| Project/Area Number |
16390181
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Mie University |
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Principal Investigator |
YOKOYAMA Kazuhito Mie University, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (00158370)
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| Co-Investigator(Kenkyū-buntansha) |
NASU Tamie Nagoya University, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (10020794)
ISHIKAWA Hitoshi Yamagata University, Graduate School of Medicine, Associate Professor, 大学院医学系研究科, 助教授 (50250915)
ENDOU Youko Mie University, School of Medicine, Part-time Lecturer, 医学部, 非常勤講師 (50193438)
KITAMURA Humihiko Mie University, Graduate Sshool of Medicine, Assistant Professor, 大学院医学系研究科, 講師 (20301145)
KAWANO Mitsuo Mie University, Graduate Sshool of Medicine, Assistant Professor, 大学院医学系研究科, 講師 (00234097)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2005: ¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 2004: ¥9,100,000 (Direct Cost: ¥9,100,000)
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| Keywords | Chemical substance / Health effects / Neuro behavioral medicine / Neuro physiology / Micro nuclei test / DNA addict / Polymor phism / P450 / NA付加体 |
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| Research Abstract |
Subjects in the development building of sick house, and workers with chemical exposures were surveyed for the purpose of clarifying the gene cluster relevant to the individual differences of the sensibility. Investigation items were neurophysiological and behavioral changes as well as genotoxicitic effects (micro nuclei test). The gene clusters made into the object of analysis by this research were those belonging to the sub family of the cytochrome P-450 in connection with chemicals metabolism, and a DNA repair genes which participates in restoration of DNA damaged by chemicals exposure. This aimed at construction of the monitoring system which can judge synthetically the individual differences of the sensibility about effects of chemicals. That is, it was analyzed synthetically how a gene pleiotype factor would be concerned with change (individual differences of sensibility) of an exposure index, or a neurotoxicity and a genetic toxicity influence index, making full use of the mathematical statistics-procedure. Report were performed at scientific meetings, while creating the original paper to the international journals. The above results were summarized for the result report (booklet object).
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