., Toyama, Y., Ikegawa, S
  • Journal Title: Am. J. Hum. Genet 81 Pages: 1271-1277
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Neuroprotective role of transgenic PAF-acetylhydrolase II in mouse models of focal cerebral ischemia (2007)
  • Author(s): Umemura, K., Kato, I., Hirashima, Y., Ishii, Y., Inoue, T., Aoki, J., Kono, N., Oya, T., Hayashi, N., Hamada, H., Endo, S., Oda, M., Arai, H., Kinouchi, H., Hiraga, K
  • Journal Title: Stroke 38 Pages: 1063-1068
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of vestibular never section on sound-evoked myogenic potentials in the sternocleidomastoid muscle of monkeys. (2007)
  • Author(s): Tsubota, M., Shojyaku, H., Hori, E., Fujisaka, M., Hyashi, N., Kurimoto, M., Htakeyama, N., Yamazaki, M., Nishijo, H., Ono, T., Yamamoto, H., Watanabe, Y
  • Journal Title: Clin. Neurophysiol 118 Pages: 1488-1493
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Specific acupuncture sensation correlates with EEGs and autonomic changes in human subjects (2007)
  • Author(s): Sakai, S., Hori, E., Umeno, K., Kitabayashi, N., Ono, T. ana Nishijo, H
  • Journal Title: Auton. Neurosci 133 Pages: 158-169
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of maternal exposure to 2,3,8-Tetrachlorodibenzo-p-dioxin on fetal brain growth and motor and behavioral development in offspring rats (2007)
  • Author(s): Nishijo, M., Kuriwaki, J., Hori, E., Tawara, K, Nakagawa, H., Nishijo, H
  • Journal Title: Toxicl. Lett 173 Pages: 41-47
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Blastocyst axis is specified independently of early cell lineage but aligns with the ZP shape (2007)
  • Author(s): Kurotaki, Y., Hatta, K., Nakao, K, Nabeshima, Y., Fujimori, T
  • Journal Title: Science 316 Pages: 719-723
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Alfa-Klotho as a regulator of calcium homeostasis (2007)
  • Author(s): Imura, A. Tsuji, Y, Murata, M., Maeda, R., Kubota, K., Iwano, A. Obuse, C., Togashi, K, Tominaga, M., Kita, N., Tomiyama, K., Iijima, J., Nabeshima, Y., Fujioka, N., Asato, R., Tanaka, S., Kojima, K, Ito, J., Nozaki, K, Hashimoto, N., Ito, T., Nishio, T., Uchiyama, T., Fujimori, T., Nabeshima, Y
  • Journal Title: Science 316 Pages: 1615-1618
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Platelet-derived growth factor (PDGF)-BB inhibits AMPA receptor-mediated synaptic transmission via PDGF receptor-beta in murine nucleus tractus solitarius (2007)
  • Author(s): Ohi Y
  • Journal Title: Brain Res 1159 Pages: 77-85
• [Journal Article] 血小板由来増殖因子の情動を含む高次脳機能における役割解明へのアプローチ (2007)
  • Author(s): 笹原 正清
  • Journal Title: Biophilia 3(4) Pages: 43-48
• [Journal Article] Therapeutic Potential of(-)-Epigallocatechin 3-O-gallate on Renal Damage in Diabetic Nephropathy Model Rats. (2006)
  • Author(s): Yamabe N.
  • Journal Title: J. Pharmacol. Exp. Ther. 319 Pages: 228-236
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A Homeodomain-Zinc Finger Protein, ZFHX4, Is Expressed in Neuronal Differentiation Manner and Suppressed in Muscle Differentiation Manner. (2006)
  • Author(s): Hemmi K.
  • Journal Title: Biol. Pharm. Bull. 29 Pages: 1830-1835
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Enhanced scavenging of lipid substances is a possible effect of corticosteroids in the treatment of cholesterol crystal embolism. (2006)
  • Author(s): Cheng C.
  • Journal Title: Pathol. Res. Pract. 202 Pages: 591-598
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Mouse brains deficient in neuronal PDGF receptor-beta develop normally but are vulnerable to injury. (2006)
  • Author(s): Ishii Y.
  • Journal Title: J. Neurochem. 98 Pages: 588-600
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Conjunctive Effects of Reward and behavioral Episodes on Hippocampal Place-Differential Neurons of Rats on a Mobile Treadmill. (2006)
  • Author(s): Dayawansa S.
  • Journal Title: Hippocampus 16 Pages: 586-595
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Unambiguous representation of overlapping serial events in the rat hippocampal formation. (2006)
  • Author(s): Furusawa A. A.
