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Individual susceptibility to chemical substances

Research Project

Project/Area Number 16390181
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionMie University

Principal Investigator

YOKOYAMA Kazuhito  Mie University, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (00158370)

Co-Investigator(Kenkyū-buntansha) NASU Tamie  Nagoya University, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (10020794)
ISHIKAWA Hitoshi  Yamagata University, Graduate School of Medicine, Associate Professor, 大学院医学系研究科, 助教授 (50250915)
ENDOU Youko  Mie University, School of Medicine, Part-time Lecturer, 医学部, 非常勤講師 (50193438)
KITAMURA Humihiko  Mie University, Graduate Sshool of Medicine, Assistant Professor, 大学院医学系研究科, 講師 (20301145)
KAWANO Mitsuo  Mie University, Graduate Sshool of Medicine, Assistant Professor, 大学院医学系研究科, 講師 (00234097)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2005: ¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 2004: ¥9,100,000 (Direct Cost: ¥9,100,000)
KeywordsChemical substance / Health effects / Neuro behavioral medicine / Neuro physiology / Micro nuclei test / DNA addict / Polymor phism / P450 / NA付加体
Research Abstract

Subjects in the development building of sick house, and workers with chemical exposures were surveyed for the purpose of clarifying the gene cluster relevant to the individual differences of the sensibility. Investigation items were neurophysiological and behavioral changes as well as genotoxicitic effects (micro nuclei test). The gene clusters made into the object of analysis by this research were those belonging to the sub family of the cytochrome P-450 in connection with chemicals metabolism, and a DNA repair genes which participates in restoration of DNA damaged by chemicals exposure. This aimed at construction of the monitoring system which can judge synthetically the individual differences of the sensibility about effects of chemicals. That is, it was analyzed synthetically how a gene pleiotype factor would be concerned with change (individual differences of sensibility) of an exposure index, or a neurotoxicity and a genetic toxicity influence index, making full use of the mathematical statistics-procedure. Report were performed at scientific meetings, while creating the original paper to the international journals. The above results were summarized for the result report (booklet object).

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (45 results)

All 2006 2005 2004 Other

All Journal Article (45 results)

  • [Journal Article] Lead and other trace metals in preeclampsia : a case-control study in Tehran, Iran.2006

    • Author(s)
      Vigeh, M.
    • Journal Title

      Environmental Research 100

      Pages: 268-275

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Gene-environmental interactions between alcohol-drinking behavior and ALDH2 and CYP2El polymorphisms and their impact on micronuclei frequency in human lymphocytes.2006

    • Author(s)
      Ishikawa, H.
    • Journal Title

      Mutation Research 594

      Pages: 1-9

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Relationship between fetal weight, placental growth and litter size in mice from mid-to late-gestation.2006

    • Author(s)
      Ishikawa, H.
    • Journal Title

      Reproductive Toxicology 21

      Pages: 267-270

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Relationships of eating disturbances to alexithymia, need for social approval, and gender identity among Japanese female undergraduate students.2006

    • Author(s)
      Kiyotaki, y.
    • Journal Title

      Personality and Individual Differences 41

      Pages: 609-618

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Decreases in CD8+T, na□ve(CD4+CD45RA+)T, and B(CD19+) lymphocytes by exposure to manganese fume.2006

    • Author(s)
      Nakata, A.
    • Journal Title

      Industtrial Health 44

      Pages: 592-597

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Gene-environmental interactions between alcohol-drinking behavior and ALDH2 and CYP2E1 polymorphisms and their impact on micronuclei frequency in human lymphocytes.2006

    • Author(s)
      Ishikawa, H.
    • Journal Title

      Mutation Research 594

      Pages: 1-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Relationship between fetal weight, placental growth and litter size inmice frommid-to late-gestation.2006

    • Author(s)
      Ishikawa, H.
    • Journal Title

      Reproductive Toxicology 21

      Pages: 267-270

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Decreases in CD8+T, nave (CD4+CD45RA+) T, and B (CD19+) lymphocytes by exposure to manganese fume.2006

    • Author(s)
      Nakata, A.
    • Journal Title

      Industtrial Health 44

      Pages: 592-597

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Decreases in CD8+T, na□ve (CD4+CD45RA+) T, and B (CD19+) lymphocytes by exposure to manganese fume.2006

