| Project/Area Number |
16390164
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
OKABE Hidetoshi Shiga University of Medical Science, Department of Clinical Labaratory Medicine, Professor (70079713)
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| Co-Investigator(Kenkyū-buntansha) |
CHANO Tokuhiro Shiga University of Medical Science, Department of Clinical Laboratory Medicine, Assistant Professor (40346028)
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| Project Period (FY) |
2004 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥14,940,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥840,000)
Fiscal Year 2007: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2006: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2004: ¥3,700,000 (Direct Cost: ¥3,700,000)
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| Keywords | RB1CC1 / mTOR / RB1 / p53 / cancer / Alzheimer / TSC / hSNF5 / INT1 / hSNF / RB / neuron / degenerative disease / siRNA / DNA methylation / in situ hybridization / immunohistochemistry |
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| Research Abstract |
To clarify the molecular status of RB1CC1 (RB1-inducible coiled-coil 1) in various human diseases, we started this project, and have intended to apply the molecular pathways into clinical medicine.
In a consequence, we identified that RB1CC1 insufficiency resulted in mTOR signaling repression through unbalanced TSC1 abundance, induced neuronal atrophy, and then were involved in the pathogenesis of Alzheimer's disease.
More recently, our study also has demonstrated that RB1CC1 is a novel mediator connecting the RB1 and p53 pathways, and that the combined evaluation of RB1CC1 and p53 status will provide a routine, accurate prognostic test for patients with breast cancer.
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