  • Journal Title: Neuroscience 137 Pages: 685-698
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Sound-evoked myogenic potentials on the sternocleidomastoid muscle in monkeys. (2006)
  • Author(s): Tsubota M.
  • Journal Title: Acta Otolaryngol. 126 Pages: 1171-1175
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Impaired regulation of gonadotropins leads to the atrophy of female reproductive system in klotho deficient mice. (2006)
  • Author(s): Toyama R.
  • Journal Title: Endocrinology 147 Pages: 120-129
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Therapeutic Potential of(-)-Epigallocatechin 3-O-gallate on Renal Damage in Diabetic Nephropathy Model Rats (2006)
  • Author(s): Yamabe, N., Yokozawa, T., Oya, T., Kim, M
  • Journal Title: J. Pharmacol. Exp. Ther 319 Pages: 228-236
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A Homeodomain-Zinc Finger Protein, ZFHX4, Is Expressed in Neuronal Differentiation Manner and Suppressed in Muscle Differentiation Manner (2006)
  • Author(s): Hemmi, K., Ma, D., Miura, Y., Kawaguchi, M., Sasahara, M., Hashimoto-Tamaoki, T., Tamaoki, T., Sakata, N., Tsuchiya, K
  • Journal Title: Biol. Pharm. Bull 29 Pages: 1830-1835
  • NAID: 110005602346
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Enhanced scavenging of lipid substances is a possible effect of corticosteroids in the treatment of cholesterol crystal embolism (2006)
  • Author(s): Cheng, C., Tsuneyama, K, Zheng, H., Oya, T., Cui, Z., Feril, L.B., Jr., Takano, Y
  • Journal Title: Pathol. Res. Pract 202 Pages: 591-598
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mouse brains deficient in neuronal PDGF receptor-beta develop normally but are vulnerable to injury (2006)
  • Author(s): Ishii, Y., Oya, T., Zheng, L., Gao, Z., Kawaguchi, M., Sabit, H., Matsushima, T., Tokunaga, A. Ishizawa, S., Hori, E., Nabeshima, Y., Sasaoka, T., Fujimori, T., Mori, H., Sasahara, M
  • Journal Title: J. Neurochem 98 Pages: 588-600
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Conjunctive Effects of Reward and behavioral Episodes on Hippocampal Place-Differential Neurons of Rats ona a Mobile Treadmill (2006)
  • Author(s): Dayawansa, S., Kobayashi, T., Hori, E., Umeno, K., Tazumi, T., Ono, T., Nishijo, H
  • Journal Title: Hippocampus 16 Pages: 586-595
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Unambiguous representation of overlapping serial events in the rat hippocampal formation (2006)
  • Author(s): Furusawa, A.A. Hori, E., Umeno, K, Tabuchi, E., Ono, T., Nishijo, H
  • Journal Title: Neuroscience 137 Pages: 685-698
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Sound-evoked myogenic potentials on the sternocleidomastoid muscle in Monkeys (2006)
  • Author(s): Tsubota, M., Shojaku, H., Hori, E., Fujisaka, M., Nishijo, H., Watanabe, Y
  • Journal Title: Acta Otolaryngol 126 Pages: 1171-1175
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Impaired regulation of gonadotropins leads to the atrophy of female reproductive system in klotho deficient mice (2006)
  • Author(s): Toyama, R., Fujimori, T., Nabeshima, Y., Itoh, Y., Tsuji, Y., Osamura, R.Y.,Nabeshima, Y
  • Journal Title: Endocrinology 147 Pages: 120-129
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mouse brains deficient in neuronal PDGF receptor-beta develop normally but are vulnerable to injury. (2006)
  • Author(s): Ishii Y
  • Journal Title: J Neurochem. 98(2) Pages: 588-600
• [Journal Article] A Homeodomain-Zinc Finger Protein, ZFHX4, Is Expressed in Neuronal Differentiation Manner and Suppressed in Muscle Differentiation Manner (2006)
  • Author(s): Hemmi K
  • Journal Title: Biol Pharm Bull 29(9) Pages: 1830-1835
• [Journal Article] Deletion of the PDGFR-{beta} gene affects key fibroblast functions important for wound healing. (2006)
  • Author(s): Gao Z
  • Journal Title: J Biol Chem. 280(10) Pages: 9375-9389
• [Journal Article] ZFH4 protein is expressed in many neurons of developing rat brain. (2005)
  • Author(s): Nogami S.
  • Journal Title: J. Comp. Neurol. 482 Pages: 33-49
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Spinal stenosis due to the ossified lesions of the lumbar spine. (2005)
  • Author(s): Kawaguchi Y.
  • Journal Title: J. Neurosurg. Spine. 3 Pages: 262-270
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease. (2005)
  • Author(s): Seki S.
