| Project/Area Number |
16390165
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
HAMASAKI Naotaka KYUSHU UNIVERSITY, Graduate School of Medical Sciences, Professor, 大学院・医学研究院, 教授 (00091265)
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| Co-Investigator(Kenkyū-buntansha) |
ABE Yoshito KYUSHU UNIVERSITY, Graduate School of Pharmaceutical Sciences, Assistant Professor, 大学院・薬学研究院, 助教授 (60315091)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥14,300,000 (Direct Cost: ¥14,300,000)
Fiscal Year 2005: ¥6,900,000 (Direct Cost: ¥6,900,000)
Fiscal Year 2004: ¥7,400,000 (Direct Cost: ¥7,400,000)
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| Keywords | Deep vein thrombosis / protein S gene mutation / protein C gene mutation / factor V Leiden / Javanese thrombophilia / protein S_<Tokushima> / 血栓性素因 / 血栓症 / プロテインC / プロテインS / 分子異常性 / 血栓症治療薬 |
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| Research Abstract |
Coagulation factor V Leiden has not been detected in Japanese patients suffering from thromboses. We have performed a systematic investigation to find out genetic risk factors for thromboses in Japanese population. Our study indicates that the frequency (19/85=0.22) of mutations of protein S gene in the Japanese patients was 5-10 times higher than that of mutations of protein S gene in Caucasian patients, and the frequency (8/85=0.09) of mutations of protein C gene was almost three times higher than that of Caucasian patients, suggesting that Protein S/Protein C anomaly is the major risk factor for Japanese thrombophilia. During this study, we established a new quantitative method for Protein S/Protein C function. In addition, we found special components, which activate Protein S/Protein C activities. Now, we have tried to apply these components for the treatment of thromboses.
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