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Epidemiologic study of the association between job stress and cancer incidence and its mechanisms

Research Project

Project/Area Number 16390170
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionThe University of Tokyo (2006-2007)
Okayama University (2004-2005)

Principal Investigator

KAWAKAMI Norito  The University of Tokyo, Graduate School of Medicine, Professor (90177650)

Co-Investigator(Kenkyū-buntansha) TSUTSUMI Akizumi  University of Occupational and Environmental Medicine, Occupational Health Training Center, Professor (10289366)
SHIMAZU Akihito  The University of Tokyo, Graduate School of Medicine, Associate Professor (80318724)
廣川 空美 (廣川 空実)  岡山大学, 大学院・医歯薬学総合研究科, 助教 (50324299)
高尾 総司  岡山大学, 大学院・医歯薬学総合研究科, 助手 (50335626)
津田 敏秀  岡山大学, 大学院・医歯学総合研究科, 講師 (20231433)
中田 光紀  独立行政法人産業医学総合研究所, 研究官 (80333384)
Project Period (FY) 2004 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥15,130,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥630,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2006: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2005: ¥5,400,000 (Direct Cost: ¥5,400,000)
Fiscal Year 2004: ¥4,500,000 (Direct Cost: ¥4,500,000)
Keywordscancer / incidence / risk factor / stress / immune function / healthy lvfestvle / 全がん / コホート研究 / 質問票 / 産業保健 / 作業環境 / 要求度-コントロールモデル
Research Abstract

The present study project investigated the association between job stressors and cancer incidence, as well as its mechanisms, by conducting two prospective cohort studies (old and new cohort studies) and smaller prospective and cross-sectional epidemiologic studies on the mediators between job stressors and cancer incidence (physiological parameters, such as immune functions, oxidative DNA damage, and health-related behaviors such as diet).
The project tested the following associations: (1) the association of job stressors based on the two major theories of job stress, i.e., "demand-control-support model" and "effort-reward imbalance model", with all cancer incidence (as well as site-specific cancer incidences), (2) the association of other psychosocial factors at work with all cancer incidence, and (3) the association of the job stressors with physiological parameters (immune functions, oxidative DNA damage) and health-related behaviors (smoking, drug, and diet).
As the results of the present research project, it is suggested that the job stressors increase the all-cancer incidence. Part of the association seems to be explained by oxidative DNA damage caused by the job stressors. Diet and other health-related behaviors may not play a major role in connecting the job stressors and cancer incidence.

Report

(5 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (46 results)

All 2008 2007 2006 2005 2004 Other

All Journal Article (41 results) (of which Peer Reviewed: 13 results) Presentation (3 results) Remarks (2 results)

  • [Journal Article] 産業ストレスの第一次予防対策:科学的根拠の現状とその応用2008

    • Author(s)
      川上憲人, 島津明人, 土屋政雄, 堤明純
    • Journal Title

      産業医学レビュー 20

      Pages: 175-195

    • NAID

      40015850765

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 国内外の産業医学に関する文献紹介-企業における組織的公正とその健康影響2008

    • Author(s)
      井上彰臣, 土屋政雄、川上憲人
    • Journal Title

      産業医学ジャーナル 31(2)

      Pages: 132-135

    • NAID

      40015893408

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Job strain and smoking cessation among Japanese male employees: A two-year follow-up study.2008

    • Author(s)
      Fukuoka E, Hirokawa K, Kawakami N, Tsuchiya M, Haratani T, Kobayashi F, Araki s, Doi H
    • Journal Title

      Acta Med Okayama 62(2)

      Pages: 83-91

    • NAID

      120002305325

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A Cross-national study on the multidimensional characteristics of the five-item psychological demands scale of the Job Content Questionnaire.2008

    • Author(s)
      Choi BY, Kawakami N, Chang SJ, Koh SB, Bjomer J, Punnett L, Karasek R.
    • Journal Title

      International Journal of Behavioral Medicine 15

      Pages: 1-13

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A Cross-national study on the multidimensional characteristics of the five-item psychological demands scale of the Job Content Questionnaire2008

    • Author(s)
      Choi BK, Kawakami N, Chang SJ, Koh SB, Bjorner J, Punnett L, Karasek R
    • Journal Title