  • Journal Title: Nat. Genet. 37 Pages: 607-612
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Green tea polyphenol and dietary fiber protect against kidney damage in rats with diabetic nephropathy. (2005)
  • Author(s): Yokozawa T.
  • Journal Title: J. Pharm. Pharmacol. 57 Pages: 773-780
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Some biochemical and histochemical properties of human liver serine dehydratase. (2005)
  • Author(s): Kashii T.
  • Journal Title: Int. J. Biochem. Cell Biol. 37 Pages: 574-589
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Deletion of The PDGFR-β gene affects key fibroblast functions important for wound healing. (2005)
  • Author(s): Gao Z.
  • Journal Title: J. Biol. Chem. 280 Pages: 9375-9389
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Effects of prenatal maternal stress by repeated cold environment on behavioral and emotional development in the rat offspring. (2005)
  • Author(s): Tazumi T.
  • Journal Title: Behav. Brain Res. 162 Pages: 153-160
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Effects of cadmium exposure during pregnancy on trace elements in fetal rat liver and kidney. (2005)
  • Author(s): Kuriwaki J.
  • Journal Title: Toxicol. Lett. 156 Pages: 369-376
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Place-related Neural Responses in the Monkey Hippocampal Formation in a Virtural Space. (2005)
  • Author(s): Hori E.
  • Journal Title: Hippocampus 15 Pages: 991-996
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Effects of facial expression on shared attention mechanisms. (2005)
  • Author(s): Hori E.
  • Journal Title: Physiol. Behav. 84 Pages: 397-405
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Impaired negative feedback suppression of bile acid synthesis in mice lacking be-ta klotho. (2005)
  • Author(s): Ito S.
  • Journal Title: J. Clin. Invest. 115 Pages: 2202-2208
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] ZFH4 protein is expressed in many neurons of developing rat brain (2005)
  • Author(s): Nogami, S., Ishii, Y., Kawaguchi, M., Sakata, N., Oya, T., Takagawa, K., Kanamori, M., Sabit, H., Obata, T., Kimura, T., Sasahara, M
  • Journal Title: J. Comp. Neurol 482 Pages: 33-49
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Spinal stenosis due to the ossified lesions of the lumbar spine (2005)
  • Author(s): Kawaguchi, Y., Oya, T., Abe, Y., Kanamori, M., Ishihara, H., Yasuda, T., Nogami, S., Hori, T., Kimura, T
  • Journal Title: J. Neurosurg. Spine 3 Pages: 262-270
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease (2005)
  • Author(s): Seki, S., Kawaguchi, Y., Chiba, K., Mikami, Y., Kizawa, H., Oya, T., Mio, F., Mori, M., Miyamoto, Y., Masuda, I., Tsunoda, T., Kamata, M., Kubo, T., Toyama, Y., Kimura, T., Nakamura, Y., Ikegawa, S
  • Journal Title: Nat. Genet 37 Pages: 607-612
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Green tea polyphenol and dietary fiber protect against kidney damage in rats with diabetic nephropathy (2005)
  • Author(s): Yokozawa, T., Nakagawa, T., Oya T., Okubo, T., Juneja, L.R
  • Journal Title: J. Pharm. Pharmacol 57 Pages: 773-780
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Some biochemical and histochemical properties of human liver serine dehydratase (2005)
  • Author(s): Kashii, T., Gomi, T., Oya, T., Ishii, Y., Oda, H., Maruyama, M., Kobayashi, M., Masuda, T., Yamazaki, M., Nagata, T., Tsukada, K., Nakajima, A. Tatsu, K., Mori, H., Takusagawa, F., Ogawa, H., Pitot, H.C
  • Journal Title: Int. J. Biochem. Cell Biol 37 Pages: 574-589
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Deletion of The PDGFR-B gene affects key fibroblast functions important for wound healing. (2005)
  • Author(s): Gao, Z., Sasaoka, T., Fujimori, T., Oya, T., Ishii, Y., Sabit, H., Kawaguchi, M., Kurotaki, Y., Naito, M., Wada, T., Ishizawa, S., Kobayashi, M., Nabeshima, Y., Sasahara, M
  • Journal Title: J. Biol. Chem 280 Pages: 9375-9389
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of prenatal maternal stress by repeated cold environment on behavioral and emotional development in the rat offspring. (2005)
  • Author(s): Tazumi, T., Hori, E., Uwano, T., Umeno, K., Tanebe, K., Tabuchi, E., Ono, T., Nishijo, H
  • Journal Title: Behay. Brain Res 162 Pages: 153-160
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of cadmium exposure during pregnancy on trace elements in fetal rat liver and kidney (2005)