    • Author(s)
      Nakata, A.
    • Journal Title

      Industtrial Health 44

      Pages: 592-597

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of pesticides on the peripheral and central nervous system in tobacco farmers in Malaysia : studies on peripheral nerve conduction, brain-evoked potentials and computerized posturography2005

    • Author(s)
      Kimura, K.
    • Journal Title

      Industrial Health 43

      Pages: 285-294

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Teratogenecity and developmental toxicity of chlorpyrifos : maternal exposure during organogenesis in mice.2005

    • Author(s)
      Tian, Y.
    • Journal Title

      Reproductive Toxicology 20

      Pages: 267-271

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Music can enhance exercise-induced sympathetic dominancy assessed by heart rate variability.2005

    • Author(s)
      Urakawa, K.
    • Journal Title

      Tohoku Journal of Experimental Medicine 206

      Pages: 213-218

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Effect of tri-o-cresyl phosphate pretreatment on high-affinity bind of diisopropyfluorophosphate to membrane-bound proteins of the chicken spinal cord.2005

    • Author(s)
      Piao, F.
    • Journal Title

      Journal of Dalian Medical University 27

      Pages: 249-252

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Oxidative DNA damage in relation to neurotoxicity in the brain of mice exposed to arsenic at environmental relevant levels.2005

    • Author(s)
      Piao, F.
    • Journal Title

      Journal of Occupational Health 47

      Pages: 445-449

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Effects of pesticides on the peripheral and central nervous system in tobacco farmers in Malaysia : studies on peripheral nerve conduction, brain-evoked potentials and computerized posturography.2005

    • Author(s)
      Kimura, K.
    • Journal Title

      Industrial Heal th 43

      Pages: 285-294

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Teratogenecity and developmental toxicity of chlorpyrifos : maternal exposure during organogenes is in mice.2005

    • Author(s)
      Tian, Y.
    • Journal Title

      Reproductive Toxicology 20

      Pages: 267-271

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Oxidative DNA damage in relation to neurotoxicity in the brain of mice exposed to arsenic at environmental relevant levels.2005

    • Author(s)
      Piao, F.
    • Journal Title

      Journal of Occupational Heal th 47

      Pages: 445-449

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of pesticides on the peripheral and central nervous system in tobacco farmers in Malaysia : studies on peripheral nerve conduction, brain-evoked potentials and computerized posturography.2005

    • Author(s)
      Kimura, K.
    • Journal Title

      Industrial Health 43

      Pages: 285-294

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Evidence of association of the CYP2E1 genetic polymorphism with micronuclei frequency in human peripheral blood2004

    • Author(s)
      Ishikawa, H.
    • Journal Title

      Mutation Research 546

      Pages: 45-53

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Differential regulation of apoptosis in the corpus luteum of pregnancy and newly formed corpus luteum after parturition in rats2004

    • Author(s)
      Takiguchi, S.
    • Journal Title

      Biology of Reproduction 70

      Pages: 313-318

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Effects of urbanization, economic development, and migration of workers on suicide mortality in Japan2004

    • Author(s)
      Otsu, A.
    • Journal Title

      Social Science & Medicine 58

      Pages: 1137-1146

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of predonisolone and complex of vitamin B1, B2, B6 and B12 on organophosphorus compound-induced delayed neurotoxicity2004

    • Author(s)
      Piao, F.
    • Journal Title

      Journal of Occuaptional Health 46

      Pages: 359-364

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Can relaxation programs with music enhance human immune function?2004

    • Author(s)
      Urakawa, K.
    • Journal Title

      Journal of Alternative and Complementary Medicine 10

      Pages: 597-598

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Effects of static load on the weight and protein content in the muscles of the mouse : a simulation of prolonged standing in the workplace2004

    • Author(s)
      Ueno, S.
    • Journal Title

      Industrial Health 42

      Pages: 401-407

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Relationship between increased blood lead and pregnancy hypertension in women without occupational lead exposure, Tehran Iran2004

    • Author(s)
      Vigeh, M.
    • Journal Title

      Archives of Environmental Health 59

      Pages: 70-75

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Evidence of association of the CYP2E1 genetic polymorphism withmicronuclei frequency in human peripheral blood2004