      International Journal of Behavioral Medicine 15

      Pages: 1-13

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Job strain and smoking cessation among Japanese male employees : Atwo-year follow-up study2008

    • Author(s)
      Fukuoka E, Hirokawa K, Kawakami N, Tsuchiya M, Haratani T, Kobayashi F, Araki S, Doi H
    • Journal Title

      Acta Med Okayama 62(2)

      Pages: 83-91

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The primary prevention of job stress : Current status of scientific evidence and its application in practice2008

    • Author(s)
      Kawakami N, Shimazu A, Tsuchiya M, Tsutsumi A
    • Journal Title

      Sangyo Igaku Review 20

      Pages: 175-195

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Organizational justice at work and its adverse health effects2008

    • Author(s)
      Inoue A, Tsuchiya M, Kawakami N
    • Journal Title

      Sangyo Igaku Journal 31(2)

      Pages: 132-135

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 産業ストレスの第一次予防対策:科学的根拠の現状とその応用2008

    • Author(s)
      川上 憲人, 島津 明人, 土屋 政雄, 堤 明純
    • Journal Title

      産業医学レビュー 20

      Pages: 175-195

    • NAID

      40015850765

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 国内外の産業医学に関する文献紹介-企業における組織的公正とその健康影響2008

    • Author(s)
      井上 彰臣, 土屋 政雄, 川上 憲人
    • Journal Title

      産業医学ジャーナル 31(2)

      Pages: 132-135

    • NAID

      40015893408

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Age standardized cancer mortality ratios in areas heavily exposed to methyl mercury.2007

    • Author(s)
      Yorifuji T, Tsuda T, Kawakami N.
    • Journal Title

      Int Arch Occup Environ Health. 80(8)

      Pages: 679-688

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Association between job stressors and heavy drinking: age differences in male Japanese workers.2007

    • Author(s)
      Hiro H, Kawakami N, Tanaka K, Nakamura K; Japan Work Stress and Health Cohort Study Croup.
    • Journal Title

      Ind Health. 45(3)

      Pages: 415-425

    • NAID

      40015480170

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The immediate effects of 10-minute relaxation training on salivary immunoglob A (s-IgA) and mood state for Japanese female medical co-workers2007

    • Author(s)
      Taniguchi T, Hirokawa K, Tsuchiya M, Kawakami N
    • Journal Title

      Acta Med Okayama 61(3)

      Pages: 139-145

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Japan Work Stress and Health Cohort Study Group. Association between job stressors and heavy drinking : age differences in male Japanese workers2007

    • Author(s)
      Hiro H, Kawakami N, Tanaka K, Nakamura K
    • Journal Title

      Ind Health 45(3)

      Pages: 415-425

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Age standardized cancer mortality ratios in areas heavily exposed to methyl mercury2007

    • Author(s)
      Yorifuji T, Tsuda T, Kawakami N
    • Journal Title

      Int Arch Occup Environ Health 80(8)

      Pages: 679-688

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The immediate effects of 10-minute relaxation training on salivary immunoglobulin A (s-IgA) and mood state for Japanese female medical co-workers2007

    • Author(s)
      Taniguchi T, Hirokawa K, Tsuchiya M, Kawakami N
    • Journal Title

      Acta Med Okayama 61(3)

      Pages: 139-145

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The immediate effects of 10-minute relaxation training on salivary immunoglovulin A(s-IgA) andmood state for japanese female medical co-workers2007

    • Author(s)
      Taniguchi T, Hirokawa K, Tsuchiya M, Kawakami N
    • Journal Title

      Acta Med Okayama 61(3)

      Pages: 139-145

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between job stressors and heavy drinking: age differences in male Japanese workers.2007

    • Author(s)
      Hiro H, Kawakami N, Tanaka K, Nakamura K: Japan Work Stress and Health Cohort Study Group.
    • Journal Title

      Industrial Health 45(3)

      Pages: 415-425

    • NAID

      40015480170

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Age standardized cancer mortality ratios in areas heavily exposed to methyl mercury2007

    • Author(s)
      Yorifuji T, Tsuda T, Kawakami N.
    • Journal Title

      International Archives of Occupational and Environmental Health 80

      Pages: 679-688

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Associations of health behaviors on depressive symptoms among employed men in Japan.2006