  • Author(s): Kuriwaki, J., Nishijo, M., Honda, R., Tawara, K., Nakagawa, H., Hori, E., Nishijo, H
  • Journal Title: Toxicol. Lett 156 Pages: 369-376
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Place-Related Neural Responses in the Monkey Hippocampal Formation in a Virtural Space (2005)
  • Author(s): Hori, E., Nishio, Y., Kazui, K., Umeno, K., Tabuchi, E., Sasaki, K., Endo, S., Ono, T., Nishijo, H
  • Journal Title: Hippocampus 15 Pages: 991-996
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of facial expression on shared attention mechanisms (2005)
  • Author(s): Hori, E., Tazumi, T., Umeno, K., Kamachi, M., Kobayashi, T., Ono, T., Nishijo, H
  • Journal Title: Physiol. Behay 84 Pages: 397-405
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Impaired negative feedback suppression of bile acid synthesis in mice lacking be-ta klotho (2005)
  • Author(s): Ito, S., Fujimori, T., Furuya, A. Satoh, J., Nabeshima, Y., Nabeshima, Y
  • Journal Title: J. Clin. Invest 115 Pages: 2202-2208
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 神経組織に発現する血小板由来増殖因子(総説) (2005)
  • Author(s): 笹原正清
  • Journal Title: 生体の科学 56(4) Pages: 292-295
• [Journal Article] A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease. (2005)
  • Author(s): Seki S
  • Journal Title: Nat.Genet. 37(6) Pages: 607-612
• [Journal Article] ZFH4 protein is expressed in many neurons of developing rat brain. (2005)
  • Author(s): Nogami S
  • Journal Title: J Comp Neurol 482(1) Pages: 33-49
• [Journal Article] Deletion of the PDGFR-{beta} gene affects key fibroblast functions important for wound healing. (2005)
  • Author(s): Gao Z
  • Journal Title: J Biol Chem. (in press)
• [Journal Article] Effects of Choto-san and hooks and stem of Uncaria sinensis on a antioxidant enzyme activities in the gerbil brain after transient forebrain ischemia. (2004)
  • Author(s): Yokoyama K.
  • Journal Title: J. Ethnopharmacol. 95 Pages: 335-343
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Protective effects of Choto-san and hooks and stems of Uncaria sinensis against delayed neural death after transient forebrain ischemia in gerbil. (2004)
  • Author(s): Yokoyama K.
  • Journal Title: Phytomedicine 11 Pages: 478-489
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression. (2004)
  • Author(s): Takeshita K.
  • Journal Title: Circulation 109 Pages: 1776-1782
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Effects of Choto-san and hooks and stem of Uncaria sinensis on a antioxidant enzyme activities in the gerbil brain after transient forebrain ischemia (2004)
  • Author(s): Yokoyama, K, Shimada, Y, Hori, E, Nakagawa, T, Takagi, S, Sekiya, N, Kohta, K, Nishijo, H, Yokozawa, T, Terasawa, K
  • Journal Title: J. Ethnopharmaco 95 Pages: 335-343
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Protective effects of Choto-san and hooks and stems of Uncaria sinensis against delayed neural death after transient forebrain ischemia in gerbil (2004)
  • Author(s): Yokoyama, K., Shimada, Y., Hori, E., Sekiya, N., Goto, H., Sakakibara, I., Nishijo, H., Terasawa, K
  • Journal Title: Phytomedicine 11 Pages: 478-489
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression. (2004)
  • Author(s): Takeshita, K., Fujimori, T., Kurotaki, Y., Honjo, H., Tsujikawa, H., Yasui, K., Jong-Kook, L., Kamiyama, K, Kitaichi, K, Yamamoto, K., Ito, M., Kondo, T., Iino, S., Inden, Y., Hiraki, M., Murohara, T., Kodama, I., Nabeshima, Y
  • Journal Title: Circulation 109 Pages: 1776-1782
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The PDGF B-chain is involved in the ontogenic susceptibility of the developing rat brain to NMDA toxicity (2004)
  • Author(s): Egawa-Tsuzuki T
  • Journal Title: Exp Neurol. 186(1) Pages: 89-98
• [Journal Article] Hepatoprotective Effect of Taxiresinol and (7'R)-7'-Hydroxylariciresinol on D-Galactosamine and Lipopolysaccharide-Induced Liver Injury in Mice. (2004)
  • Author(s): Nguyen NT
  • Journal Title: Planta Med. 70(1) Pages: 29-33
• [Journal Article] Secoisolariciresinol and isotaxiresinol inhibit tumor necrosis factor-alpha-dependent hepatic apoptosis in mice. (2004)
  • Author(s): Bankskota AH
  • Journal Title: Life Sci. 74(22) Pages: 2781-2792
• [Presentation] Neuroprotection by PAF-acetylhydrolase II in transgenic mouse models of transient focal cerebral ischemia. (2007)
  • Author(s): Kato I.
