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Construction of optimal combined chemotherapy of anti-tumor drugs based on chronotherapy

Research Project

Project/Area Number 16390159
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionKyushu University

Principal Investigator

HIGUCHI Shun  Kyushu University, Faculty of Pharmaceutical Sciences, Prof., 大学院・薬学研究院, 教授 (40218699)

Co-Investigator(Kenkyū-buntansha) OHDO Shigehiro  Kyushu University, Faculty of Pharmaceutical Sciences, Prof., 大学院・薬学研究院, 教授 (00223884)
TO Hideto  Kyushu University, Faculty of Pharmaceutical Sciences, Research Associate, 大学院・薬学研究院, 助手 (90346809)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥15,200,000 (Direct Cost: ¥15,200,000)
Fiscal Year 2005: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 2004: ¥10,800,000 (Direct Cost: ¥10,800,000)
Keywordsdosing schedule / chemotherapy / docetaxel / adriamycin / cisplatin / adverse effect / antitumor effect / decetaxel
Research Abstract

The purpose of this study was to establish the most suitable dosing-schedule (dosing-interval, dosing-sequence and dosing-time) to relieve severe adverse effects for a few combination of antitumor drugs.
1.combination of adriamycin (ADR) and docetaxel (DOC)
The DOC-ADR group in which ADR is administered at 12 h after DOC injection significantly reduces the leucopenia and body weight gain compared with all groups.
The therapeutic index of the combined chemotherapy can be improved by administering ADR and DOC at the time when the most adverse effects are relieved in each drug.
2.combination of cisplatin (CDDP) and docetaxel (DOC)
The intermittent dosing groups (ADR-DOC and DOC-ADR) were administered the second drug at 12 h after the first drug administration significantly reduces the side effects compared with the simultaneous dosing group (ADR/DOC) were both adriamycin (ADR) and docetaxel (DOC) were simultaneously administered.
3.combination of irinotecan hydrochloride (CPT-11) and docetaxel (DOC)
The combined chemotherapy was improved by administering CPT-11 and DOC at the time when the most adverse effects are relieved in each drug.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (9 results)

All 2006 2005

All Journal Article (9 results)

  • [Journal Article] 時間治療を加味した抗癌剤併用療法の構築に関する基礎的研究2006

    • Author(s)
      藤秀人
    • Journal Title

      薬学雑誌 (in press)

    • NAID

      110006154954

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Pharmacotherapy of anticancer drug depends on circadian rhythm.2006

    • Author(s)
      To H.
    • Journal Title

      Yakugaku Zasshi (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Therapeutic index by combination of adriamycin and docetaxel depends on dosing time in mice2005

    • Author(s)
      Tabuchi M., et al.
    • Journal Title

      Cancer Res. 65

      Pages: 8448-8454

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chronotherapy of Adriamycin in Japanese Outpatients with Mammary Cancer2005

    • Author(s)
      To H., et al.
    • Journal Title

      Drug in R&D 6

      Pages: 101-107

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 塩酸イリノテカンの時間薬理学的研究-骨髄抑制の日内変動に及ぼす時間制限摂食の影響2005

    • Author(s)
      秦天, et al.
    • Journal Title

      TDM研究 22

      Pages: 171-172

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Therapeutic index by combination of adriamycin and docetaxel depends on dosing time in mice2005

    • Author(s)
      Tabuchi M., To H., Sakaguchi H., Goto N., Takeuchi A., Higuchi S., Ohdo S.
    • Journal Title

      Cancer Res. 65

      Pages: 8448-8454

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chronotherapy of Adriamycin in Japanese Outpatients with Mammary Cancer2005

    • Author(s)
      To H., Saito T., Ohdo S., Higuchi S., Fujimura A., Kobayashi E.
    • Journal Title

      Drug in R&D 6

      Pages: 101-107

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chronotherapy of Irinotecan.2005

    • Author(s)
      Qin T, Goto N, To H, Tsuruta K, Ohdo S, Higuchi S.
    • Journal Title

      The Japanese Journal of Therapeutic Drug Monitoring 22

      Pages: 171-172

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Therapeutic index by combination of adriamycin and docetaxel depends on dosing time in mice2005

    • Author(s)
      Tabuchi M. et al.
    • Journal Title

      Cancer Res. 65

      Pages: 8448-8454

    • Related Report
      2005 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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