    • Author(s)
      Wada K, Satoh T, Tsunoda M, Aizawa Y; Japan Work Stress and Health Cohort Study Group.
    • Journal Title

      Ind Health. 44(3)

      Pages: 486-492

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Job Strain, worksite support, and nutrient intake among employed Japanese men and women.2006

    • Author(s)
      Kawakami N, Tsutsumi A, Haratani T, et. al.
    • Journal Title

      Journal of Epidemiology. 16(2)

      Pages: 79-89

    • NAID

      10017969799

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Psychosocial work characteristics and sickness absence in Japanese employees.2006

    • Author(s)
      Ishizaki M, Kawakami N, Honda R, et. al.
    • Journal Title

      Int Arch Occup Environ Health 79(8)

      Pages: 640-646

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Job strain and sick leave among Japanese employees: a longitudinal study.2006

    • Author(s)
      Kondo K, Kobayashi Y, Hirokawa K, Tsutsumi A, Kobayashi F, Haratani T, Araki S, Kawakami N.
    • Journal Title

      nt Arch Occup Environ Health. 79(3)

      Pages: 213-219

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Job strain and sick leave among Japanese employees : a longitudinal study2006

    • Author(s)
      Kondo K, Kobayashi Y, Hirokawa K, Tsutsumi A, Kobayashi F, Haratani T, Araki S, Kawakami N
    • Journal Title

      Int Arch Occup Environ Health 79(3)

      Pages: 213-219

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Japan Work Stress and Health Cohort Study Group. Psychosocial work characteristics and sickness absence in Japanese employees2006

    • Author(s)
      Ishizaki M, Kawakami N, Honda R, Nakagawa H, Morikawa Y, Yamada Y
    • Journal Title

      Int Arch Occup Environ Health 79(8)

      Pages: 640-646

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Job strain, worksite support, and nutrient intake among employed Japanese men and women2006

    • Author(s)
      Kawakami N, Tsutsumi A, Haratani T, Kobayashi F, Ishizaki M, Hayashi T, Fujita O, Aizawa Y, Miyazaki S, Hiro H, Masumoto T, Hashimoto S, Araki S
    • Journal Title

      J Epidemiol 16(2)

      Pages: 79-89

    • NAID

      10017969799

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Japan Work Stress and Health Cohort Study Group. Associations of health behaviors on depressive symptoms among employed men in Japan2006

    • Author(s)
      Wada K, Satoh T, Tsunoda M, Aizawa Y
    • Journal Title

      Ind Health 44(3)

      Pages: 486-492

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Job Strain, worksite support, and nutrient intake among employed Japanese men and women.2006

    • Author(s)
      Kawakami N, Tsutsumi A, Haratani T, et al.
    • Journal Title

      Journal of Epidemiology. 16(2)

      Pages: 79-89

    • NAID

      10017969799

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Psychosocial work characteristics and sickness absence in Japanese employees.2006

    • Author(s)
      Ishizaki M, Kawakami N, Honda R, et al.
    • Journal Title

      Int Arch Occup Environ Health (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Job strain and sick leave among Japanese employees : a longitudinal study.2006

    • Author(s)
      Kondo K, Kobayashi Y, Hirokawa K, Tsutsumi A, Kobayashi F, Haratani T, Araki S, Kawakami N.
    • Journal Title

      Int Arch Occup Environ Health. 79(3)

      Pages: 213-219

    • Related Report
      2005 Annual Research Report
  • [Journal Article] What accounts for the relationship between social class and smoking cessation? Results of a path analysis.2006

    • Author(s)
      Honjo K, Tsutsumi A, Kawachi I, Kawakami N.
    • Journal Title

      Soc Sci Med. 62(2)

      Pages: 317-328

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Relationship between two job stress models and coronary risk factors among Japanese part-time female employees of a retail company.2005

    • Author(s)
      Kobayashi Y, Hirose T, Tada Y, Tsutsumi A, Kawakami N.
    • Journal Title

      J. Occup Health. 47(3)

      Pages: 201-210

    • NAID

      110003723266

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Relationship between two job stress models and coronary risk factors among Japanese part-time female employees of a retail company2005