  • Organizer: 21COE Program Seminar at UC Davis. 'Integrate of New Insights between Western and Eastern Medicines'
  • Place of Presentation: Davis
  • Year and Date: 2007-08-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Neuroprotection by PAF-acetylhydrolase II in transgenic mouse models of transient focal cerebral ischemia (2007)
  • Author(s): Kato, I., Umemura, K, Ishu, Y., Inoue, T., Aoki, J., Kono, N., Oya, T., Arai, H., Hayashi, N., Hamada, H., Endo, S., Hirashima, Y., Hiraga, K
  • Organizer: 21COE Program Seminar at UC Davis. "Integrate of New Insights between Western and Eastern Medicines"
  • Place of Presentation: Davis
  • Year and Date: 2007-08-27
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Transgenic PAF-Acetylhydrolase II Protects Neurons in Mouse Models of Transient Focal Cerebral Ischemia. (2007)
  • Author(s): Kato I.
  • Organizer: 21COE Program Joint symposium of Peking, University and University of Toyama. 'Evidence-based approach to traditional medicine and modern medicine'
  • Place of Presentation: 北京
  • Year and Date: 2007-06-25
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Transgenic PAF-Acetylhydrolase II Protects Neurons in Mouse Models of Transient Focal Cerebral Ischemia. (2007)
  • Author(s): Kato, I., Umemura, K., Ishii, Y., Inoue, T., Aoki, J., Kono, N., Oya, T., Arai, H., Hayashi, N., Hamada, H., Endo, S., Hirashima, Y., Hiraga, K
  • Organizer: 21COE Program Joint symposium of Peking University and University of Toyama. Evidence-based approach to traditional medicine and modern medicine
  • Place of Presentation: Beijing
  • Year and Date: 2007-06-25
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] CaMKII alpha-transgenic Mice Shows Pathological Changes of Diabetic Nephropathy with Enhanced Expression of PDGF-B Chain and PDGF-beta Receptor. (2007)
  • Author(s): Suzuki H.
  • Organizer: 米国American Diabetes Association 総会
  • Place of Presentation: Chicago
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] マウス肺星細胞活性化における血小板由来増殖因子β受容体の役割. (2007)
  • Author(s): 森田誠市
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] PDGF-Bは酸化ストレス誘導性細胞死から神経細胞を保護し,その作用はPI3K/AKT経路を介する. (2007)
  • Author(s): 鄭 蓮順
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 皮膚培養線維芽細胞の遊走におけるPDGFβ受容体の機能解析. (2007)
  • Author(s): 徳永綾乃
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Neuroprotection of PDGF-B against oxidative stress via the PI3K/Akt signal. (2007)
  • Author(s): 鄭 蓮順
  • Organizer: Neuro 2007
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] CaMKII alpha-transgenic Mice Shows Pathological Changes of Diabetic Nephropathy with Enhanced Expression of PDGF-B Chain and PDGF-beta Receptor. (2007)
  • Author(s): Suzuki, H., Oya, T., Usui, I., Kato, I., Yamazaki, Y., Fujisaka, S., Bukhari, A. Asamizu, S., Kanatani, Y., Ihiki, M., Urakaze, M., Takasawa, S., Okamoto, H., Sasahara, M., Kobayashi, M
  • Organizer: American Diabetes Association
  • Place of Presentation: Chicago
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The role of PDGF-β in the Activation of mouse stellate cells (2007)
  • Author(s): Morita, S., Oya, T., Ishu, Y., Sabit, H., Tokunaga, A. Ishizawa, S., Matsushima, T., Kurashige, Y., Sasahara, M
  • Organizer: The 96th Annual Meeting of the Japan Society of Pathology
  • Place of Presentation: Osaka
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] PDGF- 3 protects neuron from oxidative stress via the P13K/Akt signal. (2007)
  • Author(s): Zheng, L., Ishu, Y., Oya, T., Sabit, H., Matsushima, T., Kurashige, Y., Ishizawa, S., Sasahara, M
  • Organizer: The 96th Annual Meeting of the Japan Society of Pathology
  • Place of Presentation: Osaka
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The analysis of the function of PDGF- β in fibroblast migration (2007)
  • Author(s): Tokunaga, A. Oya, T., Ishii, Y., Sabit, H., Matsushima, T., Kurashige, Y., Ishizawa, S., Kanamori, M., Sasahara, M
  • Organizer: The 96th Annual Meeting of the Japan Society of Pathology
  • Place of Presentation: Osaka
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Neuroprotection of PDGF-B against oxidative stress via the PI3K/Akt signal (2007)
  • Author(s): Zheng, L., Ishii, Y., Oya, T., Tokunaga, A. Hamashima, T., Ishizawa, S. Sasahara, M
  • Organizer: Neuro. 2007(The 30th Annual Meeting of the Japan Neuroscience Society, The 50th Annual Meeting of the Japanese Society for Neurochemistry, The 17th Annual Meeting of the Japanese Neural Network Society)
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Overexpression of PAF-acetylhydrolase II in transgenic mouse brain suppresses ischemic stress-induced neuronal cell death. (2006)
  • Author(s): Umemura K.