    • Author(s)
      Ishikawa, H.
    • Journal Title

      Mutation Research 546

      Pages: 45-53

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Differential regulation of apoptosisin the corpus luteum of pregnancy and newly formedcorpus luteum after parturition in rats2004

    • Author(s)
      Takiguchi, s.
    • Journal Title

      Biology of Reproduction 70

      Pages: 313-318

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of predonisolone and complex of vitamin B1, B2, B6 and B12 on organophosphorus compound-induced delayed neurotoxicity2004

    • Author(s)
      Piao, F.
    • Journal Title

      Journal of Occuaptional Heal th 46

      Pages: 359-364

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Can relaxation programs with music enhance human immune function?2004

    • Author(s)
      Urakawa, K.
    • Journal Title

      Journal of Al ternative and Complementary Medicine 10

      Pages: 597-598

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of static load on the weight and protein content in the muscles of the mouse : a simulation of prolonged standing in the workplace2004

    • Author(s)
      Ueno, S.
    • Journal Title

      Industrial Heal th 42

      Pages: 401-407

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of urbanization, economic development, and migration of workers on suicide mortality in Japan2004

    • Author(s)
      Otsu, A.
    • Journal Title

      Social Science & Medicine 58

      Pages: 1137-1146

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of predonisolone and complex of vitamin B1,B2,B6 and B12 on organophosphorus compound-induced delayed neurotoxicity2004

    • Author(s)
      Piao, F.
    • Journal Title

      Journal of Occuaptional Health 46

      Pages: 359-364

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Genotoxic damage in female residents exposed to environmental air pollution in Shenyang city, China.

    • Author(s)
      Ishikawa, H.
    • Journal Title

      Cancer Letters (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A polymorphism of the methionine synthase reductase gene increases chromosomal damage in peripheral lymphocytes in smokers.

    • Author(s)
      Ishikawa, H.
    • Journal Title

      Mutation Research (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The association between risk factors and low back pain among commercial vehicle driver in peninsular Malaysia : apreliminary result.

    • Author(s)
      Tamrin, S. B. M.
    • Journal Title

      Industrial Health (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Our recent experiences with sarin poisoning cases in Japan and pesticide users with references to some selected chemicals.

    • Author(s)
      Yokoyama, K.
    • Journal Title

      Neurotoxicology (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Genotoxic damage in female residents exposed to environmental air pollution in Shenyang city, China.

    • Author(s)
      Ishikawa, H.
    • Journal Title

      Cancer Letters (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A polymorphism of the methionine synthase reductase gene increases chromosomal damage in peripheral lymphocytes in smokers.

    • Author(s)
      Ishikawa, H.
    • Journal Title

      Mutation Research (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The association between risk factors and low back pain among commercial vehicle drivers in Peninsular Malaysia : a preliminary result.

    • Author(s)
      Tamrin, S. B. M.
    • Journal Title

      Industrial Health (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Our recent experiences with sarin poisoning cases in Japan and pesticide users with references to some selected chemicals.

    • Author(s)
      Yokoyama, K.
    • Journal Title

      Neurotoxicology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Genotoxic damage in female residents exposed to environmental air pollution in Shenyang city, China.

    • Author(s)
      Ishikawa, H.
    • Journal Title

      Cancer Letters (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A polymorphism of the methionine synthase reductase gene increases chromosomal damage in peripheral lymphocytes in smokers.

    • Author(s)
      Ishikawa, H.
    • Journal Title

      Mutation Research (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The association between risk factors and low back pain among commercial vehicle drivers in Peninsular Malaysia : a preliminary result.

    • Author(s)
      Tamrin, S. B. M.
    • Journal Title

      Industrial Health (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Our recent experiences with sarin poisoning cases in Japan and pesticide users with references to some selected chemicals.

    • Author(s)
      Yokoyama, K.
    • Journal Title

      Neurotoxicology (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Relationship between increased blood lead and pregnancy hypertension in women without occupational lead exposure, Tehran Iran

    • Author(s)
      Vigeh, M.
    • Journal Title

      Archives of Environmental Health (in press)

    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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