    • Author(s)
      Kobayashi Y, Hirose T, Tada Y, Tsutsumi A, Kawakami N
    • Journal Title

      J Occup Health 470

      Pages: 201-210

    • NAID

      110003723266

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Relationship between two job stress models and coronary risk factors among Japanese part-time female employees of a retail company.2005

    • Author(s)
      Kobayashi Y, Hirose T, Tada Y, Tsutsumi A, Kawakami N.
    • Journal Title

      J Occup Health. 47(3)

      Pages: 201-210

    • NAID

      110003723266

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Occupational class and exposure to job stressors among employed men and women in Japan.2004

    • Author(s)
      Kawakami N, Haratani T, Kobayashi F, Ishizaki M, Hayashi T, Fujita O, Aizawa Y, Miyazaki S, Hiro H, Masumoto T, Hashimoto S, Araki S.
    • Journal Title

      J. Epidemiol. 14(6)

      Pages: 204-211

    • NAID

      10014043987

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Work-related factors associated with visiting a doctor for a medical diagnosis after a worksite screening for diabetes mellitus in Japanese male employees.2004

    • Author(s)
      Tsuda K, Tsutsumi A, Kawakami N.
    • Journal Title

      J. Occup Health. 46(5)

      Pages: 374-381

    • NAID

      110003723221

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Occupational class and exposure to job stressors among employed men and women in Japan2004

    • Author(s)
      Kawakami N, Haratani T, Kobayashi F, Ishizaki M, Hayashi T, Fujita O, Aizawa Y, Miyazaki S, Hiro H, Masumoto T, Hashimoto S, Araki S
    • Journal Title

      J Epidemiol 14(6)

      Pages: 204-211

    • NAID

      10014043987

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Work-related factors associated with visiting a doctor for a medical diagnosis after a worksite screening for diabetes mellitus in Japanese male employees2004

    • Author(s)
      Tsuda K, Tsutsumi A, Kawakami N
    • Journal Title

      J Occup Health 46(5)

      Pages: 374-381

    • NAID

      110003723221

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Occupational Class and Exposure to Job Stressors among Emploved Men and Women in Japan2004

    • Author(s)
      Kawakami N, Haratani T, Kobayashi F. et al.
    • Journal Title

      Journal of Epidemiology 14(6)

      Pages: 204-211

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Work-related factors associated with visiting a doctor for a medical diagnosis after a worksite screening for diabetes2004

    • Author(s)
      Tsuda K, Tsutsumi A, Kawakami N
    • Journal Title

      Journal of Occupational Health 46(5)

      Pages: 374-381

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A Cross-National Study on the Multidimensional Characteristics of the Five-Item Psychological Demands Scale of the Job Content Questionnaire.

    • Author(s)
      Choi BK, Kawakami N, Chang SJ, Koh SB, Bjorner J, Punnett L, Karasek R.
    • Journal Title

      International Journal of Behavioral Medicine (in press)

    • Related Report
      2006 Annual Research Report
  • [Presentation] Supervisor Training and Mental Health among Workers : A Critical Review2008

    • Author(s)
      Kawakami N, Tsutsumi A, Shimazu A
    • Organizer
      The 7th International Conference on Occupational Stress & Health
    • Place of Presentation
      Washington DC
    • Year and Date
      2008-06-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Supervisor Training and Mental Health among Workers: A Critical Review2008

    • Author(s)
      Kawakami N, Tsutsumi A, Shimazu A
    • Organizer
      The 7th International Conference on Occupationa Stress & Health
    • Place of Presentation
      ワシントンDC(米国)
    • Year and Date
      2008-03-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Supervisor Training and Mental Health among Workers:A Critical Review2008

    • Author(s)
      Kawakami N, Tsutsumi A, Shimazu A
    • Organizer
      The 7th International Conference on Occupational Stress&Health
    • Place of Presentation
      ワシントンDC(米国)
    • Year and Date
      2008-03-06
    • Related Report
      2007 Annual Research Report
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.jstress.net

    • Related Report
      2007 Final Research Report Summary
  • [Remarks]

    • URL

      http://www.jstress.net

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2004-04-01   Modified: 2016-04-21  

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