  • Organizer: 2006 Association of Neurological Surgeons Annual Meeting
  • Place of Presentation: San Francisco(USA).
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 末梢神経再生におけるPDGF受容体およびシグナル伝達に関する検討. (2006)
  • Author(s): 山崎隆志
  • Organizer: 第95回日本病理学会総会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Malignant solitary fibrous tumor in pelvic cavity. Report of acase. (2006)
  • Author(s): 川村しのぶ
  • Organizer: 第95回日本病理学会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Giant Sertoli-stromal cell tumor with rhabdomyoblastic element of the ovary. (2006)
  • Author(s): 中川加奈子
  • Organizer: 第47回日本臨床細胞学会総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] A novel model for diabetic retinopathy. (2006)
  • Author(s): Ichsan A.M.
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
  • Place of Presentation: Kyoto
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Expression of constitutively active form of CaM kinase II in pancreatic betacells of transgenic mice leads to severe diabetes mellitus. (2006)
  • Author(s): Kato I.
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
  • Place of Presentation: Kyoto
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Mouse brains deficient in neuronal PDGF receptor-β developnormally but are vulnerable to injury. (2006)
  • Author(s): Ishii Y.
  • Organizer: 第29回日本神経科学大会(Neuro 2006)
  • Place of Presentation: 京都
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 末梢神経再生におけるPDGF受容体およびそのシグナル伝達に関する検討. (2006)
  • Author(s): Sabit H.
  • Organizer: 第29回日本神経科学大会(Neuro 2006)
  • Place of Presentation: 京都
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The role of platelet-derived growth factor receptor β in the process of mouse hepatic stellate cell activation. (2006)
  • Author(s): Morita S.
  • Organizer: 13th International Symposium on Cells of the Hepatic Sinusoid
  • Place of Presentation: Niigata
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] AMPA 受容体を介したモルモット延髄孤束核における興奮性シナプス後電流に対するPDGF-Bの作用:ノックアウトマウスを用いた検討. (2006)
  • Author(s): 大井義明
  • Organizer: 第57回日本薬理学会北部会
  • Place of Presentation: 弘前
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Overexpression of PAF-acetylhydrolase II in transgenic mouse brain supresses ischemic stress-induced neuronal cell death (2006)
  • Author(s): Umemura, K., Kato, I., Hirashima, Y., Ishii, Y., Oya, T., Hayashi, N., Hamada, H., Inoue, T., Aoki, J., Kinouchi, H., Hiraga, K., Endo, S
  • Organizer: 2006 AANS Annual Meeting
  • Place of Presentation: San Francisco, USA.
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The analysis of PDGF receptor and its signaling in peripheral nervous regeneration (2006)
  • Author(s): Yamazaki, T., Oya, T., Sabit, H., Ishu, Y., Ishizawa, S., Sasahara, M
  • Organizer: The 95th Annual Meeting of the Japan Society of Pathology
  • Place of Presentation: Tokyo
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Malignant solitary fibrous tumor in pelvic cavity. Report of a case (2006)
  • Author(s): Kawamura, S., Kiya, C., Oya, T., Sakai, Y., Nakagawa, K., Ejiri, S., Fukuoka, J
  • Organizer: The 95th Annual Meeting of the Japan Society of Pathology
  • Place of Presentation: Tokyo
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Giant Sertoli-stromal cell tumor with rhabdomyoblastic element of the ovary (2006)
  • Author(s): Nakagawa, K., Kiya, C., Moriya, S., Murosaka, C., Nakamura, T., Sakai, Y., Tanaka, T., Ejiri, S., Oya, T., Fukuoa, J
  • Organizer: The 47tn Annual Meeting of the Japan Society of Clinical Cytology
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] A novel model for diabetic retinopathy (2006)
  • Author(s): Ichsan, A.M., Kato, I., Oya, T., Tomi, M., Takasawa, S., Okamoto, H., Sasahara, M., Hayasaka, S., Hosoya, K., Hiraga K
  • Organizer: The 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
  • Place of Presentation: Kyoto
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Expression of constitutively active form of CaM kinase II in pancreatic beta cells of transgenic mice leads to severe diabetes mellitus. (2006)
  • Author(s): Kato, I., Hiraga, K, Oya, T., Sasahara, M., Takasaki, I., Tabuchi, Y., Takasawa, S., Okamoto, H
  • Organizer: The20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
  • Place of Presentation: Kyoto
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Mouse brains deficient in neuronal PDGF receptor-13 develop normally but are vulnerable to injury (2006)
  • Author(s): Ishii, Y., Oya, T., Zheng, L., Sasahara, M
  • Organizer: Neuro. 2006(The 29th Annual Meeting of The Japan Neuroscience Society)
  • Place of Presentation: Kyoto
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Activation of PDGF receptor and downstream signals in regenerating peripheral nerve (2006)
  • Author(s): Sabit, H., Yamazaki, T., Oya, T., Ishii, Y., Furuta, I., Sasahara, M
  • Organizer: Neuro. 2006(The 29th Annual Meeting of The Japan Neuroscience Society)
  • Place of Presentation: Kyoto
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The role of platelet-derived growth factor receptor 8 in the process of mouse hepatic stellate cell activation. (2006)
  • Author(s): Morita, S., Sabit, H., Oya, T., Tokunaga, A. Kudo, H., Yata, Y., Takahara, T., Ishu, Y., Ishizawa, S., Tsukada, K., Sasahara, M
  • Organizer: The13th International Symposium on Cells of the Hepatic Sinusoid
  • Place of Presentation: Niigata
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Platelet-derived growth factor(PDGF)-BB inhibits AMPA receptor-mediated synaptic transmission via PDGF receptor-beta in murine nucleus tractus solitarius (2006)
  • Author(s): Ohi, Y., Ishii, Y., Haji, A. Sasahara, M., Hattori, Y
  • Organizer: The 57th Annual Meeting of the Japanese Pharmacological Society, Northern Branch
  • Place of Presentation: Hirosaki
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] A study on proliferation, migration and apoptosis after PDGF-β knockout in dermal fibroblasts. (2005)
  • Author(s): 笹原正清
  • Organizer: 第94回日本病理学会総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The activation of ERK1/2 and JNK, but not p38, was attenuated after PDGFR-β depletion. (2005)
  • Author(s): Gao Z.
  • Organizer: 第94回日本病理学会総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Cre-loxPノックアウトシステムを用いた皮膚線維芽細胞におけるPDGFR-β機能の解析. (2005)
  • Author(s): 尾矢剛志
  • Organizer: 第37回日本結合組織学会学術大会
  • Place of Presentation: 富山
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Establishment of mutant mouse with neuron-specific PDGF receptor depletion. (2005)
  • Author(s): Sasahara M.
  • Organizer: 第28回日本神経科学大会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Systematic analyses Of retinas of transgenic mice overexpressing constitutively active form of CaM kinase II. (2005)
  • Author(s): Ichsan A. M.
  • Organizer: 日本生化学会大会
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Expression of constitutively active form of CaM kinase II in pancreatic beta cells of transgenic mice leads to severe diabetes mellitus. (2005)
  • Author(s): Kato I.
  • Organizer: 日本生化学会大会
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Neuronal accumulation of mutant neuroserpin and increased susceptibility to seizures in transgenic mice expressing FENIB-type neuroserpin. (2005)
  • Author(s): Takasawa K.
  • Organizer: 第78回日本生化学会大会
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing PAF-acetylhydrolase II(PAF-AH(II))in neurons. (2005)
  • Author(s): 梅村公子
  • Organizer: 第64回日本脳神経外科学会総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] A study on proliferation, migration and apoptosis after PDGF- β knockout in dermal fibroblasts (2005)
  • Author(s): Sasahara, M., Gao, Z., Sasaoka, T., Oya, T., Ishu, Y., Sabit, H., Ishizawa, S
  • Organizer: The 94th Annual Meeting of the Japan Society of Pathology
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The activation of ERK1/2 and JNK, but not p38, was attenuated after PDGFR- Q depletion (2005)
  • Author(s): Gao, Z., Sasahara, M., Sasaoka, T., Oya, T., Ishu, Y., Sabit, H., Ishizawa, S
  • Organizer: The 94th Annual Meeting of the Japan Society of Pathology
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The analysis of the PDGF- p function in fibroblasts using Cre-loxP knockout system (2005)
  • Author(s): Oya, T., Gao, Z., Ishu, Y., Sasaoka, T., Sabit, H., Tokunaga, A. Zheng, L., Ishizawa, S., Fujimori, T., Sasahara, M
  • Organizer: The 37th Annual Meeting of the Japanese Society for Connective Tissue Reseach
  • Place of Presentation: Toyama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Establishment of mutant mouse with neuron-specific PDGF receptor depletion (2005)
  • Author(s): Sasahara, M., Gao, Z., Oya, T., Ishii, Y., Sasaoka, T., Ishizawa, S., Matsushima, T., Kurashige, Y., Sabit, H., Zheng, L., Tokunaga, A. Fujimori, T
  • Organizer: The 28th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Systematic analyses Of retinas of transgenic mice overexpressing constitutively active form of CaM kinase II (2005)
  • Author(s): Ichsan, A.M., Kato, I., Oya, T., Sasahara, M., Takasawa, S., Okamoto, H., Hayasaka, S., Takasawa, K., Hiraga, K
  • Organizer: The78th the Japanese Biochemical Society
  • Place of Presentation: Kobe
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Expression of constitutively active form of CaM kinase II in pancreatic beta cells of transgenic mice leads to severe diabetes mellitus (2005)
  • Author(s): Kato, I., Hiraga, K., Oya, T., Sasahara, M., Takasaki, I., Tabuchi, Y., Takasawa, S., Okamoto, H
  • Organizer: The78th the Japanese Biochemical Society
  • Place of Presentation: Kobe
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Neuronal accumulation of mutant neuroserpin and increased susceptibility to seizures in transgenic mice expressing FENIB-type neuroserpin (2005)
  • Author(s): Takasawa, K., Takasawa, A. Kato, I., Ishu, Y., Sasahara, M., Hiraga, K
  • Organizer: The78th the Japanese Biochemical Society
  • Place of Presentation: Kobe
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing PAF-acetylhydrolase II(PAF-AH(II))in neurons (2005)
  • Author(s): Umemura, K., Hirashima, Y., Endo, S., Kawai, N., Inoue, T., Aoki, J., Arai, Y., Kuchi, H., Oda, M., Ishu, Y., Kato, I., Hiraga, K
  • Organizer: The 64th Annual Meeting of the Japan Neurosurgical Society
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Akt activation is attenuated after PDGFR-β knockout in fibroblast cells. (2004)
  • Author(s): Gzo Z.
  • Organizer: 第93回日本病理学会
  • Place of Presentation: 札幌
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Establishment of transgenic mice over-expressing mutant neuroserpin(G392E)in brain. (2004)
  • Author(s): 高澤久美
  • Organizer: 第77回日本生化学会大会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Expression analysis of ATBF1 and ZFH4, the zinc-finger and homeodomain family proteins(ZFH family proteins), in developing rat brains. (2004)
  • Author(s): Ishii Y.
  • Organizer: 日本神経科学会日本神経化学会合同大会
  • Place of Presentation: 大阪
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Akt activation is attenuated after PDGFR- β knockout in fibroblast cells (2004)
  • Author(s): Gao, Z., Ishii, Y., Oya, T., Takagawa, K., Kawaguchi, M., Sasaoka, T., Naito, M., Kobayashi, M., Sasahara, M
  • Organizer: The 93th Annual Meeting of the Japan Society of Pathology
  • Place of Presentation: Sapporo
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Establishment of transgenic mice over-expressing mutant neuroserpin(G392E)in brain. (2004)
  • Author(s): Takazawa, K., Takazawa, K., Kato, I., Ishii, Y., Sasahara, M., Hiraga, K
  • Organizer: The77th the Japanese Biochemical Society
  • Place of Presentation: Yokohama.
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Expression analysis of ATBF1 and ZFH4, the zinc-finger and homeodomain family proteins(ZFH family proteins), in developing rat brains (2004)
  • Author(s): Ishii, Y., Nogami, S., Kawaguchi, M., Oya, T., Sasahara, M
  • Organizer: Neuro. 2004(The 27th Annual Meeting of The Japan Neuroscience Society, The 47th Annual Meeting of the Japanese Society for Neurochemistry)
  • Place of Presentation: Osaka
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] Biophilia (2007)
  • Author(s): 笹原正清
  • Total Pages: 5
  • Publisher: アドスリー
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 脳と心の科学 (2006)
  • Author(s): 西条寿夫
  • Total Pages: 8
  • Publisher: 新興医学出版社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 生体の科学 (2005)
  • Author(s): 笹原正清
  • Total Pages: 4
  • Publisher: 医学書院
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 2.情動の神経機構.「Annual Review神経2004」 (2004)
  • Author(s): 堀 悦郎
  • Total Pages: 13
  • Publisher: 中外医学社
  • Description: 「研究成果報告書概要(和文)」より